Manya ku bujjanjabi bwa Herceptin (Trastuzumab) ku kookolo w’amabeere alina HER2

Ggwe oba omuntu mu maka go bw’azuulibwa nti alina kookolo w’amabeere, kizibu okuteeka mu bigambo okutya n’okweraliikirira kw’owulira. Kiseera kya nneewulira nnyo. Naye, ekisinga obukulu kiri nti nga tulina ssaayansi w’obusawo ow’omulembe gwe tulina kati, tusobola okuba n’essuubi. Omusawo ajja kulowooza ku bintu bingi, gamba ng’ekika kya kookolo ky’olina, emyaka gyo, n’okumanya oba olina endwadde endala, alonde obujjanjabi obusinga obulungi gy’oli. Kookolo w’amabeere atera okujjanjabibwa nga bamulongoosa, eddagala eriweweeza ku bulwadde n’okukozesa amasannyalaze.

Leero twogera ku bujjanjabi obw'enjawulo katono, obw'enjawulo. Kino kiyitibwa " obujjanjabi obugendereddwamu ." Herceptin lye limu ku ddagala eryo. Erinnya lyayo ery'obusawo ye Trastuzumab . Oyinza okuba nga wali owulidde nga bagiyita amannya amalala nga Kanjinti, Herzuma, Ogivri. Zino ziyitibwa ``biosimilars.'' Mu ngeri ennyangu, zino kkopi za biramu ez'eddagala lye limu ne Herceptin.

Obujjanjabi obugendereddwamu ne Herceptin kye ki?

Lowooza ku kino, eddagala erijjanjaba eddagala erya bulijjo terikosa butoffaali bwa kookolo bwokka, wabula n’obutoffaali obulamu obweyawukana amangu. Naye obujjanjabi obugendereddwamu si bwe butyo. Zikola nga zitunuulira ebigendererwa ebitongole. Eddagala lino lifuga obutoffaali obw’enjawulo obuyamba obutoffaali bwa kookolo okukula n’okusaasaana. Y’ensonga lwaki tezikola ku kookolo yenna. Puloteeni eddagala lye litunuulira erina okuba mu bungi mu butoffaali obwo obwa kookolo.

Eddagala lya Herceptin litunuulira puloteyina eyitibwa HER2 . (Erinnya lya kino mu bujjuvu ye `human epidermal growth factor receptor 2`). Kale, singa puloteyina eno eya HER2 ekolebwa mu kisusse mu butoffaali bwa kookolo, ekika ekyo ekya kookolo w’amabeere tukiyita `HER2-positive` kookolo w’amabeere. Obujjanjabi bwa Herceptin buweebwa abo bokka aba `HER2-positive` ekika kya kookolo w'amabeere.

Eddagala lino erya Herceptin likola litya munda mu mubiri?

Okutegeera kino, ka tusooke tulabe HER2 kye ki. HER2 ye receptor ku ngulu w’obutoffaali. Kilowoozeeko nga antenna entono ku ngulu w’akatoffaali. Antenna zino ze zifuna obubonero okuva ebweru w’akasenge ne zikola ku zo. Mu katoffaali akalamu, ebikwata HER2 bibaawo okufuga okukula kw’obutoffaali.

Naye ekintu eky'enjawulo kibaawo mu butoffaali bwa kookolo `HER2-positive`. Obutoffaali buno bulina kkopi ez’enjawulo ez’obuzaale obukola puloteyina ya HER2. Kale, obutoffaali buno bukola ekisusse ku puloteyina ya HER2. Kiringa antenna nnyingi nnyo ku cell. Olwo, obutoffaali bwa kookolo bufuna obubonero bungi nnyo "okukula, okugabanya," era ne bukula nga tebufugibwa, mangu nnyo.

Obujjanjabi bwa Herceptin busaanira kookolo wange?

Kino kibuuzo kikulu nnyo. Singa kookolo w’amabeere go aba `HER2-negative`, ekitegeeza nti obutoffaali bwa kookolo tebulina puloteyina ya HER2 ey’enjawulo, olwo obujjanjabi bwa Herceptin tebujja kukola. Kookolo w'amabeere asinga `HER2-negative`. Ebitundu nga 20% balina HER2-positive. Omusawo ajja kukubuulira ddala ekika kya kookolo ky’olina ng’ayita mu kukeberebwa.

Obujjanjabi bwa Herceptin bukozesebwa mu mitendera egyasooka egya kookolo w’amabeere, wamu ne mu mitendera egy’oku ntikko kookolo gy’asaasaana (metastatic).

• Ku kookolo asooka: Singa kookolo wo aba HER2-positive ate nga mu ntandikwa, Herceptin aweebwa okutangira kookolo okuddamu oluvannyuma lw’okulongoosebwa. Kino kitera okuweebwa n’obujjanjabi bw’eddagala oba obujjanjabi bw’endwadde z’omu lubuto. Obujjanjabi buno businga kuweebwa singa kookolo aba munene oba nga asaasaanidde mu nnywanto.

• Ku kookolo agenda mu maaso: Singa kookolo aba asaasaanidde mu bitundu by’omubiri eby’ewala (metastatic), Herceptin asobola okuyamba okuyimiriza oba okukendeeza ku kukula kwe . Oluusi, singa ekizimba kiba kinene nnyo nga tekisobola kuggyibwawo nga balongoosebwa, Herceptin n’obujjanjabi obulala bisobola okukikendeeza nga tebannalongoosebwa.

Kiki ky’osaanidde okusuubira ng’ofuna obujjanjabi?

Herceptin aweebwa nga infusion (intravenous - IV) mu musuwa. Kiweebwa nga eddagala eririmu omunnyo. Kino kikolebwa kubanga eddagala lyetaaga okufuyira butereevu mu musaayi. Kiyinza okutwala wakati w’eddakiika 30 ne 90 okumaliriza.

Waliwo n’engeri ya kino eweebwa ng’empiso. Kiyitibwa `Herceptin Hylecta`. Okunoonyereza kulaga nti kino kikola bulungi nga IV. Omusawo wo y’ajja okusalawo enkola ki esinga okukukwatako.

Ebbanga n’emirundi gy’olina okumira Herceptin kisinziira ku mutendera gwa kookolo wo n’eddagala eddala ly’omira. Singa kookolo agenda mu maaso (metastatic), oyinza okwetaaga okugenda mu maaso n’obujjanjabi kasita eddagala likola era nga tewali buzibu bwa maanyi.

Kikulu nnyo: Omusawo ajja kukebera omulimu gw’omutima gwo buli kiseera nga tonnafuna bujjanjabi bwa Herceptin n’okugujjanjaba, kubanga eddagala lino oluusi liyinza okukosa omutima.

Ng’oggyeeko kino, ebizibu ebirala biyinza okubaawo. N’olwekyo, nga tonnatandika bujjanjabi, olina okuyiga n’obwegendereza obubonero bw’olina okwegendereza ne ddi lw’olina okutegeeza omusawo mu bwangu. Obujjanjabi bwa Herceptin tebuweebwa bakyala abali embuto oba abagezaako okufuna embuto.

Obujjanjabi buno buba buwanguzi butya?

Herceptin ddagala eryakyusa enkyukakyuka mu kujjanjaba kookolo w’amabeere alina HER2 oluvannyuma lw’okukkirizibwa mu 1998.

• Ku kookolo agenda mu maaso: Herceptin bw’aweebwa yekka oba ng’aweebwa eddagala eriweweeza ku bulwadde bwa kookolo, asobola okukendeeza ku kookolo okukula n’okuyamba abalwadde okuwangaala. Kyokka oluusi eddagala lino liyinza okukola okumala akaseera ate ne lilekera awo okukola.

• Ku kookolo atandise: Wano we walabibwa obuwanguzi obusinga obunene. Okunoonyereza kulaga nti okugattako Herceptin mu ddagala oluvannyuma lw’okulongoosebwa kiyinza okukendeeza ku bulabe bwa kookolo okuddamu ebitundu nga 50% . Kino kitegeeza nti abakyala bangi abamira Herceptin bawangaala nga tebalina kookolo.

Wadde ng’obujjanjabi busooka kuweebwa mwaka gumu oba ebiri, okunoonyereza okwakakolebwa kulaga nti eri abantu bangi, okumira Herceptin okumala emyezi mitono nga 6 kimala. Gano mawulire malungi eri abo abeeraliikirira ebizibu ebiyinza okuvaamu.