Ffenna twogera ku kolesterol buli kiseera, era tumweraliikirira, si bwe kiri? Naye lowooza ku nsonga eno, wali owuliddeko ku bulwadde obw’obuzaale nga kolesterol mungi mu ngeri etaali ya bulijjo okuva mu buto, oboolyawo ne mu buto? Leero tugenda kwogera ku bulwadde obumu obw’engeri eno obutatera kulabika naye nga bukulu nnyo. Kino kiyitibwa obulwadde bwa Homozygous Family Hypercholesterolemia (HoFH). Wadde erinnya lino lizibu katono, ka tulitegeere mu ngeri ennyangu.
Obulwadde bwa Homozygous Family Hypercholesterolemia kye ki?
Mu ngeri ennyangu, buno bulwadde bwa buzaale obukaluubiriza omubiri gwaffe okuggya kolesterol "omubi", kwe kugamba, LDL (Low-Density Lipoprotein) cholesterol, mu musaayi gwaffe. Ffenna tukimanyi nti kolesterol kintu kya wax obutoffaali bwaffe kye kyetaaga. Omulimu gwa LDL cholesterol kwe kutambuza kolesterol ono mu mubiri gwonna ng’ayita mu musaayi.
Naye LDL bwe yeeyongera ennyo, kolesterol ono ow’enjawulo atandika okuzimba mu misuwa egituwa omusaayi mu mutima gwaffe, emisuwa. Ekiseera bwe kigenda kiyitawo, ebitereke bino bisobola okuziba emisuwa, ne bisalako omusaayi ne omukka gwa oxygen okutuuka ku mutima, era ne kyongera obulabe bw’okulwala omutima .
Obulwadde buno buzaalibwa. Kino kitegeeza nti osobola okuba ne kolesterol omungi okuva mu buto. Eno mbeera ya maanyi etasobola kuwona era erina okuddukanyizibwa obulamu bwonna.
Singa tebajjanjabwa, abasajja abalina embeera eno basobola okufuna obulwadde bw’omutima nga bali mu myaka 40 n’abakazi mu myaka 50. N’olwekyo, kikulu nnyo okukimanya kino n’okunoonya obujjanjabi obutuufu.
Kiki ekivaako kino?
Kino tukiyita bulwadde bwa buzaale. Mu ngeri enkakali, obulwadde buno obufuna singa osikira kkopi bbiri ez’obuzaale obutakola bulungi, emu okuva ku maama wo ate endala okuva ku kitaawo .
Mu budde obwabulijjo, ekibumba kyaffe kiggya kolesterol asusse mu musaayi. Ekibumba kirina ‘LDL receptors’ ez’enjawulo ku kino. Zino ziringa magineeti ezikwata kolesterol ne zimuggya mu musaayi. Naye mu muntu alina obulwadde buno, olw’obuzaale obusikira obulema, obusimu buno tebukola bulungi. Ekivaamu kwe kuba nti kolesterol alinnya mu ngeri etafugibwa.
Oyinza n’okuwulira ku ‘Heterozygous’ Familial Hypercholesterolemia. Kino kye kiseera obuzaale obuliko obulemu bwe busikira okuva ku muzadde omu yekka. Embeera eno si ya maanyi nga ‘Homozygous’.
Bubonero ki obulaga obulwadde buno?
Waliwo obubonero obukulu obuwerako obuyinza okukozesebwa okuzuula obulwadde buno. Ka tuzitunuulire mu mmeeza.
| Engeri | Okunnyonnyola |
|---|---|
| Omutindo gwa kolesterol omungi ennyo | Omugatte gwa kolesterol guyinza okuba 600 mg/dL oba okusingawo (omuwendo omulamu guba wansi wa 200). |
| Ebifo ebiterekeddwa mu lususu (Xanthomas) . | Ebizimba ebya kyenvu ebiringa wax wansi w’olususu ku nkokola, amaviivi n’amatabo. Bino biba bitereke bya kolesterol. |
| Ebitereke ku bikoola by’amaaso (Xanthelasmas) . | Amasavu aga kyenvu agateekebwa ku bikoola by’amaaso. |
| Enkyukakyuka mu maaso (Arcus cornealis) . | Empeta enzirugavu oba enjeru okwetooloola eriiso eriddugavu. |
| Obubonero bw’omutima | Obubonero ng’okulumwa mu kifuba (angina), okussa obubi, n’okukuba amangu omutima busobola okulabika ku myaka emito. |
Ozuula otya obulwadde buno?
Bw’oba olina obubonero buno, kikulu okulaba omusawo. Omusawo ajja kusooka kwekebejja omubiri era akubuuze ebibuuzo ebitonotono.
- Waliwo ky’otegedde ng’amabala ga kyenvu ku lususu lwo?
- Olina obulumi mu kifuba?
- Owulira ng’omukka gukutte?
- Bazadde bo nabo balina kolesterol omungi?
Olwo, omusawo ajja kukukebera omusaayi okukebera kolesterol wo. Era bayinza okukola okukebera obuzaale okulaba oba olina obuzaale obukyamu obuleeta obulwadde buno. Omusawo wo ayinza n’okukebera ab’omu maka go ab’oku lusegere.
Enkola z’obujjanjabi n’enzirukanya y’emirimu
Ekigendererwa ekikulu eky’obujjanjabi kwe kukendeeza ku kolesterol wa LDL n’okukendeeza ku bulabe bw’okufuna endwadde z’omutima.Ojja kutera okusindikibwa ew’omusawo mukugu mu ndwadde za kolesterol nga zino (Lipidologist).
Enkyukakyuka mu bulamu n’endya
Ekisooka kwe kwettanira emmere eyamba omutima nga temuli masavu matono, kolesterol ne ssukaali. Era kikulu okulekera awo okunywa sigala, okukomya omwenge, n’okukola dduyiro buli lunaku.
Eddagala
Olw’okuba kolesterol wo ali waggulu mu ngeri etaali ya bulijjo, oyinza okutandikibwa ku ddoozi nnyingi eza statins , ezikola nga ziyimiriza ekibumba okukola kolesterol.
Ng’oggyeeko ekyo, eddagala eddala erikendeeza ku bungi bwa kolesterol ayingizibwa mu mmere (e.g. Ezetimibe , PCSK9 inhibitors , Lomitapide ) liyinza okugattibwako.
Enzijanjaba ezenjawulo
Singa kolesterol tasobola kufugibwa na ddagala lyokka, enkola endala ez’obujjanjabi zijja kuba zirina okulowoozebwako.
- Apheresis: Eno nkola efaananako n’okulongoosa abalwadde b’ekibumba. Oyungiddwa ku kyuma mu ddwaaliro, omusaayi gwo ne guggyibwa mu mubiri gwo, kolesterol wa LDL ne gusengejebwa, omusaayi ogwayonjebwa ne guzzibwa mu mubiri gwo. Buno bujjanjabi butwala essaawa eziwera era nga bwetaaga okukolebwa buli kiseera.
- Okukyusa Ekibumba: Singa tewali n’emu ku bujjanjabi obwo waggulu ekola bulungi, okukyusa ekibumba kiyinza okuba eky’okusembayo. Ekibumba ekipya ekiramu kirina ebirungo bya LDL ebisobola okuyamba okufuga kolesterol. Kuno kulongoosa kwa maanyi nnyo, era okuwona kuyinza okutwala emyezi 6 okutuuka ku mwaka.
Bw’oba oyisibwa mu bujjanjabi obw’amaanyi bwe butyo, kikulu nnyo okunoonya obuyambi mu nneewulira okuva mu b’omu maka n’emikwano. Kino kyogere mu lwatu n’omusawo wo.
Obubaka Obutwala Awaka
- Homozygous Familial Hypercholesterolemia mbeera ya buzaale ya maanyi, naye nga tetera kubaawo, ereeta kolesterol okubeera omungi ennyo.
- Kino kiri bwe kityo kubanga basikira obuzaale bubiri obulema okuva ku nnyaabwe ne kitaabwe.
- Bw’ozuula n’okutandika obujjanjabi ku myaka emito, obulabe bw’okufuna endwadde z’omutima ku myaka emito busobola okukendeera.
- Obujjanjabi buba bwa bulamu bwonna era buyinza okuzingiramu eddagala, endya, dduyiro, era nga kiyinzika okuba nga n’obujjanjabi obw’enjawulo (apheresis).
- Singa omuntu mu maka go abadde n’obulwadde bw’omutima oba kolesterol omungi ng’akyali muto, kiba kya magezi okukeberebwa kolesterol ng’omusawo bw’akuwa amagezi.
- Si ggwe wekka mu lugendo luno. Kola n‟omusawo wo, ab‟omu maka go, n‟ebibiina ebiwagira okusobola okuddukanya obulungi embeera eno.
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