I thisen siam chhuah a tlahniam em? He dinhmun hlauhawm tak Aplastic Anemia an tih hi han sawi ila!

I chau leh chau reng reng bawk em? Thil tenawm tak i tih hnuah pawh thawk harsa i ti em? A nih loh leh i taksa hmun tinah hliam leh thisen chhuak mai mai i nei em? A châng chuan hengte hi thil pangngai angin kan ngaihven vak lo mai thei. Mahse, a châng chuan heng natna lan chhuahna hnuaiah hian thil pawi zawk thup a awm thei. Aplastic Anemia hi chutiang hmuh tur awm lo tak pakhat chu a ni a, chu chu hmuh fo loh, mahse natna hlauhawm tak a ni thei tihna a ni. Chuvangin vawiin hian he thu hi chipchiar tak leh awlsam takin kan sawi dawn a, chutiang chuan nang pawhin he thu hi i hrethiam zawk ang.

A awlsam zawngin, aplastic anemia chu eng nge ni?

A awlsam zawngin sawi ila, aplastic anemia tih hi kan taksa chhunga ruhro (bone marrow) a thawk tha lo a nih chuan a ni. I hria em, kan ruh chhunga bone marrow an tih hi kan taksa mamawh thisen sen, thisen var leh platelet siamtu a ni. Chuvangin, aplastic anemia hi ruhro hian heng cell te hi a siam tha thei lo a nih chuan a lo awm thin.

Thisen siamna factory khar nghal mai ang mai a ni. Chuti a nih chuan eng nge thleng? Taksa hian a mamawh thisen cell a hloh a. Hei hian natna khirh tak tak vei theihna a tipung a , thisen chhuah tihtawp a ti harsa a, lung natna ang chi harsatna dang a thlen thei bawk. A natna lan chhuah dan thunun theihna tur enkawlna a awm. Mahse, a tihdam vek theihna awmchhun chu stem cell transplant hmangin a ni .

Hetiang dinhmun hi engtiang chiahin nge a awm? Chutiang chuan kan hlau tur em ni?

Dik tak chuan he natna Aplastic Anemia an tih hi a tlem deuh a ni . Chumi awmzia chu mi zawng zawng tuar thei natna a ni lo tihna a ni. Entirnan, United States-ah chuan kum tin mi 300 atanga 900 inkar chauhvin he natna hi an vei tih hmuhchhuah a ni. Europe ramah chuan zirchianna chuan he natna hian mi maktaduai khatah mi pahnih vel a vei niin an sawi.

Kum eng pawh a nghawng thei a, mahse kum 15 leh 25 inkar leh kum 60 chunglam ah a tam ber a, chuvangin, chau reng reng leh he natna hi i vei em tih ngaihtuah reng reng hi a tul lovah lungngai suh. Amaherawhchu, a natna lan chhuah dan hriat chian a pawimawh.

Aplastic Anemia natna lan chhuah dan chu engte nge ni?

He natna lan chhuah dan hi vawi khatah a lang vek lo. Vawi tam tak chu heng symptoms te hi kar emaw thla emaw chhungin a lang zauh zauh thin. Chuvângin, a tîrah chuan a danglamna chu i hre lo mai thei. Mahse, mi ṭhenkhat chuan natna lan chhuahna na tak an nei thut mai thei. Heng symptoms te hi i nei em tih enfiah rawh:

• Viral infection (flu leh khawsik ang chi) hi a tam zawk a, a dam theih nan a tlangpui aia rei a daih.
• Chauhna leh hahna nasa tak awm reng.
• Taksa zawng zawngah hliam a lang a, a nih loh leh hliam te tak te pawhin thisen chhuah a reh theih nan hun rei tak a mamawh a ni.
• Thâwk harsa tih hriat (dyspnea) ., a bîk takin hna tê tê thawh hunah.
• A vun rawng chu a hma aia a sen deuh niin a lang.
• Luak chhuak thei.
• Lu na.
• Khawsik.

Chûng chhinchhiahna ṭhenkhat chu natna dang, na lo zâwk avânga lo awm thei a ni tih hre reng ang che. Entirnan, khawsik i neih chuan hah leh khawsik i neih hi thil awmdan pangngai a ni. Chuvangin heng symptoms zinga pakhat emaw pahnih emaw i neih a, aplastic anemia i nei nia i ngaih chuan hlauthawng suh. Mahse, kar tam tak chhung chu i dam lo a, tuar theih loh khawpa i chau reng a nih chuan doctor pan a, thurawn dil chu a tha ber ngei ang.

Engvangin nge aplastic anemia hi a lo awm? A chhante chu engte nge ni?

Dik tak chuan mi thenkhatin aplastic anemia an vei chhan chiang takin mithiamte chuan an la hre lo. Mahse, kan taksa hriselna (immune system) —natna laka min humhimtu system-in min hriatthiam loh vang leh kan ruhro (bone marrow) ngei a rawn beih avangin a ni fo thin a, chuta stem cells te chu a tichhia a ni. Heng stem cells te hi thisen cell thar siamtu an ni.

Chu bakah chuan chhan dang engemaw zatin hei hi a nghawng thei a ni:

Damdawi lam dinhmun thenkhat:

• Autoimmune diseases , lupus ang chi hi kan immune system-in kan taksa ngei a beih natna a ni.
• Viral infection thenkhat, entirnan, virus te, Epstein-Barr virus, cytomegalovirus (CMV), parvovirus B19 , leh human immunodeficiency virus (HIV) te .
• Paroxysmal nocturnal hemoglobinuria hi acquired condition a ni a, thisen sen (red blood cells) te chu a chhe chak hle a ni.
• Naupai hi a châng chuan hei hi a thlen thei a, mahse a tlem hle.

Chhuan hrang hrang atanga lo chhuak dinhmun:

Mi thenkhatah chuan aplastic anemia hi inherited bone marrow failure syndromes nen a inzawm thei a ni. Chungte chu ‘inherited bone marrow failure syndromes’ an ti a. Entirna thenkhat chu:

• Fanconi thisen tlakchhamna (anemia) a awm
• Dyskeratosis hi a pianphung atanga lo chhuak a ni
• Shwachman-Diamond natna a ni
• Diamond-Blackfan thisen tlakchhamna
• Pearson natna a ni

Damdawi lam enkawlna thenkhat:

Damdawi lam enkawlna thenkhat pawh hian he natna hi a tipung bawk.

• Autoimmune natna enkawlna thenkhat.
• Cancer tan radiation leh chemotherapy hmanga enkawl a ni. Hengte hi enkawlna chak tak an nih avangin ruhro (bone marrow) a tichhe thei a ni.

Tin, hun rei tak chhunga chemical thenkhat carcinogens , arsenic leh benzene , te nena inzawmna chuan he hlauhawmna hi a tipung thei bawk.

Hei hian eng harsatna nge a thlen theih?

Aplastic anemia vei chuan heng ang harsatna hi a nei thei a, chung zinga ṭhenkhat chu nunna atana hlauhawm tak a ni thei:

• Anemia: Hei hian taksaa thisen volume a tlahniam tihna a ni. Hei hian hah lutuk leh thawk harsatna ang chi thil a thlen thei a ni.
• Infection na tak: Thisen var a tlahniam chuan natna do theihna a tlahniam a.
• Thisen chhuah tam lutuk: Platelet a tlahniam avangin thisen a tikhawlo rei zawk.
• Heart rhythm mumal lo (Arrhythmia) emaw, heart failure emaw a awm thei.
• Myelodysplastic syndrome hi ruhro chhunga cell te chu a pangngai lo taka an thanlenna a ni.

Engtin nge Aplastic Anemia hi hriat theih?

Doctor-te chuan he natna hi an enfiah che a, thisen test te, a chang chuan genetic test te hmangin an hmuchhuak thin. Heng test-ah hian:

• Complete blood count (CBC) with differential: Hei hian i thisen chhunga red cell awm zat, white cell chi panga awm zawng zawng leh platelet awm zat a teh a ni.
• Peripheral blood smear: Thisen sample lak a, microscope hmanga enfiah a, thisen cell leh platelet awm dan leh a pianzia enfiah a ni.
• Reticulocyte count: Hei hian thisen sen (reticulocyte) lo piang thar, puitling lo awm zat a teh a ni.
• Bone marrow aspiration leh bone marrow biopsy: Hetah hian ruhro sample tlemte lak a ni a, a tlangpuiin hip ruh atanga lak a ni a, anesthesia hmangin lak a ni. Chumi hnuah microscope hmangin an enfiah a, ruhro (bone marrow) dinhmun dik tak chu an enfiah a ni. Hei hi diagnosis finfiahna atana test ber a ni.

Enkawlnate chu engte nge ni?

I dinhmun a zirin enkawlna kawng hrang hrang a inang lo. Entirnan, mi thenkhat chuan cancer enkawlna emaw, autoimmune natna enkawlna emaw avanga aplastic anemia an nei thin. Chutiang hunah chuan doctor-te chuan chutiang enkawlnate chu thlak danglam an tum mai thei.

I thisen cell count chu a tlangpui aia hniam mahse symptom lian tham i neih loh chuan i doctor chuan moderate aplastic anemia i nei a ti mai thei. Chutiang a nih chuan i doctor chuan i hriselna leh thisen zat a enfiah fo mai thei. Chutiang chuan i dinhmun a chhe zual ang tih a hriat chuan hma i la thuai thei ang.

Aplastic anemia natna khirh zawk enkawlnaah chuan:

• Immunosuppressants: Heng damdawi te hian i immune system hnathawh dan a control a, i ruhro a beih loh nan a titawp a ni. Heng damdawi entirnan antithymocyte globulin injection (Atgam®) leh cyclosporine (Sandimmune®) te hi a ni.
• Thisen pek dan: 1.1.Hei hian thisen sen leh platelet tlakchham tawhte thlak a huam a ni. Hei hian natna a tidam lo a, mahse a natna lan chhuah dan a ti reh thei a ni.
• Antibiotics: Aplastic anemia vei te hi bacteria infection an vei theihna a sang hle. Chuvangin, natna hrik enkawlna atan antibiotics pek a ni.
• Allogeneic stem cell transplantation: Hei hi he natna enkawlna ber a ni. Hetiang tih danah hian donor hrisel tak (a tam zawkah chuan chhungte emaw, matched donor emaw) atanga stem cell hrisel tak tak te chu damlo ruhro chhiaah an dah lut thin. Hemi hnu hian thisen cell hrisel thar a lo piang tan a.

Enkawlna hian eng side effect nge a neih?

Side effect pawh hi enkawl dan azirin a inang lo bawk:

• Graft-versus-host disease: Hei hi allogeneic stem cell transplantation- a lo awm thei complication a ni . Chumi awmzia chu transplanted cells te hian damlo taksa lakah hna an thawk tihna a ni.
• Immunosuppressant damdawi hian natna kai theihna a tipung a ni.
• Thisen pek fo (hemochromatosis / iron overload) avanga taksaa iron level sang.

Hei hi ven theih a ni em?

Vanduaithlak takin tunah hian aplastic anemia ven dan tur hriat a la awm lo.

A dam kim thei ang em?

Ni e, a then phei chuan allogeneic stem cell transplantation hlawhtling tak chuan he natna hi a tidam vek thei a ni. A tlangpuiin naupang leh kum 40 hnuai lamte chu puitling aiin he enkawlna hi an hlawhtling zawk a ni.

Damchhuah theihna chance engzat nge awm?

Hei hi thil tam takah a innghat tak zet a ni. I kum, i enkawl dan, i natna nasat dan, etc. Zirna pakhatah chuan a pumpuiah chuan mi 96% chu stem cell transplant hnuah an dam chhuak a ni. He zirchianna vek hian naupang leh puitling kum 40 hnuai lam 100% chu enkawl a nih hnu kum nga chhungin an dam tih hmuhchhuah a ni bawk.

Mahse, heng statistics te hi mipui tam tak thil tawn atanga lak chhuah a ni. Chutiang bawk chuan an nghawng lo thei che a ni. Hemi chungchanga zawhna i neih chuan Doctor nen inbiak a tha ber. I dinhmun ang zela thu hriatna a pe thei a ni.

Aplastic Anemia ka neih chuan engtin nge ka in enkawl ang?

Hetiang dinhmun hi i neih chuan i in enkawl tha a pawimawh. I doctor enkawl dan tur dik taka zawm a pawimawh a, i natna lan chhuah dan pawh ngaihven a pawimawh bawk. Heng thilte hi i ti thei bawk ang:

• Hliam tam zawk thlen thei thil tih loh tur. Thisen chhuah theihna i nei sang zawk. Chuvangin rugby, hockey, wrestling ang chi infiamna lam atanga inthiarfihlim hi a tha ber.
• Virus leh germs lakah inveng rawh.Infection i vei tam zawk. I doctor hnenah eng vaccine nge i tan a tha tih zawt rawh. Kut sil fo la, mi damlo (khawsik, flu, pum na nei te ang chi) lakah inthiarfihlim rawh.
• Chawlh hahdam tawk rawh. Anemia hi hei hi a complication a nih avangin i chau hle mai thei a, thawk pawh i thawk harsa thei bawk. Nitin hna thawh a harsa thei bawk. Chuvangin, i theih hunah ni lovin, a tul hunah chawl la, mut tha rawh.
• Ei leh in hrisel ei rawh. Sa thau lo, thlai, thei leh whole grains te telna balanced diet hian i chakna level a ti sang thei a ni. Nutritionist hnen atanga thurawn i lak theih chuan i ei leh in atanga hlawkna tam ber i hmuh theih dan tur i zir thei ang.
• Exercise engemaw zat nei rawh. Exercise light tak hian stress tihziaawmna kawngah a pui thei a ni. Mahse, exercise thar i tan hmain doctor nen inbiakna neih hmasak phawt ang che.

Engtikah nge Doctor i hmuh ang?

Hetiang a nih chuan doctor ko nghal rawh:

• I khawsik 38 degree Celsius (100.4 degree Fahrenheit) emaw a aia sang emaw i neih chuan .
• I symptoms a na zual a nih chuan.

Doctor hnenah eng zawhna nge ka zawh ang?

Aplastic anemia i neih chuan i doctor hnenah heng zawhnate hi i zawt mai thei:

• Ka dinhmun chhan ber chu eng nge ni?
• Ka dinhmun hi a pawi em?
• Eng enkawlna nge i rawt?
• Enkawlna hian eng side effect nge a neih?
• Symptoms ka nei lo. Enkawlna ka mamawh dawn em?
• Symptoms ka nei a. Ka enkawl dan tur chu engte nge ni?

Aplastic Anemia hi cancer a ni em?

No. Aplastic anemia hi cancer a ni lo. Mahse, aplastic anemia vei ṭhenkhat chu thisen cancer chi khat leukemia tih chu an vei thei a ni.

Aplastic anemia hi thisen lama harsatna awm lo mahse na tak a ni. I immune system-in nangmah ngeiin i ruhro a beih a, i taksa mamawh thisen cell leh platelet a siam theih lohna tura a tihkhawtlai hian a thleng tlangpui. A chhan awm thei tam tak a awm a, chuvang chuan i lungkham a, i hlau thei bawk. Mahse, doctor-te chuan a chhan chiang tak hmu thei lo mah se, chu natna chu enkawl theih a ni a, a châng chuan tihdam theih a ni bawk. Aplastic anemia i neih chuan i doctor chuan i tana tha tur enkawlna tur leh an side effects te a hrilhfiah ang che. Chuvangin, huaisen la, i doctor thurawn zawm rawh.

Kan hnen atanga Take-Home Message pakhat

Aplastic Anemia hi a hming i hriat chuan a hlauhawm thei hle. A chhan chu natna khirh tak a nih vang a ni. Mahse, a enkawlna a awm tih hre reng ang che. A natna lan chhuah dan i hriat hmasak a, doctor thurawn i zawn a, enkawl i tan chuan he natna hi i thunun thei fo a, i tidam thei hial a ni.

A pawimawh ber chu sawifiah theih loh khawpa hahdamna, natna i neih fo emaw, thisen chhuah dan pangngai lo emaw i neih chuan ngaihthah mai mai suh la , doctor pan mai mai suh. I hriat hmasak poh leh enkawlna a hlawhtling ngei ang. Nangmah chauh i ni lo va, he zinkawngah hian doctor, chhungte leh ṭhiante pawh an awm vek a ni.

` Aplastic Anemia, Aplastic Anemia, Anemia, Bone Marrow, Thisen Natna, Stem Cell Transplant, Immune System