Nerve tichhe thei natna hmuh tur awm lo (hATTR Polyneuropathy) tan Amvuttra damdawi .

I kut leh keah i rilru a buai emaw, i tingling emaw mai mai em? Nge i taksa ruh chak lohna leh kal harsa i nei em? A châng chuan, heng symptoms te hi kan la hriat loh natna hlauhawm tak avanga lo awm thei a ni. Vawiin hian chutiang dinhmun pakhat leh a enkawlna thar chungchang kan sawi dawn a ni.

hATTR chu eng nge ni? Amvuttra hian engtin nge hna a thawh?

A awlsam zawngin hATTR (Hereditary Transthyretin-Mediated Amyloidosis) hi thlahtute atanga lo chhuak natna a ni. Natna pawl pakhat amyloidosis an tih zingah a tel a ni. Heng natnaah hian kan taksaa protein thenkhatte chu an pianzia a inthlak a, kawng dik lo takin an pungkhawm a, taksa peng hrang hrangah an dah khawm thin.

hATTR natnaah hian hetiang hian protein pakhat Transthyretin (TTR) tih chu a awm a. TTR hi a takah chuan protein tha tak a ni a, kan liver-ah a siam a, thyroid hormone leh vitamin A te chu taksa pum puiah a phurh luh theih nan a pui a ni. Mahse, hATTR natna vei chuan TTR gene-ah hian inthlak danglamna tlemte a nei a, chu chu mutation a ni. Chuvang chuan TTR protein siam chhuah chu a pianzia dik lo takah a awm ta a ni. He protein pianzia dik lo hi a pung khawm a, nerve, heart, leh digestive system ang chi hmunah te amyloid tia koh deposit angin a awm khawm a ni.

Heng deposit te hi nerve vel a an awm khawm chuan an chhe vek thin. Hei hi polyneuropathy kan ti a ni . Chutah chuan a hmaa kan sawi tawh ang khan natna lan chhuah dan, inflammation, numbness, na, leh kal harsa tih te hi a lo awm ta a ni.

Damdawi Amvuttra hian he TTR protein pangngai lo tak hi liver atanga siam chhuah a tihtlem avangin hna a thawk a ni. Hei hian taksaa amyloid deposit awmkhawm a ti tlem a, symptoms control nan leh natna zual zel tur venna emaw tihkhawtlai emaw a pui thin.

I doctor chuan i ei leh in leh exercise tih dan pawh thlak danglam turin a rawt bawk ang a, chubakah i natna lan chhuah dan tur pawh a enkawl bawk ang. Tun hnai thleng khan he natna enkawlna tur awmchhun chu symptom control leh a tul chuan liver emaw heart transplant emaw a ni. Mahse tunlai damdawi Amvuttra ang chi hian tunah chuan natna thlentu bulpui ber TTR protein tihtlem hmangin natna hi i thunun thei ta a ni.

He damdawi hi engtin nge i hman?

Amvuttra hi vun hnuaia injection a ni a . Health professional, doctor emaw trained nurse emaw pek a ni. Kum khatah vawi li (thla thum danah) pek thin a ni. I doctor office-ah emaw, clinic-ah emaw, in lamah pawh vaccine dawng turin ruahmanna i siam thei a ni.

Engtin nge he damdawi hi zirchian a nih?

Damdawi thar dang ang bawkin Amvuttra hi a that leh him loh hriat nan clinical trial-ah test a ni tawh bawk. He trial-ah hian Amvuttra dawngtu pawl pakhat chu placebo , active ingredient tel lo dummy treatment dawngtu pawl nen khaikhin a ni. Hetiang hian damdawi hian hna a thawk tak tak em tih kan hre thei ang.

He zirchiannaah hian hATTR natna vei leh a chhuak polyneuropathy te an tel a ni. An nerve chak lohna, taksa chakna leh nitin hnathawh theihna te chu special scoring system hmangin an teh a ni.

He zirchianna result atanga a lan dan chuan Amvuttra dawngtu damlote hian an neurological function leh quality of life a ti tha zawk a ni. An neurological score a tlahniam a, symptoms a ṭhat laiin, placebo dawngtu te erawh chuan symptoms a pung thung.

Engtikah nge damdawi hian nghawng a neih chu ka hriat tan ang?

Hei hi a rang thei ang bera tihfel a ni lo. Damdawi chuan i taksaah hna a thawk zauh zauh a, thla engemaw zat chhungin i natna lan chhuahna a tlahniam emaw, a ṭhat chhoh emaw i hmu thei a ni . He enkawlna hian hun rei tak chhunga a tum ber chu natna kal zel dan tur thunun a ni. Chuvangin i symptoms te hi en reng a pawimawh hle.

I doctor hnenah heng thilte hi fimkhur turin hrilh rawh:

• Ṭanpuina tel lova kal theihna
• Ke ruh leh ke ruh (limbs) leh tingling
• Taksa reflexes te
• Ding chunga thisen sang control

Hrilhfiahna nghal i hmu lo a nih pawhin a hun taka i vaccine lak hi lo thlir ve suh. I doctor chuan i hmasawnna enfiah nân thisen test, scan, a nih loh leh taksa enfiahna chi hrang hrang a ti thei bawk.

Side effects leh engtin nge kan enkawl ang?

Amvuttra hmanga side effect hmuh tam ber chu:

• Kut emaw ke emaw a na
• Joint natna
• Thâwk harsa

Chu bakah, Amvuttra hian i vitamin A level a tihhniam thei bawk . Chuvangin i doctor chuan thisen test a ti ang a, enkawl hma leh enkawl lai hian i vitamin A level a enfiah ang. I mit hmuhnaah danglamna i hmuh chuan, a bik takin zan lama mit hmuhna lama harsatna i neih chuan i doctor hnenah hriattir nghal rawh.

Hengte chauh hi side effect awm thei a ni lo. I rilru hahdamna tur symptom thar i neih chuan doctor hnenah hrilh nghal rawh.

Damdawi dangah harsatna a awm thei em?

Amvuttra hian ei leh in, in tur leh damdawi dang nena inzawmna lian tham a thlen tih hriat a ni lo. Mahse, damdawi, vitamin, herbal products leh supplement i ei zawng zawngte chu doctor hnenah hrilh vek a tha ber.