Yu gɛt prɔblɛm wit yu kidni? Lɛ wi lan bɔt Rɛnal Sɛl Kansa (RCC)!

Yu dɔn ɛva tink gud wan bɔt yu kidni dɛn? Kidni na tu smɔl bɔt rili impɔtant ɔgan dɛn na wi bɔdi. Dɛn tan lɛk filta dɛn na wi bɔdi. Bɔt sɔntɛnde, dɛn kidni ya kin gɛt prɔblɛm bak. Tide wi go tɔk bɔt wan pan di kayn kansa we kin apin na di kidni, "Renal Cell Carcinoma" ɔ RCC . Nɔ wɔri, wi go tɔk bɔt dis simpul wan, di we we yu go ɔndastand.

Wetin na rεnal sεl kansa (RCC)?

Fɔ tɔk am simpul wan, rεnal sɛl kansa (RCC) na di kayn kεnsar we kin kכmכn pas ɔl na di kidni. wi kidni dεm gεt wan rili fayn nεtwכk fכ tכb dεm we dεn kכ l tכbul . dis tכb dεm na dεn de transpכt di bכdi in wata εn nyutriεnt dεm insay di bכdi εn pul di dɔti dεm we de insay di urine. na insay dεn tכbul dεm ya RCC de bigin fכ fכm. Na lɛk 85% pan di kidni kansa na dis kayn.

Bɔku tɛm, RCC kin bigin lɛk smɔl smɔl kansa sɛl dɛn na wan kidni. Dɛn kin kɔl dis bak tumbu . Bɔt sɔmtɛm, bɔku bɔku lumps kin fɔm na wan kidni, ɔ na ɔl tu di kidni dɛm.

Wetin na di men kayn RCC?

Difrɛn kayn RCC dɛn de. Tink bɔt am lɛk se yu gɛt difrɛn pipul dɛn na di sem famili. Dis klasification de bays pan aw di kansa sel dεm de luk כnda maykroskכp, dεn DNA , כ jεnεtik mεtirial. Sɔm men kayn dɛn de:

• Klia sel rεnal sεl kכrεkshכn (ccRCC): Dis tכp de akכnt fכ lεk 85% fכ RCC. I gɛt in nem bikɔs di kansa sɛl dɛn de sho klia wan ɔnda maykroskɔp.
• Papillary renal cell carcinoma: Dis kayn de mek bitwin 10% ɛn 15% pan ɔl di rεnal sεl kansa dεm. Dɛn gi am di nem fɔ di tin dɛn we de kɔmɔt na do we tan lɛk finga ( papillae ) we de pan dɛn tɔŋ ya.
• kromofob rεnal sεl kכrεkshכn: Dis tכp de akכnt bitwin 5% εn 10%. Dɛn sɛl ya kin gɛt layt kɔlɔ bak, we fiba klia sɛl dɛn, bɔt dɛn kin big smɔl.
• RCC we nɔ klas: Na lɛk 6% pan di RCC dɛn nɔ kin ebul fɔ klas insay ɛni big kayn. Bɔt sayɛnsman dɛn de kɔntinyu fɔ tray fɔ put dis grup we dɛn nɔ put insay di grup insay nyu we dɛn, bay tin dɛn lɛk di maykroskɔpik kwaliti dɛn we di sɛl dɛn gɛt ɛn dɛn DNA .

Yu go dɔn yɛri dɔktɔ dɛn de yuz di wɔd dɛn "localized" ɔ "advanced" ɔ "metastatic" we dɛn de tɔk bɔt RCC. Lokal RCC min se di kansa de na di kidni nכmכ, εn i kin dכn spre to di tisu dεm we de nia. RCC we gɛt mɛtastasI min se di kansa dɔn skata to ɔda pat dɛn na di bɔdi. De kayn wae yu gɛt de sho aw fɔ trit yu ɛn chans fɔ wɛl.

Aw kɔmɔn tin na RCC?

Ɔlsay na di wɔl, dɛn kin ripɔt lɛk 400,000 nyu kes dɛm fɔ RCC ɛvri ia. Insay Amɛrika, di nɔmba na lɛk 80,000. Pan ɔl we ɛnibɔdi kin gɛt RCC, i kin bɔku pan man dɛn we ol bitwin 60 ɛn 80 ia .

Wetin na di sayn dɛm fɔ rεnal sɛl kansa?

Bɔrku pipul nɔr kin gɛt ɛni sayn wae de kam fɔs. Di sayn dɛm kin bigin fɔ sho we di kansa de gro ɛn bigin fɔ afɛkt di tisu ɔr ɔgan dɛm we de rawnd am.

Di sayn dɛm fɔ RCC kin bi:

• Blɔd we de na di urine (hematuria). Dis na di sayn wae kin kam pan pɔrsin.
• Flank pen: Dis de tɔk bɔt pen we de apin na di tu say dɛn na di bɔdi, ɔp di wɛst ɛn dɔŋ di rib dɛn.
• Fɔ fil lɛk se yu gɛt smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl.
• Fiva we kin kam witout rizin.
• Nayt swet dɛn.
• We yu de lɔs yu wet we yu nɔ ɛksplen.

Apat frɔm dat, sɔm sayn dɛn bak we de sho se pɔsin nɔ gɛt bɛtɛ blɔd , lɛk we i nɔ de blo fayn ɛn we i taya. Ɔ di sayn dɛm fɔ wan sik we dɛn kɔl paraneoplastic syndromes kin apia bak. insay dis kayn we, tin dεm lεk כ mon dεm de kכmכt frכm kansa tכmכro dεm, we de mek difrεn chenj dεm na di bכdi.

Wetin na di tin dɛn we kin mek pɔsin gɛt RCC?

RCC kin apin we abnכmal sεl dεm na di kidni tכ bul dεm bigin fכ gro we dεn nכ kin kכntro. Dɛn nɔ no yet di rayt tin we mek i apin. Bɔt sayɛnsman dɛn dɔn no sɔm tin dɛn we kin mek pɔsin gɛt RCC.

Wetin na di tin dɛn we kin mek pɔsin gɛt dis sik?

Di risk fɔ gɛt RCC kin bɔku if yu gɛt dɛn tin ya:

• Smok: Di mɔ yu de smok, na di mɔ yu go gɛt prɔblɛm.
• Fat pasmak: Di mɔ yu bɔdi mas indeks (BMI) bɔku, na di mɔ yu go gɛt prɔblɛm.
• Ay blɔd prɛshɔn (Hypertension).
• Krכnik kidni sik: Dis kin inklud dεn wan dεm wae de gεt lכng tεm dayalaysis tritmεnt.
• Kronik Epataytis C infεkshכn.
• Yuz sɔm pen kil fɔ lɔng tɛm (e.g. NSAID, asetaminofɛn).
• Fɔ dɔn gɛt redyushɔn tɛrapi to di bɛlɛ eria.
• We pɔsin gɛt tin dɛn we kin mek pɔsin gɛt kansa, lɛk kadmiɔm ɛn asbest .
• Siklɔs sik: Dis kin gɛt fɔ du wit wan kayn RCC we nɔ kin bɔku.
• Famili histri bɔt kidni kansa.
• jεnεtik mכtεshכn: Dis na chenj dεm na di DNA fכ di sεl dεm.
• Tuberous sklerɔsis kɔmpleks.
• Di sik we dɛn kɔl Von Hippel-Lindau (VHL).

If yu gɛt wan pan dɛn tin ya we kin mek yu gɛt prɔblɛm, yu dɔktɔ kin tɛl yu fɔ du ɛgzam na yu kidni ɔltɛm, ɛn dis kin ɛp fɔ no kansa kwik kwik wan.

Aw fɔ no RCC?

Na lɛk 25% pan di pipul dɛm wae gɛt RCC kin no se dɛn gɛt dis sik afta di kansa dɔn skata smɔl, we min na we di sayn dɛm bigin fɔ sho.

Bɔt di gud nyus na dat, di imej tɛst dɛn we dɛn kin du fɔ ɔda rizin dɛn naw de no mɔ ɛn mɔ bɔt di RCC tɔŋ dɛn we kin apin, bifo di simptom dɛn apia. Dis dɔn mek mɔ pipul dɛn de gɛt tritmɛnt fɔ di kansa we i de mɛn pas ɔl.

Test fɔ no if pɔsin gɛt RCC

Dɔktɔ dɛn kin yuz imej tɛst fɔ no if pɔsin gɛt kansa ɛn fɔ plan fɔ trit am. Di tɛst dɛn we dɛn kin du mɔ na:

• Ultrasound scan: Dis min se dɛn kin sɛn ay frikshɔn sawnd wev dɛn tru di bɔdi tisu ɛn mek pikchɔ dɛn we pɔsin kin si pan monita. Altra saund kin ɛp fɔ no if di lump ful-ɔp wit wata (we kin bi sist ) ɔ sɔlid (we kin apin mɔ pan kansa lumps).
• Computed tomography (CT) scan: Dis kin mek sɔm pikchɔ dɛn we de gi ditayli pikchɔ bɔt di insay pat pan di bɔdi. I go mɔs bi se yu go gɛt fɔ injɛkt wan day we dɛn kɔl kɔntrast insay wan vein ɛn mek yu skan bifo ɛn afta dat. Dis day de travul go na di kansa ɛn sho am klia wan.
• Magnetic resonance imaging (MRI) scan: Dis kin yuz big magnet, redio wev, ɛn kɔmpyuta fɔ mek ditayli pikchɔ dɛn bɔt di insay pat pan di bɔdi. Yu dɔktɔ kin tɛl yu fɔ du MRI if yu nɔ ebul fɔ du CT skan (fɔ ɛgzampul, if yu nɔ gɛt alɛji fɔ di day we wi bin dɔn tɔk bɔt), ɔ if di rizɔlt fɔ ɔltra saund ɛn CT skan nɔ klia.

Pan ɔl we dɛn kin du bayɔpsi fɔ no if pɔsin gɛt kansa, dɛn nɔ kin du dis na RCC. Bayopsi min se dɛn kin tek smɔl smɔl tisu frɔm di tumbu ɛn chɛk am ɔnda maykroskɔp fɔ si if kansa sɛl dɛn de.

Bɔt bɔku tɛm fɔ bayɔpsi RCC kin gɛt prɔblɛm bikɔs i kin pwɛl di kidni. So, bɔku tɛm dɔktɔ dɛn kin tɛst fɔ si if dɛn gɛt kansa sɛl dɛn afta dɛn dɔn pul di wan ol tumbu as tritmɛnt. If imej sho se di kansa dɔn skata, dɛn kin tek di kansa sɛl dɛn frɔm ɔda say pas di kidni ɛn tɛst dɛn.

tεst dεn sεl dεm ya na di כnli we fכ no fכ sכri us kayn RCC yu gεt (if i nכ klia frכm imej). I kin ɛp bak fɔ no us tritmɛnt dɛn we go wok fayn fɔ da kayn kansa de.

Stej ɔf rεnal sɛl kansa

We yu no di stej we yu kansa de, dat de ɛp yu dɔktɔ fɔ ɔndastand aw fa yu kansa dɔn skata. I kin tɛl yu bak if di kansa de na di say we yu de ɔ i de go ɔdasay . Dis infɔmeshɔn kin ɛp yu fɔ plan yu tritmɛnt ɛn gi yu wan aidia bɔt di prɔgnosis.

Dɔktɔ dɛn kin yuz wan sistɛm we dɛn kɔl TNM (tumor, lymph node, metastasis) fɔ no di stej we RCC de. Dɛn kin klas di kansa insay stej I to IV. Stej I, II, εn III kεnsar dεm dεn kכl dεm lכkal, we stej IV na mεtastas RCC.

• Stej I RCC: Di kansa smɔl pas 7 sɛntimita ɛn i nɔ dɔn spre na do na di kidni.
• Stej II RCC: Di kansa big pas 7 sɛntimita, bɔt i nɔ dɔn spre na do na di kidni.
• Stej III RCC: di tכmכro kin bi eni saiz εn i dכn spre to di tisu dεm we de nia di kidni.
• Stej IV RCC: Di kansa dɔn spre pas di kidni to di limf no dɛm ɛn ɔda ɔgan dɛm.

Impɔtant: Fɔ no di stej we di kansa de na impɔtant tin fɔ no aw fɔ trit yu, so tek tɛm tɔk bɔt dis wit yu dɔktɔ.

Usay RCC de spre fɔs?

Bɔku tɛm, di RCC we de mɛtastas kin go na yu limf no dɛm, yu lɔng dɛm, yu bon dɛm, yu liva, ɛn yu bren. Sɔntɛnde i kin skata to yu ovaria ɔ tɛstikul.

Wetin na di tritmɛnt fɔ rεnal sɛl kansa?

Di tritmɛnt kin dipen pan bɔku tin, lɛk di stej we di kansa de ɛn yu ɔl wɛl bɔdi. Tritmεnt fכ lokaliz RCC difrεnt frכm tritmεnt fכ mεtastas RCC .

Lokalized rεnal sel kansa tritmεnt

Di tritmɛnt fɔ dis na fɔ pul di kansa, ɔ fɔ pwɛl di kansa yuz ablashɔn tɛknik (kil sɛl dɛn wit ɔt ɔ kol pasmak).

Ɔpreshɔn na di tritmɛnt we dɛn kin yuz mɔ fɔ lokaliz RCC.

• Radikal nεfrεktכmi: Dis involv fכ pul di kidni wit di kεnsar εn sכm pan di tisu dεm we de rawnd (lεk di limf no dεm εn di adrenal gland dεm, usay di kεnsar sεl dεm kin de). Fɔ bɔku pipul dɛn, wan kidni we gɛt wɛlbɔdi na in go du fɔ dɛn.
• Patɛl nɛfrɛktɔmi: .Dis min se dɛn fɔ pul di pat nɔmɔ na di kidni we gɛt kansa. Dɛn kin du dis ɔpreshɔn if yu kansa smɔl. Dis kin sev sɔm pan yu kidni fɔ wok. Dis na impɔtant tin if yu nɔ gɛt tu wɛlbɔdi kidni.

If yu nɔto gud pɔsin fɔ ɔpreshɔn, yu dɔktɔ kin tɛl yu fɔ du di we aw dɛn fɔ pul yu bɔdi . Dɛn tin ya na:

• Krayotɛrapi: Dɛn kin kil di kansa sɛl dɛn bay we dɛn de put dɛn pan kol pasmak.
• Radiofrequency ablation: Dɛn kin bɔn di kansa sɛl dɛn bay we dɛn put dɛn pan ay ɔt.

Metastatik rεnal sεl kansa tritmεnt

di tritmεnt f כ mεtastas RCC involv fכ fכt di kεnsar sεl dεm ɔlsay na di bכdi. Dɛn kin du ɔpreshɔn fɔ pul di tumbu, bɔt i nɔ go du fɔ pul di kansa we dɔn pas ɔlsay. Bɔt if yu pul di tumbu, dat kin ɛp fɔ mek di sik nɔ bɔku ɛn i kin mek dɛn nɔ bigin fɔ yuz ɔda tritmɛnt dɛn.

Di tritmɛnt dɛn we dɛn kin yuz mɔ na imyunotɛrapi ɛn targeted therapy . Dipen pan difrɛn tin dɛn, dɛn kin gi dɛn mɛrɛsin ya dɛn wan ɔ dɛn kin gi dɛn togɛda.

Imyunotɛrapi tritmɛnt dɛn

Immunotherapy de wok bay we i de mek yu imyun sistɛm strɔng, ɛp am fɔ fɛn ɛn fɛt di kansa sɛl dɛm. Sɔm pan dɛn mɛrɛsin ya na:

• Avelumab (Avelumab - Bavencio®) we gɛt di sik.
• Ipilimumab (Ipilimumab - Yervoy®) we gɛt di sik.
• Nivolumab (Nivolumab - Opdivo®) .
• Pεmbrolizumab (Pεmbrolizumab - Keytruda®) .

Di tritmɛnt dɛn we dɛn kin yuz fɔ mɛn pipul dɛn we dɛn dɔn tayt

di tεrapi dεm we dεn tכk bכt de wok bay we dεn de intafεr di prכsεs fכ di kεnsar sεl mכltiplikεshכn. Dis tritmɛnt de mek di blɔd nɔ de go na di kansa sɛl dɛn, ɛn dis kin mek dɛn nɔ gro. Sɔm pan dɛn mɛrɛsin ya na:

• Axitinib (Axitinib - Inlyta®) we gɛt di sik.
• Bɛvasizumab (Bɛvasizumab - Avastin®) .
• Kabozantinib (Kabozantinib - Kabometyx®) .
• Evεrכlimus (Evεrכlimus - Afinitor®) .
• Lenvatinib (Lεnvatinib - Lenvima®) .
• Pazopanib (Pazopanib - Votrient®) we gɛt di sik.
• Sorafenib (Sorafenib - Nexavar®) we de na di bɔdi.
• Sunitinib (Sunitinib - Sutent®) we gɛt di sik.
• Tɛmsirɔlimus (Tɛmsirɔlimus - Torisel®) .
• Tivozanib (Tivozanib - Fotivda®) we de na di bɔdi.

Dipen pan di stej we di kansa gɛt, usay i dɔn skata, aw i tranga, ɛn aw yu de du ɔda tritmɛnt dɛn, yu dɔktɔ kin tɛl yu bak fɔ du ɔda tritmɛnt dɛn fɔ di kansa, lɛk redyushɔn tɛrapi .

Yu tink se RCC kin wɛl ɔltogɛda?

I dipen pan di patikyula diagnosis we yu gɛt. Lokalized RCC we dɛn kɔlPipul dɛn we gɛt ay risk lokaliz RCC we dɛn dɔn pul dɛn kansa bay ɔpreshɔn kin gɛt gud lɔng tɛm autkam. Pipul dɛm wae gɛt ay risk lokaliz RCC kin gɛt imyunotɛrapi bak afta dɛn dɔn pul di kansa fɔ mek dɛn ebul fɔ du wɛl fɔ lɔng tɛm.

Naw, no mɛrɛsin nɔ de fɔ advans RCC we dɔn skata pas di kidni. Bɔt as sayɛnsman dɛn de fɛn bɛtɛ tritmɛnt dɛn we de tɔch sɔm patikyula kansa sɛl dɛn, pipul dɛn we gɛt mɛtastas RCC de liv lɔng naw.

Wetin na di lukin-grɔn fɔ RCC dɛn?

Naw di dɔktɔ dɛn kin ebul fɔ no RCC fɔs, we dɛn kin trit di kansa mɔ. Fɔ no di sik kwik kwik wan ɛn di tritmɛnt dɛn we dɛn dɔn mek fayn, dɔn mek di pipul dɛn we de liv bɛtɛ. 90% pan di pipul dɛm wae gɛt stej I RCC kin liv fɔ fayv ia. Semweso, pan ɔl we di layf we pipul dɛn we gɛt stej IV RCC kin liv bin de fɔ sɔm mɔnt, bɔku pan dɛn naw de liv fɔ sɔm ia.

Yu tink se dɛn kin ebul fɔ stɔp RCC?

RCC nɔ kin ebul fɔ stɔp ɔltɛm. Bɔt yu kin ridyus di prɔblɛm we yu gɛt. Fɔ ɛgzampul, nɔ fɔ smok (ɔ lɛf fɔ smok if yu du am) na wan pan di bɛst tin dɛn we yu go du fɔ mek yu nɔ gɛt kansa. I impɔtant bak fɔ mek yu gɛt wɛl bɔdi, it fayn it, ɛn kɔntrol ay blɔd prɛshɔn.

Aw a go tek kia ɔf misɛf?

Tɔk to yu dɔktɔ bɔt wan plan fɔ kia fɔ yu fɔ ɛp yu fɔ kɔntrol yu kansa simptom dɛm ɛn di sayd ɛfɛkt dɛm we yu tritmɛnt gɛt. Fɔ ɛgzampul, sɔm pipul dɛn kin nid fɔ bigin fɔ du dayalaysis afta dɛn dɔn du dɛn ɔpreshɔn if wan ɔ ɔl tu di kidni dɛn nɔ de wok fayn. E fayn fɔ no aw dɛn tritmɛnt ya go afɛkt yu.

Yu kin nid ɛp fɔ manej di sayd ɛfɛkt dɛm wae de kam wae yu gɛt targeted therapy ɔr immunotherapy . Aks yu dɔktɔ wetin fɔ ɛkspɛkt bifo yu bigin tritmɛnt.

Us kwɛstyɔn dɛn a fɔ aks mi dɔktɔ?

• Us kayn RCC a gɛt?
• Aw fa mi kansa dɔn skata (wetin na di stej)?
• Wetin na di bɛnifit ɛn bad tin dɛn we de pan di tritmɛnt dɛn we de?
• Wetin na di sayd ɛfɛkt ɔ kɔmplikeshɔn dɛm wae a fɔ no bɔt bifo a go gɛt tritmɛnt?
• Aw ɔltɛm a fɔ kam fɔ chɛk-ap afta tritmɛnt?
• Us chenj a fɔ ɛkspɛkt pan mi layf we a de du tritmɛnt?
• Wetin na di prɔgnosis fɔ mi kɔndishɔn?

Yu rεnal sεl kansa (RCC) kεnsar tritmεnt εkspiriεns go dipכnt pan plεnti tin dεm, inklud yu כvala hεlth, di kayn εn stej כf RCC, εn aw yu rεspכns to tritmεnt. Bɔt ɛnibɔdi we dɛn no se gɛt kansa na in kidni go bɛnifit if dɛn gɛt tayt padi biznɛs wit dɛn mɛdikal tim. Nɔr shem fɔ aks kwɛstyɔn bɔt yu diagnosis, de gud ɛn bad tin fɔ di tritmɛnt opshɔn dɛm, ɛn de autkam wae yu de ɛkspɛkt. Yu dɔktɔ na di bɛst pɔsin fɔ ɛksplen wetin i min fɔ yu fɔ gɛt RCC.

Fɔ dɔn, tin dɛn we wi fɔ mɛmba

Pan ɔl we di rεnal sɛl kansa (RCC) na siriɔs kכndyushכn, di rεt we i de kכl dεm dɔn bכku we dεn de no am kwik kwik wan εn trit am fayn. If yu gɛt ɛni sayn, mɔ blɔd na yu urine, pen na yu groin, wan lump na yu an, ɔ yu famili histri bɔt kidni kansa, go to dɔktɔ wantɛm wantɛm. Yu kin ridyus yu risk fɔ gɛt dis sik bay wae yu nɔr smok ɛn liv fayn layf. Nɔr frayd fɔ tɔk to yu dɔktɔ if yu gɛt ɛnitin fɔ wɔri bɔt. Nɔto yu wan de.

` Kidni kansa, rεnal sel kansa, RCC, kidni tכmכro, kansa simptom, kansa tritmεnt, kidni hεlth