We yu yɛri di wɔd "kansa," di nɛks wɔd we kin kam na yu maynd go mɔs bi "kimotɛrapi." Wi ɔl no aw i nɔ kin izi fɔ trit ɛn i kin mek i fil pen. Bɔku tɛm wi kin tink bɔt am as pɔsin we de lɔs in ia ɛn bɔdi we nɔ gɛt layf. Bɔt yu no se mɛrɛsin sayɛns dɔn go bifo sote i dɔn mek nyu tritmɛnt dɛn we de ambɔg di kansa sɛl dɛn nɔmɔ ɛn we nɔ de pwɛl di sɛl dɛn we gɛt wɛlbɔdi? Dat na wan pan di patikyula, advans tritmɛnt dɛm wae wi go tɔk bɔt tide. Dɛn kɔl am Targeted Therapy .
Fɔ tɔk am simpul wan, wetin na Targeted Therapy?
Imajin se yu de drɔp bɔm pan ɛnimi dɛn we wɔ de. We yu drɔp bɔm ɔltɛm, nɔto di ɛnimi dɛn nɔmɔ kin pwɛl, bɔt di pipul dɛn we nɔ gɛt wɛpɔn ɛn os dɛn we de rawnd dɛn kin pwɛl. Kimotɛrapi tan lɛk dat smɔl. I kin kil di kansa sɛl dɛm, bɔt i kin pwɛl di wɛlbɔdi sɛl dɛm na wi bɔdi we kin sheb kwik kwik wan (fɔ ɛgzampul, di ia sɛl dɛm, di mɔt sɛl dɛm).
Bɔt, imajin se snaypa de, i de luk ɛksaktɔli pan di target ɛn na di ɛnimi nɔmɔ i de shot. Nɔbɔdi nɔ go du bad to ɛnibɔdi we de rawnd am. Na dat Targeted Therapy de du.
Targeted Therapy na wan tritmɛnt we rili advans we de no di patikyula kwaliti dɛn we di kansa sɛl dɛn gɛt, we de tɔch dɛn, ɛn pwɛl kansa pan ɔl we i nɔ de pwɛl di sɛl dɛn we gɛt wɛlbɔdi. Dɛn kin kɔl dis bak Prɛsishɔn Mɛdisin.
Insay dis tritmɛnt, yu dɔktɔ we de mɛn yu kansa kin luk fɔ di jɛnɛtik muteshon we dɔn tɔn wan nɔmal sɛl na yu bɔdi to kansa sɛl. Dɔn, dɛn kin no sɔm patikyula tin dɛn we dɛn kin atak na di kansa sɛl ɔ insay di kansa sɛl we da jɛnɛtik chenj de mek, ɛn pik drɔgs dɛn we kin atak dɛn tin dɛn de nɔmɔ.
Aw dis tritmɛnt kin rili wok?
Fɔ ɔndastand dis, lɛ wi jɔs ɔndastand aw kansa kin kam fɔs.
Ɛni sɛl na wi bɔdi gɛt sɔm tin dɛn we i fɔ du. Wi de kɔl am DNA. I tan lɛk wan buk we de tɔk bɔt aw fɔ kuk. Di instrɔkshɔn dɛn we de na dis buk de tɛl wan sɛl fɔ sheb, gro, ɛn day wan patikyula tɛm.
We kansa de kam, fɔ sɔm rizin di instrɔkshɔn dɛn we de na dis buk we de tɔk bɔt aw fɔ mek it nɔ kin fayn. Dat min se chenj (mכteshכn) de na di jin dεm. Dɔn di sɛl dɛn kin bigin fɔ sheb we dɛn nɔ ebul fɔ kɔntrol. Na dat kin bi kansa.
Insay Targeted Therapy, dɔktɔ dɛn kin wok bay we dɛn ɔndastand dis prɔses stɛp bay stɛp:
1. Fɔ fɛn di rɔng instrɔkshɔn: Fɔs, di tɛst dɛn kin no ustɛm di rɔng jenɛtik instrɔkshɔn, dat na di jɛnɛtik muteshɔn , de na yu kansa sɛl dɛn.
2. 2. .tכgεt sεlεkshכn: nεks, wi de no us spεsifi k protin dεm כ כda mכlikul dεm de fכm pan כ insay di kεnsar sεl as a rizulεt fכ dis mistek instrכkshכn. Dat na wi "target."
3. Disayn di rayt drɔg: Dɔn, dɛn mek wan drɔg fɔ tay to di target we dɛn dɔn no. Dis dכg kin kil di kεnsar sεl כ blכk di signal path dεm we de εp di sεl fכ sheb.
Bikɔs dɛn kin tɔch di tritmɛnt jɔs dis we, di ifɛkt pan wɛlbɔdi sɛl dɛn nɔ kin bɔku.
Wetin na di men kayn tritmɛnt wae dɛn kin gi yu?
Difrɛn kayn we dɛn de fɔ dis tritmɛnt. Dɛn kin sheb dɛn akɔdin to di we aw dɛn de wok. Na sɔm pan di men kayn dɛn ya:
- Smɔl mɔlikul drɔgs: Dɛn drɔgs ya na rili smɔl smɔl drɔgs, so dɛn kin go insay di kansa sɛl dɛn, atak di target dɛn we de insay di sɛl, ɛn stɔp di sɛl dɛn fɔ gro.
- Immunotherapy: Dis na difrɛn we fɔ du am smɔl. Wetin wi de du ya na fɔ mek wi yon imyun sistɛm pwɛl fɔ pwɛl di kansa sɛl dɛn. Bɔku ɔda tritmɛnt dɛn de ɔnda dis ambɔla.
- Monoclonal antibodies: Dis na spεshal protin dεm we dεn mek na lab, jכs lεk di antibodi dεm we wi bכdi de mek. Dɛn kin atak di target dɛn we de na di say we di kansa sɛl dɛn de ɛn gi signal to di imyun sistɛm fɔ pwɛl di kansa.
- Antibodi-drug conjugates: Dis na wan we we rili kleva. Na ya, wan pawaful kemo drɔg de atak di monoklɔnal antibodi. We di antibodi dɔn fɛn di rayt kansa sɛl ɛn stik to am, di mɛrɛsin de kɔmɔt dairekt insay di kansa sɛl. I tan lɛk pasɛl, we dɛn kin sɛn am na di rayt ples.
Us kayn kansa dɛn kin trit fayn fayn wan wit dis tritmɛnt?
Dɛn nɔ go ebul fɔ yuz Targeted Therapy fɔ ɔl di kansa dɛn. Bɔt tide dɛn kin yuz dis tritmɛnt we dɛn kin yuz fɔ bɔku kayn kansa fayn fayn wan. Sɔm pan dɛn na:
- Brɔst kansa
- Kansa na di lɔng
- Prɔstat kansa
- Blɔd kansa (e.g. Mɔltipɛl mayloma, Akyu lukimiya) .
- Kansa na di skin (e.g. Melanoma) .
- Kansa we de na di kɔlɔrɛkt
- Kidni kansa
- Tayrɔyd kansa
- Kansa na ed ɛn nɛk
- Kansa na di sɛvikal
Dis list de gro ɛvride, as risach de ɔltɛm fɛn nyu jɛnɛtik difrɛns ɛn drɔgs we de tɔch dɛn.
Aw dɛn kin gi di tritmɛnt ɛn wetin yu kin ɛkspɛkt?
Naw, pas 100 kayn mɛrɛsin dɛn de we dɛn kin yuz fɔ mɛn pipul dɛn. Di we aw yu de gɛt dis tritmɛnt kin difrɛn difrɛn wan bay di kayn kansa we yu gɛt, di kayn mɛrɛsin we yu de tek, ɛn wetin yu dɔktɔ disayd fɔ du.
- As pil: Sɔm mɛrɛsin dɛn kin kam lɛk pils we yu kin tek na os.
- As injɛkshɔn: Dɛn kin gi sɔm insay di bɔdi as injɛkshɔn.
- Intravenous (IV): Bɔku tɛm, dɛn kin gi dis tritmɛnt insay di bɔdi tru wan vein, lɛk salin.
Di tɛm fɔ tritmɛnt sɛf kin difrɛn. Yu kin nid fɔ tek tritmɛnt ɛvride, ɛvri wik, ɔ ɛvri mɔnt. Sɔm tritmɛnt dɛn kin tek lɔng tɛm, ɛn ɔda wan dɛn kin dɔn insay sɔm tɛm we dɛn dɔn sɛt.
We yu de du yu tritmɛnt, yu dɔktɔ go de chɛk yu ɔltɛm. I kin du blɔd tɛst ɛn CT skan fɔ chɛk aw di tritmɛnt de wok fayn ɛn aw yu de fil. Yu go gɛt di chans bak fɔ tɔk to yu dɔktɔ bɔt ɛni prɔblɛm we yu go gɛt we yu de trit yu.
Ki Difrɛns Bitwin Kimotɛrapi ɛn Targeted Tɛrapi
Wan kwɛstyɔn we bɔku pipul dɛn gɛt na uswan pan dɛn tu we ya bɛtɛ. Fɔ ɔndastand dat, lɛ wi luk di difrɛns bitwin dɛn tu we ya.
| Di kwaliti we pɔsin gɛt | Tɛrapi we dɛn de tɔk bɔt | Kimotɛrapi |
|---|---|---|
| Aw i de wok | Atak כnli spεshal tכgεt dεm na di kεnsar sεl dεm (lεk snaypa atak) . | I de pwɛl ɛni sɛl we de sheb kwik kwik wan (we gɛt kansa ɛn we gɛt wɛlbɔdi). (Lɛk bɔm atak) |
| Efεkt pan hεlty sεl dεm | Sɔntɛm i nɔ go bɔku. | If yu it am tumɔs, dat kin pwɛl di ia, skin, ɛn di dijestiv trakt sɛl dɛn. |
| Di sayd ɛfɛkt dɛn we kin apin | i kin difrεnt dipכnt pan di kayn mεdikeshכn (e.g. skin rash, dayariya, hεy blכd prεshכn). | Di kɔmɔn sayd ɛfɛkt dɛm na fɔ vɔmit, nɔs, yu ia de lɔs, ɛn taya. |
| Ajɔstmɛnt | I dipen pan di jenɛtik kwaliti dɛm fɔ di kansa. I nɔ fit ɔlman. | Dɛn kin yuz am fɔ bɔku kayn kansa. |
Di impɔtant tin na dat, no "best" tritmɛnt nɔ de. Yu dɔktɔ go disayd di tritmɛnt we go fayn ɛn we go wok fɔ yu. Sɔntɛnde, dɛn kin yuz dɛn tu tritmɛnt ya togɛda.
Lɛ wi no bak bɔt di bad tin dɛn we kin apin to wi.
Pan ɔl we di tritmɛnt we dɛn kin gi pɔsin we dɛn want fɔ mɛn kin mek di sɛl dɛn we gɛt wɛlbɔdi nɔ pwɛl, i nɔ kin gɛt ɛni bad bad tin we kin apin to dɛn. Di sayd ɛfɛkt dɛn kin difrɛn frɔm wan drɔg to ɔda drɔg ɛn frɔm wan pɔsin to ɔda pɔsin. Sɔm kɔmɔn sayd ɛfɛkt dɛn na:
- Daya: Na stɔl we nɔ gɛt bɛtɛ trɛnk.
- Prɔblɛm dɛn na di skin: dray skin, rash, it.
- di εnzym dεm na di liva we de εlevεt: dεn kin no dis tru blכd tεst.
- Haypatɛnshɔn: Di blɔd prɛshɔn de go ɔp .
- Blɔd klɔt: Risk fɔ mek blɔd klɔt fɔm na di blɔd vesel dɛn.
- At sik: Sɔm mɛrɛsin kin afɛkt aw at de wok.
- Dilay we wund de wɛl.
- Blɔd we de kɔmɔt na di bɛlɛ: Blɔd de na di stɔl ɔ blak stɔl.
- Chenj in ia kɔlɔ.
Nɔ fred fɔ yɛri dɛn tin ya. Yu dɔktɔ go tɛl yu bɔt ɔl dis. Dɔn bak, i go gi yu di mɛrɛsin ɛn advays dɛn we yu nid fɔ kɔntrol dɛn sayd ɛfɛkt ya ɛn ridyus di impak we dɛn kin gɛt. If yu fil ɛnitin we nɔ fayn, nɔ de te fɔ tɛl yu dɔktɔ.
Mɛsej we dɛn kin kɛr go na os
- Targeted Therapy na wan tritmɛnt we rili advans we de tɔch di kansa sɛl dɛn nɔmɔ ɛn i nɔ de pwɛl di sɛl dɛn we gɛt wɛlbɔdi.
- Dis tritmɛnt nɔr fayn fɔ ɔl kansa ɔr ɔl sikman. I dipen pan di patikyula jenɛtik kwaliti dɛm fɔ yu kansa.
- Di sayd ɛfɛkt dɛn kin difrɛn frɔm di kemotɛrapi. Sɔm sayd ɛfɛkt kin apin, bɔt yu mɛdikal tim go ɛp yu fɔ kɔntrol dɛn.
- Tɔk opin wan wit yu dɔktɔ we de mɛn yu kansa bɔt di bɛst tritmɛnt fɔ yu kansa. Aks ɔl yu kwɛstyɔn dɛn ɛn mek ɛni dawt we yu gɛt klia wan.
- Mɛdikal sayɛns de go bifo ɛvride. So, kip yu op fɔ gɛt kansa tritmɛnt.
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