Yu tink se di las blɔd tɛst we yu bin gɛt sho se yu kɔlɔstrel lɛvɛl dɔn ay smɔl? Yu bin fil smɔl frayd ɛn wɔri we yu si se yu "bad kɔlɔstrel" ɔ LDL lɛvɛl sɛf bin ay? If na so, yu dɔktɔ go dɔn tɛl yu fɔ bigin tek wan ‘Statin’ kayn mɛrɛsin. So tide, mek wi tok rili simpul abaut ‘Statins’, we impotant to plenti pipul.
Okay, wetin na dis ‘Statins’?
Fɔ tɔk am simpul wan, ‘Statins’ na wan kayn mɛrɛsin we dɔktɔ dɛn kin gi fɔ mek di kɔlɔstrel we de na yu blɔd go dɔŋ, mɔ di "bad" kɔlɔstrel.
We wi de tɔk bɔt kɔlɔstrel, wi kin yɛri bɔt tu kayn dɛn ɔltɛm, nɔto so?
1. LDL (Low-Density Lipoprotein): Dis na wetin wi kin kɔl "bad" kɔlɔstrel . Tink bɔt yu blɔd vesel dɛn lɛk paip we de kɛr wata. Wetin dis LDL kɔlɔstrel de du na fɔ put lɛk ɔyl slɔd insay da paip de, ɛn smɔl smɔl i de mek di we fɔ mek blɔd flɔ smɔl smɔl. Sɔm kayn ‘statin’ kin ridyus dis bad bad kɔlɔstrel bay 50% ɔ mɔ.
2. HDL (High-Density Lipoprotein): Dis na wetin wi kin kɔl "gud" kɔlɔstrel . I de pik bad bad kɔlɔstrel we dɔn gɛda na di at ɛn kɛr am go na di liva fɔ pul am na di bɔdi. I tan lɛk pɔsin we de gɛda dɔti.
Statin nɔ jɔs de ridyus bad LDL kɔlɔstrel, bɔt i de ɛp bak fɔ ridyus triglisɛrɛyd, we na ɔda kayn fat na di blɔd, ɛn i de mek di gud HDL kɔlɔstrel lɛvɛl go ɔp smɔl.
Dɛn kin tɛl yu fɔ tek dɛn mɛrɛsin ya wan tɛm insay di de, di sem tɛm. Sɔm statin dɛn kin wok fayn we dɛn tek dɛn na nɛt. Dis na bikɔs wi bɔdi kin mek mɔ kɔlɔstrel na nɛt. Bɔt sɔm nyu statin dɛn kin wok jɔs lɛk aw dɛn kin tek dɛn ɛnitɛm pan di de. Yu dɔktɔ go ɛksplen dis to yu.
Aw dis mɛrɛsin de wok insay di bɔdi?
Dis na stori we rili intrestin. Imajin se na yu liva na di men faktri we de mek kɔlɔstrel. infakt, 75% pan di kכlestכl we wi bכdi nid de kכmכt na wi liva. Di ɔda wan de kɔmɔt frɔm di it we wi de it.
So, di liva gεt wan εnzym we implεnt fכ dis kכlestכl-mεkshכn prכsεs. Dɛn kɔl am `HMG-CoA ridɔktaz`. di `Statin` dכg de akt lεk get-kipa, we de blכk di `HMG-CoA reductase` εnzym fכ rich di liva. Dɔn di liva kin lɔs wan raw matirial we i nid fɔ mek kɔlɔstrel. dis kin mek di kכlestכl we di liva de mek kin dכn bכku bכku wan. Yu ɔndastand?
Fɔ tɔk am simpul wan, ‘Statin’ na drɔg we de ridyus di bad bad kɔlɔstrel we de na di blɔd bay we i de ambɔg di we aw di kɔlɔstrel de kɔmɔt na di liva.
Wetin mek wi nid ‘Statins’?
Di men rizin na fɔ ridyus di risk fɔ gɛt at atak ɛn strok.
As a bin se bifo, we bad kɔlɔstrel de bɔku na di blɔd, i kin de na di wɔl dɛn na di blɔd vesel dɛn. Insay mɛrɛsin, wi kin kɔl dis ‘Atherosclerosis’ . di kכlestכl we de bil dis we dεn kכl am ‘plak’. Dis kin mek di ples we de insay di blɔd vesel dɛn nɔ bɔku ɛn i kin mek di blɔd nɔ flɔ.
Imajin wetin go apin if wan at we de gi blɔd to di at blok lɛk dis? Di at nɔ de gɛt di ɔksijɛn ɛn di tin dɛn we i nid. Dat kin mek pɔsin gɛt at atak. Ɛn if dis ‘plek’ bɔs na wan at we de gi blɔd to di bren ɛn blɔd klɔt fɔm, i kin mek pɔsin gɛt strok.
Statin de mek di kɔlɔstrel smɔl, ɛn dis kin ridyus di risk fɔ dɛn kayn denja tin ya bad bad wan.
Wetin na di kayn ‘statin’ we dɛn kin yuz mɔ?
difrεn kayn ‘statin’ dεm de. Yu dɔktɔ go tɛl yu di kayn we we go fayn fɔ yu, ɛn i go tink bɔt yu wɛlbɔdi, di kɔlɔstrel we yu gɛt, ɛn ɔda tin dɛn.
| Jɛnɛrik Nem fɔ ‘Statin’. | Kɔmɔn Brand Nem dɛn |
|---|---|
| Atorvastatin we dɛn kɔl am | Lipitor®, Kaduet®, ɛn ɔda pipul dɛn |
| Rosuvastatin we dɛn kɔl Rosuvastatin | Krestɔ®, Ɛzalɔr Sprinkl® |
| Simvastatin we dɛn kɔl Simvastatin | Zocor®, Vytorin® (wit ɛzetimib) . |
| Pravastatin we dɛn kɔl Pravastatin | Pravachol® we dɛn kɔl |
| Lovastatin we dɛn kɔl lovastatin | Mevakɔr® we dɛn kɔl |
| Fluvastatin we dɛn kɔl Fluvastatin | Lescol® we dɛn kɔl |
Sɔntɛnde, ‘statin’ kin kam insay di sem pil wit ɔda drɔg. Fɔ ɛgzampul, wan mɛrɛsin we dɛn kɔl ezetimibe wit simvastatin.
Udat dɛn kin rɛkɔmɛnd fɔ tek ‘Statins’?
Dɔktɔ go gi yu wan statin bay di ɔl risk fɔ gɛt at sik. Dis kin dipen pan bɔku tin, lɛk yu ej, yu man ɔ uman, yu famili istri, ɛn if yu de smok. Dɛn kin advays fɔ yuz statin fɔ dɛn pipul ya:
- Fɔ di wan dɛn we nɔ ebul fɔ ridyus dɛn kɔlɔstrel lɛvɛl (espɛshali di LDL lɛvɛl we pas 190 mg/dL) pan ɔl we dɛn de it ɛn ɛksesaiz .
- Fɔ pipul dɛm we gɛt dayabitis ɛn bitwin 40-75 ia, wit LDL kɔlɔstrel lɛvɛl we pas 70 mg/dL.
- Fɔ di wan dɛn we dɔn ɔlrɛdi gɛt at atak, strok, ɔ peripheral artery disease (PAD) .
- Fɔ pipul dɛm wae ol 40-75 ia wae gɛt LDL lɛvɛl pas 70 mg/dL, wae gɛt bɔrku risk fɔ gɛt hat sik.
- If pɔsin na di famili (mama ɛn papa, brɔda ɛn sista) dɔn gɛt at sik we i yɔŋ ɛn gɛt ay kɔlɔstrel lɛvɛl.
Ɛni bad tin de we kin apin to dis?
Dis na prɔblɛm fɔ bɔku pipul dɛn. Na tru se, lɛk ɛni mɛrɛsin, statin kin gɛt sayd ɛfɛkt. Bɔt di impɔtant tin na dat bɔku pipul dɛn nɔ kin gɛt ɛni bad bad tin we kin apin to dɛn. Ivin smɔl smɔl sayd ɛfɛkt dɛn we kin apin go dɔn as dɛn de kɔntinyu fɔ tek di mɛrɛsin.
| Sayd ɛfɛkt we pɔsin kin gɛt | Tɔk bɔt |
|---|---|
| Kɔmɔn (bɔku tɛm nɔto siriɔs) sayd ɛfɛkt dɛm | |
| Mɔsul ɛn jɔyn pen | Dis na di sayd ɛfɛkt we dɛn kin ripɔt mɔ. I kin fil lɛk se na jenɛral pen. |
| Ed de at | Smɔl ed kin at. |
| Prɔblɛm dɛn we de na di dijestiv sistɛm | Nɔs, blo, flat, ɔ kɔnstipɛshɔn kin apin. |
| Siriɔs sayd ɛfɛkt dɛn we dɛn nɔ kin si (we nid fɔ gɛt dɔktɔ advays) . | |
| Liva we dɔn pwɛl | Di sayn dɛm lɛk fɔ yɔlɔ na yu yay (jaundice), yu urine dak, ɛn yu taya pasmak. |
| Rabdomyolysis we dɛn kɔl Rhabdomyolysis | Dis na tin we nɔ kin apin so ɔltɛm . Di sayn dɛm na we yu de fil pen bad bad wan na yu groin, yu wik, ɛn yu de urine we gɛt dak kɔlɔ. |
| Di shuga na di blɔd we de go ɔp | Dis risk kin go ɔp smɔl pan di wan dɛm wae gɛt risk fɔ gɛt dayabitis. |
Impɔtant: If yu gɛt ɛni sayd ɛfɛkt, nɔ ɛva stɔp fɔ tek yu mɛrɛsin fɔ yusɛf. Di bɛst tin fɔ du na fɔ tɔk to yu dɔktɔ bɔt am. Yu kin ebul fɔ sɔlv di prɔblɛm bay we yu chenj di kayn statin we yu de tek ɔ bay we yu ajɔst di doz.
Pipul dɛn de we nɔ fɔ tek statin?
Yɛs. Dɛn nɔ kin fayn fɔ yuz statin fɔ uman dɛn we gɛt bɛlɛ, mama dɛn we de gi pikin in bɛlɛ, ɛn pipul dɛn we gɛt sɔm siriɔs sik dɛn na dɛn liva. Yu fɔ tɛl yu dɔktɔ bak bɔt ɛni ɔda mɛrɛsin we yu de tek. Frut jus, mɔ grep ɛn pomegranate jus, kin intarakt wit sɔm statin, so aks yu dɔktɔ bɔt dat bak.
Wetin go apin if yu stɔp fɔ tek di mɛrɛsin?
Wae yu stɔp fɔ tek wan statin, yu kɔlɔstrel lɛvɛl go bak to usay i bin de. Dat min se yu risk fɔ gɛt at atak ɛn strok go bak ɔp. So bɔku tɛm na mɛrɛsin fɔ ɔl yu layf.
Ustɛm fɔ go to dɔktɔ wantɛm wantɛm
If yu gɛt ɛni wan pan dɛn sik ya we yu de tek wan statin, go to dɔktɔ wantɛm wantɛm.
- If yu fil se yu nɔ go ebul fɔ bia, yu de fil bad bad wan ɔ yu gɛt wikɛd na yu mɔsul ɔ yu jɔyn dɛn.
- If yu gɛt bɔdi pen wit fiva .
- Na yu yonIf yu yay ɔ yu skin tan lɛk yɔlɔ (jaundice).
- If yu urine tɔn dak kɔlɔ lɛk ti lif wata .
If dis kayn tin apin, i go fayn fɔ go na ɔspitul in Imejɛnsi Tritmɛnt Yunit (ETU).
Mɛsej we dɛn kin kɛr go na os
- Statin na wan klas we de wok fayn we de mek bad kɔlɔstrel (LDL) nɔ bɔku ɛn i nɔ de mek pɔsin gɛt at atak ɛn strok.
- Dis drɔg de wok bay we i de stɔp di liva fɔ mek i nɔ gɛt kɔlɔstrel.
- Ivin if yu de tek wan statin, i rili impɔtant fɔ kɔntinyu fɔ it fayn it ɛn ɛksesaiz. Nɔ tink se jɔs bikɔs yu de tek mɛrɛsin, yu kin it ɛnitin we yu want.
- If yu gɛt ɛni sayd ɛfɛkt, tɔk to yu dɔktɔ ɛn nɔ stɔp di mɛrɛsin.
- Nɔ ɛva stɔp fɔ tek wan statin if yu dɔktɔ nɔ advays yu, bikɔs dis kin mek yu gɛt mɔ wɛlbɔdi bak.
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