I fa hian khawsik a nei fo em? SAIDs (Systemic Autoinflammatory Diseases) vang a ni thei ang em?

Aw, tunlai hian i naupang te hian khawsik a nei fo em? I dam leh tawh nia i ngaih lai tak chuan a rawn lang leh ta em ni? A chang chuan hei hi a chhan chu virus emaw bacteria tlanglawn tak a ni lo thei bawk. Vawiin hian condition pakhat kan sawi dawn a, a buaithlak deuh a, mahse hriat a pawimawh hle. Hei hi SAIDs an ti a, chu chu Systemic Autoinflammatory Diseases tihna a ni. Tun hma chuan hei hi (Periodic Fever Syndromes) emaw (Recurrent Fever Syndromes) emaw an ti thin.

SAID tih hi eng nge ni? A awlsam zawngin i hrethiam ang u.

A awlsam zawngin, SAIDs hi kan taksa pianpui immune system-a malfunction emaw regulatory problem emaw avanga lo awm natna chi khat a ni . Hei vang hian naupang chu natna hrik (virus emaw bacteria emaw ang chi) nei lo pawhin khawsik a nei fo thei a ni.

A pawimawh ber chu heng SAIDs an tih te hi (Autoimmune Diseases) (entir nan (Rheumatoid Arthritis) emaw (Lupus) emaw i hriat tawh mai thei. (Autoimmune) natnaah chuan kan taksa (adaptive immune system)-a tihsual engemaw zat a awm avangin, chu system chuan a cell hrisel tak takte chu a bei thin. Mahse SAID-ah chuan thil danglam tak a thleng thin.

SAID hi autoimmune natna aiin a tlem zawk hle. Anni hi rochun atanga lo piang an ni fo a , genetic mutation avanga lo awm an ni .

A tlangpuiin, mahse a ni lo, SAID symptoms hi naupang a naupan lai atanga intan a ni a, naute emaw, naupang tê emaw a nih lai pawhin . I fa hian he natna nen hian "periods" a nei thei a, khawsik leh symptom dang a nei thei bawk. Heng hun inkar chhung hian i fa hian symptom a nei lo thei. SAIDs hi damdawi awm lo mah se , i fate natna lan chhuah dan thunun thei tur enkawlna a awm fo thin.

SAID chi hrang hrangte chu engte nge ni?

Researcher-te chuan SAID chi hrang hrang 60 vel an hmuchhuak tawh a, a thar pawh hmuhchhuah a la ni reng a ni. SAID chi hrang hrang hman tlanglawn tak tak thenkhat chu hetiang hi a ni:

• Familial Mediterranean fever (FMF): Hei hi genetically inherited, recurrent fever syndromes zingah chuan a tam ber a ni. Naupangte pum, rilru leh ruh na tak tak a thlen thei a ni.
• Periodic fever, aphthous-stomatitis, pharyngitis, adenitis (PFAPA): Hei hi naupang kum 4 an tlin hmain a intan tlangpui a, a chang chuan kum 10 an tlin hnuah pawh a takin a dam thei a ni.
• Tumor necrosis factor receptor-associated periodic syndrome (TRAPS): Hei hi naupan lai te, tleirawl lai te, puitling lai pawhin a thleng thei.
• Mevalonate kinase deficiency (MKD): Tun hma chuan Hyper-IgD syndrome'' tia sawi thin a ni a, hei hi naupang kum khat a tlin hmain a intan tlangpui.
• NLRP3 nena inzawm autoinflammatory natna: 1.1.Hei hi a hmain (Cryopyrin-associated periodic syndromes - CAPS) an ti thin. Hemi chhungah hian subtype dang pathum a awm bawk.
• Puitling atanga lo chhuak Still’s disease (AOSD): A hming ang bawkin hei hi puitling atanga lo chhuak naupangte natna Systemic Juvenile Idiopathic Arthritis (JIA) a ni.
• NOD-2-associated granulomatous disease (Blau syndrome): Hei hi kum 4 an tlin hmain a intan tlangpui a, naupang vun, mit leh ruhkawr a nghawng ber a ni.

✨ Hearing health Verified Partner

Medical grade state-of-the-art hearing aids

Advanced hearing aids designed for clear hearing and noise control in the ear.

Check Availability →

SAIDs natna lan chhuah dan chu engte nge ni?

SAIDs symptoms hi naupan lai atanga tan a ni tlangpui. A lan chhuah dan ber leh langsar ber chu periodic fever a ni . Khawsik lai hian mi an hrisel thei tlangpui a, natna lanchhuahna an nei lo. Mahse, SAID chi hrang hranga chiang taka awm symptom dang a awm thei bawk. Eng nge an nih i en ang u:

• FMF: Hei hian naupang pum, a rilru leh ruhte a ti na thei a, a na hle bawk . Ke hnuai lam emaw, ke ruh emaw-ah pawh vun a awm thei bawk.
• PFAPA: Hei hian rilru na, hmui na, leh kawr chhunga lymph node hring te a thlen thei . Entirnan, i fain tonsillitis leh hmui ulcer a neih fo ang chi symptoms a neih chuan PFAPA a ni thei.
• TRAPS: Hei hian trunk/torso leh arms ah chills leh muscle na a thlen thei . Tin, kut leh ke atanga intan, taksa chhunga darh chhuak, vun sen na tak a siam thei bawk.
• MKD: Hei hian natna lan chhuahna a thlen thei a, chu chu khawsik, lu na, pum na, ei duh lohna, leh flu ang chi natna a thlen thei a ni .
• NLRP3 natna: He natna hian vun natna, lu na, malaise, ruh natna, leh mit/conjunctivitis pink a thlen thei a ni.
• AOSD: Hei hi vun natna, ruh natna, leh ruh natna te a ni . Mi thenkhat chuan rilru na, pum na, hahna, leh malaise te pawh an nei thei bawk.
• Blau syndrome: Hei hian i naute kut, ke, emaw, midsection emaw-ah vun natna a thlen thei . Tin , ruh natna leh mit natna a thlen thei bawk .

SAIDs awm chhante chu engte nge ni?

SAID tam tak hi genetic diseases an ni . Chu chu, gene bik pakhata mutation (variant) bik chuan syndrome tin a thlen tihna a ni. Kan taksa hian hna tin tih dan tur min hrilhtu instruction (gene) set khat a nei tih han ngaihtuah teh, chu lehkhabuah chuan letter pakhat a dik lo a nih chuan hna dang zawng zawng chu a kal sual thei a ni.

SAID chi hrang hrang leh a kaihhnawih genes te chu hetiang hi a ni:

• FMF: 1.1.Gene MEFV hi protein (pyrin) siam dan tur hrilhfiahna petu a ni.
• PFAPA: Hei hi a chhan dik tak hi hriat chian a la ni lo .
• TRAPS: Gene TNFRSF1A tih hi a ni. Hei hian (tumor necrosis factor receptor - TNFR) tih protein siam turin a hriattir a ni.
• MDK: Gene chu MVK tih a ni. Hei hian (mevalonic kinase) tih protein siam turin a hrilh a ni.
• NLRP3 natna: Gene NLRP3. Hei hian (cryopyrin) tih protein siam turin a hrilh a ni.
• AOSD: Hei hi a chhan dik tak hi hmuhchhuah a la ni lo .
• Blau syndrome: Gene NOD2 tih hi a ni. Hei hian (NOD2) tih protein siam chhuah dan tur a hrilh a ni.

Hengte hi genetic factors avanga lo awm a nih chuan nu leh pa sualna a ni lo tih hriat a pawimawh. Hengte hi biological process complex tak tak an ni.

SAIDs avanga harsatna awm thei

Heng natnate hi enkawl dan dik tak neih a pawimawh hle . A chhan chu, taksaah inflammation a awm chhunzawm zel chuan (Amyloidosis) tih natna a thlen thei a ni. (Amyloidosis) hi kal chhunga protein awm khawm a ni . Hei hian kal (kidney) a tichhe vek thei a ni . Chuvangin natna lanchhuahna a awm chuan damdawi lam pan vat a pawimawh.

SAID te hi engtin nge an hriat chhuah?

Dik tak chuan SAIDs hmuhchhuah hi a harsa deuh thei a , a chhan chu a natna lan chhuah dan hi natna khirh dang, lupus emaw lymphoma emaw ang chi te nen a inang thei a ni. Chuvangin, i fate dinhmun dik tak hriatchhuah leh enkawl dan tur , inflammatory diseases chungchanga special training nei doctor (Rheumatologist) pan a pawimawh hle .

I fate rheumatologist chuan SAIDs hi a hriat theih nan thil engemaw zat a hmang ang. I fate natna lan chhuah dan leh i chhungkuaa tu emaw chuan heng natna hi an nei tawh em tih a zawt ang (biological family history). Doctor chuan i fa hian Periodic Fever Syndrome a nei tih a ringhlel thei a, chu chu:

• Khawsik i neih fo chuan
• Chhungkaw zingah hetiang hian periodic fevers nei tawh an awm a nih chuan
• Chutiang khawsik vei duh pawl zinga mi i nih chuan

Eng test nge hman thin?

Doctor chuan a natna hriat chian nan test eng emaw zat neih a rawt thei a ni. Chûng zîngah chuan:

• Lab test: (C-reactive protein - CRP) leh (Complete Blood Count - CBC) ang chi test te hian taksaah inflammation a awm leh awm loh enfiah theih a ni. Heng test te hi khawsik a awm chuan (positive) an ni a, khawsik a reh chuan a normal value-ah an kir leh thin.
• Zun test: 1.1.Urine protein test hmangin zun chhungah protein a tam em tih enfiah theih a ni. MKD-ah chuan zun test-naah organic acids a awm leh awm loh enfiah chuan mevalonic acid level a sang hle ang.
• Genetic testing: Hei hian genetic variant a awm leh awm loh a enfiah thei. Mahse, SAID vei naupang thenkhat chuan genetic variant hmuhchhuah hi an nei lo mai thei. Chuvangin test result chu negative ni mahse SAID a awm theihna tur chu a awm thei lo.

SAIDs hi engtin nge enkawl an nih?

SAIDs enkawl dan hi natna chi leh nasat dan azirin a inang lo . Heng natnate hi tihdam kim theih ni lo mah se, naupang natna lan chhuah dan chu damdawi hman hmangin a thunun tha thei a ni . Entirnan, i fain kum khatah vawi engemaw zat chauh heng khawsik hi a vei a nih chuan, natna tidamtu leh nonsteroidal anti-inflammatory drugs (NSAIDs) te hian a natna lan chhuahna chu a thunun thei tlangpui. Amaherawhchu, natna hi a na zawk a nih chuan doctor chuan enkawl dan dang a rawn rawt thei a ni.

Chutiang enkawlna thenkhat chu hetiang hi a ni:

• FMF: Hei hi damdawi (Colchicine) tih hmanga enkawl theih a ni a, chu chuan inflammation a tiziaawm thei a ni. (Colchicine) i ei thei lo a nih chuan (Biologic) chi khat (Canakinumab) tih hi i enchhin thei ang.
• PFAPA: PFAPA flare-ups hi steroid (a tam zawkah chuan prednisone) pek hian a ti tawi thei a ni. Naupang thenkhat chuan an natna lan chhuah dan chu an thunun thei a, chu chu chawhmeh natna enkawlna atana hman thin Cimetidine an hmang a ni.
• TRAPS: Damdawi (Canakinumab) hi TRAPS tan a tha hle. Tin, prescription anti-inflammatory medications (Glucocorticoids) te pawh hian symptoms a tiziaawm thei bawk.
• MKD: (Canakinumab) hi MKD enkawlna atan duhthlan tur tha tak a ni. Khawsik lai hian (NSAIDs) emaw (Steroids) emaw hman a \angkai thei bawk.
• NLRP3 natna: Immunomodulators dang Canakinumab leh Rilonacept, Anakinra te hi NLRP3 natna enkawl nan a tha hle.
• AOSD: AOSD tan hian anti-inflammatory damdawi chi hrang hrang hman a ni. Chung zingah chuan (Steroids), (Natna tidanglam thei Anti-Rheumatic Drugs - DMARDs), leh (Biologics) te an tel.
• Blau syndrome: Naupang natna lan chhuah dan azirin immunosuppressants, tumor necrosis factor (TNF) inhibitor, leh/ emaw topical eye medications te hi enchhin theih a ni.

SAIDs condition hi a mah chauhin a tha chho em?

SAID thenkhat chu dam chhung zawng a daih thei . Mi dangte chu kum engemaw zat an awm thei a, kum upat deuh deuhin an ṭha chho thei bawk. Thil awm dân ṭhenkhat chu dam chhûnga awm a nih laiin, hun kal zêlah khawsik tamna chu a tlahniam thei a, a lan chhuah dân pawh a na lo thei bawk . I doctor chuan i fa dinhmun bik chungchangah chipchiar takin a pe thei che a ni.

SAID vei naupang enkawl chu thil harsa tak a ni thei. Nangmah ngei pawhin SAID i nei tawh mai thei, mahse i mimal thil tawnte hmangin i fa enkawl dan tur leh he dam chhung zawnga an dinhmun hi an hmachhawn theih nan i pui thei ang.

A pawimawh ber chu SAIDs intricacies hre chiang tak specialist te hnen atanga enkawlna lak hi a ni. I fate natna lan chhuah dan enkawl kawngah an pui thei a, naupan lai hun tha ber an neih theih nan an pui thei bawk.