Lung natna atana Amvuttra damdawi ATTR-CM an tih hi kan sawi dawn em ni? (ATTR-CM leh Amvuttra) te chuan an sawi.

Kan taksaa protein chi khat dik lo taka a khawlkhawm a, thinlung leh nerve ang chi taksa peng pawimawh tak takah a awm chuan natna lo awm thin hi i hre lo mai thei. Hengte hi natna hmuh tur awm lo tak tak an ni fo thin. Damdawi lamah chuan he protein deposition chi hi amyloidosis an ti a. Vawiin hian natna hmuh tur awm lo tak, ATTR-CM an tih, a bik takin thinlung a nghawng thin, chu chu heng protein te hi thinlung ruh (heart muscle)-ah a awm a, chu chu tunlai damdawi Amvuttra an tih te kan sawi dawn a ni.

ATTR-CM hi eng nge ni tak tak?

A awlsam zawngin sawi ila, ATTR-CM hi, genetic defect emaw, tar chhoh zel avanga pianphung atanga lo awm emaw, kan taksaa lo piang protein TTR chu a pianzia a inthlak a, a inzawm khawm a, heart muscle wall-ah a insiam lut thin a ni. Hei hi a hming kimchang chu Transthyretin Amyloid Cardiomyopathy a ni.

Ngaihtuah teh, kan thinlung bangte hi pump tha tur chuan a flexible a ngai a ni. Mahse, heng protein-te hi an lo pun chhoh chuan thinlung bangte chu a thim a, a nghet lo . Hei hi cardiomyopathy kan ti a. Hei hian thinlung hian thisen a pump tha thei lo a ni. Hun a kal zel a, hei hi heart failure thlengin a kal thei a ni.

ATTR-CM vei thenkhat chuan symptoms engmah an nei lo a, thenkhat erawh chuan heart attack pangngai ang chi symptoms an nei thung.

• Thâwk hahna tlem (dyspnea) .
• A hring, a bik takin ke leh ke ruh ah a hring
• Buaina emaw, beidawnna emaw
• Heart rate sang emaw heartbeat mumal lo emaw
• A rilru a na

Hei hian stairs chhoh te, inchhung hna thawh te, a nih loh leh hla vak lo kal te ang chi thil i tih hian i chau thuai thei a ni.

Tin, thinlung nena inzawm lo symptom dang pawh a awm thei bawk. Entirnan, chak lohna, kut leh kea natna emaw, na emaw , thawk hah lutuk , luak chhuak emaw, muthilh emaw, leh chaw ei lama harsatna te.

Amvuttra damdawi hian engtin nge hna a thawh?

Hei hi hrethiam tur chuan protein pakhat TTR tih hi tlem kan hriat hmasak a ngai a ni. TTR (Transthyretin) hi kan thin (liver) atanga siam chhuah a ni ber a. A hnathawh ber chu thyroid hormone leh vitamin A taksa pum puia phurh luh a ni.

ATTR-CM vei teah chuan genetic defect a awm avangin TTR protein chu a pianzia dik lo takin a siam chhuak thin. He protein pianzia dik lo hi a pungkhawm a, thinlungah a dah khawm a ni.

Damdawi Amvuttra hian gene silencer angin hna a thawk a . Chu chu, he damdawi hian liver-ah a kal nghal a, chu TTR protein dik lo chu a block tihna a ni.Gene siam mek hnathawh a ti tlem a ni. Radio-a volume tihhniam ang mai a ni.

Amvuttra hi vun hnuaia injection a ni. He vaccine hi thla thum danah healthcare professional in a pe thin a ni .

He damdawi hlawhtlinna hi engtin nge an test?

Damdawi thar dang ang bawkin AMVUTTRA hian a thatzia hi zirchianna lian tak hmangin an finfiah tawh a ni. He zirchiannaah hian ATTR-CM vei mi 655 te chu Amvuttra vaccine pek an ni a, group dang chu kum thum chhung thla 12 danah damdawi awm lo placebo vaccine pek an ni bawk.

Researcher-te chuan he damdawi hi a hlawk em tih tehna atan thil engemaw zat an enfiah a.

• Minute ruk chhunga kal test: Hei hian minute 6 chhunga chakna pangngaia i kal theih dan tur a teh a ni. He hlat zawng hi i thinlung dinhmun a chhe zual zel chuan a tlahniam thin.
• New York Heart Association (NYHA) classification: Hei hian heart failure symptoms nasat dan a teh a ni. Class pali (I, II, III, IV) a awm a. Class number a san poh leh natna a na zual thin.

• Quality of Life Questionnaire (KCCQ-OS): Hei hian natnain damlo nunphung a nghawng dan tehna a ni.

Research chuan eng nge a hmuh?

Kum thum chhunga enkawlna hun tawp lamah chuan zirchiangtute chuan an result chu an zirchiang a.

A thil hmuhchhuah ber chu Amvuttra dawngtu damlote chu heart failure vangin thihna emaw, damdawi ina dah nghal emaw, emergency room (ETU) tlawh emaw an ni a, placebo (dummy vaccine) dawngte nen khaikhin chuan 28% in an tlahniam zawk a ni .

Thil pawimawh dang chu thla 42 tawp lamah chuan Amvuttra dawngtu group-ah hian eng thil vang pawha thihna hlauhawmna chu 35%-in a tlahniam a ni.

Tin, Amvuttra dawngtu damlote chuan kea kal theihna leh nunphungah pawh controlled decline an nei bawk.

Mahse, heng zirchianna result te hi mi zawng zawng tan a inang lo mai thei tih hre reng ang che. Nang leh i doctor hian Amvuttra hi i tan a tha em tih leh a hlawknain a nghawng tha lo aiin a tam zawk em tih chu in rel dun a ngai dawn a ni.

A rah chhuah leh a side effect te i zir chiang ang u.

Results hmuh tur hian eng chen nge hun a duh?

Amvuttra hi damdawi a ni a, hun kal zelah hna a thawk thin. Chuvang chuan a rah chhuah chu hmuh nghal theih a ni lo. Thla engemaw zat emaw a aia rei emaw a ngai thei a, symptoms-ah hmasawnna eng emaw zat a awm thei.

Side effects te hi engtin nge kan enkawl ang?

Amvuttra side effect lian ber pakhat chu thisen a vitamin A level tlahniam hi a ni. Hei hi a chhan chu TTR protein hi taksa pum puia vitamin A phurtu a nih vang a ni. Damdawi hian TTR siamchhuah a tihtlem chuan vitamin A transport pawh a tlahniam bawk.

• I doctor chuan i vitamin A level enfiah turin thisen test a ti fo ang. Heng test te hi a hun taka tih a pawimawh hle.
• Vitamin A tamna ei tur (e.g. carrot, sweet potato, spinach, egg, milk, red bell peppers ) te chu i eitur ah te dah la.
• I mit hmuh danah inthlak danglamna (a bik takin zan lama mit hmuhna tlahniam) i hmuh chuan doctor hnenah hriattir nghal rawh.
• I vitamin A level a zirin i doctor chuan vitamin A supplement ei turin a rawt thei ang.

Hengte chauh hi Amvuttra hian a side effects a nei lo. I rilru tibuaitu symptom dang i neih chuan i doctor nen inbiakna neihpui ngei ang che .