Yu dɔn ɛva gɛt prɔblɛm fɔ kɔntrol yu kɔlɔstrel, pan ɔl we yu dɔn tray difrɛn mɛrɛsin dɛn, it, ɛn ɛksesaiz? Sɔntɛnde, i kin apin. Dis kin tranga mɔ we yu gɛt bɔku bɔku kɔlɔstrel na yu famili. Tide, wi de tɔk bɔt wan nyu klas fɔ drɔgs we kin ɛp. Dɛn kɔl dɛn tin ya PCSK9 inhibito dɛn.
Wetin na dɛn PCSK9 Inhibitors ya?
Fɔ tɔk am simpul wan, dɛn tin ya na pawaful mɛrɛsin dɛn we de mek pɔsin nɔ gɛt bɔku kɔlɔstrel, we dɛn kin gi as injɛkshɔn. dεn de fכs t כk bכt LDL kכlestכl (Low-Density Lipoprotein Cholesterol) , di "bad kכlestכl" we wi כl no se i bad fכ wi bכdi. Dɔktɔ dɛn kin gi dɛn mɛrɛsin ya to pipul dɛn we nɔ bin dɔn gɛt di tin dɛn we dɛn want frɔm ɔda mɛrɛsin dɛn we gɛt kɔlɔstrel, lɛk statin, ɔ pipul dɛn we gɛt bɔku kɔlɔstrel na dɛn famili.
Aw dis mɛrɛsin de wok insay di bɔdi?
Fɔ ɔndastand dis, lɛ wi tek wan smɔl ɛgzampul. Imajin se di bad kɔlɔstrel (LDL) we de na yu blɔd na wan kayn dɔti. Fɔ pul dis dɔti ɛn klin di blɔd, wi liva gɛt spɛshal "garbage can" na in fes. Dis na wetin wi kin kɔl LDL rεsεpכ ta dεm pan mεdikal . wetin dεn rεsεpכta dεm ya de du na fכ kech di LDL kכlestכl we de insay di bכdi εn tek am insay di liva fכ pwεl am.
Naw, na wan ɔda wan de kam. Dat na wan prɔtin we dɛn kɔl PCSK9 . Na wi liva de mek bak dis. bכt di wok we dis PCSK9 protin de du na fכ pwεl di LDL rεsεpכta dεm (wi dכti kan) we de pul kכlestכl. we di lεvεl fכ PCSK9 inkrεs na di bכdi, bכku LDL rεsεpכta dεm de dכn. Dɔn di we aw dɛn kin pul di kɔlɔstrel na di blɔd kin go dɔŋ, ɛn di kɔlɔstrel we de na di blɔd kin go ɔp.
So, wetin di PCSK9 inhibito vaksin de du na fכ blכk da dεstruktiv PCSK9 protin de εn stכp am fכ wok. Dɔn wi LDL riseptɔ dɛn nɔ de pwɛl, ɛn dɛn kin wok fri wan. Di rizulyt na dat, dɛn kin pul mɔ LDL kɔlɔstrel na di blɔd, ɛn di kɔlɔstrel lɛvɛl kin ridyus bad bad wan. I rili simpul, nɔto so?
Udat dɛn kin advays dis mɛrɛsin fɔ?
Dis nɔto wan saiz mɛrɛsin we pɔsin kin gɛt. Yu dɔktɔ go disayd if dis mɛrɛsin fayn fɔ yu bay sɔm tin dɛn.
| Pozishɔn | Tɔk bɔt |
|---|---|
| Ay kɔlɔstrel we ɔda mɛrɛsin nɔ de kɔntrol | If yu LDL lɛvɛl stil ay pan ɔl we yu tek di maksimal doz fɔ wan statin ɛn ɔda kɔlɔstrel mɛrɛsin dɛn. |
| Di kɔndishɔn dɛn we gɛt ay kɔlɔstrel we dɛn kin gɛt frɔm dɛn mama ɛn papa | Pipul dεm wae bin gεt bכku bכku kכlestכl lεvεl frכm we dεn bin sכmtεm bikoz fכ jεnεtik kכndishכn lεk Familial Hypercholesterolemia. |
| Fɔ di wan dɛn we gɛt rili ay risk fɔ gɛt at sik | If yu dɔn ɔlrɛdi gɛt mayokardial infarkshɔn ɔ strok, ɛn di risk fɔ mek dis kayn tin apin tumara bambay rili bɔku. |
Aw a go gɛt dis mɛrɛsin?
Dɛn kin gi dɛn tin ya as injɛkshɔn, nɔto pil. Dipen pan wetin yu dɔktɔ tɛl yu, yu go gɛt dis injɛkshɔn na ɔspitul ɔ klinik ɛvri sɔm wik ɔ mɔnt. Di tu men kayn dɛn we dɛn de yuz naw na Sri Lanka na Alirocumab (Praluent®) ɛn Evolocumab (Repatha®) .
Afta yu dɔn bigin dis tritmɛnt, yu dɔktɔ go du yu blɔd tɛst ɔltɛm ɛn wach yu kɔlɔstrel lɛvɛl fɔ si aw i go wok.
Wetin na di bɛnifit ɛn sayd ɛfɛkt dɛn?
Di men bɛnifit fɔ dis mɛrɛsin na dat i rili wok fɔ ridyus di LDL kɔlɔstrel lɛvɛl. Sɔm stɔdi dɛn sho se dɛn kin ridyus di LDL lɛvɛl bitwin 50% ɛn 70% . Dis kin ridyus di risk fɔ gɛt at atak, strok, ɛn ɔda at sik dɛn bad bad wan.
Pan ɔl we bɔku pipul dɛn nɔ kin gɛt siriɔs sayd ɛfɛkt, sɔm kin gɛt smɔl smɔl tin dɛn.
- Swel, rɛd, ɔ pen na di say we dɛn injekt am
- Fɔ fil taya (Fatigue) .
- Mɔsul dɛn kin pen
- Simptom dɛm we tan lɛk kol
Na smɔl tɛm nɔmɔ, sɔm pipul dɛn kin gɛt sɔm ifɛkt pan dɛn liva ɔ kidni fɔ wok. Dis na di rizin we mek i rili impɔtant fɔ go to yu dɔktɔ ɔltɛm fɔ mek dɛn chɛk yu . If yu gɛt ɛnitin we nɔ kɔmɔn, tɛl yu dɔktɔ wantɛm wantɛm.
Yu tink se i nɔ go du fɔ jɔs yuz dis mɛrɛsin?
Dis na kwɛstyɔn we rili impɔtant. Di ansa na, "Nɔ, nɔto inof." PCSK9 inhibito dεm nכto majik. Dɛn na jɔs wan pat pan wan ɔl tritmɛnt plan.
Mɛmba se fɔ kɔntrol di kɔlɔstrel nɔto jɔs fɔ tek wan pil. Na fɔ chenj yu wan ol layf.
We yu de gɛt dis vaysin, yu fɔ rili tek kia ɔf dɛn tin ya:
- Fɔ it tin dɛn we go mek yu gɛt wɛlbɔdi: Nɔ it bɔku ɔyl, shuga, ɛn sɔl, ɛn it mɔ frut, vɛjitebul, ɛn it dɛn we gɛt bɔku fayv.
- Ɛksesaiz ɔltɛm: Du ɛksɛsayz lɛk fɔ waka ɔ rɔn fɔ at le 30 minit insay di de, at le 5 dez insay di wik.
- Stress management: Fɔ rilaks di maynd tru tin dɛm lɛk yoga ɛn meditashɔn.
- Slip fayn: Gɛt 7-8 awa gud slip ɛvride.
- Fɔ lɛf fɔ smok: Fɔ lɛf fɔ smok ɛn tin dɛn we dɛn kin yuz fɔ smok kɔmplit wan.
Yu go gɛt di bɛst rizɔlt frɔm PCSK9 inhibitor tɛrapi we yu kam togɛda dɛn chenj ya na yu layf. Nɔ ɛva stɔp fɔ tek di mɛrɛsin ɔ chenj di doz if yu dɔktɔ nɔ advays yu.
Mɛsej we dɛn kin kɛr go na os
- PCSK9 inhibito dεm na pawaful tכp injεkshכn we dεn kin yus fכ lכs di hεy LDL kכlestכl lεvεl dεm we כda tritmεnt dεm nכ de kכntro.
- dis de protεkt di liva in LDL rεsεpכta dεm εn mek di prכsεs fכ pul kכlestכl na di bכdi mכr efyushכn.
- Dis na tritmεnt we dכkta kin כnli rεkomεnd fכ spεshal kes dεm (e.g., hεriditri hεy kכlestכl, hεri risk fכ at sik).
- I rili impɔtant fɔ mek yu gɛt wɛlbɔdi layf we yu de gɛt dis tritmɛnt.
- Kɔntinyu fɔ du dis tritmɛnt jɔs bay yu dɔktɔ in advays, ɛn kɔntinyu fɔ tɔk to am ɔltɛm.
💬 Comments (0)
No kɔmɛnt nɔ de yet. Ad yu kɔmɛnt ya fɔ di fɔs tɛm.
Ad yu kɔmɛnt