Yu go mɔs dɔn yɛri bɔt "sulfa drugs." Sɔntɛm dɔktɔ dɔn gi yu krim fɔ put pan yu skin ɛn se, "Dis na sɔlfa drɔg." Wetin rili na sɔlfɔnamid? Na jɔs antibayɔtiks dɛn ? Nɔ, di stori lɔng pas dat fa fawe. Mek wi go to di bottom of dis tide.
Fɔ tɔk am simpul wan, wetin na dɛn sɔlfɔnamid ya?
Salfonamides na wan klas ɔf drɔgs we dɛn kin mek wit sɛntetik, dat na, na lɛbɔraytri. Dɛn nɔto tin dɛn we kin apin na di wɔl. כl di dכg dεm we de insay dis klas dεm gεt di εlimεnt “sכlfa” insay dεn kεmikכl strכkchכ. Na dat mek dɛn kɔl dɛn “sulfonamides.”
Naw lɛ wi si aw dɛn tin ya de wok. εspεshali we dεn gi am to baktri infεkshכn, wetin dεn dכg ya de du na fכ stכp di baktri fכ mek sכmtin we dεn kכl " folate " we dεn nid. Wi no bak se folate na vaytamɛn B9 . Jɔs tink bɔt dis, dis tin we dɛn kɔl folate impɔtant fɔ mek baktri dɛn liv ɛn skata. So we di sulfonamide drɔgs dɛn go insay di bɔdi, dɛn kin go ɛn stɔp di baktri dɛm fɔ mek dis folate. I tan lɛk se yu angri we yu nɔ gɛt tin fɔ it, di bɔdi kin wik smɔl smɔl ɛn day.
“Dɔn nɔto prɔblɛm de fɔ wi bɔdi?” yu kin tink. Nɔ, na bikɔs wi, dat na, mɔtalman, kin gɛt di folate we wi bɔdi nid frɔm di it dɛn we wi de it. Wi nɔ de mek folate insay wi bɔdi. So dis mɛrɛsin nɔ kin afɛkt di sɛl dɛn na wi bɔdi da we de.
Bifo dɛn fɛn penisilin , insay di 1930 dɛm, sɔlfonamid na bin wan pan di bɛst mɛrɛsin dɛm we bin de fɔ trit baktriyal infɛkshɔn. Da tɛm de , dɛn drɔgs ya bin ɛp fɔ ridyus di nɔmba fɔ pipul dɛn we kin day bikɔs ɔf sik dɛn we kin kam wit ɔda pipul dɛn . Bɔt tide, dɛn nɔ jɔs de yuz dɛn fɔ gɛt baktriyal infɛkshɔn. Dɛn kin yuz drɔgs we de na dis klas fɔ bɔku ɔda sik dɛn .
Us sik dɛn dɛn kin yuz sɔlfɔnamid fɔ?
Trade, dɛn bin de yuz dɛn mɔ fɔ trit ɛn protɛkt baktriyal infɛkshɔn. Bɔt tide, dis klas fɔ drɔgs dɔn evolv bɔku. Dɛn kin yuz sɔlfonamid fɔ mɛn bɔku bɔku sik dɛn, lɛk tayp 2 dayabitis, ay blɔd prɛshɔn, HIV infɛkshɔn, ɛn melanoma, we na wan kayn kansa na di skin.
Lɛ wi si us ɔda mɛrɛsin dɛn de insay dis kategori ɛn us sik dɛn de yuz dɛn fɔ. Fɔ mek i izi fɔ wi, wi go sheb dɛn tin ya to tu pat.
1. Sɔlfonamid dɛn we dɛn kin yuz as antibayɔtik
Dɛn tin ya na mɔ mɛrɛsin dɛn we dɛn kin gi fɔ baktriyal infɛkshɔn.
| Di kayn antibayɔtik dɛn: sulfonamides |
|---|
| Mafenid (Sulfamylon®) we dɛn kɔl . |
| Sulfadiazene (Silvadene® ɔ Thermazene®) – (dɛn kin yuz am fɔ bɔn) . |
| Sɔlfamɛtizɔl we dɛn kɔl |
| Sɔlfisoksazɔl we dɛn kɔl |
| Sulfasalazine (Azulfidine®) – (Dɛn kin yuz am bak fɔ ɔlsɛrativ kɔlayt) |
| Sulfadoxine – (dɛn kin yuz am fɔ mɛn malaria) . |
2. Sɔlfonamid dɛn we nɔ gɛt antibayɔtik
Dɛn tin ya nɔto drɔgs we de kil baktri dɛm. Dɛn kin yuz dɛn fɔ mɛn bɔku ɔda sik dɛn. Dis list lɔng smɔl, bɔt i de gi yu wan aidia bɔt aw dis klas fɔ drɔgs bɔku.
| Di Nem fɔ Drug | Yuz dɛn |
|---|---|
| Asetoheksamid, Klɔrpropamid, Tolazamid, Tolbutamid | Tayp 2 dayabitis |
| Furosemide (Lasix®), Bumetanide, Torsemide, Klɔrtalidɔn, Haydroklɔrotiazayd, Indapamid | Dɛn kin yuz diuretics fɔ trit swel we kin kam bikɔs ɔf ay blɔd prɛshɔn ɛn kɔnjɛstiv at fayl. |
| Sɛlɛkɔksib (Sɛlɛbrɛks®) . | Jɔyn pen ɛn swel kɔndishɔn lɛk at at sik. |
| Darunavir (Prezista®) we dɛn kɔl di . | Wan antiretroviral drɔg fɔ HIV infɛkshɔn. |
| Sumatriptan (Imitrex®) we de na di bɔdi. | Fɔ maygren ed we de at. |
| Sildenafil (Viagra®, Revatio®) we de na di bɔdi. | Erectile dysfunction ɛn pulmonary arterial haypatɛnshɔn. |
| Tamsulosin (Flɔmaks®) we dɛn kɔl . | Fɔ di prɔblɛm dɛn we pɔsin kin gɛt we i de urinari we di prɔstat gland dɔn big (benign prostatic hyperplasia). |
| Zonisamid (Zonegran®) we dɛn kɔl zonisamid (Zonegran®) . | Di sik wae kin kam pan pɔrsin wae gɛt epilepsy. |
I pɔsibul fɔ mek yu gɛt alɛji to sɔlfonamid?
Yɛs, yu kin ebul. Yu go mɔs dɔn yɛri pipul dɛn se, "A gɛt alɛji to sɔlfa drɔgs." Bitwin 3% ɛn 8% pan di pipul dɛm na di wɔl gɛt alɛji to sɔm kayn sɔlfa drɔg. Bɔt dis na lɛk di sem tin wit di alɛji to penisilin.
Di impɔtant tin na dis: jɔs bikɔs yu bin gɛt alɛji to wan sɔlfonamid drɔg nɔ min se yu gɛt alɛji to ɔl di ɔda drɔgs dɛn we de na dis klas. Dis na sɔntin we dɔktɔ dɛn kin gri wit naw.
So, if yu bin dɔn gɛt alɛji fɔ wan sɔlfonamid bifo, mek shɔ se yu tɛl yu dɔktɔ bifo yu bigin fɔ tek nyu mɛrɛsin. I go ebul fɔ tɛl yu bɔt ɔda mɛrɛsin we fayn fɔ yu.
Wetin na di bad tin dɛn we dis kayn mɛrɛsin gɛt?
Lɛk ɛni mɛrɛsin, sɔlfɔnamid kin gɛt sɔm prɔblɛm dɛn ɛn sɔm sayd ɛfɛkt dɛn. Di men wan dɛn na:
- Baktri rɛsistɛns: We yu yuz di sem antibayɔtik fɔ lɔng tɛm, sɔm baktri dɛn kin gɛt rɛsistɛns to da mɛrɛsin de. Dis min se di mɛrɛsin nɔ de wok pan dɛn baktri dɛn de igen. Dis kin apin bak wit sɔlfonamid.
- Lɔs ɔf ɛfɛkt pan sɔm baktri dɛm: Sɔm kayn baktri dɛm nɔr kin ebul fɔ bia wit dɛn mɛrɛsin ya.
- Siriɔs sayd ɛfɛkt: Dɛn tin ya nɔ kin apin so ɔltɛm , bɔt sɔm pipul dɛn kin gɛt rili siriɔs skin riakshɔn lɛk Stivins-Jɔnsin sindrom ɛn pɔyzin ɛpidamal nɛkrɔlaysis .
Dɛn sayd ɛfɛkt ya kin difrɛn bad bad wan frɔm wan pɔsin to ɔda pɔsin ɛn frɔm wan mɛrɛsin to ɔda mɛrɛsin. So, yu dɔktɔ na di bɛst say fɔ no bɔt di mɛrɛsin we dɛn gi yu, di bɛnifit dɛn we i gɛt ɛn di prɔblɛm dɛn we i gɛt. Aks am bɔt am.
BactrimTM na sulfonamide bak?
Yɛs, sɔm pat pan am. BactrimTM gɛt sulfamethizole, we na wan kayn sɔlfonamid. Apat frɔm dat, i gɛt ɔda mɛrɛsin bak we dɛn kɔl trimethoprim. Dɛn tu de wok togɛda.
Celebrex® na sulfonamide bak?
Yɛs. Celecoxib (dεn kin kכl am di brand nem Celebrex®), we dεn kin yus fכ trit at at pen, na sulfonamide bak.
Dis mɛrɛsin kin mek kristal dɛn fɔm na di urine?
Yɛs, sɔm sɔlfa drɔgs kin mek kristal fɔm na di urine. Bɔt dis nɔto kɔmɔn sayd ɛfɛkt. Yu dɔktɔ go advays yu if di mɛrɛsin we yu de tek go mek dis sik ɛn wetin yu kin du fɔ mek i nɔ apin (fɔ ɛgzampul, drink bɔku wata).
Mɛsej we dɛn kin kɛr go na os
- Salfonamides nɔto jɔs antibayɔtiks. Na big klas fɔ drɔgs we dɛn kin yuz fɔ mɛn difrɛn sik dɛn.
- Dɛn kin yuz dis klas fɔ mɛrɛsin fɔ bɔku sik dɛn, frɔm baktriyal infɛkshɔn to dayabitis, ay blɔd prɛshɔn, ɛn maygren.
- Alɛji kin apin to sɔlfa drɔgs. Bɔt bikɔs yu nɔ gɛt alɛji fɔ wan kayn mɛrɛsin, dat nɔ min se yu go gɛt alɛji fɔ ɔl di mɛrɛsin dɛn we de na da klas de.
- Bifo yu bigin fɔ tek ɛni nyu mɛrɛsin, mek shɔ se yu tɛl yu dɔktɔ bɔt ɛni ɔda mɛrɛsin we yu gɛt ɛn ɛni ɔda mɛrɛsin we yu bin dɔn gɛt trade.
Salfonamid, sɔlfa drɔgs, sɔlfonamid, antibayɔtik, drɔg alɛji, Stivins-Jɔnsin sindrom, Bactrim, Celebrex, Lasix
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