Bɔku tɛm yu pikin kin gɛt kol, kɔf, in yes, ɔ infɛkshɔn na in skin? Yu tink se wan sik kin bɛtɛ bifo ɔda wan? Bɔku tɛm, wi kin tink se di pikin in imyuniti de smɔl ɛn i de kech sik na skul ɛn na say dɛn we i de ple. Bɔt pan tin dɛn we nɔ kin apin so ɔltɛm, dis kin bi bikɔs ɔf wan patikyula jɛnɛtik kɔndishɔn we dɛn kɔl WHIM Syndrome . Pan ɔl we dɛn nɔ kin tɔk bɔku bɔt dis, i rili impɔtant fɔ no bɔt am.
Wetin na dis WHIM sindrom?
Fɔ tɔk am simpul wan, WHIM syndrome na wan sik we nɔ kin apin so ɔltɛm we kin afɛkt wi bɔdi in imyun sistɛm. Dɛn pul di nem WHIM frɔm di fɔs lɛta dɛn pan di 4 men sayn dɛm fɔ dis sik.
- Wɔt (wɔt) .
- Hypogammaglobulinemia (di smɔl smɔl antibodi dɛn we de na di blɔd) .
- Infɛkshɔn (infɛkshɔn we kin kam bɔku tɛm) .
- Myeloalveolar hemorrhage (wayt blɔd sɛl dɛn kin kɔnjɛshɔn na di bon mɛro) .
Imajin se wi bɔdi gɛt bɔku wayt blɔd sɛl dɛn. Di wok we dɛn sojaman ya de du na fɔ fɛt ɛnimi dɛn lɛk baktri ɛn vayrɔs we de mek pɔsin sik. Insay pɔsin we gɛt WHIM sindrom, di sojaman dɛn we impɔtant pas ɔl na dis ami, we na di wayt blɔd sɛl dɛn we dɛn kɔl nyutrofil , kin stɔp na dɛn bays, we na di bon mɛro. Dɛn nɔ kin ebul fɔ kɔmɔt, insay di blɔd, fɔ fɛt sik. So, di bɔdi in difens sistɛm kin wik, ɛn dɛn kin bigin fɔ sik bɔku tɛm.
I nɔr kin so ɔltɛm dat dɛn biliv se i kin afɛkt wan pan ɛvri 5 milyɔn pikin dɛm we dɛn bɔn, so yu nɔr dɔn yɛri bɔt am bifo.
Wetin na di sayn dɛm wae de sho se yu gɛt WHIM syndrome?
Dɛn sayn ya kin difrɛn frɔm wan pɔrsin to ɔda pɔrsin. Sɔm pipul dɛn kin gɛt sɔm kayn sik wae nɔr kin pasmak. Ɔda pipul dɛn kin gɛt bad bad sik dɛn we kin mek dɛn layf de pan denja. Dɛn sayn ya kin bigin wae dɛn smɔl, bɔt sɔmtɛm dɛn nɔr kin no bɔt dis sik te i big.
| Tayp we gɛt kwaliti dɛn | Tin dɛn we yu kin si bɔku tɛm |
|---|---|
| Sayn dɛn we kin apin we pɔsin smɔl we i smɔl |
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| Sɔm sik dɛn we kin apin leta |
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Ɛspɛshali bɔt wɔt ɛn kansa risk
Bɔku pipul dɛn we de arawnd wi kin gɛt di sik we dɛn kɔl human papillomavirus (HPV), we kin mek pɔsin gɛt wɔt. Bɔt pan pɔsin we gɛt wɛlbɔdi imyun sistɛm, dis vayrɔs kin dɔnawe wit in bɔdi klos to ɔtomɛtik wan. Bɔt bikɔs di imyun sistɛm fɔ pɔsin we gɛt WHIM sindrom wik, i nɔ kin izi fɔ fɛt dis HPV vayrɔs. So, di vayrɔs kin de na di bɔdi fɔ lɔng tɛm, we kin mek pɔsin gɛt wɔt, ɛn sɔm tɛm dɛn, i kin mek i gɛt kansa mɔ ɛn mɔ.
Wetin kin mek dis apin? Yu tink se dis kin pas?
di men kכz fכ WHIM sεndrכm na di mכtεshכn na di jin we dεn kכl `CXCR4` na wi bכdi. Tink bɔt dis jin as program we de sho wi sɛl dɛn. we dis jin chenj, di wayt bכdi sεl dεm we wi bin dכn tכk bכt (Neutrophils) stכp fכ kכmכt na di bon mכro.
Bikɔs dis na tin we pɔsin kin gɛt frɔm in jɛnɛtiks, i nɔ kin ebul fɔ pas frɔm pɔsin to ɔda pɔsin bay we i de sniz ɔ tɔch am . Bɔt, i kin pas frɔm mama ɛn papa to pikin dɛn. If ɛni wan pan dɛn mama ɛn papa gɛt dis jin muteshon, ɛni pikin we dɛn gɛt gɛt 50% chans fɔ gɛt di sik .
Aw yu kin no dis sik kɔrɛkt wan?
Bikɔs dis na sik we nɔ kin bɔku, i nɔ kin izi fɔ no if yu gɛt wan tɛst nɔmɔ. Yu dɔktɔ go tek tɛm luk yu ɛn yu pikin in sik, aw ɔltɛm dɛn kin gɛt di sik, ɛn afta dat i kin tɛl yu fɔ du sɔm tɛst dɛn.
- Kɔmplit Blɔd Kɔnt (CBC): Dis kin chɛk fɔ si if di wayt blɔd sɛl dɛn, mɔ di nyutrofil dɛn we de na di blɔd nɔ bɔku.
- Antibodi test (Immunoglobulin G - IgG blɔd tɛst):dis tεst dεn kin du fכ si if di lεvεl dεm fכ di antibodi dεm we de fכt infεkshכn lכw.
- Bone Marrow Biopsy: Insay dis prosidur, dεn kin tek sכm sכm sכm bon mכro frכm di hip bon כnda mild anεsthεsia εn dεn kin egzamin am כnda maykroskכp. dis kin kכrekt fכ no if di wayt bכdi sεl dεm de trכp insay di bon mכro (myelokathexis).
- Jεnεtik Tεst: Dis tεst kin kכnfכm if mכtεshכn de na di `CXCR4` jin we de mek WHIM sεndrכm.
Di kwik we dɛn no di sik, na di mɔ i nɔ go gɛt prɔblɛm dɛn lɛk fɔ go na ɔspitul ɔltɛm, fɔ nɔ yɛri fayn, ɛn fɔ pwɛl in lɔng.
Wetin na di tritmɛnt dɛm fɔ WHIM syndrome?
Nɔr mɛrɛsin nɔr de fɔ dis sik yet. Bɔt sɔm tritmɛnt dɛn de wae kin ɛp yu fɔ kɔntrol di sik, protɛkt yu frɔm infekshɔn, ɛn ɛp yu fɔ liv nɔrmal layf.
Di kayn drɔgs dɛn we dɛn kin yuz
- Xolremdi: Dis na nyu mɛrɛsin we dɛn dɔn gri fɔ insay 2024. I de ɛp fɔ pul wayt blɔd sɛl dɛn we dɔn stɔp na di bon mɛro. Dis kin ridyus di risk fɔ gɛt infɛkshɔn bay lɛk 40%.
- G-CSF tritmɛnt: Dis na shot. I de mek di bon mכro wok εn i de εp fכ mek mכr wayt blכd sεl dεm.
- IgG tεrapi: fכ di wan dεm we gεt lכw antibodi lεvεl, di imyun sistεm de strכng bay we dεn gi antibodi dεm frכm כdasay.
- Antibayɔtik: We baktri infɛkshɔn (lɛk nyumonia, infɛkshɔn na di skin) kam, yu dɔktɔ go gi yu dɛn tin ya fɔ kɔntrol am.
Tritmɛnt fɔ di wɔt
If di wɔt kin apin bɔku tɛm, yu kin go to dɔktɔ we de mɛn di bɔdi fɔ mek dɛn pul am. Bɔku we dɛn de fɔ du dat.
- Krayosɔjɛri we dɛn kin du
- Ilɛktrosɔjri we dɛn kin du
- Laser tritmɛnt
- Di kayn spɛshal tin dɛn we dɛn kin kɔt
Aw fɔ liv wɛl bɔdi wit WHIM sindrom?
We yu de liv wit dis kayn sik we nɔ kin apin so ɔltɛm, yu fɔ tink mɔ bɔt yu wɛlbɔdi.
- Gud it: Fɔ it fayn fayn tin dɛn rili impɔtant fɔ mek yu imyun sistɛm strɔng. Put mɔ vɛjitebul, frut, ɔl gren, fish, ɛn chukchuk insay yu it.
- Ɛksesaiz: Ɛksesaiz kin ɛp fɔ mek di bɔdi strɔng ɛn i kin mek di bɔdi ebul fɔ fɛt di sik. Du sɔntin we yu lɛk, lɛk spɔt, waka, ɔ swim, ɛvride.
- Protekshɔn frɔm infɛkshɔn:
- Avɔyd ples dɛn we pipul dɛn kin bɔku as yu ebul.
- Wash yu an bɔku tɛm wit sop.
- Tɔk to yu dɔktɔ ɛn disayd us vaysin yu ɛn yu famili nid.Tɔk spɛshal bɔt tin dɛn lɛk di HPV vaysin, nyumonia vaysin, ɛn di influenza vaysin we dɛn kin gi ɛvri ia.
Apat frɔm yu famili dɔktɔ, yu kin nid difrɛn dɔktɔ dɛn fɔ ɛp yu, lɛk dɔktɔ we de mɛn yu bɔdi, we de mɛn yu bɔdi, ɛn dɔktɔ we de mɛn yu skin.
Mɛsej we dɛn kin kɛr go na os
- WHIM syndrome na wan sik we nɔ kin apin so ɔltɛm, we pɔsin kin gɛt we i kam pan jɛnɛtiks. Nɔto yu fɔlt ɔ yu pikin in fɔlt.
- If yu pikin de gɛt infekshɔn ɔltɛm we nɔ kɔmɔn, i rili impɔtant fɔ tɔk to dɔktɔ bɔt am ɛn nɔ tek tɛm .
- Dis sik nɔ kin pas, bɔt i kin kɔmɔt frɔm mama ɛn papa to pikin dɛn.
- Pan ɔl we dɛn nɔr dɔn gɛt kɔmplit mɛrɛsin fɔ dis yet, di tritmɛnt dɛm wae de naw kin kɔntrol di sik dɛm, ridyus di prɔblɛm dɛm, ɛn kip gud kwaliti layf.
- Tɔk opin wan wit yu dɔktɔ bɔt ɛnitin we de mɔna yu ɔr de wɔri bɔt yu wɛl bɔdi.
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