Yu gɛt bɔku ayɛn na yu bɔdi, bɔt yu nɔ de fil fayn? Yu tink se na sideroblastic anemia?

Bɔku tɛm yu kin fil taya ɛn yu nɔ kin ebul fɔ blo fayn? Sɔntɛnde, yu kin fil lɛk se yu blɔd prɛshɔn smɔl? Dɛn tin ya kin bi sayn dɛm fɔ kɔmɔn anemia. Bɔt sɔntɛnde, wan rizin kin de we rili kɔmpleks biɛn dis. Tide wi go tɔk bɔt wan blɔd sik we nɔ kin apin smɔl, bɔt we impɔtant fɔ no bɔt. Dat na sideroblastic anemia, ɔ as dɔktɔ dɛn kin kɔl am `(Sideroblastic Anemia - SA)`.

So wetin na Sideroblastic Anemia?

Fɔ tɔk am simpul wan, dis na tin we nɔ kin apin so ɔltɛm we kin afɛkt di we aw wi bɔdi de mek rɛd blɔd sɛl dɛn, we na di rɛd sɛl dɛn we de na wi blɔd. If yu gɛt dis sik, yu nɔ gɛt bɔku rɛd blɔd sɛl, we min se yu gɛt anemia. Bɔt pan di sem tɛm, i sɔprayz fɔ no se yu gɛt bɔku ayɛn bak. Wetin mek dis de apin? Na bikɔs yu bɔdi nɔ de yuz di ayɛn we i nid fɔ mek rɛd blɔd sɛl dɛn fayn fayn wan.

Udat dɛn dis kayn tin kin afɛkt mɔ?

dis kכndyushכn we dεn kכl `(Sideroblastic Anemia)` kin apin tu we dεm. Wan pan dɛn na di saydrɔblastik anemia we dɛn bɔn wit ɔ CSA . Dat min se, sɔm pikin dɛn kin bɔn wit dis sik. Di ɔda wan na akwyayz sideroblastic anemia . Dis na di kayn we we pipul dɛn kin gɛt mɔ. I kin kam bikɔs ɔf ɔda sik dɛn we gɛt fɔ du wit blɔd, we pɔsin de yuz sɔm mɛrɛsin dɛn, ɔ we pɔsin de yuz sɔm minral dɛn pasmak.

jכs tink, pikin dεm εn yכŋ pikin dεm we dεn bכn wit dis kכndyushכn kin gεt hεlth prכblεm dεm we de mek dεn layf de pan denja bikoz fכ di ayron we pasmak na dεn bכdi, we dεn kכl ``ayn כvalod.'' If big pipul dεn gεt dis sik, dεn kin gεt kכndyushכn lεk hat sik εn sirosis na di liva.

Gud nyus de! Pan ɔl we dɔktɔ dɛn nɔ kin ebul fɔ mɛn di wan dɛn we dɛn bɔn wit `(Sideroblastic Anemia), mɛrɛsin dɛn de we kin kɔntrol di sik dɛn ɛn mek dɛn nɔ gɛt siriɔs prɔblɛm dɛn. כltu, sכm kayn `(Sideroblastic Anemia)` we de divεlכp leta na layf kin kכmכt.

Dis sik, we na di kayn we we dɛn bɔn pikin, kin afɛkt pikin dɛn, smɔl pikin dɛn, ɛn ivin yɔŋ pipul dɛn. Sɔntɛnde, di sayn dɛm fɔ CSA kin rili smɔl. So ivin if dɛn bɔn yu wit am, sɔm pipul dɛn nɔ kin gɛt ɛni big prɔblɛm wit dɛn wɛlbɔdi te dɛn ol.

di leta tכp, we dεn kכl ``Acquired CSA,'' kin apin bכku tεm pan pipul dεm we gεt blɔd dizayd we dεn kכl ``myelodysplastic syndrome.'' I kin kכz bak bay we dεn de εkspos to minral dεm lεk lid εn zink, yus fכ sכm mεdikeshכn, כ εnitin we de afekt di bכdi in ebul fכ yuz kכpa.

Aw dis sik kin afɛkt mi bɔdi?

Pipul wae gɛt sideroblastic anemia kin sho sayn dɛm fɔ anemia. Dat min se dɛn kin fil taya pasmak fɔ natin.Fɔ fil taya, gɛt prɔblɛm fɔ blo, ɛn ɔda tin dɛn Nɔto dat nɔmɔ, dɛn kin gɛt ɔl tu di ``macrocytic anemia'' (rεd bכdi sεl dεm we big pas nכmal) εn ``maycrocytic anemia'' (rεd bכdi sεl dεm we sכm pas nכmal). Dɛn tu kayn anemia ya kin bi sayn bak fɔ ɔda kayn anemia.

Wetin na di tin dɛm wae kin mek pɔrsin gɛt sideroblastic anemia?

As wi bin dɔn tɔk bifo tɛm, dis kin de we dɛn bɔn am, ɔ i kin kam leta bikɔs ɔf ɔda mɛrɛsin, we i gɛt sɔm mɛtal, minral, ɔ mɛrɛsin.

fכ כndastand di tin dεm we de mek wi bכn wit saydכblastik anemia (congenital SA), i go fayn fכ no sכm bכt aw wi rεd bכdi sεl dεm de wok.

Wan shɔt introdukshɔn bɔt rɛd blɔd sɛl dɛn

Rɛd blɔd sɛl na di kayn sɛl we bɔku pipul dɛn kin gɛt na wi blɔd. Rɛd blɔd sɛl dɛn we gɛt wɛlbɔdi ɛn machɔ impɔtant fɔ kɛr ɔksijɛn go na wi bɔdi in tisu dɛn. Rɛd blɔd sɛl dɛn kin du dis wit di ɛp we wan prɔtin we dɛn kɔl ɛmoglobin de ɛp. Ɛmoglobin na di tin we de gi rɛd blɔd sɛl dɛn rɛd kɔlɔ.

Rɛd blɔd sɛl dɛn nid ayɛn fɔ mek ɛmoglobin. Nɔmal wan, wi bon mɛro kin mek stem sɛl dɛn. leta dεn stεm sεl dεm ya de divεlכp to rεd bכdi sεl dεm we nכ machכ we dεn kכl εrythrocytes. Dɛn sɛl dɛn ya we nɔ machɔ gɛt di rayt ɛmoglobin ɛn ayɔn we dɛn nid fɔ mek rɛd blɔd sɛl dɛn we gɛt wɛlbɔdi ɛn machɔ.

Bɔt, if yu gɛt sideroblastic anemia, yu bɔdi nɔ go ebul fɔ yuz dis ayɛn. Dis kin mek wi gɛt tu prɔblɛm dɛn. If yu nɔ gɛt ayɛn, yu rɛd blɔd sɛl dɛn nɔ de mek inof ɛmoglobin fɔ kɛr ɔksijɛn go ɔlsay na yu bɔdi. Bɔt di ayɛn we yu nɔ yuz kin gɛda na yu bon mɛrɔ. dis kin mek wan kayn sεl we nכ nכmal we dεn k כl ringed sideroblast . Siderɔblast na rɛd blɔd sɛl we nɔ machɔ ɛn we gɛt ayɛn ring rawnd in nyukliɔs. Dɔktɔ dɛn kin si dɛn ring ya we dɛn de luk di stem sɛl dɛn na di bon mɛro ɔnda maykroskɔp. Sideroblastic anemia gɛt in nem frɔm dɛn ayɛn ring ya. Dɛn ayɛn ring dɛn ya de sho se di sɛl dɛn de kip ayɛn instead fɔ yuz am. Dɛn kɔl dis ayɛn we de bɔku . Dis ayɔn ɔvalod na in de mek bɔku pan di siriɔs wɛlbɔdi prɔblɛm dɛn we kin apin bikɔs ɔf di sideroblastic anemia.

Wetin na di kayn sik we dɛn kɔl Congenital Sideroblastic Anemia (CSA)?

Tri kayn SA de we dɛn bɔn wit. Dɛn tin ya kin apin bikɔs sɔm jin dɛn kin chenj we kin afɛkt di we aw di rɛd blɔd sɛl dɛn de wok. Lɛ wi tek wan luk pan wetin dɛn bi:

• X-linked sideroblastic anemia we gɛt fɔ du wit am:Dis na di kayn we we dɛn kin gɛt we dɛn bɔn pikin dɛn we nɔ gɛt bɛtɛ blɔd. i de kכz fכ wan mכtεshכn na di jin we de mek wan spεsifi k εnzym we dεn kכl ``ALAS2``, we de mek di hεmoglobin dכn. Pipul dεm we gεt dis kכndyushכn gεt pale, sכm sכm pas nכmal rεd bכdi sεl dεm (maykrosaytik). Dɛn kin gɛt bɔku ayɛn bak na dɛn bɔdi.
• כtosomal rεsεsiv saydכblastik anεmia (ARCSA): Dis na di sεkכn tכp we kכmכn pas כl. ARCSA kin afɛkt bebi ɛn pikin dɛn we rili yɔŋ. Na siriɔs sik we kin mek pɔsin in layf de pan denja sɔntɛnde. I kin apin we di ayɔn we de na di blɔd tumɔs.
• Maternal: Na lɛk 20% pan ɔl di CSA pasɛnt dɛn kin fɔdɔm insay dis kategori. dis na biכs di jin MT-ATP6 de mכt, we de afekt di fכnshכn fכ yu maytochכndria. (Maytochכndria na di כgan dεm we de insay wi sεl dεm. na dεn de rispansabl fכ di men enεji sכs fכ di sεl dεm. di maytochכndria dεm de kכnvכlt di enεji frכm it to fכm we di sεl dεm kin yuz.)

Wetin na di kayn akwyayz sideroblastic anemia we kin apin leta na layf?

tu kayn sideroblastic anemia de we de divεlכp leta na layf - praymari εn sεkכnd. Praymari SA de rifer to SA we gɛt fɔ du wit wan kɔndishɔn we dɛn kɔl myelodysplastic syndrome. Sεkɔndari SA de tכk bכt SA we kin divεlכp afta dεn dכn εkspos to sכm mεtal dεm, kεmikכl dεm, εn mεdikeshכn dεm. Tin dɛm wae kin mek yu gɛt sɛkɔndari sideroblastic anemia na:

• Alcohol: Alcohol use disorder na di men tin we kin mek pɔsin gɛt sideroblastic anemia we kin bigin leta.
• Hevi mɛtal pɔyzin: Dis inklud lid pɔyzin ɛn asɛnik pɔyzin.
• Vitamin B we nɔ de: Vitamin B de ɛp fɔ mek wan tin we dɛn kɔl hεm, we kin chenj to ɛmoglobin. Heme na wetin de ɛp fɔ kɛr ɔksijɛn.
• Kɔpa we nɔ de: Kɔpa de ɛp fɔ mek wan ɛnzaym we de protɛkt pɔsin frɔm aynɔ we pasmak.
• Zink ovados: If yu tek bɔku zink, i kin afɛkt di we aw di bɔdi de yuz ayɛn ɛn absɔb kɔpa. Sɔm pipul dɛn kin tek zinc supliment ɛn dis kin apin.
• Mɛrɛsin: Sɔm antibayɔtik, kemotɛrapi, ɔmon, ɛn mɛrɛsin we de mek pɔsin nɔ gɛt kɔpa kin mek pɔsin gɛt sɛkɔndari saydrɔblastik anemia. Dɔktɔ dɛn kin trit dis kayn SA bay we dɛn kin tɛst di mɛrɛsin dɛn we yu de tek ɛn pul di mɛrɛsin dɛn we dɛn tink se de mek yu gɛt SA.

Wetin na di sayn dɛm wae de sho se yu gɛt sideroblastic anemia?

Lɛk bɔku kayn anemia, di sayn dɛm fɔ sideroblastic anemia na:

• Taya pasmak:Dis min se yu fɔ fil taya so dat yu nɔ go ebul fɔ du di wok dɛn we yu de du ɛvride.
• Dispnea: Dis na wae yu de fil wae yu de swɛla ɔr yu nɔr de blo fayn.
• Hat palpitations: Dis na wae yu de fil se de hat de bit tu fast, ɔr na abnɔmal we.
• Ed de at.

Pipul dεm we gεt X-linked sideroblastic anemia kin gεt כda simptom dεm bikoz dεn nכ hεmoglobin εn di ayron lεvεl dεm na di bכdi de inkrεs. Dɛn sayn ya na:

• Liva we big: Yu liva de du bɔku impɔtant wok dɛn na di bɔdi.
• di splin we big: yu splin na כgan we de lεk di sayz fכ wan fist we kכlכs we de na di כp bכdi. Yu nɔ go notis se yu splin big pas aw i fɔ bi, ɔ yu kin gɛt dɔl pen na yu bɛlɛ we de ɔp.
• Skin we gɛt brɔnz kɔlɔ: If yu bɔdi kip bɔku ayɛn, yu skin kin gɛt brɔnz brawn kɔlɔ.
• Dayabitis we dɛn nɔ ebul fɔ kɔntrol.

Aw dɔktɔ dɛn kin no se pɔsin gɛt saydrɔblastik anemia?

Bikɔs sideroblastic anemia kin de we dɛn bɔn yu ɔ i kin divɛlɔp leta, yu dɔktɔ go fɔs tɛst yu fɔ kɔnfɔm ɔ ruul ɔut akwyayz sideroblastic anemia. If dεn disayd se i nכto akwyayz sideroblastic anemia, dεn go du mכr tεst fכ no us kayn congenital sideroblastic anemia yu gεt. Na sɔm pan di tɛst dɛn we dɛn kin du:

• kכmplit bכdi kכnt (CBC): di risכlt dεm fכ di `(CBC)` de sho di sayz εn shep fכ di sεl dεm na yu bכdi, כl di nyu bכdi sεl dεm we yu bכdi de mek, εn, insay di `(SA)` kes, כl di machכ εn immature rεd bכdi sεl dεm yu gεt.
• Peripheral blood smear: Dis na wan we we dɔktɔ dɛn kin yuz fɔ chɛk di blɔd sɛl dɛn. Pan ɔl we sɔm blɔd tɛst dɛn kin yuz mashin fɔ chɛk dɛn, insay dis kes, dɔktɔ dɛn kin yuz maykroskɔp fɔ chɛk di blɔd sɛl dɛn.
• Ayɔn stɔdi: Dis tɛst de sho yu ayɛn lɛvɛl.
• Bone marrow aspiration: Dis na prosidur fכ tek sεmpl fכ di likid pat pan yu bon mכro.
• Bone marrow biopsy: Insay dis tɛst, dɔktɔ dɛn kin tek smɔl sampul pan yu bon marrow ɛn chɛk di bon marrow cells.
• Tɛst fɔ di jɛnɛtiks:Jεnεtik tεst kin εp fכ kכnfכm כ rכl כut spεshal jεnεtik kכndishכn dεm. I kin ɛp yu bak fɔ ɔndastand aw i kin pas di sik to yu pikin dɛn.

Aw dɔktɔ dɛn kin trit sideroblastic anemia?

Dɔktɔ dɛn kin yuz difrɛn tritmɛnt fɔ di sik we dɛn bɔn wit ɛn we dɛn kin gɛt saydrɔblastik anemia. Dɛn tritmɛnt ya kin difrɛn difrɛn wan bay aw yu sik, so yu dɔktɔ go tɔk bɔt di bɛst tritmɛnt fɔ yu. Fɔ ɛgzampul, dɛn kin gi pɔsin we gɛt X-linked SA (CSA) vaytamɛn B6 ɛn mɛrɛsin dɛn we de mek i nɔ gɛt ayɛn. If SA na bikɔs ɔf lid pɔyzin, yu dɔktɔ go trit di lid pɔyzin. I bɛtɛ fɔ tɔk to yu dɔktɔ bɔt dis.

Aw a go mek dis nɔ apin?

Bɔku tɛm, di saydrɔblastik anemia kin kam bikɔs ɔf wan jɛnɛtik muteshɔn. Pan ɔl we dɛn nɔ kin ebul fɔ avɔyd dis kayn sik we dɛn kin bɔn wit saydrɔblastik anemia, dɛn kin trit am. If yu gɛt X-linked `(CSA)` ɛn yu simptom dɛn nɔr tu, ɔr if pɔrsin na yu famili (mama ɛn papa, brɔda ɛn sista, ɔ pikin dɛm) gɛt `(CSA)`, i fayn fɔ aks yu dɔktɔ bɔt jenɛtik tɛst.

Bɔt tin dɛn de we yu kin du fɔ mek sɔm kayn CSA we yu dɔn gɛt nɔ go divɛlɔp leta. Dis na di step dɛm we yu kin du:

• Fɔ avɔyd aksidɛntal lid ɔ asɛnik pɔyzin.
• If yu de tek zinc supliment fɔ tin dɛm lɛk kɔmɔn kol, aks yu dɔktɔ bɔt di rayt doz.
• Limit yu rɔm we yu de drink. If yu drink rɔm, dat kin mek yu gɛt sideroblastic anemia. Tray fɔ ridyus di rɔm we yu de drink ɛvride. If yu nid ɛp, aks yu dɔktɔ fɔ tɛl yu fɔ du di rayt program dɛn.

Wetin a go ɛkspɛkt wit dis sityueshɔn?

Yu prɔgnosis dipen pan di kayn sideroblastic anemia we yu gɛt. Fɔ ɛgzampul, if yu gɛt X-linked congenital sideroblastic anemia, yu dɔktɔ kin trit yu sik wit vaytamɛn B6 ɛn mɛrɛsin dɛn we de mek yu nɔ gɛt ayɔn. If yu dɔn gɛt sideroblastic anemia, we na bikɔs ɔf lid pɔyzin, yu dɔktɔ kin trit di lid pɔyzin.

Aw a kin kia fɔ misɛf?

Bɔrku pipul dɛm wae gɛt sideroblastic anemia nid fɔ de wach dɛn ayɔn lɛvɛl ɔltɛm fɔ mek dɛn nɔr gɛt mɔ ayɔn ɔvalod. If yu dɔn gɛt sideroblastic anemia trade, aks yu dɔktɔ wetin yu kin du fɔ mek yu nɔ gɛt nyu SA.

Sideroblastic anemia na wan sik we nɔ kin apin na di blɔd we nɔ kin apin so ɔltɛm. Sɔm pipul dɛn no wetin mek dɛn gɛt sideroblastic anemia, bɔt ɔda wan dɛn nɔ kin no. If yu gɛt sideroblastic anemia, yu kin aks yu dɔktɔ dɛn kwɛstyɔn ya:

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* Us kayn `(SA)` a gɛt?

* Wetin mek a gɛt `(SA)`?

* Wetin na di tritmɛnt dɛn we a kin gɛt?

* Wetin na di bad tin dɛn we di tritmɛnt kin du?

* Wetin a go ɛkspɛkt afta a dɔn gɛt tritmɛnt?

* A kin pas `(SA)` to mi pikin dɛm?

So, wetin na di impɔtant tin dɛn we wi nid fɔ mɛmba frɔm dis stori?

Sideroblastic anemia na wan sik we nɔ kin apin so ɔltɛm bɔt i kin rili siriɔs. SA na sɔntin we de ambɔg di bɔdi in ebul fɔ mek wɛlbɔdi rɛd blɔd sɛl dɛn. Bɔku tɛm, pipul dɛn we gɛt SA kin gɛt tumɔs ayɛn na dɛn blɔd. Bɔku tɛm, i izi fɔ trit dis ayɛn we pasmak. Bɔt pan bebi ɛn yɔŋ pikin dɛn we dɛn bɔn wit SA, di ayɔn we pasmak kin mek dɛn gɛt wɛlbɔdi prɔblɛm we kin mek dɛn layf de pan denja.

Imajin, if dɛn bɔn yu smɔl pikin wit sideroblastic anemia, dɛn dɔktɔ dɛn go bigin fɔ trit di sik wantɛm wantɛm. Fɔ gɛt pikin ɔ smɔl pikin we rili sik, i kin rili mek yu fred ɛn i kin mek yu at pwɛl. Yu dɔktɔ dɛn ɔndastand dis ɛn dɛn go du ɔl wetin dɛn ebul fɔ ɛp yu ɛn yu pikin we dɛn de du tritmɛnt ɛn afta dɛn dɔn trit yu. So, if yu ɔ sɔmbɔdi na yu famili gɛt dɛn sik ya, i impɔtant fɔ go to dɔktɔ wantɛm wantɛm fɔ advays.

` Ayɔn, anemia, saydrɔblast, bon mɛro, ɛmoglobin, jin, blɔd sik