Yu go mɔs dɔn yɛri bɔt drɔgs lɛk Viagra. Bɔku pipul dɛn no se dɛn mɛrɛsin ya na drɔgs we dɛn kin gi fɔ mek dɛn nɔ ebul fɔ du mami ɛn dadi biznɛs di we aw Gɔd nɔ want. Bɔt yu no se dɛn kin yuz drɔgs dɛn we de na difrɛn klas, we dɛn kɔl Phosphodiesterase Inhibitors, fɔ mɛn bɔku bɔku sik dɛn, frɔm at sik to lɔng sik, skin sik, ɛn jɔyn sik? Tide, lɛ wi tɔk bɔt dis wɔndaful klas fɔ drɔgs. Lɛ wi jɔs ɔndastand wetin dɛn bi, aw dɛn de wok, ɛn wetin na di gud ɛn bad tin dɛn.
Fɔ tɔk am simpul wan, wetin na di Fɔsfɔdiɛstɛras Inhibitɔ dɛn (PDE inhibito dɛn)?
Dɛn tin ya na wan kayn mɛrɛsin we de mek di blɔd vesel dɛn na wi bɔdi big, mek dɛn nɔ stif, ɛn mek blɔd flɔ izi. Imajin se we wata paip klos, if yu mek am big smɔl, di wata go flɔ izi wan. Dis kin mek di blɔd prɛshɔn nɔ bɔku ɛn i kin mek di blɔd flɔ fayn fayn wan na difrɛn pat dɛn na di bɔdi. Bikɔs ɔf dis kayn mɛrɛsin, dɛn kin yuz dis kayn mɛrɛsin fɔ mɛn bɔku bɔku sik dɛn.
Aw dis mɛrɛsin de wok?
Fɔ ɔndastand dis, wi nid fɔ no fɔs bɔt wan smɔl kemikal mɛsenja na wi bɔdi. I nem na Phosphodiesterases , ɔ PDE fɔ shɔt. Dis PDE na wan kayn ɛnzaym . di εnzym dεm lεk sכm sכm εp dεm we de spid εn mek כda kεmikכl prכsεs dεm na wi bכdi izi.
difrεn tכp dεm fכ dεn PDE εnzym dεm de na wi bכdi. Sayɛnsman dɛn dɔn yuz nɔmba dɛn fɔ no difrɛns. di spεshal tin na dat εvri tכp PDE de mכst aktv na spεshal εria dεm na di bכdi.
- PDE-3: Dis kayn kin de mɔ na yu at ɛn di say we yu de blɔd blɔd . I de involv bak fɔ mek di blɔd klɔt.
- PDE-4: Dis kin de mɔ na di lɔng dɛn . I de wok bay we i de tayt di mɔsul dɛn na di say dɛn we di briz de blo.
- PDE-5: Dis kayn de de na di lכng dεm εn di man in jεnitalia .
so, dכg dεm we dεn kכl Phosphodiesterase Inhibitors (PDE inhibitors) de wok bay we dεn de blכk di aktiviti fכ di PDE εnzym dεm we wi bin mεnshכn oba. I tan lɛk se yu de lɔk domɔt. Sɔm PDE inhibitor drɔgs dɛn kin wok rili sɛlɛktiv wan . dat min se, dεn de tכk bכt כnli wan spεsifi k tכp, lεk PDE-5. Ɔda drɔgs dɛn de we de wok we dɛn nɔ de pik . Dat min se, dɛn kin afɛkt ɔl kayn PDE te to sɔm mak.
Us kɔndishɔn dɛn kin trit wit dis mɛrɛsin?
Di klas ɔf drɔgs we dɛn kɔl PDE inhibitors dɔn gɛt aprɔval frɔm ɛjɛnshi dɛm lɛk di U.S. Food and Drug Administration (FDA) fɔ trit pas wan duzin mɛdikal kɔndishɔn dɛm. Na sɔm pan dɛn.
| Di sik kategori | Medikal kɔndishɔn ɛn simpul ɛksplen |
|---|---|
| Di we aw di at ɛn blɔd de go ɔlsay |
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| Sik dɛn we kin mek pɔsin gɛt inflammatory |
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| Sik dεm we de na di man riprodaktiv sistεm |
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| Sik dɛn we de na di say we pɔsin de blo |
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Wetin na di bɛnifit dɛn we PDE Inhibitors gɛt?
Dis kayn mɛrɛsin kin rili bɛnifit fɔ trit sɔm mɛrɛsin dɛn. Bɔku rizin dɛn de fɔ dis.
- I izi fɔ yuz: Dɛn mɛrɛsin ya kin gɛt bɔku bɔku we dɛn. Dɛn kin gɛt dɛn as ɔral pil, krim we dɛn kin put pan pɔsin in bɔdi, ɛn IV injɛkshɔn. Sɔm mɛrɛsin dɛn nid fɔ tek ɛvride, ɛn ɔda wan dɛn kin jɔs tek we dɛn nid am.
- Tritmɛnt we dɛn kin tɔk bɔt: As a bin dɔn tɔk, sɔm mɛrɛsin dɛn kin tɔch wan patikyula kayn PDE nɔmɔ, so dɛn nɔ kin gɛt ɛnitin we dɛn nɔ want (sayd ifɛkt) pan ɔda pat dɛn na di bɔdi. I tan lɛk se di drɔg de wok jɔs usay di sik de.
- Bɔku bɛnifit dɛn we wan mɛrɛsin kin gi: Sɔntɛnde, tu tin dɛn we gɛt fɔ du wit dis kin apin to di sem pɔsin. fכ egzampl, benign prostatic hyperplasia (BPH) εn erectile dysfunction (ED) dεn tu kin apin tכgeda. Di PDE-5 inhibito tadalafil na apruv fɔ trit ɔl tu di kɔndishɔn dɛn. Semweso, mɛrɛsin dɛn de we kin mɛn ɔl tu di gaut ɛn di at at sik we gɛt fɔ du wit am.
Wetin na di sayd ɛfɛkt ɛn risk dɛm fɔ dis mɛrɛsin?
Di tin we impɔtant pas ɔl na fɔ tek ɔl dɛn mɛrɛsin ya ɔnda dɔktɔ advays nɔmɔ. Di sayd ɛfɛkt kin difrɛn frɔm wan mɛrɛsin to ɔda mɛrɛsin ɛn frɔm wan pɔsin to ɔda pɔsin.
di men sayd ifekt dεm dipכnt pan us kayn PDE inhibito di dכg de pan.
| PDE Inhibitor Tayp | Smɔl ɛn mɔdaret sayd ɛfɛkt dɛn | Sɔm bad bad tin dɛn we kin apin to yu (tɛl yu dɔktɔ wantɛm wantɛm) . |
|---|---|---|
| PDE-3 Inhibitɔ dɛn (de afɛkt di at ɛn di blɔd vesel dɛn) | Ed pen, wik, swel, nɔs, vɔmit, bɛlɛ pen, diziz, skin rɔsh. | At ritm irɛgyulariti (ari ritmia), chɛst pen, blɔd prɛshɔn we de dɔŋ, blɔd ɔ brus we nɔ kɔmɔn, liva we de pwɛl. |
| PDE-4 Inhibitɔ dɛn (i kin afɛkt di lɔng ɛn inflamɛns) | We yu de lɔs yu wet, yu nɔs, yu de vɔmit, yu gɛt dayarɛa, yu gɛt infɛkshɔn na di ɔpa respiratɔri trakt, yu ed de at, yu nɔ de slip, yu de inflamɛns na di say we yu injɛkshɔn. | Di pwɛl hat sik wae dɔn de, wae pɔrsin kin tink bɔt fɔ kil insɛf, wae pɔrsin kin fil pasmak (it, swel, rash). |
| PDE-5 Inhibitɔ dɛn (i kin afɛkt di we aw pɔsin nɔ ebul fɔ du mami ɛn dadi biznɛs ɛn di pulmonari haypatɛyshɔn) | Ed we de at, flash, nos we de stɔp, bak we de at, mɔsul pen, nɔs, diziz, ɛn sɔntɛm yu go si layt we gɛt blu kɔlɔ (fɔ shɔt tɛm). | Priapism: Na di erection we de mek yu fil pen we de te pas 4 awa we yu nɔ de du mami ɛn dadi biznɛs. Dis na mɛdikal imejensi. Chenj/we yu nɔ de si ɔ yɛri wantɛm wantɛm, yu liva de pwɛl. |
| Nɔnsɛlektiv Inhibitɔ dɛn (e.g. kafin, tiofilin) | Nɔr kin rɛst, nɔr kin slip, yu kin shek, yu kin gɛt nɔs, yu kin vɔmit, yu kin gɛt dayarɛa, yu kin gɛt diziz, yu ed kin at. | Fast at bit, at bit we nɔ de bit ɔltɛm, chɛst de pen, siz. |
Speshal wɔnin: If yu de tek mɛrɛsin lɛk naytroglycerin ɔnda yu tɔng fɔ mek yu chɛst pen, ɛn yu gɛt chɛst pen insay 24 awa afta yu tek wan PDE-5 inhibitor (e.g. Sildenafil, Tadalafil), go na di ɔspitul in imejensi dipatmɛnt (ETU) wantɛm wantɛm. If yu put dɛn tu mɛrɛsin ya togɛda, dat kin mek yu blɔd prɛshɔn go dɔŋ we denja.
Udat nɔ fɔ tek dis mɛrɛsin?
Fɔ sɔm pipul dɛm, dis kayn mɛrɛsin wae dɛn kɔl PDE inhibitors nɔr kin fayn bikɔs ɔf dɛn ɔda mɛrɛsin ɔr ɔda mɛrɛsin dɛm wae dɛn de tek. Wi kin kɔl dɛn tin ya we nɔ gɛt fɔ du wit di sik . Tu kayn tin dɛn de:
1. Absolut kɔntraindikshɔn dɛn:
- To ɛni PDE inhibitor: If yu bin dɔn gɛt siriɔs alɛji (hypersensitivity) to dis mɛrɛsin ɔ wan we fiba am bifo.
- Fɔ Cilostazol: If yu gɛt ɛni kayn at prɔblɛm.
- Fɔ PDE-5 inhibito dɛm (lɛk Sildenafil, Tadalafil): siriɔs at sik, nɔ stebul chɛst pen (un stebul angina), at atak ɔ strok we dɛn jɔs dɔn.
2. Rilativ kɔntraindikshɔn dɛn:
- Fɔ PDE-5 inhibitor: If yu de tek naytrɛt ɔ alfa-blɔka, yu fɔ tɔk to yu dɔktɔ bikɔs dɛn kin mek yu blɔd prɛshɔn go dɔŋ bad bad wan.
- Fɔ Cilostazol: If yu gɛt prɔblɛm wit blɔd.
- Fɔ Pentoxifylline: If yu jɔs dɔn gɛt blɔd na yu bren ɔ yu yay.
If yu gɛt bɛlɛ, yu de tray fɔ gɛt bɛlɛ, ɔ yu de gi pikin in bɛlɛ, tɔk to yu dɔktɔ ɔltɛm bifo yu tek ɛni mɛrɛsin. pruf de fכ se sכm PDE inhibito dεm kin afekt di pikin insay animal stכdi dεm.
Ustɛm yu fɔ go to dɔktɔ?
If yu sik chenj ɔr afɛkt di tin dɛm wae yu de du ɛvride, i go fayn fɔ tɛl yu dɔktɔ. Bɔt if yu gɛt ɛni wan pan dɛn tin ya , go na ɔspitul ɔ imejensi rum (ETU) wantɛm wantɛm.
- Di sayn dɛm fɔ at atak: yu chɛst de pen, yu nɔ de blo fayn, yu de swet, yu de tɔn diziz, yu de nɔs.
- Priapism: Na di erection we de mek yu fil pen we de te pas 4 awa we yu nɔ de du mami ɛn dadi biznɛs. Dis kin mek pɔsin pwɛl sote go if dɛn nɔ trit am kwik kwik wan.
- Yu nɔ de si ɔ yɛri wantɛm wantɛm: If yu nɔ de si fayn, yu nɔ de si fayn, ɔ yu nɔ de yɛri igen, go to dɔktɔ wantɛm wantɛm. If yu delay, dat kin mek yu gɛt damej fɔ ɔltɛm.
Mɛsej we dɛn kin kɛr go na os
- Phosphodiesterase inhibitors (PDE inhibitors) na wan klas we rili yusful fɔ mɛrɛsin we dɛn nɔ kin jɔs yuz fɔ du mami ɛn dadi biznɛs, bɔt fɔ bɔku sik dɛn we gɛt fɔ du wit at, lɔng, skin, ɛn jɔyn.
- Ɔl dɛn mɛrɛsin ya fɔ jɔs tek we dɔktɔ tɛl yu fɔ tek am.Tɛl yu dɔktɔ bɔt ɛni ɔda sik we yu gɛt ɛn ɛni ɔda mɛrɛsin we yu de tek.
- Sɔm bad tin kin apin, so na fɔ no bɔt dɛn bifo yu bigin fɔ tek di mɛrɛsin.
- If yu gɛt siriɔs sayn lɛk pen na yu chɛst, yu nɔ de blo fayn fɔ pas 4 awa, ɔ yu nɔ de si/yeri wantɛm wantɛm, go to Imejɛnsi Dipatmɛnt (ETU) wantɛm wantɛm.
- If yu yuz dis mɛrɛsin we yu nɔ gɛt dɔktɔ in prɛskrishɔn, bay we yu aks ɔda pipul dɛn ɔ aks na famasi, dat kin mek yu gɛt siriɔs prɔblɛm dɛn, ivin dat kin mek yu day.
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