I pum a na fo bawk em? Bile acid malabsorption a ni thei!

Tin, ril tam tak, chu chu ril\amna (diarrhea) i vei bawk em? Tin, chawlh hahdam harsa tak, a chang chuan tui tak tak, ni khatah vawi engemaw zat ril\am i vei bawk em? Tichuan hei hi i tan thil pawimawh tak a ni mai thei. Vawiin hian Bile Acid Malabsorption (BAM) tih hming pu dinhmun kan sawi dawn a ni. A hming hi a buaithlak deuhin a lang thei a, mahse awlsam takin han sawifiah ila.

Bile Acid Malabsorption hi eng nge ni?

A awlsam zawngin, hei hi kan chaw ei leh in lama natna a ni . A bik takin, chronic diarrhea , chu chu continuous diarrhea thlentu lian tak a ni thei. Kan intestines a bile acids te hi taksain a hip lut tha lo a nih chuan intestines ah a pung khawm thin. Tichuan a chhunga chemical balance chu a tibuai ta a ni. Hetianga bile acid tam lutuk avang hian kan colon hian tui tam zawk chhuah tir turin thuchah a thawn thin. Chuvang chuan watery diarrhea a awm thin. Pipe atanga tui tla ang maiin ngaihtuah la, mahse chu tui chu thunun theih loha a kal chuan hetiang hi a thleng thin.

Bile acid hi eng nge ni?

Tunah chuan, "Heng bile acid te hi eng nge ni?" Bile hi kan liver atanga siam thil a ni . Liver hian kan thisen a tihfai hian bawlhhlawh, toxins, thisen cell thi, leh cholesterol tam lutuk te chu a thenfai a, bile a siam thin. He bile chhunga acid chi hrang hrangte hi an inzawm khawm a , bile acid an siam thin . Heng acid te hian bile liquid chhunga lipids awm reng turin a pui thin.

He liver atanga bile lo chhuak hi bile duct kaltlangin kan small intestine ah a thawn lut a, chu chuan ei tur a digest thei a ni. Small intestine-ah hian heng bile acids te hian taksain kan ei tur thau awmte chu a digest a, a hip lut thin. Chu hna chu an thawh zawh chuan heng bile acid te hi kan taksaah an lut leh a, thisen kaltlangin liver-ah an kal a, bile siam nan an hmang leh ta a ni. Hei hi recycling process ang mai a ni.

"Malabsorption" tih hi eng nge ni?

"Malabsorption" tih awmzia chu kan intestine hian kan absorb tur chemicals te chu a hip tha thei lo tihna mai a ni. Hei hi intestines ngeia harsatna vang pawh a ni thei a, chemical imbalance vang pawh a ni thei bawk. Entîr nân, chemical chi khat a tam lutuk emaw, a tlem lutuk emaw chuan intestine-in a hip ṭha thei lo mai thei.

He dinhmun hian tute nge a nghawng ber?

Tun hma chuan bile acid malabsorption (BAM) hi mi tam takah hriat a ni lo a, a chhan chu dik taka hriat theihna tur kawng a awm loh vang a ni. Mahse, tun hnaia zirchianna atanga a lan dan chuan functional diarrhea disorders (FDDs) .BAM vei zinga 30% tal chuan an nei thei nia chhut a ni. Functional diseases chu a chhan chiang tak nei lo leh damdawi lam enfiahna atanga awlsam taka hriat theih loh dinhmun a ni. Entirnan, natna pakhat (Irritable Bowel Syndrome - IBS) .

BAM hi a hnuaia damdawi lam harsatna nei teah hmuh theih a ni:

• Microscopic colitis a awm thei
• Crohn natna a ni
• HIV kaihhnawih enteritis
• Bacteria infection hnua ril\am chhunzawm zel
• Exocrine pancreatic insufficiency a awm thei lo

Tin, he natna hi damdawi lam enkawlna thenkhat dawngtu te zingah pawh a awm thei bawk:

• Surgery hmanga ileum, small intestine tawp ber chu lakchhuah emaw tihdanglam emaw.
• Gallbladder lakchhuahna operation (cholecystectomy) tih a ni .
• Radiation therapy , a bik takin pum leh pelvis-ah te.
• Chemotherapy hmanga enkawlna .
• Type 2 diabetes tan damdawi hman thin Metformin hman dan.

Hei hi eng symptoms nge ni?

A lan chhuah dan tlangpui chu:

• Tui hmanga ril\am
• Bathroom-a kal a ngai fo thin
• Pum chhunga natna hrik awm
• Bathroom-a kal duhna leh stool-a vawn harsat

Mi thenkhat chuan a hnuaia symptoms te hi an nei thei bawk:

• Pum a hring chhuak
• Gas leh a natna a thlen thin
• Thil thau tak tak (Steatorrhea) .
• Indigestion (indigestion) a awm lo

Hun rei tak chhunga nghawng a neihte chu:

• Tui tlakchhamna (dehydration).
• Chawlh hahdam tawk mahse hahdamna
• Lu na
• Luak chhuak thei
• Luhai
• Mi thenkhat chu an thau chho a, thenkhat chuan an thau bawk.

Vawi tam tak chu, heng natna vei zinga a chanve vêl chuan natna lan chhuahna an nei reng a ni . A chanve dang chuan a chang chuan symptoms an nei ve chauh a ni .

Engvangin nge bile acid diarrhea hi a lo awm?

Bile acid malabsorption chhinchhiahna ber chu bile acid diarrhea (BAD) a ni. Hei hi kan intestine lian (colon) -a bile acids awmkhawm vang a ni a, chutah chuan ei tur bawlhhlawh chu bawlhhlawhah a chantir thin. A tlangpuiin kan small intestine-a bile acids 95% chu small intestine hmun hnuhnung ber, ileum-ah hian intestine lian tak a thlen hmain a insiam leh thin.

Mahse, chutianga bile acid tam lutuk chu a hip lut lo a nih chuan bawlhhlawh dangte nen chuan intestine lian takah an kal lut thin. Intestine lianah chuan heng bile acid te hian intestine lining a ti na a. Hei hian tui a tichhuak tam zawk a, zun hmalam pantu ruh te chu a thawk nasa zawk thin. Hei vang hian diarrhea hi a awm fo va, a lo awm thut a, pum na a awm bawk.

Bile acid absorption tlahniam chhante chu engte nge ni?

Tunah chuan zawhna awm thei chu, engvangin nge heng bile acids te hi intestines ah an awm khawm? Zirchiangtute chuan BAM hi a chhan awm thei paliah an ṭhen a. A châng chuan hengte hi primary leh secondary tiin an thliar hrang bawk .

• Primary BAM: Hei hi kan thin (liver) in bile acids (type 2 leh 4) a siam tam lutuk vang a ni.
• Secondary BAM: Hei hi natna emaw, operation emaw, radiation therapy (type 1 leh 3) avanga kan intestine te a chhiat chuan a thleng thin.

Type 1 BAM: Hei hi ileum-a harsatna awm vang a ni a, chu chu small intestine tawp ber a ni. Hei hi malabsorption dik tak an ti a, a chhan chu buaina hi bile acid cycle-a absorption stage atanga intan a nih vang a ni. Damdawi lam dinhmun dang pakhat angin i small intestine a tawp ber chu surgery hmanga lakchhuah, tihdanglam emaw, bypass emaw a nih chuan Type 1 BAM i nei thei bawk. Ileum hi Crohn natna leh radiation therapy ang chi natnain a tichhe thei bawk. Thil chhiatna nasa tak a awm chuan absorption a tichhe thin.

Type 2 BAM: Hei hi "idiopathic" an ti \hin. Hei hian rang takin, chhan awm lovin a thleng tihna a ni. Amaherawhchu tuna kan zirchiannaah chuan kan intestine leh liver inkara chemical signaling system-a harsatna awm vang a ni tih a lang. He signaling system hian a tlangpuiin enterohepatic circulation a control thin. Heng signal te hian liver chu engtikah nge bile acid tam zawk siam tur leh thawn tur tih te, engtikah nge a tihtawp tur tih te, engtikah nge a lakluh leh tur tih te leh engtikah nge a recycle tur tih te a hrilh thin. Mahse Type 2 BAM ah chuan "stop" tih thuchah chu a kal tha tawk lo. Chuvângin, liver chuan bile acid a thawn chhunzawm zêl a—ileum-in a lakluh theih aia tam a thawn chhuak a ni.

Type 3 BAM: Hei hi kan ei leh in kawng dang bakah ileum a nghawng natna avanga lo awm a ni. Entirnan, celiac natna , chronic pancreatitis , leh Small Intestinal Bacterial Overgrowth (SIBO) ang chi natna te.

Type 4 BAM: Hei hi zunthlum damdawi metformin ei avanga side effect angin a awm a, hei hian bile acid tam lutuk a siam chhuak thin.

Hetiang dinhmun hian hun rei tak chhunga nghawng a neihte chu engte nge ni?

Bile acid malabsorption nasa tak a awm chuan hun kal zelah bile acid tlakchhamna a lo awm thei a ni.Hei hi a thleng thei a ni. Chu chu, bile acid tam lutuk chu stool-ah a chhuak a, liver-ah recycle leh a nih loh chuan liver hian bile acid siam turin bile acid a nei tlem hle tihna a ni. Small intestine-ah bile a tlem chuan i chaw ei leh ei leh in a nghawng a ni.

Small intestine-a bile acids tlakchhamna hian thau leh thau-a inthiar theih vitamin (A, D, E, leh K) te hi a lakluhna a ti tlem a ni. Hei hian malnutrition leh fat-soluble vitamin tlakchhamna nena inzawm harsatna bik a thlen thei a ni. Entirnan, vitamin D tlakchhamna hian ruh a nghawng a, vitamin A tlakchhamna hian mit a tichhe bawk.

A bik takin Type 1 BAM vei te pawhin vitamin B12 tlakchhamna an nei thei bawk . Hei hi a chhan chu vitamin B12 hi ileum kaltlangin a hip lut a ni. Hetiang a nih chuan a tlakchhamna hi BAM ngei vang ni lovin, Type 1 BAM thlentu dinhmun - chu chu ileum hnathawh that loh vang a ni. Hei hi natna lan chhuahna, luak chhuak, leh hahna te hian a zui thei bawk.

Bile acid tlakchhamna i neih chuan thau hipna a ti tlem a, calorie i hal tlem thei lo a nih chuan i thau a tlahniam thei a ni. Mahse, a then phei chuan bile acid absorption tha lo hian taksa rihna a tipung thei a ni. Hei hi metabolism nen a inzawm niin a lang. BAM emaw, a thlentu dinhmunte hian i taksain calorie a hman dan leh thau anga a dahkhawm dan a nghawng thei a ni.

He natna hi engtin nge an hriat chhuah?

Tuna damdawi lam kaihhruaina chuan a chhan chiang tak nei lo, ril\am reng reng nei apiang chu bile acid malabsorption test tur a ni. Mahse heng test te hi hmun tinah a awm lo. Doctor thenkhat chuan hei hi an enfiah ang a, bile acid sequestrants an tih damdawi an pe ang a, chu chuan hahdamna a pe em tih an en ang.

Bile acid malabsorption hriat theihna tur test engemaw zat a awm a:

• SeHCAT test: Hei hi BAM hriat theihna atana test tha ber nia ngaih a ni a, mahse ram tam tak, Sri Lanka telin hetiang ti thei tur hian facility an nei lo. Hei hi nuclear medicine imaging test a ni a . Chu chu taksaah radioactive substance dose hniam tak inject a ni a, computer-in taksa chhunga a kal dan a enfiah a, thlalak a la thin tihna a ni. He test-ah hian he radioactive substance nen hian SeHCAT an tih synthetic bile acid awmna capsule i ei a ni. He capsule hi small intestine ah a kal a, i taksaa bile acids te hian a rang thei ang bera a hip lut thin. Gamma camera hian i taksaa SeHCAT level chu ni hmasa berah leh ni sarih hnuah a teh thin. Ni sarih hnuah pawh SeHCAT 85% aia tlem a la awm chuan BAM a nei tih hriat theih a ni.

• Serum C4 test a nih chuan:Hei hi thisen test a ni. SeHCAT test hnuah chuan a tha ber dawttuah ngaih a ni. Thisen chhunga enzyme pakhat C4 an tih level a teh thin. C4 level hi i liver-in bile acid a siam chhuah zat nen a inzawm a ni. I C4 level a san chuan primary BAM (type 2 leh 4) i nei tih hriattirna tha tak a ni. Secondary BAM (type 1 leh 3) nei te tan pawh C4 level a sang thei a, chu chu liver hian bile acid tam zawk a siam tan a, chu chuan absorption tlahniam chu a khum thei a ni. Chuvangin he test hi mi tam tak tan a tangkai hle. Mahse, natna thenkhat nei te tan pawh result dik lo a pe thei a, chu chu cholesterol sang leh metabolic non-alcoholic fatty liver disease te hi a ni .

• Fecal Bile Acid Test (Fecal BA test): Hei hian i ek chhunga bile acid awm zat a teh thin. Hei hi bile acid malabsorption tehna kawng dik ber a ni. Mahse, technically chuan a buaithlak deuh a, health center thlan bikteah chauh tih theih a ni. He test hi inbuatsaihna bik a ngai a ni. A hmain ni engemaw zat chu special diet i zawm a ngai ang a, chutah chuan darkar 48 chhung chu stool sample i la ang. Specialist te chuan i bawlhhlawh chu bile acids a awm leh awm loh lab-ah an test ang. I bile acid level a san chuan bile acid tam lutuk chu small intestine-ah a lut a, large intestine-ah a lut a, bile acid diarrhea a thlen tihna a ni.

Enkawlna tha ber berte chu engte nge ni?

Bile acid malabsorption enkawlna hmasa ber chu damdawi chi khat , bile acid sequestrants emaw bile acid binders emaw an tih a ni. Cholestyramine leh colestipol te hi an ei tam ber a ni. Colesevelam hi unlicenced option a ni a, mahse mi thenkhat chuan hman a awlsam zawk.

Heng bile acid sequestrants te hi positive charged particle an ni a, intestine chhunga negative charged bile acids te nen an inzawm a, chu chuan a tenau zawka a inthen darh a, chu chu a hip lut thei lo. He binding hian bile acids te hian intestine lianah hna an thawk a, diarrhea a thlen loh nan a veng bawk. Hei hian BAM symptoms a tihziaawm theih nan a pui a ni.

Enkawlna hian side effect a nei em?

Heng damdawi te hi powder angin a awm tlangpui. Liquid nen chawhpawlh a, lak a ngai a ni. Mi thenkhat chuan a thlum leh a texture chu ei harsa an ti. Midangte chuan BAM symptoms bakah side effect nuam lo tak tak an nei bawk. Chûng zîngah chuan chaw ei kham , luak chhuak, puak chhuak, leh gas te pawh a tel.

Tin, bile acid sequestrants te hian small intestine a fat-soluble vitamin te nen an inzawm thei bawk. Hei hian small intestine-in a hip lut thei lo thei a ni. Mi thenkhat bile acid sequestrant ei thinte chuan vitamin supplement an ei a ngai mai thei. Tin, chaw ei kawng (digestive system) kal pelh thei zawnga ei a ngai thei bawk a, chu chu injection hmanga ei a ngai thei bawk .

He natna hi a dam kim thei ang em?

Bile acid malabsorption hi tihdam theih a nih leh nih loh chu a chhan a zirin a ni. A chhan thenkhat chu tihdam theih a ni a, thenkhat erawh chu tihdam theih a ni lo. A chhan bulpui ber chu direct-a enkawl a nih chuan a châng chuan BAM dinhmun hi a ṭha chho thei bawk. Thil dangah chuan a chhan chu tihdam theih a ni lo a nih pawhin a natna lan chhuah dan chu hlawhtling taka enkawl theih a nih theihna chance tha tak a awm.

Pawimawh: Hlauthawng suh! BAM hi enkawl theih a ni. A pawimawh ber chu doctor thupek zawm hi a ni.

Eng thilin nge symptoms a ti na zual?

Bile acid cycle hi i ei leh in a thau awm zat atanga lo chhuak a ni. Small intestine-ah thau a tam lutuk chuan liver hian chemical signal a dawng a, chu chuan "bile tam zawk thawn rawh" a ti a ni. Bile tam zawk tih awmzia chu bile acid tam zawk chu intestine lianah a lut tihna a ni. Chuvangin doctor-te chuan BAM enkawlna atana pui turin thau tlem ei tur an rawt a ni.

Engtikah nge doctor i hmuh ang?

A chhan hriat loha persistent diarrhea i neih chuan i doctor hnenah bile acid malabsorption chungchang zawt rawh. Hei hi hriat chian loh leh hriat chian loh a nih avangin doctor zawng zawngin an ngaihtuah nghal vek dawn lo. Chuvangin i doctor hnenah test turin hrilh la, a nih loh leh a hre chiangtu specialist hnenah refer rawh.

Mi tam tak chuan kum tam tak chhung chu an ril\amna chhan dik tak leh enkawlna \ha tak zawngin kum tam tak an hmang \hin. Bile acid malabsorption nei tan chuan chu ni chu a tawp mai dawn tih beiseina a awm. Condition hriat chian zawk leh hriat awlsam zawk a nih chuan diagnosis a tha zawk ang.

Bile acid malabsorption thlentu tam tak awm mahse, a enkawl dan chu a awm zawng zawngah a inang vek a ni. Doctor chuan BAM a rinhlelh chuan enkawlna a pe thei a, chu chu a finfiah theihna tur atan pawh a ni mai thei. BAM vei tam tak chuan bile acid sequestrants leh ei leh in thlak danglam hmangin an natna lan chhuah dan chu hlawhtling takin an enkawl thei a ni.

Hriat reng tur pawimawh ber berte (Take-Home Message) .

Okay, chuvangin vawiin a kan sawi tawh kha han khaikhawm ila:

• Bile acid malabsorption (BAM) hi ril\am natna thlentu lian ber a ni thei.
• Hei hi a chhan chu bile acids hi intestine-in a hip lut tha lo va, intestine lianah a pung khawm a, tui ang maia riltam a thlen thin vang a ni.
• Damdawi lam thil chi hrang hrang, surgery leh damdawi thenkhat te hian hetiang hi a thlen thei a ni.
• A lan chhuah dan chu luak chhuak fo, pum na, leh pum na a ni thei.
• He natna hi SeHCAT test, serum C4 test, leh fecal bile acid test te ang chi test hmangin hriat theih a ni .
• Enkawlna ber chu bile acid sequestrants an tih damdawi leh thau tlem ei hi a ni .
• A chhan azirin a dam kim thei a, a dam lo thei bawk a, mahse a natna lan chhuah dan erawh chu uluk taka thunun theih a ni.
• I riltam reng reng, sawifiah theih loh i neih chuan doctor thurawn la ngei ang che.Tin, BAM chungchang pawh zawt bawk ang che.

Ngaihtuah buai suh, he natna hi i hrethiam a, uluk taka i enkawl chuan nang pawhin hahdamna i hmu thei ang. Hrisel takin awm rawh!

` Bile acids, ril\am, intestine, absorption, liver, symptoms, enkawl dan