Yu plasma sɛl dɛnsɛf nɔ de wok fayn? Dis plasma sɛl lukimiya denja?

Yu dɔn ɛva yɛri bɔt wan sik we dɛn kɔl ‘Plasma Cell Leukemia’? Di nem kin tan lɛk se i de mek pɔsin fred smɔl. Bɔt fɔ tru, na siriɔs kansa we nɔ kin apin so ɔltɛm we kin afɛkt wan kayn sɛl na wi bɔdi we dɛn kɔl plasma sɛl. Nɔ wɔri, wi go ɛksplen ɔltin di simpul we we yu go ɔndastand.

Wetin na Plasma Sɛl Lukimia?

Okay, so lɛ wi fɔs luk wetin na Plasma Cell Leukemia. Fɔ tɔk am simpul wan, na wan ɔda kayn kansa we kin gɛt smɔl mɔ agresiv, we kin skata kwik kwik wan we dɛn kɔl Multiple Myeloma.

Wi ɔl gɛt wan spɛshal kayn sɛl we dɛn kɔl plasma sɛl na wi bɔdi. Dis na di sɛl dɛm we de mek antibodi dɛm, we na di impɔtant tin dɛm we de ɛp wi bɔdi fɔ fɛt sik, lɛk infekshɔn. Dɛn plasma sɛl dɛn ya tan lɛk di wan dɛn we de gayd wi bɔdi in yon bɔdi.

Bɔt, sɔntɛnde dɛn plasma sɛl ya, i sɔri fɔ no se, kin bigin fɔ biev nɔmal, lɛk kansa sɛl dɛn . Na da tɛm de di prɔblɛm dɛn kin bigin. כltu, insay di kes fכ ‘Multiple Myeloma’, dεn abnכmal, bad plasma sεl dεm ya kin de mכst insay wi bon mכro . Bɔn mɛro na di pat we saf ɛn we tan lɛk spɔnj insay wi bon dɛn.

Bɔt pan Plasma Cell Leukemia, sɔntin we difrɛn smɔl kin apin. Na ya, dɛn plasma sɛl dɛn de we nɔmal, we gɛt kansa, kin brok kɔmɔt na di bon mɛro, go insay wi blɔd, dat na di blɔd, ɛn bigin fɔ travul ɔlsay na di bɔdi. Imajin, wetin de apin ya tan lɛk sɔm denja kriminal dɛn we de rɔnawe kɔmɔt na prizin ɛn mek trɔbul ɔlsay na di siti.

Dis na di men difrɛns bitwin ‘Multiple Myeloma’ ɛn ‘Plasma Cell Leukemia’. Dis na di rizin we mek dɛn kin tek Plasma Cell Leukemia (PCL) as sik we kin ambɔg mɔ ɛn we kin skata kwik kwik wan.

Udat kin gɛt dis sik pas ɔlman?

Naw yu kin de wɔnda udat kin gɛt dis sik we dɛn kɔl Plasma Cell Leukemia. As wi kin si, dis sik kin mɔs pan man dɛm wae ol bitwin 55 ɛn 65. Dɔn bak, sɔm stɔdi dɔn sho se dis sik kin pasmak pan Blak pipul dɛm .

Bɔt di tin we impɔtant pas ɔl na dat, ɔltogɛda, dis na tin we nɔ kin apin so ɔltɛm . Infakt, plasma cell leukemia (PCL) na di kayn we we nɔ kin bɔku pan di kansa grup we dɛn kɔl multiple myeloma. dεn ripot se i de mek wan rili sכm pasεnshכn, we na lεk 2% to 3% pan כl di plasma sεl kεnsar dεm. So i nɔto sik we bɔku pipul dɛn kin gɛt.

Tritmɛnt dɛn de fɔ dis. Dɛn tritmɛnt ya kin ɛp fɔ kɔntrol aw di kansa de gro, ridyus di sayn dɛm ɛn mek yu layf izi, ɛn ivin mek yu ebul fɔ liv lɔng te to sɔm mak. Bɔt bɔku tɛm, i nɔ kin izi fɔ mɛn dis sik kpatakpata . Bɔt i nɔ fayn fɔ lɛ wi lɛf fɔ gɛt op. Bikɔs dɛn dɔn gɛt nyu tritmɛnt dɛn, naw dɔktɔ dɛn dɔn ebul fɔ mek di wan dɛn we gɛt Plasma Cell Leukemia liv lɔng. Bɔt bɔku ɔda tin dɛn de fɔ no bɔt dis wok bay we dɛn de du mɔ risach.

Sɔm kayn plasma sɛl lukimiya (PCL) de?

Yɛs, tu men kayn plasma sɛl lukimiya (PCL) de. Lɛ wi lan bɔt dɛn ɔl tu.

• Praymari PCL: Dis na we pɔsin kin gɛt plasma sɛl lukimiya (PCL) we i nɔ bin dɔn gɛt mɔltipɛl mayloma bifo. Dis min se di abnɔmal plasma sɛl dɛn de rɔn na di blɔd di tɛm we dɛn no di sik. Dis na wetin dɛn kin si pan di mɔtalman we gɛt PCL ( lɛk 60%) . Na lɛk wan pan ɔl wan milyɔn pipul dɛm na di jenɛral pipul dɛm kin afɛkt dis praymari PCL kɔndishɔn.

• Sεkɔndari PCL: Dis kin apin we pɔsin dɔn ɔlrɛdi gɛt mכltipכl mayloma, bכt as tεm de go, di sik kin kam tranga εn i kin tכn to plasma sεl lukimiya (PCL). dis min se PCL de divεlכp lεk wan siriכs fכm fכ mayloma. Risach sho se bitwin 0.5% ɛn 4% pan di wan dɛn we gɛt mɔltipɛl mayloma kin gɛt sɛkɔndari PCL. Na lɛk 40% pan di PCL pasɛnt dɛn kin fɔdɔm insay dis kategori.

Wetin na di sayn dɛm fɔ plasma sɛl lukimiya (PCL)?

Di sayn dɛm fɔ plasma sɛl lukimiya (PCL) kin difrɛn frɔm wan pɔrsin to ɔda pɔrsin. Bɔt sɔm kɔmɔn sayn dɛn de we wi go luk pan:

• Taya: Fɔ fil taya ɔltɛm, fil lɛk se yu nɔ ebul fɔ du natin.
• Anemia: Fɔ tɔk am simpul wan, dis na we pɔsin nɔ gɛt blɔd. Di bɔdi kin blak, yu kin taya, ɛn yu kin fil taya ivin we yu de klaym stej. Dis na bikɔs dɛn bad plasma sɛl dɛn de kin mek di rɛd blɔd sɛl dɛn we gɛt wɛlbɔdi nɔ ebul fɔ mek.
• Blɔd we de kɔmɔt mɔ ɛn mɔ: Ivin smɔl wund kin tek lɔng tɛm fɔ lɛ i stɔp fɔ blɔd, ɛn i kin mek yu gɔm blɔd ɔ yu gɛt brus na yu skin.
• Bɔn pen: Bɔn pen kin apin, mɔ na say dɛn lɛk di spayna, rib, ɛn hip.
• Bɔn we kin brok: Sɔntɛnde, di bon dɛn kin wik so dat bon kin brok ivin if i fɔdɔm simpul wan, ivin if i nɔ gɛt ɛni big injuri.
• di kalsiכm lεvεl dεm we de na di bכdi de go כp (Hypercalcemia):Dis na sɔm kayn siriɔs sik. We di kalsiɔm we de na di blɔd go ɔp, sɔm sayn dɛn lɛk fɔ nɔs, fɔ vɔmit, fɔ dray na yu mɔt, fɔ kɔnfyus, ɛn fɔ tɔsti pasmak.
• Infekshɔn ɔltɛm: As di bɔdi in imyuniti de go dɔŋ, sik dɛn lɛk kol ɛn flu kin apin bɔku tɛm, ɛn wans dɛn dɔn apin, dɛn kin tek lɔng tɛm fɔ mek dɛn wɛl.
• di kidni dεm we de pwεl: Di protin dεm we dεn abnכmal plasma sεl dεm de mek kin pwεl di kidni dεm.

If yu gɛt wan ɔr mɔr pan dɛn sik ya, nɔr panik, bikɔs dɛn kin bi sayn fɔ ɔda sik. Bɔt if dɛn sik ya kɔntinyu, i go fayn ɔltɛm fɔ go to dɔktɔ fɔ advays.

Wetin kin mek pɔsin gɛt plasma sɛl lukimiya (PCL)?

Infakt, sɔm pipul dɛn we de stɔdi bɔt dis nɔ dɔn no yet di rayt tin we kin mek pɔsin gɛt plasma sɛl lukimiya (PCL). Bɔt wetin dɛn no na dat, i kin kam bikɔs ɔf di chenj dɛn we dɛn kin gɛt na di jin dɛn na di plasma sɛl dɛn we dɛn de gro. Fɔ tɔk am simpul wan, mistek dɛn de na di DNA fɔ di plasma sɛl dɛn.

Bɔt wetin mek dɛn chenj ya we de apin na di jɛnɛtiks kin apin stil na sɔntin we wi nɔ no . I nɔ kin izi fɔ tɔk klia wan wetin na di envayrɔmɛnt, di we aw pipul dɛn de liv dɛn layf, ɔ ɔda tin dɛn we kin mek i apin. Bikɔs dis na sik we nɔ kin bɔku, fɔ du risach bɔt am kin tranga smɔl bak.

Aw dɛn kin no se pɔsin gɛt plasma sɛl lukimiya (PCL)?

Fɔ no fɔ tru if pɔsin gɛt plasma cell leukemia (PCL), i go nid fɔ du bɔku tɛst dɛn.

1. Blɔd tɛst: Dis na di men tin we dɛn fɔ du. Dɛn kin tek wan sɛmpul pan yu blɔd ɛn mɛzhɔ di nɔmba fɔ di plasma sɛl dɛn we nɔ de insay am. insay PCL, mכr dan 5% pan yu tכtal wayt bכdi sεl dεm na dεn abnכmal plasma sεl dεm ya.

2. Bon mכro bayopsi: Dis na fכ tek sכm sכm sεmpl fכ yu bon mכro εn chεk am fכ abnכmal plasma sεl dεm. Dɛn kin du dis frɔm di hip bon. Pan ɔl we i kin mek yu fil pen smɔl, i rili impɔtant fɔ no if yu gɛt di sik.

3. Imej tɛst: Dɛn kin du tɛst lɛk CT skan (Computed Tomography scan) ɔ MRI (Magnetic Resonance Imaging) bak fɔ si if di sik dɔn pwɛl di bon dɛn.

Na afta yu dɔn du ɔl dɛn tɛst ya nɔmɔ di dɔktɔ go tɛl yu if yu gɛt PCL ɔ yu nɔ gɛt am, ɛn if na so, wetin na di sik.

Aw dɛn kin trit plasma sɛl lukimiya (PCL)?

Dɛn kin trit plasma sɛl lukimiya (PCL) pan wan wan pɔsin. Dis min se nɔto ɔlman dɛn kin gi di sem tritmɛnt. Di mɛdikal tim go tek tɛm stɔdi yu sik ɛn tɛl yu bɔt aw fɔ trit yu ɔ aw fɔ trit yu togɛda we go fayn fɔ yu.

di sem tritmεnt dεm dεn kin yus fכ PCL lεk fכ mכltipכl maylכma. Na sɔm pan dɛn:

• Kimotɛrapi: Dis kin min fɔ gi pawaful mɛrɛsin fɔ kil di kansa sɛl dɛn. εgzampl dεm na `Dכksorubisin (Adriamycin®), `Cisplatin` εn `Sayklofosfamid (Cytoxan®).`
• Immunotherapy: Dis kin min fɔ mek yu yon imyun sistɛm ebul fɔ fɛt di kansa sɛl dɛn. dis inklud nyu tritmεnt dεm lεk monoklonal antibodi dεm (e.g., Daratumumab (Darzalex®)), bispεsifi k antibodi dεm (e.g., Teclistamab (Tecvayli®)), εn chimeric antigen rεsεpכta (CAR) T-sεl tεrapi.
• Targeted therapy: Dɛn mɛrɛsin ya de wok bay we dɛn de target sɔm patikyula mɔlyul dɛn we de ɛp di kansa sɛl dɛn fɔ gro ɛn liv, ɛn dis kin mek dɛn nɔ wok. dis dεm inklud proteasom inhibito dεm (e.g., Bortezomib (Velcade®), Carfilzomib (Kyprolis®), Ixazomib (Ninlaro®)) εn immunomodulator dεm (e.g., Lenalidomide (Revlimid®), Pomalidomide (Pomalyst®).
• Autologous Stem Cell Transplant: Dis involv fכ transplant hεlty stεm sεl dεm we dεn tek frכm di sikman sεf afta di kεmothεrapi. Bɔt nɔto ɔlman fit fɔ gɛt dis tritmɛnt. Na di dɔktɔ disayd.

Apat frɔm dɛn tritmɛnt ya, yu dɔktɔ kin tɛl yu bak fɔ gi yu palliative care services fɔ ɛp fɔ kɔntrol yu sik, fɔ ridyus pen, ɛn fɔ gi yu kɔmfɔt na yu maynd ɛn bɔdi we yu de du dis tranga waka.

Impɔtant: We yu rid bɔt dɛn tritmɛnt ɛn mɛrɛsin ya, dat kin mek yu kɔnfyus smɔl. Bɔt na yu mɛdikal tim de disayd ɔl dis. Dɛn go ɛksplen ɔltin to yu. Nɔ fred fɔ aks dɛn ɛni kwɛstyɔn we yu gɛt.

Wetin na di layf we pipul dɛn we gɛt plasma sɛl lukimiya (PCL) kin liv?

Dis na tɔpik we rili at fɔ tɔk bɔt. Plasma cell leukemia (PCL) na wan sik we kin rili bad, we kin skata kwik kwik wan, ɛn bɔku tɛm i kin kil pɔsin . Nɔr to 10% pan di pipul dɛm wae gɛt dis kansa kin liv pas fayv ia afta dɛn dɔn no se dɛn gɛt dis kansa. in jεnarכl, pipul dεm we gεt praymar PCL de liv sכm lכng pas dεn wan dεm we gεt sεkכnd PCL.

Di layf we yu go liv kin dipen pan bɔku tin, lɛk aw di sik kin tranga, di kayn tritmɛnt we yu kin gɛt, ɛn aw yu bɔdi kin du dɛn tritmɛnt dɛn de.

Dɛn se di wan dɛn we kwalifay fɔ transplant stem sɛl kin liv lɛk tri to 4 ia so . Bɔt, sɔm pipul dɛn kin liv lɔng pas dat. Wan stɔdi bin ripɔt se wan PCL pasɛnt bin dɔn de na rɛmishɔn fɔ nayn ia bifo di sik kam bak.

Tide, di layf we dɛn sik pipul ya de liv dɔn lɔng smɔl we yu kɔmpia am to sɔm dikɛd ia bifo. Pan ɔl we na smɔl impɔtant tin, i stil na big tin. Risach pipul dɛn stil de wok pan dis wit bɔku intres.

Yu tink se dɛn kin mek pɔsin nɔ gɛt plasma sɛl lukimiya (PCL)?

Bɔt i sɔri fɔ no se, no we nɔ de fɔ mek dɛn nɔ gɛt plasma sɛl lukimiya (PCL). Bikɔs wi nɔ kin ebul fɔ kɔntrol di chenj dɛn we de apin na di jɛnɛtiks we kin mek i apin, i kin rili shɔt bak, ɛn dis kin mek i nɔ izi fɔ stɔdi ɛn fɛn we fɔ mek i nɔ apin. Bɔt di wan dɛn we de stɔdi bɔt dis sik de kɔntinyu fɔ fɛn we fɔ no di sik kwik kwik wan.

Aw a kin kia fɔ misɛf?

We dɛn no se yu gɛt wan sik lɛk plasma cell leukemia (PCL), i nɔmal fɔ fil se yu nɔ shɔ bɔt di tumara bambay, ɛn fɔ gɛt difrɛn kayn filin dɛn, lɛk fɔ fred, vɛks, sɔri, pwɛl at, ɛn fil gilti. Natin nɔ bad fɔ fil dɛn filin ya. Di tin we impɔtant pas ɔl na fɔ tɔk to pɔsin bɔt aw yu de fil. Tɔk to pɔrsin wae yu trɔst, yu fambul mɛmba, yu padi, ɔr yu dɔktɔ bɔt sɔpɔt savis dɛm. Dɛn kin ɛp yu fɔ kip yu kwaliti layf afta dɛn dɔn no se yu gɛt di sik ɛn we dɛn de trit yu.

Ustɛm a fɔ go to di dɔktɔ?

Yu go de nia yu mɛdikal tim ɔl di tɛm we yu de trit yu. Bɔt if yu gɛt nyu sik ɔ if i tan lɛk se yu sik de wɔs, yu fɔ mek yu dɔktɔ no wantɛm wantɛm.

Us kwɛstyɔn dɛn a fɔ aks mi dɔktɔ?

If yu gɛt plasma sɛl lukimiya (PCL), yu kin gɛt bɔku kwɛstyɔn dɛn. Na sɔm impɔtant kwɛstyɔn dɛn we yu fɔ aks yu dɔktɔ:

• Aw fa di kansa dɔn skata? (Aw di kansa dɔn go bifo?)
• Wetin na di tritmɛnt dɛn we a kin gɛt?
• A fit fɔ gɛt stem sɛl transplant?
• Aw lɔŋ a kin liv wit tritmɛnt?
• Us tin dɛn we a go ebul fɔ yuz?

Ɛni kansa na tin we kin chenj in layf. Bɔt we yu gɛt wan sik we nɔ kin bɔku, we rili siriɔs lɛk plasma sɛl lukimiya (PCL), i kin rili yu wan ɛn i kin mek yu at pwɛl. Yu kin fil lɛk se nɔbɔdi nɔ ɔndastand wetin yu de go tru. If i pɔsibul, jɔyn wan sɔpɔt grup.. Dɔn yu kin mit ɛn tɔk to ɔda pipul dɛn we de go tru di sem tin dɛn we yu de du. Trust di wan dɛn we yu lɛk, yu mɛdikal tim. Dɛn ɔl de fɔ ɛp yu, fɔ sɔpɔt yu fɔ mek yu kɔntinyu fɔ gɛt yu kwaliti layf afta dɛn dɔn no se yu gɛt di sik ɛn we dɛn de du tritmɛnt. Yu nɔ nid fɔ go tru dis waka yu wan.

Mɛsej we dɛn kin kɛr go na os

Plasma Cell Leukemia (PCL) na wan bad bad, rare fכm fכ mכltipכl mayloma. Insay dis kayn kansa, di plasma sɛl dɛn we nɔ de na di bɔdi kin go ɔlsay na di blɔd. Di sayn dɛm kin difrɛn, lɛk fɔ taya, fɔ gɛt blɔd, ɛn fɔ gɛt pen na yu bon. Pan ɔl we dɛn tink se na di chenj dɛn we de apin na di jɛnɛtiks, dɛn nɔ no di rayt tin we kin mek i apin.

Dɛn kin no if pɔsin gɛt di sik bay we dɛn de du blɔd tɛst, bon mɛro bayɔpsi, ɛn we dɛn de tek imej. Di tritmɛnt dɛn we dɛn kin pik na kemotɛrapi, imyunotɛrapi, tɛrapi we dɛn de tɔk to, ɛn fɔ transplant stem sɛl.

Pan ɔl we dis na siriɔs sik, di layf we pɔsin kin liv dɔn go ɔp smɔl wit nyu tritmɛnt dɛn. De tin wae impɔtant pas ɔl na fɔ go to dɔktɔ kwik kwik wan if yu gɛt sɔm kayn sik, yu gɛt di rayt tritmɛnt, ɛn yu gɛt trɛnk na yu maynd. Yu mɛdikal tim ɛn di wan dɛn we yu lɛk go bi big trɛnk fɔ yu pan dis joyn.

` Plasma Sεl Lukimiya, Kεnsar, Mכltipכl Maylכma, Blכd Kεnsar, Bon Mכro, Kansa Simptom dεm, Kεnsar Tritmεnt