We wi yɛri di wɔd ‘cholesterol’, bɔku pan wi kin kray smɔl, nɔto so? Ɛspɛshali we di dɔktɔ se, "Yu bad kɔlɔstrel, dat na, LDL lɛvɛl, ay smɔl," wi kin fred smɔl. Wetin wi de it ɛn drink, ilɛksɛf wi de du ɛksɛsayz ɔ wi nɔ de du ɛksɛsayz, ɛn sɔntɛnde, tin dɛn we wi kin gɛt frɔm wi jɛnɛtiks kin afɛkt dis bak. So, klos to wi ɔl dɔn yɛri bɔt ‘statin’ tayp pils we dɛn kin gi fɔ kɔntrol kɔlɔstrel. Bɔt fɔ sɔm pipul dɛn, dɛn drɔgs ya nɔmɔ nɔ go du fɔ dɛn, ɔ dɛn nɔ go ebul fɔ yuz dɛn. Tide wi de tɔk bɔt wan smɔl advans, nyu kayn drɔg we dɛn kin yuz pan dɛn kayn kes ya. Dat na Repatha.
Wetin na Repatha? Aw i kin mek di kɔlɔstrel nɔ bɔku?
Fɔ tɔk am simpul wan, Repatha na shot we de stɔp di "bad" kɔlɔstrel, ɔ LDL (Low-Density Lipoprotein) kɔlɔstrel lɛvɛl na wi bɔdi. Dis nɔto pil we wi kin tek, bɔt na injɛkshɔn we dɛn kin injɛkt ɔnda di skin.
Naw luk aw dis de wok, i wɔndaful. Imajin se wi liva na di filta we de pul bad kɔlɔstrel na di blɔd. bכt wi bכdi gεt wan protin bak we dεn kכl PCSK9 (Proprotein Convertase Subtilisin Kexin type 9) . Dis tan lɛk pɔsin we de ridyus di efyushɔn fɔ da filta de, we de ambɔg am. we di PCSK9 protin de inkrεs, di liva in ebul fכ pul LDL frכm di bכdi de dכn.
wetin Repatha de du na fכ inhεbit di aktvכti fכ dat 'mεsכp' PCSK9 protin . we dεn stכp am, di liva in filta kin wok wit maksimal efyushכn bak witout nכ intafεreshכn, i kin kech εn aktivli pul di bad kכlestכl (LDL) we de na di bכdi. Yu ɔndastand? Dis min se dis mɛrɛsin de ɛp wi bɔdi in yon natura prɔses we de kɔntrol kɔlɔstrel.
Udat dɛn kin rɛkɔmɛnd dis Repatha mɛrɛsin fɔ?
Dis nɔto mɛrɛsin fɔ ɔlman. Dɔktɔ go jɔs tɛl am fɔ du am pan sɔm patikyula kes dɛn.
- Fɔ big pipul dɛn we gɛt at sik we dɔn de: Dɛn kin yuz dis mɛrɛsin fɔ ridyus di risk fɔ gɛt at atak, strok, ɔ ɔda at sik. Dɛn kin gi am wit ɔda mɛrɛsin dɛn we gɛt kɔlɔstrel, lɛk statin.
- Fɔ pipul dɛm we gɛt ay kɔlɔstrel we dɛn gɛt frɔm dɛn jɛnɛtiks: Sɔm pipul dɛn gɛt rili ay kɔlɔstrel lɛvɛl bikɔs ɔf di jɛnɛtik kɔndishɔn dɛm we dɛn kin pas frɔm jɛnɛreshɔn to jɛnɛreshɔn. Dɛn kɔl dɛn tin ya Hɛtɛrozaygɔs Famili Haypa Kɔlestɔlemia (HeFH) ɛn Homozaygɔs Famili Haypa Kɔlestɔlemia (HoFH) . Ripatha na fɔ big pipul ɛn pikin dɛn we dɔn pas 10 ia wit dɛn kɔndishɔn ya fɔ kɔntrol di LDL lɛvɛl.
Di tin we impɔtant pas ɔl na dat, i impɔtant fɔ fala wɛlbɔdi it ɛn ɛksesaiz we yu de yuz dis mɛrɛsin.Repatha nɔto majik, na jɔs wan pat pan di tritmɛnt plan.
Wetin na di bɛnifit ɛn ifɛkt dɛn we dis mɛrɛsin gɛt?
Klinik stεdi dεm pan Repatha dεn sho prכmis risכlt. Dɛn stɔdi ya kɔmpia Repatha wit wan plasɛbo (wan dɔmi tritmɛnt) ɛn wit ɔda kɔlestɔl mɛrɛsin dɛn lɛk statin.
Lɛ wi ɛksplen dis mɔ wit di tebul we de dɔŋ ya.
| Udat dɛn kin advays dis mɛrɛsin fɔ? | Ki bɛnifit dɛn we dɛn pruv bay tɛst |
|---|---|
| Big pipul dɛm wae dɔn ɔlrɛdi gɛt hat sik (wit ɔda mɛrɛsin dɛm lɛk statin) . | Ridyus di risk fɔ gɛt at atak, strok, ɛn day bikɔs ɔf at sik bad bad wan. |
| Big pipul ɛn pikin dɛn we dɔn pas 10 ia wit ay kɔlɔstrel bikɔs ɔf di jɛnɛtik kɔz | i rili fayn εn i de ridyus di lεvεl fכ "bad" kכlestכl (LDL) na di bכdi. |
Aw yu go no if di mɛrɛsin de wok?
Yu dɔktɔ go ɔda fɔ mek dɛn du blɔd tɛst (lipid profayl tɛst) ɔltɛm . Afta yu dɔn stat Repatha, yu kin notis se yu LDL kɔlɔstrel lɛvɛl dɔn rili ridyus insay lɛk 12 wiks .
Lɛ wi no bak bɔt di yus ɛn di sayd ɛfɛkt dɛm fɔ Repatha.
Aw fɔ yuz dis?
Repatha kin kam as sirinj we dɛn dɔn ful-ɔp bifo tɛm ɔ injɛkta pen. Dɛn kin injekt am ɔnda di skin ɛvri tu wik ɔ wan tɛm insay di mɔnt, i go dipen pan di doz we dɛn tɛl yu fɔ gi yu.
Di tin we impɔtant pas ɔl: I rili impɔtant fɔ lan ɛksaktɔli aw fɔ yuz dis frɔm yu dɔktɔ fɔs. Bifo yu yuz am fɔ di fɔs tɛm, aks fɔ mek dɛn sho klia wan aw fɔ du am.
Wetin na di bad tin dɛn we kin apin to pɔsin?
Lɛk ɛni mɛrɛsin, Repatha kin mek smɔl smɔl sayd ɛfɛkt, pan ɔl we nɔto ɔlman kin gɛt dɛn.
| Kɔmɔn sayd ɛfɛkt dɛn | Tips fɔ mek yu nɔ du am ɔ fɔ mek yu nɔ ebul fɔ du am |
|---|---|
| Rɛd, pen, ɛn brus na di say we dɛn injekt. | - כltεm rotate di injεkshכn sayt (e.g., wan say na di bכdi, di nεks tεm di כda say). - Tek di vaysin kɔmɔt na frij, lɛ i sidɔm fɔ 30-45 minit , dɔn injɛkt am afta i dɔn rich rum tɛmpracha. |
| Di sayn dɛm we tan lɛk kol (fiva, bɔdi we de at). | Bɔku tɛm, dɛn tin ya kin apin fɔ shɔt tɛm nɔmɔ. If yu gɛt ɛni prɔblɛm, tɔk to yu dɔktɔ. |
| Bak pen, ay blɔd shuga lɛvɛl. | Tɛl yu dɔktɔ if ɛni sayd ɛfɛkt de mɔna yu ɔ i nɔ de chenj. |
Point dɛn we yu fɔ pe spɛshal atɛnshɔn to:
- Latɛks Alɛji: Sɔm injɛkshɔn nidul dɛn kin gɛt latɛks na dɛn swɛt. If yu gɛt alɛji fɔ lɛtɛks, mek shɔ se yu tɛl yu dɔktɔ bɔt dis.
- Bεlε εn bεlε: If yu bεlε, yu de tray fכ bεlε, כ yu de gi bεlε, i impɔtant fכ tεl yu dכkta bifo yu yuz dis mεdisin, biכs nכ inof data de fכ i sef pan dεn situeshכn dεm ya.
Aw a go gɛt dis mɛrɛsin?
Dis nɔto mɛrɛsin we yu kin bay na famasi. Dɛn nid fɔ gɛt prɛskrishɔn frɔm dɔktɔ.
Bɔku tɛm, di pɔsin we de kia fɔ yu fɔs ɔ di dɔktɔ we de mɛn yu at go disayd if yu nid dis mɛrɛsin ɛn tɛl yu fɔ gi yu am. Dipen pan yu dɔktɔ in advays, yu kin ebul fɔ gɛt am frɔm spɛshal famasi ɔ sɔntɛm tru yu lokal famasi.
Nɔ ɛva bigin, stɔp, ɔ chenj di doz fɔ ɛni mɛrɛsin we yu nɔ gɛt dɔktɔ advays. Ɔltɛm, go to yu dɔktɔ bifo yu disayd fɔ du ɛnitin.
Mɛsej we dɛn kin kɛr go na os
- Repatha na injεkshכn we de sכbkutan we de lכs di hכy LDL ("bad") kכlestכl lεvεl.
- Dis kin fayn mɔ fɔ di wan dɛn we gɛt ay risk fɔ gɛt at sik ɛn di wan dɛn we gɛt prɔblɛm wit dɛn jɛnɛtik kɔlɔstrel.
- i de blok wan protin we dεn kכl PCSK9, we de εp di liva fכ pul di LDL kכlestכl na di bכdi.
- Dis kin jɔs gɛt wit dɔktɔ in prɛskrishɔn. I rili impɔtant fɔ fala wetin yu dɔktɔ tɛl yu fɔ du.
- Sɔm sayd ɛfɛkt lɛk fɔ rɛd ɛn kol lɛk sayn na di say we dɛn injekt kin apin, ɛn yu fɔ tɛl yu dɔktɔ bɔt dɛn.
- Di bɛst rizɔlt kin bi bay we yu yuz Repatha wit wɛlbɔdi layf.
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