Teebereza nti ekitundu kimu kyokka eky’omubiri gwo, okugeza omukono, ekigere oba ekitundu ekimu eky’olususu, kikula mangu mu ngeri etaali ya bulijjo okusinga ebirala. Eno embeera etatera kulabika nnyo ng’abantu abamu bazaalibwa nayo. Mu ngeri y’obusawo, ekibinja kino eky’embeera tukiyita PIK3CA-Related Overgrowth Spectrum, oba PROS mu bufunze. Kino ddala kireeta obuzibu bungi eri omuntu akiraba, awamu n’omuntu akifuna. Leero, mu kiwandiiko kino, tugenda kwogera ku PROS eno ky’eri ne ku Vijoice, eddagala erisooka okukkirizibwa naddala eri embeera eno.
Know your body mass index (BMI) and weight classification
Ddala PROS kye ki?
Mu ngeri ennyangu, PROS mbeera ya buzaale. Ffenna tulina obuzaale mu mibiri gyaffe obufuga okukula, okwawukana, n’okufa kw’obutoffaali. PIK3CA y'emu ku buzaale obukulu bwe butyo. Lowooza ku gene eno nga switch efuga okukula kw'obutoffaali bwaffe.
Naye mu muntu alina PROS, waliwo ekikyamu, oba enkyukakyuka, mu ggiini ya PIK3CA. Kino kireetera switch okusibira mu kifo kya on. Olwo puloteyina eyogerwako n’etandika okukola amangu ennyo ate nga nnyo. N’ekyavaamu, ebitundu by’omubiri ebimu, okugeza, olususu, emisuwa , amagumba , n’obwongo, bitandika okukula nga tebifugibwa.
Ekikulu nti PROS tekosa buli kitundu kya mubiri. Kiyinza okwawukana okuva ku kitundu ky’omubiri ekimu okudda ku kirala, era okusinziira ku muntu. N’olwekyo, obubonero nabwo bwa njawulo nnyo.
N’okutuusa kati, tewaaliwo ddagala lyonna eriwonya PROS. Obujjanjabi bwali businga kukwata ku kuddukanya bubonero. Ng’ekyokulabirako, eddagala eriweweeza ku bulumi, okusiiyibwa n’okukonziba, n’okulongoosa okuggyawo ebimera ebitali bya bulijjo. Kyokka, waaliwo akabi k’okukula okwo okuddamu okukula oluvannyuma lw’okulongoosebwa.
Eddagala lya Vijoice (alpelisib) likola litya?
Wano eddagala lya Vijoice we liyingirira Vijoice lye ddagala erisooka okutunuulira ekivaako PROS, okukola ennyo okuva ku nkyukakyuka y’obuzaale.
Ekirungo ekikola mu kino ye alpelisib . Eddagala lino mu butuufu likozesebwa ku bika bya kookolo w'amabeere ebimu . Ensonga lwaki ekyo kiri bwe kityo eri ntiObutoffaali bwa kookolo bukula olw’okukola ennyo kw’ekkubo lya PIK3, nga bwe kiri mu PROS.
Kale Vijoice ky’akola kwe kuzibira ekkubo lya PIK3, erikola nga ‘switch’ ekwatiddwa mu mbeera ya ‘on’. Kino kikendeeza ku kukula kw’obutoffaali mu ngeri etaali ya bulijjo, kikendeeza ku bunene bw’ebitundu ebikula edda, era kifuga obubonero.
Eddagala lino ligasa ki?
Okunoonyereza okwakoleddwa ku ddagala lino (EPIK-P1 ne EPIK-P3) kulaga emigaso mingi eri abalwadde.
| Omugaso | Ennyinyonnyola ennyangu |
|---|---|
| Okukula okutono (ebiwundu) . | Kizuuliddwa nti abantu bangi abaamira eddagala lino babadde n’ebizimba byabwe eby’amasavu ebyakula mu ngeri etaali ya bulijjo (lipomas) n’obuzibu bw’emisuwa nga bikendedde mu bunene ebitundu 20% oba okusingawo. |
| Okukendeera kw’obwetaavu bw’okulongoosebwa | Abaana nga 70% n’abantu abakulu 90% abamira Vijoice tebeetaaga kulongoosebwa. |
| Okukendeeza ku bubonero | Abalwadde bategeezezza nti obubonero ng’obulumi, okusiiwa, n’obukoowu bukendedde nnyo. |
| Okufuula emirimu egya bulijjo egyangu | Abalwadde nga 81% abeetabye mu kunoonyereza kuno baategeezezza nti obusobozi bwabwe okukola emirimu gya buli lunaku n’omutindo gw’obulamu bwalongooka bw’ogeraageranya n’abaali tebannaba kufuna ddagala. |
Ekikulu: Ebivaamu bino biyinza obutaba bye bimu eri buli muntu. Yogerako n’omusawo wo oba eddagala lino likusaanira era n’emigaso n’obulabe bwe biri.Kirungi okwogera nabo n’osalawo.
Biki ebisinga okuvaamu ebizibu n’engeri y’okubiddukanyaamu?
Okufaananako n’eddagala lyonna, Vijoice asobola okuleeta ebizibu . Wabula bino ebisinga biba bitono oba bya kigero era bisobola okuddukanyizibwa.
| Side effect | Engeri y’okuddukanyaamu n’ebyo by’olina okussaayo omwoyo |
|---|---|
| Embiro | Nywa amazzi mangi ng’amazzi n’omubisi. Bw’ofuna obubonero ng’ekiddukano eky’amaanyi, okuzimba olubuto, oba omusaayi oba omusulo mu musulo gwo, tegeeza omusawo wo mu bwangu . |
| Okubulwa amazzi mu mubiri | Ekiddukano kiyinza okuvaako okuggwaamu amazzi mu mubiri. Weegendereze obubonero ng’okuziyira ennyo, okukoowa, n’okukendeeza ku musulo. Bino bisobola okukosa ensigo zo, n’olwekyo tegeeza omusawo amangu ago. |
| Amabwa mu kamwa (Stomatitis) . | Amabwa mu kamwa n’obulumi biyinza okubaawo. Weewale eby’okunaaba mu kamwa ebirimu omwenge. Okunaaba akamwa n’amazzi ag’omunnyo agabuguma. Weewale emmere erimu ebirungo era erimu asidi. |
| Ssukaali okweyongera mu musaayi (Hyperglycemia) . | Omusawo ajja kukebera ssukaali mu musaayi gwo nga tonnatandika kumira ddagala lino ne mu kiseera ky’okujjanjabibwa. Buulira omusawo wo bw’oba olina obubonero ng’ennyonta esukkiridde, okufulumya omusulo ennyo oba okukoowa. Abantu abalina obulwadde bwa sukaali balina okwegendereza naddala ku nsonga eno. |
| Okugonza enviiri (Alopecia) . | Enviiri ziyinza okugwa oba okugonza nga zijjanjabwa. Kozesa shampoo ezitali za maanyi. Yogerako n’omusawo wo ku nsonga eno. |
Wayinza okubaawo obuzibu ku ddagala eddala?
Yee. Vijoice asobola okukwatagana n’eddagala eddala erimu. Mu ngeri ennyangu, eddagala erimu liyinza okukendeeza ku bulungibwansi bwa Vijoice. Vijoice era esobola okukyusa obulungi bw’eddagala eddala erimu.
Okugeza eddagala nga carbamazepine eriwonya obulwadde bw’okusannyalala, rifampin eriwonya akafuba, n’ebiva mu muddo nga St. John’s wort bisobola okukosa kino.
N’olwekyo, nga tonnatandika ddagala lino, kyetaagisa okutegeeza omusawo wo ku ddagala lyonna ly’omira mu kiseera kino (omuli vitamiini, ebiva mu bimera, n’eddagala eriweweeza ku bulumi) asobole okukola enkyukakyuka yonna eyeetaagisa.
Obubaka Obutwala Awaka
- PROS mbeera etali ya bulijjo ng’ebitundu by’omubiri bikula mu ngeri etaali ya bulijjo olw’enkyukakyuka mu buzaale obuyitibwa PIK3CA.
- Vijoice (alpelisib) lye ddagala erisooka okukkirizibwa okutunuulira enkola enkulu ereeta obulwadde buno.
- Kino kiyinza okuyamba okukendeeza ku kukula okutali kwa bulijjo, okukendeeza ku bwetaavu bw’okulongoosebwa, n’okutumbula omutindo gw’obulamu.
- Ebizibu ebivaamu ng’ekiddukano, ssukaali okweyongera mu musaayi, n’amabwa mu kamwa biyinza okubaawo, era kikulu nnyo okubiddukanya n’okutegeeza omusawo.
- Kikulu nnyo okutegeeza omusawo wo ku ddagala eddala lyonna ly’omira. Totandika oba kulekera awo kumira ddagala lyonna nga tolina magezi ga musawo.
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