Di mɛrɛsin we yu de tek na denja kɔndishɔn? Lɛ wi lan bɔt di sik we dɛn kɔl Serotonin Syndrome?

Tide wi go tɔk bɔt wan kɔndishɔn wae siriɔs smɔl, bɔt yu kin kɔntrol am izi wan if yu no bɔt am. Yu kin de tek mɛrɛsin fɔ pwɛl hat ɔr ɔda sik. Sɔntɛnde, dɛn mɛrɛsin ya kin mek wi bɔdi chenj ɛn mek wi gɛt prɔblɛm dɛn we wi nɔ bin ivin ebul fɔ imajin. Wan pan dɛn kayn tin ya na di sik we dɛn kɔl sɛrotonin syndrome.

Wetin na di sik we dɛn kɔl Serotonin Syndrome?

Fɔ tɔk am simpul wan, Serotonin Syndrome na wan drɔg riakshɔn we kin mek yu layf de pan denja sɔm tɛm, i kin apin we tumɔs kemikal we dɛn kɔl sɛrotonin de na yu bɔdi.

Tink bɔt am, sɛrotonin na wan rili impɔtant kemikal mɛsenja we di nɛv sɛl dɛn na wi bren ɛn ɔda pat dɛn na di bɔdi de mek. Fɔ tɔk di kɔrɛkt tin, na mɛsenja we de kɛr mɛsej bitwin di nɛv sɛl dɛn. Wi kin kɔl dis nyurotransmitta . Dis sɛrotonin kin afɛkt bɔku tin dɛn lɛk aw wi kin fil, aw wi kin slip, ɛn aw wi kin want fɔ it.

Bɔrku pipul kin tek mɛrɛsin wae de afɛkt sɛrotonin (serotonergic) sef wan pan di dos dɛm wae dɛn kin gi, lɛk aw dɛn dɔktɔ tɛl dɛn. Bɔt, di sik we dɛn kɔl sɛrotonin syndrome kin apin mɔ we yu bigin fɔ tek nyu mɛrɛsin ɔ yu kin mek di mɛrɛsin we yu dɔn ɔlrɛdi tek bɔku, mɔ if di mɛrɛsin mek yu sɛrotonin lɛvɛl go ɔp. If yu bɔdi chenj aw i de yuz sɛrotonin, ɔ if yu nɔ ebul fɔ handle di sɛrotonin lɛvɛl we dɔn go ɔp, yu kin gɛt sɔm sayn dɛm fɔ sɛrotonin sindrom.

Dis sik kin kɔmɔt frɔm smɔl smɔl sayn dɛm lɛk dayarɛa ɛn nɔs to bad bad sayn dɛm lɛk ay fiva ɛn siz. Sɔntɛnde, siriɔs sɛrotonin sindrom kin mek pɔsin in layf de pan denja if dɛn nɔ no ɛn trit am kwik.

Dɔktɔ dɛn bin fɔs no se di sik we dɛn kɔl sɛrotonin syndrome insay di 1960 dɛm, afta dɛn dɔn gri fɔ di fɔs mɛrɛsin dɛm we de mek pɔsin fil bad. Tide, as mɔ ɛn mɔ mɛrɛsin dɛn de we de afɛkt di sɛrotonin, dɛn de ripɔt bɔku bɔku pipul dɛn we gɛt sɛrotonin sindrom.

Udat go ebul fɔ divɛlɔp dis?

Infakt, ɛnibɔdi kin gɛt dis, ilɛksɛf i ol. If yu yuz ɛni mɛrɛsin we dɛn kin gi yu, mɛrɛsin we yu kin bay we yu nɔ bay, ɔr mɛrɛsin we nɔ rayt we de afɛkt yu sɛrotonin lɛvɛl, yu de pan denja fɔ gɛt sɛrotonin sindrom.

Wetin na di sayn dɛm wae kin kam pan dis?

Di sayn dɛm ɛn aw i kin tranga fɔ gɛt sɛrotonin syndrome kin difrɛn frɔm wan pɔrsin to ɔda pɔrsin. Dɛn kin nɔr kin pasmak, nɔr kin pasmak, kin tranga, ɛn ivin kin kil pɔrsin.

If yu de tek mɛrɛsin we de afɛkt sɛrotonin ɛn yu gɛt ɛni wan pan dɛn sik ya, kɔl yu dɔktɔ wantɛm wantɛm ɔ go na imejensi rum.

Smɔl smɔl sayn dɛn

• Fɔ fil lɛk se yu de fred smɔl ɛn nɔ izi fɔ yu.
• Fɔ fil se yu de fil lɛk yu nɔs ɛn yu de vɔmit.
• Bɛlɛ we de blo (dayarɛa).
• di blak pupil dεm na di yay dεm de bi big (dilated pupils).
• Fɔ fil lɛk se yu an ɛn fut dɛn de shek (Tremor).

Di simptom dɛn we nɔ kin bɔku

• A kin fil se a nɔ de rɛst ɛn a kin fil bad.
• di mכsul dεm de twitch, di mכsul dεm de kכntrikshכn we yu nכ want, di mכsul dεm de spam, di mכsul dεm de rigid.
• I de swet bɔku bɔku wan, i de shek shek bikɔs ɔf di kol.
• Di yay dɛn de muv abnɔmal wan frɔm wan say to di ɔda say.

Di sayn dɛn we kin mek pɔsin gɛt siriɔs sik

• Big big kɔnfyushɔn, lɛk se dɛn de ambɔg in kɔnshɛns, pɔsin kin fɔgɛt usay i de ɛn us tɛm i de (Kɔnfyushɔn, disorientation, delirium).
• di hat rεt de inkrεs bכku bכku wan (rapid hat rεt).
• Di ay blɔd prɛshɔn.
• Di ay tɛmpracha na di bɔdi pas 38.5 digri sɛlshiɔs (101.3 digri F).
• Seizures de kam.
• Di at bit nɔ kin de bit ɔltɛm.
• A kin lɔs kɔnshɛns ɛn a kin fɔdɔm.

Aw kwik di sayn dɛm kin apia?

Dɛn sayn ya kin bigin fɔ apia insay sɔm awa , ɔ afta yu dɔn bigin fɔ tek nyu mɛrɛsin we de afɛkt di sɛrotonin lɛvɛl ɔ afta yu dɔn inkrisayz di doz fɔ wan mɛrɛsin we yu de tek naw. Klose to ɔlman kin gɛt di sik insay 24 awa afta dɛn tek mɛrɛsin ɔ prɔdak we de afɛkt sɛrotonin.

Wetin mek dis kin apin? Wetin na di rizin dɛn?

Di men tin we kin mek yu gɛt sɛrotonin sindrom na we di sɛrotonin lɛvɛl de go ɔp na yu bɔdi. Dis kin apin pan tin dɛm lɛk dis:

• We yu de yuz mɔ pas wan mɛrɛsin we de afɛkt di sɛrotonin lɛvɛl.
• We yu bigin fɔ tek nyu mɛrɛsin we de mek yu gɛt sɛrotonin, ɔ we yu de inkrisayz di doz fɔ wan mɛrɛsin we yu de tek naw.
• If yu tek tumɔs mɛrɛsin we gɛt fɔ du wit sɛrotonin, sɔntɛm na aksidɛnt ɔ na bay wilful.
• We yu de yuz sɔm ilɛgal drɔgs, ɛbul prɔdak , ɔ ɔva-di-kɔnta drɔgs we de afɛkt di sɛrotonin lɛvɛl.

Us mɛrɛsin ɛn ɔda tin dɛn kin afɛkt di sɛrotonin lɛvɛl?

Naw lɛ wi si us kayn mɛrɛsin kin afɛkt di sɛrotonin lɛvɛl ɛn mek pɔsin gɛt sɛrotonin sindrom.

Di mɛrɛsin dɛn we de mek pɔsin nɔ fil bad

Pan dɛn tin ya, di mɛrɛsin dɛn we de mek pɔsin nɔ fil bad na dɛn impɔtant pas ɔl. Dis na di drɔgs we de afɛkt di sɛrotonin lɛvɛl pas ɔl. Dis sik kin apin bɔrku tɛm wae dɛn kin yuse dɛn antidipreshan ya togɛda wit ɔda mɛrɛsin dɛm wae kin afɛkt sɛrotonin, lɛk triptan fɔ maygren ɔr opioid fɔ mek yu nɔr fil pen.

Na sɔm kayn mɛrɛsin wae de mek pɔrsin fil bad ɛn sɔm ɛgzampul dɛm:

• `Sεlektiv sεrotonin riuptek inhibito dεm (SSRI): Dis grup inklud dεm lεk `fluoxetine (Prozac®), `citalopram (Celexa®), `sertraline (Zoloft®), `paroxetine (Paxil®)` εn `escitalopram (Lexapro®).` Dis na dεn wan dεm we dεn kin yus mכst εn dat mek dεn wan dεm we gεt bכku bכku wan wit sεrotonin sεndrכm.
• Serotonin-norepinephrine riupteke inhibitors (SNRI): Ɛgzampul fɔ dɛn na duloxetine (Cymbalta®), venlafaxine (Effexor®), desvenlafaxine (Pristiq), levomilnacipran (Fetzima) ɛn milnacipran (Savella).
• `Trisaykli antidipreshan`: Dis grup inklud drɔgs lɛk `amitriptyline (Elavil®)`, `clomipramine (Anafranil®)`, ɛn `nortriptyline (Pamelor®)`.
• `Monoamine oxidase inhibitors (MAOIs): Drug dεm lεk `phenelzine (Nardil®)`, `selegiline (Emsam®)` εn `tranylcypromine (Parnate®)` de insay dis kεtכgכri.
• sεrotonin mכdulet dεm: lεk nεfazodכn εn trazodכn (Desyrel®).
• wan egzampl fכ dis na `Norepinephrine riuptek inhibito`: `bupropion (Wellbutrin®).`

Ɔda Mɛrɛsin dɛn

Apat frɔm di mɛrɛsin dɛn we de mek pɔsin fil bad, ɔda mɛrɛsin dɛn de we kin afɛkt di sɛrotonin lɛvɛl na di bɔdi. Di risk kin bɔku mɔ we dɛn jɔyn dɛn mɛrɛsin ya wit ɔda mɛrɛsin dɛn we kin afɛkt sɛrotonin bak. Dɛn kin yuz dɛn mɛrɛsin ya fɔ:

• Fɔ siriɔs pen: Pen kil we kɔmɔt na di opioid klas, lɛk tramadol (Ultram®), meperidine (Demerol®), tapentadol (Nucynta®), haydrokodɔn (Hysingla ER®), ɔksikɔdɔn (Oxycontin®), fentanyl (Actiq®), ɛn mɛtadɔn.
• Kɔf: Sɔm ɔva-di-kɔnta (OTC) kɔf ɛn kol mɛrɛsin dɛm lɛk dɛkstromɛtɔrfan kin afɛkt di sɛrotonin lɛvɛl.
• Fɔ maygren ed pen: Triptan dɛn inklud almotriptan (Axert®), ɛlitriptan (Relpax®), ɛn sumatriptan (Imitrex®).
• Fɔ HIV/AIDS: `ritonavir (Norvir®)`.
• Antibayɔtiks: laynzolid (Zyvox®).
• Mεdisin dεm fכ nכs εn vכmit: lεk `mεtoklopramid (Reglan®)`, `granisetron (Sustol®)`, `ondansetron (Zofran®)`.
• Di tin we de mek pɔsin fil fayn: litiɔm (Lithobid®).

Ɔda Prodakt dɛn

Apat frɔm mɛrɛsin, sɔm tradishɔnal ɛvbɔdi, it, ɛn drɔgs we nɔ rayt kin afɛkt di sɛrotonin lɛvɛl bak ɛn mek dis sik.

• Ɛbul supamakit: Dɛn tin ya kin inklud tin dɛn lɛk ginseng, Sɛnt Jɔn wɔt, Sirian rue, ɛn natmɛk.
• Drug dɛn we nɔ rayt: Tin dɛn lɛk ɛkstazi, LSD, kɔkɛyn, amfɛtamin, ɛn mɛtamfɛtamin.
• Di tin dɛn we dɛn kin yuz fɔ it:Triptofan we de na di wɔl.

Di wan dɛn we sabi bɔt mɛrɛsin stil de lan bɔku tin bɔt di sik we dɛn kɔl sɛrotonin syndrome. If yu gɛt ɛni kwɛstyɔn bɔt di mɛrɛsin dɛn we yu de tek ɛn if dɛn de afɛkt di sɛrotonin, tɔk to yu dɔktɔ ɔ di pɔsin we de na di famasi usay yu de gɛt yu mɛrɛsin.

Aw dɔktɔ dɛn kin no dis?

Naw lɛ wi si aw dɔktɔ dɛn kin no bɔt dis. Fɔ tru, nɔ patikyula tɛst nɔ de fɔ kɔnfɔm serotonin sindrom. Bɔku tɛm, yu dɔktɔ go no am bay we i de chɛk yu, aks yu bɔt di sik dɛn we yu gɛt, ɛn lan bɔt di mɛrɛsin dɛn we yu de tek we de afɛkt yu sɛrotonin lɛvɛl.

Yu kin ɛp yu dɔktɔ bay we yu de tɔk klia wan bɔt ɔltin we yu de tek (drɛg dɛn we yu de tek, mɛrɛsin dɛn we yu nɔ de bay, sɔpɔtmɛnt, ɛbul mɛrɛsin, ivin drɔgs we nɔ rayt). (Bi ɔnɛs, nɔ fred. Di dɔktɔ de fɔ ɛp yu, nɔto fɔ jɔj yu.)

Yu dɔktɔ kin du tɛst dɛn bak lɛk dɛn wan ya:

• Blɔd ɛn urine tɛst fɔ chɛk di lɛvɛl dɛn fɔ di mɛrɛsin dɛn we yu de tek.
• Test fɔ si if yu ɔda ɔgan dɛn de wok fayn.
• Test fɔ si if ɛni infekshɔn de na di bɔdi, sɔntɛm ivin na spɛshal tap.
• Dɛn kin du ɛkstrem rayt ɔ CT skan na di chɛst fɔ mek shɔ se nɔ ɔda tin nɔ de (we gɛt di sem kayn sik) ɔ fɔ chɛk fɔ ɔda prɔblɛm dɛn.

Aw dɛn kin trit dis?

De tritmɛnt wae yu go gɛt go dipen pan aw yu sik de kam tranga.

• Smɔl smɔl sayn dɛm: If di sayn dɛm nɔr smɔl, if yu stɔp di mɛrɛsin ɔr chenj di doz kin sɔlv di sik insay 24 to 72 awa . If di sik nɔ sɔlv kwik, dɛn kin gi yu wan mɛrɛsin we de blok di sɛrotonin lɛk sayprohɛptadin (Periactin®).
• Mɔdaret simptom dɛm: If yu symptoms na moderate, dɛn go kip yu na ɔspitul fɔ at le 24 awa fɔ si if yu symptoms improve wit tritmɛnt.
• Di bad bad tin dɛn we kin apin to yu: If di sik rili bad, dɛn go admit yu na di Intensive Care Unit (ICU) usay dɛn go de wach yu bɔdi ɛn yu ɔgan dɛn gud gud wan.

Dipen pan di sayn dɛm, dɛn kin gi dɛn tritmɛnt ya:

• Wan mɛrɛsin we de mek pɔsin fil fayn lɛk bɛnzodiazepine kin ridyus di sayn dɛn lɛk we pɔsin de agyu, we di mɔsul dɛn kin stif, ɛn we pɔsin kin gɛt sik.
• di salin `(IV fluid)` dεn de gi fכ ridyus di wata we de rεtεn εn fiva, εn dεn de gi כksijεn tru wan `(mask)` to di fes fכ impruv di כksijεn lεvεl na di bכdi.
• Mɛrɛsin fɔ kɔntrol di at rit ɛn blɔd prɛshɔn.
• Fɔ ridyus di fiva we rili ay (41.1 digri sɛlshiɔs / 106 digri Fahrenheit), dɛn kin put wan tiub fɔ mek i nɔ ebul fɔ blo fayn, dɛn kin gi pɔsin mɛrɛsin fɔ mek i fil fayn, ɛn dɛn kin gi pɔsin mɛrɛsin fɔ mek di mɔsul dɛn rilaks.
• If ɔda tritmɛnt dɛn nɔ de mek pɔsin fil fayn kwik kwik wan, dɛn kin gi pɔsin wan mɛrɛsin we de blok di sɛrotonin we dɛn kɔl sayprohɛptadin.

If na wan mɛrɛsin we de mek yu fil bad, i kin tek sɔm wiks fɔ mek di mɛrɛsin kɔmɔt na yu bɔdi kpatakpata ɛn fɔ mek yu sik dɛn nɔ de igen.

Di tin we impɔtant pas ɔl: Nɔ stɔp fɔ tek ɛni mɛrɛsin ɔ chenj di doz we yu nɔ tɔk to yu dɔktɔ. Bɔt if yu gɛt siriɔs sik ɔ if yu sik de wɔs, go to dɔktɔ kwik kwik wan. Serotonin syndrome kin mek pɔsin in layf de pan denja.

Us prɔblɛm dɛn kin apin?

If dɛn nɔ trit am, di sɛrotonin sindrom kin mek i gɛt prɔblɛm dɛn lɛk:

• Di sik dɛn we kin mek pɔsin sik.
• I nɔ kin izi fɔ yu fɔ blo.
• Kidni we nɔ de wok fayn. We tin dɛn we de mek di mɔsul dɛn brok gɛda na di blɔd ɛn di kidni dɛn de filta am, i kin mek di kidni pwɛl bad bad wan if dɛn nɔ trit am.
• Kɔma stet.
• Ivin day kin apin.

Aw wi de sev dis?

• I rili impɔtant fɔ pe atɛnshɔn gud wan to ɛni mɛrɛsin we yu de tek. Rid ɔl di wɔnin dɛn we de na di mɛrɛsin paket ɔ di infɔmeshɔn liflet we de wit am. I go tɛl yu if risk de fɔ gɛt sɛrotonin syndrome.
• Nɔ stɔp ɛni mɛrɛsin we yu nɔ tɔk to yu dɔktɔ.
• Kip ɔl di dɔktɔ we de trit yu no bɔt ɔl di mɛrɛsin dɛn we yu de tek (dɛrɛskrishɔn mɛrɛsin, ɔva-di-kɔnta mɛrɛsin, tradishɔnal ɛvbɔdi, sɔpɔtmɛnt, ivin drɔgs we nɔ rayt).
• If yu de tek triptan fɔ maygren wit antidipreshan (especially SSRI ɔ SNRI), yu dɔktɔ fɔ wach yu gud gud wan. Dɛn kin tink se di prɔblɛm rili smɔl, sɔntɛm i nɔ kin ivin de. Bɔt mɛmba se yu gɛt wok fɔ du: If yu gɛt ɛni wan pan di sayn dɛn we wi dɔn tɔk bɔt na dis atikul, kɔl yu dɔktɔ wantɛm wantɛm.
• If yu fala dɛn tin ya we yu fɔ tek tɛm wit, dat go ɛp yu ɛn yu dɔktɔ fɔ no di sayn dɛn we de sho se yu gɛt sɛrotonin syndrome kwik kwik wan. If yu no di sik kwik kwik wan, dat kin ɛp fɔ mek yu nɔ gɛt siriɔs sik.

Wetin wi fɔ ɛkspɛkt pan dis sityueshɔn?

If dɛn no ɛn trit dɛn kwik, bɔku pipul dɛn de sik go dɔn ɔlsay insay 24 to 72 awa.

Afta yu dɔn wɛl, yu dɔktɔ kin:

• Ridyus di doz fɔ di mɛrɛsin we mek dis kɔndishɔn to di doz we smɔl pas ɔl.
• Stɔp fɔ gi tu ay doz mɛrɛsin dɛn we de afɛkt sɛrotonin togɛda.
• Swich to ɔda mɛrɛsin we nɔ de afɛkt sɛrotonin.

Ustɛm a fɔ kɔl mi dɔktɔ ?

• If yu gɛt sayn dɛm fɔ serotonin syndrome (ɔ yu gɛt sayn dɛm wae de wɔs), kɔl yu dɔktɔ wantɛm ɔ go na di imejensi rum. Tek tɛm mɔ if yu dɔn bigin fɔ tek nyu mɛrɛsin, yu dɔn inkrisayz di doz fɔ di mɛrɛsin we yu de tek naw, ɔ yu de tek mɛrɛsin dɛn we yu no se de afɛkt di sɛrotonin lɛvɛl.
• Nɔ stɔp fɔ tek mɛrɛsin ɔ chenj di doz we yu nɔ tɔk to yu dɔktɔ.
• Mek shɔ se ɔl yu dɔktɔ dɛn no bɔt ɔl di mɛrɛsin dɛn we yu de tek.
• Rid di wɔnin ɛn infɔmeshɔn liflet dɛn we de kam wit yu mɛrɛsin fayn fayn wan.
• Lan bɔt di sayn dɛm wae de sho se yu gɛt sɛrotonin syndrome. Yu fɔ no bɔt dɛn sik ya mɔ if yu de tek mɛrɛsin fɔ mek yu nɔ fil bad.
• If yu gɛt ɛni kwɛstyɔn bɔt yu mɛrɛsin ɔr di sayn dɛm, aks yu dɔktɔ ɔr fama.
• If yu notis sɔm sayn dɛm, ɔr if yu sik de wɔs, nɔr fɔgɛt fɔ kɔl yu dɔktɔ kwik kwik wan ɔr go na imejensi rum.

Wetin na di mɛsej we wi want fɔ kɛr go na os frɔm dis stori?

• Serotonin Syndrome na wan sik wae kin siriɔs, bɔt i kin wɛl if dɛn manej am fayn fayn wan.
• Tɔk opin wan wit yu dɔktɔ bɔt ɛni mɛrɛsin we yu de tek, mɔ if yu de bigin fɔ yuz nyu wan ɔ yu de chenj di mɛrɛsin we yu de tek.
• Yu fɔ no di sayn dɛn we de sho se yu gɛt dis sik. If yu gɛt ɛni dawt , go to dɔktɔ ɛn nɔ westɛm.
• Mɛmba se yu no yu wɛlbɔdi biznɛs pas ɔlman, so i impɔtant fɔ no bɔt ɛni chenj.

` Serotonin sindrom, serotonin, antidipreshan, drɔg sayd ɛfɛkt, bren kemikal, nyurotransmitta, drɔg riakshɔn