Thisen var cell count tlahniam i tawk em? Autoimmune Neutropenia (AIN) chungchang hi i zir dawn teh ang!

Engvangin nge kan taksa hriselna (immune system) hian min humhim ai chuan, a chang chuan kan cell-te hi a rawn bei tan thei tih i ngaihtuah ngai em? Chu chu thil buaithlak deuh, mahse hriatthiam theih tak , Autoimmune Neutropenia (AIN) tih a ni. Thil thleng chu kan taksa hriselna (immune system) hian kan taksaa thisen var chi pawimawh tak, `neutrophils` an tih chu a rawn bei a, chuvangin he thu hi awlsam takin, i hriatthiam theih angin i sawi ang u.

Chuti a nih chuan, Autoimmune Neutropenia (AIN) hi eng nge ni?

A awlsam zawngin sawi ila, `Autoimmune Neutropenia` (AIN) hi thisen kaihhnawih natna a ni. Heta thil thleng hi kan taksa hriselna (immune system) hian min venghim tura ngaih chuan kan thisen var, `neutrophils` an tihte chu a rawn bei sual a ni. Hei hi han mitthla teh, kan ram humhalhtu sipaite’n kan mite ngei an rawn beih sual ang hian.

`Neutrophils` tih hi eng nge ni?

Neutrophils hi kan taksa hriselna atana pawimawh tak a ni. Kan taksaah sipai te tak te ang mai an ni. An hna ber chu taksaa thil tha lo lut, natna thlentu bacteria leh fungi te zawn chhuah leh tihchhiat hi a ni. Chuvangin, `Autoimmune Neutropenia` chungchangah hian keimahni immune system hian heng `neutrophils` cell hlu tak takte hi a tichhia a, chuvangin thisena `neutrophils` awm zat chu a pangngai aia hniamin a tlahniam a ni.

AIN hi chi hnih a awm a, chungte chu:

1. Primary Autoimmune Neutropenia (AIN): Hei hi naute leh naupang tê têah hmuh a ni ber . Heta thil thleng hi chhan dang awm lovin `neutrophils` hi a tlahniam a ni. Mahse thu lawmawm tak chu he dinhmun hi kum tlemte chhungin a reh tlangpui.

2. Secondary Autoimmune Neutropenia (AIN): Hei hi naupang kum upa zawk leh puitlingah a tam zawk . Hetah hian neutrophil count tlahniam hi damdawi lam thil dang vang a ni. Entirnan, natna hrik emaw, thisen lama harsatna dang emaw, autoimmune disease dang (immune system-in a taksa a beih theihna dinhmun) a ni thei. He secondary AIN condition hi a tlangpuiin chronic a ni .

Neutropenia an tih neutrophil hi engtiang chiahin nge a tlem?

Autoimmune Neutropenia hi Neutropenia an tih, natna zau zawk chi khat chauh a ni. Neutropenia hi thisen microliter (microL) khata neutrophil awm zat a zirin mild, moderate, severe tiin an thliar hrang a ni.

• Mild Neutropenia: MicroL khatah neutrophil 1,000 – 1,500 vel a awm.
• Neutropenia hniam lam: MicroL khatah neutrophil 500 – 1,000 vel a awm.
• Neutropenia na tak: MicroL khatah neutrophil 500 aia tlem a awm.

A pawimawh ber chu heng value te hi doctor in a nemnghet tur a ni. Hemi chungchangah hian rinhlelhna i neih chuan damdawi lam thurawn lak a pawimawh hle.

Engtin nge AIN hian ka taksa a nghawng?

AIN-in a nghawng dan che hi mi hrang hrangah a inang lo thei. Thil engemaw zat ah a innghat a, chuvangin he thu hi doctor nen inbiakna neih a tha ber. I neutrophil count a tlahniam lutuk chuan infection i vei theihna a sang zawk . A châng chuan heng natna hrik te hi nunna atana hlauhawm tak a ni thei a, a bik takin damdawi lam pan vat loh chuan.

Mahse, a then phei chuan autoimmune neutropenia hian infection na lo tak tak chauh a thlen thei a ni. A nih loh leh asymptomatic a ni thei bawk. Chuvangin doctor nen thawhhona tha tak neiin i neutropenia thlentu chu eng nge ni tih hriat a pawimawh hle. A chhan azirin i doctor chuan i dinhmun a enfiah thei a, natna i control theih nan a pui thei bawk.

Autoimmune Neutropenia (AIN) hi tuin nge vei?

• Primary AIN: Hei hian naute leh naupang te a nghawng ber a ni . Thla 8 vel a nih chuan hmuhchhuah a ni tlangpui.
• Secondary AIN: Hei hi autoimmune natna dang, lupus emaw rheumatoid arthritis emaw nen a thleng fo thin. Naupang secondary AIN nei hi kum 10 vel an ni tlangpui a, puitling AIN vei hi kum 40 leh 60 inkar an ni tlangpui.

Autoimmune neutropenia hi engtiang chiahin nge a awm?

Primary AIN hi a tlem hle . Naupang kum 10 hnuai lam 100,000 zinga pakhat vel chauh a nghawng a, chuvangin a tlem zia chu i hmu thei ang.

Autoimmune Neutropenia natna lan chhuah dan chu engte nge ni?

Autoimmune Neutropenia hian symptom lian tham a thlen ngai lo. Mahse, a chang chuan hri kai chhinchhiahna i hmu thei. Entir nan:

• Beng natna: Hei hi a lan chhuah tam ber pakhat a ni. I fate chu beng a na reng tih han ngaihtuah teh, doctor i pan chuan beng natna dang a ni tih an hrilh che a ni.
• Thluak lam natna: Khawsik, khuh leh khawsik fo thin.
• Kawng natna: Kawngkhar natna leh hmui natna (gingivitis) ang chi thil.
• Vun natna a awm.
• Pneumonia natna (Pneumonia) a ni.
• Meningitis natna (Meningitis) a awm.
• Zun kawng natna (UTIs) te.
• Sepsis: Hei hi natna khirh tak, nunna atana hlauhawm tak a ni.

Primary AIN nena inzawm natna hi a tlangpuiin a na lo hle a, mahse secondary AIN-ah hian natna khirh tak tak , pneumonia, meningitis, leh sepsis te hi a tam zawk.

Eng thilin nge autoimmune neutropenia hi a thlen?

AIN hi neutrophil level hniam chhan a zirin primary emaw secondary emaw-ah dah a ni.

A rilru a buai em em a, a rilru a hah em em bawk a. Primary Autoimmune Neutropenia (Primary AIN) .

Primary AIN ah chuan antibodies te hian neutrophils te chu an target a, an tichhia a ni. Antibodies hi kan immune system-a protein chi khat a ni. An hna pangngai chu taksaa lut tur thil tha lo, virus leh bacteria te tihchhiat hi a ni. Mahse tun dinhmunah chuan zirchiangtute chuan kan antibody ngei hian heng neutrophils te hi engvangin nge a beih tih chiang takin an la hre lo.

Secondary Autoimmune Neutropenia (Secondary AIN) a awm a, a chhuahna tur hmun leh a hmanna tur a awm lo.

Secondary AIN-ah chuan chhan dang emaw, dinhmun dang emaw avanga neutrophils awm zat a tlahniam thin. Hei hian immune system hian neutrophils te chu a tichhia a ni.

Hei hi a thlen thei thil thenkhat chu:

• Autoimmune natna dangte: Entirnan, rheumatoid arthritis, lupus, leh autoimmune hemolytic anemia te hi a ni.
• Cancer: Entirnan, `granular lymphocyte leukemia lian tak`.
• Hri kai: `HIV`, `Parvovirus`, `hepatitis B` ang chi hri kai.
• Tumors: `Wilms tumor`, `Hodgkin natna` ang chi te hi a ni.
• Neurological natna: Entirnan, multiple sclerosis.
• Kidney emaw bone marrow emaw thlak danglam a ni.
• Damdawi thenkhat: A bik takin cancer damdawi pek thin chemotherapy thenkhat.

Engtin nge Autoimmune Neutropenia hi hmuhchhuah a nih? (Diagnosis) tih a ni.

I khawsik emaw, natna hrik i neih emaw chuan i doctor chuan thisen hnathawh laiin i neutrophil count a hniam tih a hmu thei a, a chhan hriat theih nan. AIN hmuhchhuah hi a harsa deuh thei a, a chhan awm thei tam tak a awm avangin. I doctor chuan i neutrophil count tlahniam thei tur thil dang a paih chhuah hnuah AIN a hmuchhuak thei a ni.

`Autoimmune Neutropenia` hriatchhuah emaw, enfiah emaw tur chuan i doctor chuan a hnuaia test te hi a ti thei ang:

• Complete blood count (CBC): CBC hian i thisena neutrophils awm zat a enfiah thei a. Heng level te hi a inang lo thei a, i doctor chuan neutropenia confirm nan leh i neutrophil level enfiah nan CBC pakhat aia tam a ti fo ang. CBC pangngai hian i AIN hi a chronic em tih hriat theih nan a pui thei bawk.
• Peripheral blood smear: Thisen sample chu microscope hmangin an enfiah a, neutrophils awm dan leh an awm dan an enfiah thin. Hei hian diagnosis-ah pawh a pui hle.
• Vitamin B12, folate, leh copper test: Heng test te hian heng nutrients te hi a tlakchham leh awm loh a enfiah thei a ni. Taksa hian neutrophil siam nan hengte hi a mamawh a ni.
• Liver function test: Hengte hian liver function leh viral hepatitis a awm leh awm loh a enfiah thei bawk.
• HIV leh virus dang zirchianna: HIV ang chi virus infection hian thisen var (white blood cells) a tihhniam phah thei bawk.
• Flow cytometry: Hei hi laboratory test a ni a, cell-ah natna chhinchhiahna a awm leh awm loh enfiah a ni. Neutropenia hi autoimmune condition avanga lo awm a nih leh nih loh hriat nan hman a ni.
• Imaging: AIN hi cancer vang nia rinhlelhna a awm a, chu chu lymphoma ang chi a nih chuan MRI emaw CT scan emaw tih theih a ni.
• Bone marrow aspiration leh biopsy: Hetah hian doctor chuan bone marrow sample te tak te a la a, natna chhinchhiahna a awm leh awm loh a enfiah thin. Hei hian neutropenia hi thisen cancer, leukemia ang chi avanga lo awm a nih leh nih loh hriat theih nan a pui thei a ni.

I doctor chuan i thisenah neutrophils beitu antibodies a awm leh awm loh enfiah turin thisen test a ti thei bawk. Test hman tlanglawn ber chu I-GIFT (Indirect granulocyte immunofluorescence test) leh GAT (Granulocyte agglutination test) te an ni.

Vanduaithlak takin heng test te hi AIN hmuhchhuahna kawngah hian rintlak an ni ngai lo. I neutropenia awm chhan leh test hun a zirin heng test te hian antibodies a hmu lo thei a, false-positive result pawh a pe thei bawk. False-positive result chu test-a antibodies awm loh laiin a awm tih a hriat chuan a ni.

Doctor chuan neutropenia hi natna bik avanga lo awm a nih a rinhlelh chuan test dang tih belh a ti thei bawk.

Autoimmune Neutropenia hi engtin nge enkawl a nih?

Enkawlna chu i dinhmun nasat danah a innghat a ni. Entirnan, naute asymptomatic neutropenia nei chuan CBC leh neutrophil count neih reng a ngai mai thei a, mahse enkawl vat a ngai lo mai thei. I naute hian natna a vei fo a nih chuan i doctor chuan natna hrik a kai loh nan prophylactic antibiotics a pe thei ang. Antibiotics hi infection enkawl nan pek thin a ni tlangpui a, mahse heng prophylactic antibiotics te hi infection a awm loh nan pek thin a ni.

Secondary AIN nei tan chuan doctor chuan neutrophil level hniam chhantu underlying condition chu a enkawl ang . Tin, hetiang hian an ziak thei bawk:

• Granulocyte colony-stimulating factor (G-CSF): Hei hi neutropenia natna khirh tak takte enkawlna ber a ni. Taksain neutrophils tam zawk siam turin a pui thin. G-CSF hian primary AIN nena inzawm infection awm fo te pawh a veng thei bawk.
• Corticosteroids: Corticosteroids, prednisone ang chi hian i taksa immune system response a titawp a, neutrophils beitu antibodies a tihtlem phah a ni.
• Enkawlna dang: Damdawi dang IVIG, rituximab, leh alemtuzumab te pawh hi natna khirh tak, autoimmune neutropenia na tak nei te tan pawh hman a ni tawh bawk.

Autoimmune Neutropenia hi ven theih a ni em?

Primary AIN emaw Secondary AIN emaw pawh hi ven theih a ni lo . Mahse, `Autoimmune Neutropenia` nena inzawm harsatna, chu chu natna hrik lo awm hi i veng thei a ni. Chutiang ti tur chuan hri kai laka inven nan a tul anga hma i lak a ngai a ni. Entirnan, mipui tamna hmun pumpelh te, kut sil fo te, damlo laka inthiarfihlim te.

Autoimmune Neutropenia vei hian eng ang hmalam hun nge a beisei theih ang?

Primary AIN hi a tlangpuiin a mah chauhin a resolve thin . Naupang AIN vei zinga 95% vel chu kum hnih atanga kum thum an tlin chuan an neutrophil level chu a pangngaiin an awm leh thin. Primary AIN nei naupang zawng zawng deuhthaw hian kum 11 an tlin chuan an dam kim vek a, hei hi a thlamuanthlak tak zet a ni lawm ni?

Thil dang, secondary AIN tia koh, i dam lehna chu thil engemaw zatah a innghat a, a bik takin i neutropenia thlentu dinhmun hnuaia awm chu a innghat a ni. Chu dinhmun enkawl leh natna hrik venna chuan i neutrophil count chu a pangngaia a awm leh theih nan a pui thei a ni.

Engtikah nge damdawi lam thurawn ka lak ang?

Autoimmune neutropenia na tak i neih a , khawsik i neih chuan doctor pan nghal rawh . A châng chuan, i doctor chuan khawsik i neih chuan ei tûr antibiotics a lo hrilh lawk tawh mai thei. A tam zawkah chuan damdawi inah enkawl i ngai dawn a ni.

Autoimmune neutropenia na tak, hun rei tak chhunga awm i neih chuan i doctor chuan eng symptom nge i hriat tur tih leh harsatna i tawh loh nan eng nge i tih theih tih a hrilhfiah ang che.

Hriat reng tur: Nangmah emaw i fa emaw AIN vei nia hriat i nih chuan i doctor nen a nghawng dan tur sawipui rawh. Symptom leh a chhan hrang hrang a awm laiin, thu lawmawm tak chu G-CSF ang chi enkawlna hian neutrophil level tihsan kawngah a hlawk hle a ni.

I fain AIN a neih chuan i doctor-in a tih angin thisen test neihpui thin ang che. Infection chhinchhiahna awmte chu fimkhur la, i hriat chuan a rang thei ang bera enkawl la, harsatna awm thei tur ven nan.

Thupui tawi (Take-Home Message) 1.1.

Okay, chuvangin tunah chuan kan sawi tawh `Autoimmune Neutropenia` (AIN) kha in hriatthiam ka beisei.

• AIN hi keimahni immune system hian kan thisen var ‘neutrophils` an tih te a tichhe thin.
• Hei hi naupang tê (Primary AIN) emaw, puitling (Secondary AIN) emaw-ah a thleng thei. Naupang tê tête primary AIN hi a mah chauhin a reh fo ṭhin.
• A hlauhawm ber chu hri kai fo hi a ni.
• Thisen test leh test dangte pawh a awm a, chu chu a hriat theih nan a ni.
• Enkawlnaah hian enfiahna, natna hrik dona damdawi, G-CSF, leh corticosteroids te a tel a ni.
• A pawimawh ber chu hlauthawng lo leh hlauthawng lo la, nangmah emaw i fa emaw hian heng symptoms te hi i neih chuan doctor thurawn la rawh. A hmaa hmuhchhuah a nih a, uluk taka enkawl a nih chuan AIN nei pawhin nun hrisel tak i hmang thei a ni.

Hemi chungchanga zawhna dang i neih chuan i doctor nen inbia ngei ang che. Thurawn tha ber ber pe thei che an ni.

` Neutropenia, Autoimmune Neutropenia, Thisen var, Immune System, Infection, Thisen Natna, Naupang enkawlna