Lɛ wi lan bɔt di mɛrɛsin dɛn we dɛn kin gi fɔ at sik ɛn fɔ mek pɔsin nɔ ebul fɔ du mami ɛn dadi biznɛs? (Fɔsfɔdiɛstɛrayz Inhibitɔ dɛn) .

Sɔntɛm yu dɔn si sɔmbɔdi na yu famili, sɔntɛm yu papa ɔ yu ɔnkul, de tek mɛrɛsin fɔ at sik, ay blɔd prɛshɔn, ɔ fɔ mek i nɔ ebul fɔ tinap tranga wan. Semweso, dɔktɔ dɛn kin gi dɛn difrɛn mɛrɛsin fɔ sik dɛn na di skin, sik dɛn we de mek pɔsin nɔ ebul fɔ blo fayn lɛk asma, ɛn ɔda tin dɛn.Yu no se wan rili impɔtant klas de fɔ mɛrɛsin we dɛn kin yuz fɔ mɛn bɔku pan dɛn sik ya? Dat klas ɔf mɛrɛsin, we na Phosphodiesterase Inhibitors, na in wi go tɔk bɔt na dis atikul tide, simpul ɛn pɔlitiks.

Fɔ tɔk am simpul wan, wetin na dɛn Phosphodiesterase Inhibitors ya?

Dis kin tan lɛk se na kɔmplikɛt nem, bɔt fɔ tru, i rili simpul. Dis na wan klas ɔf drɔgs we de ɛp fɔ rilaks ɛn mek di blɔd vesel dɛn na wi bɔdi big, ɛn dis kin mek i izi fɔ mek dɛn go ɔlsay. We blɔd flɔ fayn, dɛn kin kɔntrol blɔd prɛshɔn bak. Dis na di rizin we mek dɛn kin yuz dɛn mɛrɛsin ya fɔ trit bɔku bɔku sik dɛn, frɔm prɔblɛm dɛn we kin apin to pɔsin in skin, jɔyn, at, ɛn lɔng te to we pɔsin nɔ ebul fɔ du mami ɛn dadi biznɛs.

Aw dis mɛrɛsin de wok insay di bɔdi?

wi bכdi gεt wan kayn εnzym we dεn kכl Phosphodiesterases (PDEs) . Fɔ tɔk am simpul wan, ɛnzaym dɛn tan lɛk smɔl smɔl ɛp dɛn we de mek di kemikal dɛn we de na wi bɔdi go kwik kwik wan. difrεn tכp dεm de fכ dεn PDE εnzym dεm ya. Dɛn gi dɛn nɔmba ɛn dɛn de sheb dɛn. di spεshal tin na dat εvri tכp PDE εnzym de fכn na patikyula ples dεm na di bכdi.

di fכsfodiεstεrayz Inhibitor dεm (PDE Inhibitors) de wok bay we dεn de blכk di aktvכti fכ di PDE εnzym dεm we wi bin dכn tכk bכt. I tan lɛk se yu de lɔk domɔt. sכm PDE Inhibitor dεm de tכk to wan tכp εnzym nכmכ (sεlektiv), we כda wan dεm kin afekt PDE εnzym dεm in jεnarכl (nכn sεlektiv).

Wetin na di men tin dɛm wae dɛn kin trit wit dis mɛrɛsin?

Dɛn dɔn gri fɔ yuz dɛn mɛrɛsin ya fɔ mɛn pas wan duzin difrɛn sik dɛn. Lɛ wi luk sɔm pan di men kategori dɛn.

Di sik dɛn we kin kam pan di at ɛn di blɔd we de kɔmɔt na di blɔd

• Decompensated heart failure: We di at wik ɛn nɔ ebul fɔ pɔmp blɔd to di bɔdi as nid de.
• Pulmonary hypertension: Di blɔd prɛshɔn we de na di blɔd vesel dɛn na di lɔng dɛn.
• di bכdi fכ fכlכ di limb dεm (Pεrifεral atεri sik - PAD): bכdi nכ de fכm, spεshal wan to di lεg dεm.
• Fɔ mek blɔd nɔ klɔt afta dɛn dɔn du di ɔpreshɔn: We blɔd nɔ klɔt afta dɛn dɔn du di ɔpreshɔn, dat kin mek pɔsin gɛt prɔblɛm dɛn lɛk strok, at atak, ɛn pulmonary embolism. Plɛnti dɛn.
• Thrombocythemia: Na di pletlɛt dɛn we de mek di blɔd pasmak, we de ɛp fɔ mek di blɔd klɔt.

Inflammatory diseases na di skin ɛn di jɔyn dɛm

• Eczema (Atopic dermatitis): Na inflamɛns, itchy rɛdnɛs na di skin.
• Psoriasis: Na inflammatory kondishכn na di skin we de kכz fכ wan ova aktif imyun sistεm.
• Psoriatic arthritis: Inflameshɔn na di joyn dɛm we kin apin wit psoriasis.

Sik dɛm we gɛt fɔ du wit di man riprodaktiv sistɛm

• Benign prostatic hyperplasia: Di prɔstat gland de swel bikɔs ɔf tin dɛn we nɔto kansa.
• Erectile dysfunction: I nɔ kin izi fɔ gɛt erection.

Sik dɛn we de na di say we pɔsin de blo

• Chronic obstructive pulmonary disorder (COPD): Na grup fɔ sik dɛn we kin mek i nɔ izi fɔ blo.
• Nionatal apnea: I nɔ kin izi fɔ blo we kin apin to pikin dɛn we dɛn bɔn bifo tɛm , mɔ di wan dɛn we dɛn bɔn bifo 7 wik.

Wetin na di bɛnifit dɛn we dis mɛrɛsin de gi?

Bɔku bɛnifit dɛn de fɔ yuz dɛn mɛrɛsin ya.

• Fɔm dɛn we izi fɔ yuz: Dɛn tin ya kin kam lɛk pils we dɛn kin tek bay mɔt, krim we dɛn kin put pan pɔsin in bɔdi, ɛn we dɛn kin gi yu IV injɛkshɔn. Sɔm mɛrɛsin dɛn nid fɔ tek ɛvride, ɛn ɔda wan dɛn kin jɔs tek we dɛn nid am.
• Tɛrapi we dɛn de tɔk to:As wi bin dɔn tɔk, bikɔs dɛn kin tɔch di tritmɛnt to wan patikyula kayn PDE ɛnzaym nɔmɔ, di sayd ɛfɛkt dɛn we dɛn nɔ want kin ridyus bad bad wan.
• Bɔku bɛnifit dɛn we wan mɛrɛsin gɛt: Sɔntɛnde, dɛn kin trit tu sik dɛn we kin apin togɛda wit wan mɛrɛsin. fכ egzampl, dεn kin gi pכsin we gεt כl tu di prכstat we big εn εrectile dysfunction di PDE-5 inhibitor tadalafil . Semweso, dɛn kin yuz Apremilast fɔ trit ɔl tu di psoriasis ɛn psoriatic arthritis.

Lɛ wi no bak bɔt di bad tin dɛn we kin apin to wi ɛn di bad tin dɛn we kin apin to wi.

Lɛk ɛni mɛrɛsin, dɛn tin ya kin mek pɔsin gɛt sayd ɛfɛkt. Dɛn sayd ɛfɛkt ya kin dipen mɔ pan di kayn PDE inhibitor we yu de tek.

Dis dɔŋ ya na sɔm poshubul sayd ɛfɛkt dɛm wae gɛt fɔ du wit di men kategori dɛm fɔ di mɛrɛsin dɛm.

Ustɛm yu nɔ fɔ tek dis mɛrɛsin?

Dis mɛrɛsin kin denja fɔ sɔm pipul dɛn. If yu gɛt ɛni wan pan dɛn tin ya, yu fɔ rili tɔk to yu dɔktɔ bifo yu tek dis mɛrɛsin.

• Fɔ ɛni PDE inhibitor: If yu bin dɔn gɛt siriɔs alɛji (hypersensitivity) to ɛni mɛrɛsin ɔ sɔntin bifo.
• Cilostazol (PDE-3): Dɛn nɔ kin fayn fɔ yuz dis if yu gɛt ɛni kayn at prɔblɛm.
• PDE-5 inhibitors: Yu fɔ avɔyd fɔ tek dɛn tin ya if yu gɛt siriɔs at sik, yu jɔs gɛt at atak ɔ strok, ɔ yu gɛt angina we nɔ stebul.
• If yu de tek naytrɛt , we yu tek PDE-5 inhibitors kin mek yu blɔd prɛshɔn go dɔŋ tumɔs.
• Sɔm PDE inhibito dɛm (e.g. Cilostazol) nɔr fayn if yu gɛt blɔd disɔda.

Yuz am we yu gɛt bɛlɛ

If yu gɛt bɛlɛ ɔ yu de plan fɔ gɛt bɛlɛ, i go fayn fɔ mek yu nɔ tek sɔm kayn PDE inhibitors. Kɔnsul yu dɔktɔ bɔt dis.

Ustɛm yu fɔ go to dɔktɔ wantɛm wantɛm?

I bɛtɛ fɔ tɛl yu dɔktɔ if yu gɛt ɛni ɔda kayn sik we yu de yuz dis mɛrɛsin. Bɔt if ɛni wan pan dɛn tin ya apin, go na ɔspitul in Imejɛnsi Dipatmɛnt (ETU) ɛn nɔ de te.

• Di sayn dɛm we de sho se pɔsin gɛt at atak:Tin dɛm lɛk chɛst pen, tayt, at fɔ blo, swet, diziz, nɔs.
• Priapism: Na erection we de mek yu fil pen we de las fɔ pas 4 awa we yu nɔ de du mami ɛn dadi biznɛs. Dis na wan sik wae nid fɔ gɛt tritmɛnt kwik kwik wan.
• Wantɛm we yu nɔ de si ɔ yɛri: Dɛn fɔ trit dɛn tin ya bifo damej fɔ ɔltɛm.

Dɛn mɛrɛsin ya rili impɔtant, dɛn kin sev layf ɛn dɛn kin ɛp fɔ mek pɔsin in layf bɛtɛ. Bɔt dɛn fɔ tek dɛn ɔltɛm we dɔktɔ tɛl dɛn fɔ tek dɛn ɛn di we aw dɛn fɔ tek dɛn.