Eddagala erimu lireeta obulwadde bw’okubulwa amagezi? (Ka tuyige ku ddagala eriweweeza ku bulwadde bwa Anticholinergic Drugs).

Ffenna tulina okutya awalala mu mitima gyaffe nti bazadde baffe, oba ffe kennyini, tujja kutandika okwerabira ebintu nga bwe tunagenda tukaddiwa. Ekirowoozo ky’okufiirwa okujjukira kwaffe n’obusobozi bw’okulowooza obulungi ddala kitiisa. Wadde ng’okukaddiwa kye kisinga okuvaako okubulwa okujjukira kuno oba obulwadde bw’okubulwa amagezi, kati waliwo okwogera ku nsonga endala ey’akabi. Kwe kugamba, ezimu ku ddagala lye tukozesa ku ndwadde ez’enjawulo.

Eddagala lino eriziyiza cholinergic lye liruwa?

Mu ngeri ennyangu, eddagala eriweweeza ku cholinergics kiraasi ya ddagala. Zikolebwa mu kimera ekiyitibwa Belladonna. Ekimera kino mu butuufu kiyinza okuba eky’obutwa mu ddoozi ezimu. Kyokka, ebirungo ebiri mu kimera kino bisobola okufuga oba okuziyiza emirimu gy’obusimu bwaffe okutuuka ku ddaala eritali limu, n’olwekyo bikozesebwa okukola eddagala erifugibwa.

Teebereza, enkola yaffe ey’obusimu eringa omukutu gw’obusimu obusaasaanidde mu mubiri gwonna. Obwongo bwaffe bwe businga okubeera wakati. Ebiragiro ebiweebwa okuva awo bigenda mu mubiri gwonna nga biyita mu butoffaali buno obw’obusimu. Buli kimu okuva ku kutambula kwaffe, okulowooza, okukuba kw’omutima, okussa, okwebaka, n’enkola y’obusimu bwaffe obutaano bifugibwa enkola eno ey’obusimu.

Waliwo ababaka b’eddagala abatambuza obubaka nga bayita mu nkola eno ey’obusimu. Tuziyita obusimu obutambuza obusimu (neurotransmitters). Acetylcholine y’omu ku babaka ng’abo abakulu ennyo. Kale, eddagala eriweweeza ku cholinergic kye likola kwe kuziyiza omubaka ono ayitibwa acetylcholine. Okuyita mu ekyo, ebimu ku bikolwa by’obusimu bifugibwa.

Eddagala lino lingi likozesebwa okujjanjaba embeera z’obujjanjabi.

Eddagala erimu eritera okukozesebwa

Eddagala lino lijja mu ngeri y’empeke, amatondo g’amaaso n’empiso. Ebimu ku byokulabirako bye bino:

• Diphenhydramine: Kino kika kya ddagala erikozesebwa okujjanjaba alergy. Eddagala lya Sri Lanka erya Piriton lirimu ekirungo ekifaananako bwe kityo ekiyitibwa chlorpheniramine. Zino nazo zigwa mu kiraasi y’emu ey’eddagala eriziyiza cholinergics.
• Benztropine: Akozesebwa ku bubonero bwa Parkinson.
• Dicycloverine: Akozesebwa ku bulumi mu lubuto naddala mu mbeera nga Irritable Bowel Syndrome (IBS).
• Oxybutynin: Eddagala eriweebwa abantu abalina obuzibu okufuga omusulo.
• Hyoscyamine: Akozesebwa ku bulumi bw’ebinywa by’olubuto n’ekibumba.

Mu ngeri ennyangu, obulwadde bw’okubulwa amagezi kye ki?

Obulwadde bw’okubulwa amagezi kigambo kya bulijjo ekikozesebwa ku mbeera ezitali zimu ezikosa obusobozi bw’omuntu okulowooza, okujjukira oba okusalawo. Businga kubeera mu bakadde.

Embeera eno eyinza okukosa omuntu:

• Obusobozi bw’okussa essira
• Okwogera n'abalala (empuliziganya) .
• Obusobozi bw’okulonda ekituufu okuva mu kikyamu (discretionary intelligence) .
• Okujjukira
• Obusobozi okulowooza mu ngeri entegeerekeka n’okugonjoola ebizibu

Oluusi, ebika by’obulwadde bw’okusannyalala nga Alzheimer’s bisobola n’okuleeta enkyukakyuka mu muntu n’enneeyisa ye.

Ani ali mu bulabe obw’amaanyi obw’okulwala obulwadde bw’okusannyalala?

• Emyaka: Okukaddiwa kye kisinga okuleeta akabi.
• Obulwadde bw’omutima: Abantu abalina ebyafaayo bya puleesa, kolesterol omungi, n’okusannyalala bali mu bulabe bwa maanyi obw’okulwala obulwadde bw’okubulwa amagezi.
• Ensengekera y’obuzaale: Singa omuntu ow’oku lusegere mu maka abadde n’obulwadde bwa Alzheimer, obulabe bwo obw’okubufuna buyinza okweyongera ebitundu nga 10% - 30%.
• Obuvune ku bwongo obuva ku buvune: Obuvune obw’amaanyi oba obutasalako ku mutwe nabwo busobola okwongera ku bulabe.

Naye oluusi okubulwa okujjukira kuno kuyinza okuba okw’akaseera obuseera. Eddagala erimu, obutaba na vitamiini, n’obusimu bwa thyroid obutakwatagana nabyo bisobola okuvaako okubulwa okujjukira okumala akaseera.

Kale ddala eddagala lino lireeta obulwadde bw’okubulwa amagezi?

Abanoonyereza baakola okunoonyereza okunene okuzuula. Kuno kwali kunoonyereza kwa myaka kkumi. Abantu nga 3,500 abasukka mu myaka 65 be beetaba mu kino. Tewali n’omu ku bantu bano yalina bulwadde bw’okubulwa amagezi ng’okunoonyereza kuno kutandika.

Abanoonyereza bano baakuuma ebiwandiiko by’eddagala lyonna abeetabye mu kugezesebwa kuno lye baamira, eryo eryawandiikibwa omusawo n’eryo erisangibwa ku ddagala eritali lya ddagala, gamba nga piridine. Baagezesa okujjukira n’okulowooza kw’abeetabye mu kugezesebwa buli luvannyuma lwa myaka ebiri.

Okunoonyereza kuno we kwaggweera, abantu 797 ku beetabye mu kunoonyereza kuno baali bafunye obulwadde bw’okubulwa amagezi. Ku abo, 637 baalina obulwadde bwa Alzheimer.

Abanoonyereza bwe baali beekenneenyezza ebikwata ku bantu bano, baakola ekintu ekyewuunyisa. Bazudde akakwate akakulu wakati w'abantu abakozesa eddagala eriweweeza ku cholinergic n'abo abafuna obulwadde bw'okubulwa amagezi . Era baazudde nti omuntu gy’akoma okukozesa eddagala lino okumala ebbanga, emikisa gy’okulwala obulwadde bw’okubulwa amagezi gye gikoma okuba egy’amaanyi .

Lwaki kino kigenda mu maaso?

Emu ku ndowooza enkulu eri nti erina akakwate n’ekirungo ekiyitibwa neurotransmitter acetylcholine, mu butonde ekitono mu bwongo bw’abantu abalina obulwadde bwa Alzheimer. Mu butuufu, eddagala erimu erikozesebwa okujjanjaba obulwadde bwa Alzheimer likola nga lyongera ku bungi bwa acetylcholine mu bwongo.

Kale, eddagala eriweweeza ku cholinergic liziyiza omubaka wa acetylcholine, kale abanoonyereza balowooza nti eyo eyinza okuba ensonga. Naye okunoonyereza okusingawo kwetaagibwa ku nsonga eno.