Yu de sɔfa wit pen we so bad dat yu nɔ ebul fɔ ivin imajin? Sɔntɛm na bak pen, kansa pen, ɔ nerve pen. Bɔrku tɛm, i kin rili at fɔ kɔntrol dis kayn bad bad pen wit pen kil lɛk Panadol ɛn ibuprofen. Sɔntɛnde, ivin if dɛn gi dɛn strɔng mɛrɛsin fɔ mek dɛn nɔ fil pen, sɔm pipul dɛn kin gɛt mɔ sayd ɛfɛkt. So, tide wi go tɔk bɔt wan spɛshal mɛrɛsin we dɔktɔ dɛn kin tɔn to we ɔl ɔda tritmɛnt dɛn nɔ wok. Dat na di Ziconotide injɛkshɔn.
Fɔ tɔk am simpul wan, wetin na Ziconotide?
Ziconotide na spɛshal mɛrɛsin we dɛn kin yuz fɔ mɛn bad bad pen we nɔ de dɔn . I nɔ tan lɛk mɛrɛsin we dɛn kin yuz fɔ mɛn pen ɔltɛm. Nɔmal wan, wan pil we wi kin tek we wi gɛt pen kin wok bay we i de go na di say we di pen de na di bɔdi. Bɔt Ziconotide de wok difrɛn we.
Fɔ tɔk am simpul wan, we wi fil pen na wi bɔdi, na we wan sayn we de kɔmɔt na di say we di pen de go na di bren tru di nɛv dɛn. wetin Ziconotide de du na fכ blok dεn pen signal dεm ya we de travul tru di spεnal kכd to di bren . I tan lɛk se dɛn dɔn stɔp di pen mɛsej af-af bifo i rich na di bren. Dis na di rizin we mek i kin kɔntrol ivin bad bad pen we ɔda mɛrɛsin dɛn nɔ kin ebul fɔ kɔntrol.
Di tin we impɔtant pas ɔl na dat, dɛn kin gi dis nɔmɔ we ɔl di ɔda mɛrɛsin dɛn we de mek pɔsin fil pen nɔ wok ɔ dɛn nɔ kin ebul fɔ bia wit di sayd ɛfɛkt dɛn we dɛn kin gɛt, ɛn we spɛshal pɔsin de wach am strikt wan.
Aw dɛn kin gi dis mɛrɛsin? Dis na injɛkshɔn we dɛn kin gi am ɔltɛm?
Nɔ, dis nɔto shot lɛk aw wi kin gɛt na di sholda ɔ di bɔdi. Dɛn kin gi dis di kayn we we rili spɛshal.
Dɛn kin injɛkt dis mɛrɛsin dairekt insay di wata we de rawnd yu spayna (sɛribrospaynal fluid) . Dɛn kɔl dis injɛkshɔn insay di bɔdi. Bikɔs i nɔ kin izi fɔ gi dis injɛkshɔn ɛvride, dɔktɔ dɛn go put spɛshal pɔmp (pɔmp we pɔsin kin put insay pɔsin in bɔdi) ɔnda yu skin, bɔku tɛm na yu bɛlɛ.
Dis pɔmp tan lɛk smɔl kɔmpyuta. I kin rilis mɛrɛsin pan wan patikyula tɛm, pan wan patikyula doz. Di dɔktɔ kin program dis pɔmp ɛn ful-ɔp am bak wan patikyula tɛm. Di mɛdikal tim go tich yu bak aw fɔ yuz dis pɔmp.
Wetin mek dis kayn kɔmplikɛt sistɛm?
Dɛn kin yuz dis we bikɔs di mɛrɛsin nid fɔ go dairekt to di nervɔs sistɛm. If nɔto dat, if dɛn gi am na di blɔd lɛk aw dɛn kin du am, i nɔ go wok bɛtɛ ɛn i go gɛt mɔ sayd ɛfɛkt.
Tin dɛm wae yu fɔ tɛl yu dɔktɔ bifo yu bigin tritmɛnt
Bikɔs dis na mɛrɛsin we rili pawaful, i impɔtant fɔ tɛl yu dɔktɔ bɔt yu kɔmplit wɛlbɔdi istri bifo yu bigin fɔ trit yu. Mek shɔ se yu tɛl dɛn if yu gɛt ɛni wan pan dɛn tin ya:
- Mental wɛl bɔdi prɔblɛm: Yu dɔn ɛva gɛt wan sik lɛk pwɛl hat, wɔri, saykosis , ɔr yu ɔ sɔmbɔdi na yu famili dɔn ɛva tray fɔ kil yusɛf?
- Blɔd disɔda: Yu gɛt prɔblɛm wit yu blɔd we nɔ de klɔt izi wan?
- Infεkshכn: Tεl wi bכt εni infεkshכn we de naw na yu bכdi, spεshal infεkshכn we de involv di spayna.
- Spinal kanal blok: Dɔktɔ dɔn ɛva tɛl yu bɔt spɛshal kanal we blɔk?
- Alɛji: If yu gɛt alɛji to dis zikɔnotayd mɛrɛsin ɔ ɛni ɔda mɛrɛsin, it, ɔ day.
- Bɛlɛ: If yu gɛt bɛlɛ, yu de tray fɔ gɛt bɛlɛ, ɔ yu de gi pikin in bɛlɛ, mek shɔ se yu tɛl yu dɔktɔ.
Wetin na di sayd ɛfɛkt dɛn we pɔsin kin gɛt we i tek dis mɛrɛsin?
Lɛk ɛni mɛrɛsin, ziconotide kin mek yu gɛt sayd ɛfɛkt. Sɔm kin siriɔs, ɛn ɔda wan dɛn kin kɔmɔn. I impɔtant fɔ no bɔt dɛn tin ya.
| Sayd ɛfɛkt dɛn ɛn wetin fɔ du | |
|---|---|
| Siriɔs sayd ɛfɛkt dɛm we yu fɔ ripɔt to yu mɛdikal tim wantɛm wantɛm | |
| Alɛji Riakshɔn dɛn | Skin rash, it, swel na di fes, lip, tong ɔ trot. |
| Di chenj dɛn we de apin na di maynd ɛn di we aw pɔsin de biev | Bɔrku rεstlɛs, agyumɛnt, kɔnfyus, si ɔr yɛri tin wae nɔr rial (hallucinations), tink bɔt fɔ kil yusɛf, pwɛl hat pasmak. |
| Di sayn dɛn we de sho se pɔsin gɛt Mɛningaytis | Fiva, stif nɛk, i nɔ kin izi fɔ si layt, ed kin at bad bad wan, nɔs, ɛn vɔmit. (Dis kin bi sayn dεm fכ infεkshכn na di bren כ spεnal kכd). |
| Mɔsul dɛn we de pwɛl (Rhabdomyolysis) . | Wik we nɔ kɔmɔn, di mɔsul dɛn de pen, di urine we de dak yɔlɔ ɔ brawn, di urine we de kɔmɔt na di bɔdi nɔ de bɔku. |
| I nɔ kin izi fɔ tink ɛn mɛmba | I nɔ kin izi fɔ pe atɛnshɔn, i nɔ kin mɛmba, i nɔ kin izi fɔ tɔk. |
| Sayd ɛfɛkt dɛn we nɔ kin siriɔs, bɔt dɛn fɔ ripɔt to di dɔktɔ if dɛn kɔntinyu fɔ de | |
| Kɔnfyus | Mild kɔnfyushɔn. |
| Diziz we pɔsin kin gɛt | Diziz, we yu nɔ de balans. |
| Vɔmit | Kam fɔ vɔmit. |
| Nɔ ebul fɔ kɔntrol di yay | Di we aw pɔsin de muv di yay we pɔsin nɔ ebul fɔ kɔntrol. |
Speshal pɔynt dɛn we wi fɔ tek tɛm wit
Alkol ɛn ɔda drɔgs dɛn
Nɔ drink rɔm we yu de tek dis mɛrɛsin fɔ ɛni rizin . Ziconotide kin mek yu nɔr de wach, balans, ɛn riakshɔn tɛm. If yu drink rɔm, dat kin mek dis sik siriɔs.
Dɔn bak, yu fɔ rili tek tɛm we yu de tek ɔda mɛrɛsin dɛn we de mek yu slip (e.g., sɔm kɔf srɔp, alɛji mɛrɛsin, slip pils). Tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek, ivin di vaytamɛn ɛn ɛbul mɛrɛsin dɛn.
Drayv ɛn ɔpreshɔn mashin dɛn
Nɔ drayv ɔ yuz mashin we denja te yu no gud gud wan aw dis mɛrɛsin de afɛkt yu. Dɔn bak, fɔ mek yu nɔ gɛt diziz ɔ fɔ mek yu nɔ fil fayn, nɔ grap wantɛm wantɛm we yu sidɔm ɔ ledɔm. Get grap sloslo.
Wetin fɔ du if di doz go ɔp?
Bikɔs dɛn kin gi dis tru pɔmp, bɔku tɛm dɛn nɔ kin ad di doz. Bɔt if yu tink se yu dɔn tek bɔku mɛrɛsin bikɔs di pɔmp nɔ wok fayn ɔ ɔda rizin, kɔl di Nashɔnal Pɔyzin Infɔmeshɔn Sɛnta na di Kɔlɔmbɔ Nashɔnal Ospital wantɛm wantɛm, ɔ go na di Imejɛnsi Tritmɛnt Yunit (ETU) na di ɔspitul we de nia yu.
Rifil Apɔntinmɛnt dɛn
Yu dɔktɔ go gi yu wan de fɔ ful yu pɔmp bak wit mɛrɛsin. Nɔ skip dɛn de dɛn ya. If fɔ sɔm rizin yu nɔ ebul fɔ mek am, kɔl yu mɛdikal tim wantɛm wantɛm ɛn chenj di tɛm fɔ du am.
Mɛsej we dɛn kin kɛr go na os
- Ziconotide na pawaful mɛrɛsin wae dɛn kin yuse fɔ pen pasmak, wae nɔr dɔn ansa ɔda tritmɛnt dɛm.
- dis de kכmכt to di wata we de rawnd di spεnal kכd tru wan spεshal implantabl pכmp we dεn implant כnda di skin.
- Yu fɔ tɛl yu dɔktɔ bɔt ɔl yu wɛl bɔdi prɔblɛm, mɔr lɛk yu maynd prɔblɛm ɛn alɛji, bifo yu bigin fɔ trit yu.
- Go to dɔktɔ kwik kwik wan if yu gɛt siriɔs sayd ɛfɛkt lɛk kɔnfyushɔn, chenj na yu bihayvya, fiva, ɛn yu nɛk stif.
- Nɔ drink rɔm ɔltogɛda we yu de tek dis tritmɛnt. Tek tɛm bad bad wan we yu de drayv ɛn yuz mashin dɛn.
- If ɛni chenj, inkris, ɔr nyu pen de pan yu pen, mek yu dɔktɔ no.
👩🏽 ⚕️ Ɔda kwɛstyɔn dɛn (FAQ dɛn)
💬 Wetin dɛn de yuz di Ziconotide / Prialt vaysin fɔ?
Dis nɔto ɔdinari mɛrɛsin fɔ mek pɔsin fil pen! Dis na wan mɛrɛsin we rili pawaful (Nɔn-opioid) we dɛn kin gi na ɔspitul tru wan ‘Intrathecal pump’ we dɔktɔ put insay di pɔsin in spaynal kɔd/spinal kɔd fɔ pul 100% pan di ‘Severe Chronic Pain’ we nɔ kin bia we nɔ kin rilif ivin di strɔng mɛrɛsin (Morphine) fɔ di wan dɛn we gɛt kansa, di wan dɛn we gɛt siriɔs nyurolɔjik dizayd dɛn!
💬 Wetin dɛn mek dis drɔg (Ziconotide) wit, we strɔng pas mɔfin?
Amazing stori! Dɛn bin fɛn ɛn mek dis mɛrɛsin frɔm di pɔyzin we de kil (Conotoxin) we di ‘snɛl we rili denja/pɔyzin (Conus magus / Cone snail)’ de mek! we dis pכyzin rich di spεnal kכd, i de blכk/klos 100% pan di kalsiכm get dεm (N-tayp kalsiכm chεnal dεm) na di nεv dεm we de kכri pen to di bren. Dis kin kɔt di pen mɛsej we de go na di bren kpatakpata.
💬 Wetin na di sayd ifekt dεm we de mek yu gi dis spεshal mεdisin to di spεnal kכd (Intrathecal)?
Di sayd ɛfɛkt dɛn we dis kin gɛt kin rili bad! (Blak Bɔks Wɔnin). Bikɔs dis drɔg kin go dairekt to di bren/spɛnal kɔd, sɔm sik pipul dɛn kin gɛt skizofrenia/krayzi we dɛn nɔ kin ebul fɔ bia (Hallucinations). Dɔn bak, bad bad wɔri, paranoia, ɛn bad bad ‘tink bɔt fɔ kil yusɛf’ kin apin wantɛm wantɛm! Di ɔda big tin we de mɔna am na dat di pɔsin gɛt ay chans fɔ nɔ mɛmba ɛnitin (Cognitive impairment).
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