Castleman Disease hi eng nge ni? A awlsam zawngin sawi ila!

I kawr emaw, i kawrfual emaw-ah heng bump te te hi i nei tih i hre tawh em? A châng chuan khawsik emaw, flu emaw i neih hian a thleng ṭhin. Mahse, hei hi chutiang thil awlsam tak chungchang a ni lo. Hei hi thil awm lo mahse hriat tur pawimawh tak a ni. Castleman Disease kan ti a .

A awlsam zawngin sawi ila, Castleman Disease hi kan taksa immune system a overactive tihna a ni . Ngaihtuah teh, natna thlentu hrik kan taksaah a luh chuan kan taksa hriselna (immune system) chuan sipai indonaa kal ang maiin a do a. Natna a dam chuan chu sipai chu a ngawi leh ta a. Mahse Castleman Disease vei tan chuan he immune system hi ‘on’ reng a ni. Hei hian taksa chhungah hun rei tak chhung inflammation a siam a, chu chuan kan taksa peng hrang hrang a tichhe thei a ni.

Hetih lai hian kan lymph node te – chu bump te te chu kan tih ang chi te hi a ni – chu filter ang maiin an che thin. Germ leh immune cell zawng zawng chu an filter vek a ni. Chuvangin, immune system hian hna a thawk reng avangin heng lymph node te pawh hian overtime hna an thawk bawk. Tichuan an chhunga cell te chu an lo thang lian lutuk a, lymph node te chu a lo hring chhuak ta a ni. He swelling chauh ni lovin Castleman Disease-ah pawh heng lymph node tissue-ah hian inthlak danglamna a awm hial a ni.

Hei hi natna hmuh tur awm lo tak a ni . Entîr nân, United States-ah chuan kum tin hri kai thar 4,300 aṭanga 5,200 chauh hmuh chhuah a ni. Chuvangin doctor-te chuan he thil hi an la zir nasa hle a ni. Mahse, he natna hi i vei tih hmuhchhuah a nih chuan i tan bik enkawlna bik i dawng ang.

Castleman Disease chi hrang hrangte chu engte nge ni?

He natna hi chi hnih a awm a.

Unicentric Castleman natna (UCD) natna a ni.

Unicentric Castleman disease (UCD) chu i taksa hmun khata lymph node pakhat emaw, tlemte emaw chauh a lo lian a ni . I kawr chauh ngaihtuah la, a nih loh leh i armpit chauh ngaihtuah rawh. Castleman damlo hmun li a\anga hmun thum vel chu he category-ah hian an tel a ni.

Multicentric Castleman natna (MCD) natna a ni.

Multicentric Castleman disease (MCD) hi taksa hmun khat chauh ni lovin, taksa hmun hrang hrangah lymph node a lo hring chhuak thin a ni. A dik zawka sawi chuan doctor-te chuan he MCD chi hi hetiang hian an then belh leh a:

• POEMS-associated MCD: POEMS hi thisen lama harsatna awm lo tak a ni. A chang chuan MCD nen hian POEMS hi a awm thei bawk.
• HHV-8-associated MCD: Hetiang chi hi Human Herpes Virus-8 (HHV-8) tih virus kai avanga lo awm a ni. HIV hrik i vei emaw, immunocompromised i nih chuan he MCD chi hi i vei theihna a sang zawk.
• A chhan hriat loh MCD (Idiopathic MCD - iMCD):Hei hi MCD chi hrang hrang zingah chuan a tam ber a ni. ‘Idiopathic’ tih awmzia chu a chhan dik tak hriat loh a ni.

Tunah chuan he chhan hriat loh iMCD hian sub-part pathum a nei bawk a:

• TAFRO syndrome nena inzawm iMCD: A châng chuan iMCD hi TAFRO syndrome tih hming puin a zui thei bawk. TAFRO tih hming hi a natna lan chhuah dan hawrawp hmasa ber atanga lak a ni. Chungte chu: Thrombocytopenia (thisen platelet hniam), Anasarca (tui hmanga taksa hring), Fever , Renal (kidney) dysfunction, leh Organomegaly (thin emaw liver emaw tihzauh) te an ni.
• iMCD with Idiopathic Plasmacytic Lymphadenopathy (iMCD-IPL): He subtype-ah hian platelet a sang thei. I thisen var (white blood cells) hian antibody tam lutuk a siam thei bawk.
• iMCD not otherwise specified (iMCD-NOS): Hetiang chi, iMCD-NOS an tih hi a chhan dik tak pawh hriat a ni lo va, TAFRO nen pawh a inzawm lo.

Castleman Disease natna lan chhuah dan chu engte nge ni?

Castleman natna lan chhuah dan hi i neih chi hrang hrang a zirin a inang lo. A tam zawkah chuan unicentric Castleman disease (UCD) i neih chuan symptom lian tham i nei lo mai thei. Lymph node hring (swollen lymph nodes) hi i hriat theih awmchhun a ni mai thei. Mahse, a châng chuan lymph node hring chuan a bula taksa peng dang a press chuan symptoms a awm thei.

Mahse, MCD i neih chuan a symptoms a lang chiang zawk. Lymph node hring (ssllen lymph nodes) bakah hian a lan chhuah dan te pawh i hmu thei bawk:

• Khawsik
• Chauhna (hei hi thisen tlakchhamna chhinchhiahna a ni thei) .
• Zanah thawk hah
• Nausea leh luak chhuak
• Chhan awm lovin taksa rihna tihtlem
• I ke, i ke ruh emaw, i pum emaw a hring
• Spleen lian (splenomegaly) emaw, thin lian (hepatomegaly) emaw .
• Kut leh kea natna (peripheral neuropathy) .

Castleman Disease hi eng thilin nge a thlen?

Unicentric Castleman disease (UCD) awm chhan dik tak hi hriat chian a la ni lo a, mahse HHV-8 an tih virus kai hi multicentric Castleman disease (MCD) lo awm chhan nia hriat a ni .

Scientist-te chuan UCD leh iMCD thlentu dang awm thei te chu an la chhui mek a ni. Entirnan, HHV-8 tih loh natna dang, gene mutations , leh autoimmune response te an enfiah a ni.

He natna vei theihna hlauhawm ber chu tute nge ni?

UCD emaw iMCD emaw vei theihna tur risk factor bik erawh hriat a la ni lo. Mahse, HIV hrik kai emaw, i taksa hriselna tichak lo thei natna dang emaw i neih chuan HHV-8-associated MCD vei theihna a sang zawk a ni.

Castleman natna hi kum eng pawhah a awm thei a, mahse kum 30 leh 60 inkar zingah a awm tam ber .

Castleman Disease avanga harsatna awm thei te chu engte nge ni?

Castleman natna hian cancer vei theihna a tipung a, a bik takin lymphoma .

Tin, a tlem hle nachungin, UCD vei te hi natna khirh tak Paraneoplastic Pemphigus (PNP) tih hi an vei thei a ni. MCD hian i taksa peng hrang hrang tichhe thei natna hrik i vei theihna a tipung bawk. He chhiatna hi uluk taka enkawl a nih loh chuan nunna atana hlauhawm tak a ni thei.

Lungngai suh, i doctor chuan i dinhmun chu a enfiah reng ang a, a theih phawt chuan chutiang harsatna lo thleng tur venna atan a pui ang che.

Doctor-te hian engtin nge Castleman Disease hi an hriat theih?

Castleman Disease natna lan chhuah dan hi natna tlanglawn dang, flu emaw, khawsik emaw ang chi te nen a inang thei a ni. Chuvangin i doctor chuan chutiang dinhmun chu a paih chhuak hmasa ang. Tichuan, Castleman Disease hmuhchhuah nan test an nei ang a, a chi chu an hre thei ang.

Test leh kalphung hrang hrangah hian:

• Lab test: I doctor chuan i thisen cell count chu a dik lo leh Castleman natna microscopic sign dang a awm leh awm loh a enfiah ang. HIV test pawh an order thei bawk . HHV-8 kaihhnawih MCD i neih chuan i HIV test chu a positive thei a ni.
• Imaging test: CT scan leh PET scan ang chi test hian i taksaa lymph node hring (swelled lymph nodes) te chu a hmuchhuak thei a, chubakah Castleman natna chhinchhiahna dang, liver emaw spleen lian emaw te pawh a enfiah thei bawk.
• Lymph node biopsy: Castleman natna i vei leh neih loh hriat chian theihna awmchhun chu biopsy neih hi a ni. Hei hian lymph node atanga tissue te tak te lak a, microscope hmanga enfiah a huam a ni. Hei hian natna chhinchhiahna a awm leh awm loh a hril ang.

Castleman Disease hi engtin nge enkawl a nih?

Castleman natna enkawl dan hi i neih chi hrang hrang a zirin a inang lo.

Unicentric Castleman Disease (UCD) enkawl dan tur a ni.

UCD enkawlna ber chu lymph node natna vei te chu surgery hmanga lakchhuah a ni . A châng chuan operation hmain radiation therapy emaw immunotherapy emaw i mamawh thei bawk. Heng enkawlnate hian lymph node-a lo thang lian te chu a ti tlem a, chu chuan lakchhuah a awlsam phah hle.

Mahse surgeon-te’n lymph node a nghawng chu an la chhuak thei lo a, symptom i neih loh chuan i doctor-in a enkawl ai chuan a enkawl mai thei. Symptoms i neih a, operation i tih theih loh chuan MCD enkawlna tur an rawt mai thei.

Multicentric Castleman natna (MCD) enkawl dan tur .

MCD hi UCD aiin enkawl a harsa deuh. Taksa pumpuiah a darh avangin surgery emaw radiation therapy emaw hi hman a ni lo. Chu ai chuan enkawlna chu HHV-8 infection i neih leh neih loh leh natna a nasat danah a innghat zawk a ni.

I doctor chuan enkawlna hrang hrang a hmang thei a, chungte chu:

• Corticosteroids: Heng damdawi te hian inflammation a tihziaawm bakah symptoms atanga relief a pe bawk.
• Chemotherapy damdawi: Chemotherapy damdawi hian i lymphatic system-a cell lian lutuk chu a control a. Rituximab hi HHV-8-associated MCD damdawi atana hman tlanglawn tak a ni.
• Immunotherapy: He enkawlnaah hian monoclonal antibodies ang chi thil hman a ni . Hengte hian i taksa immune response a ti reh thei a ni. Siltuximab (Sylvant®) hi U.S. Food and Drug Administration (FDA)-in iMCD enkawlna atana a pawmpui awmchhun a ni.
• Antiviral drugs: HHV-8 kaihhnawih MCD i neih chuan HIV emaw HHV-8 infection enkawlna atan antiviral drugs i mamawh mai thei.

Engtikah nge Doctor ka hmuh ang?

I kawr, i kawrfual, a nih loh leh i kawrfual-ah hnim hring emaw, a lo thang lian emaw i hmuh chuan doctor pan nghal rawh . Tin, a chunga kan sawi tak Castleman Disease symptom dang kar tlemte hnua a lo tha lo i neih chuan i doctor hnenah pawh hrilh bawk ang che.

He natna hi eng chen nge i dam theih ang?

UCD vei tam zawk tan chuan prognosis, a nih loh leh outlook hi a tha hle. Lymph node natna vei te lakchhuah hian natna a tidam thei a ni. Enkawlna nen chuan UCD hian dam rei zawng a nghawng lo tlangpui.

Mahse MCD vei te hmalam hun chu MCD an neih chi leh natna nasat danah a innghat a ni. Mi thenkhat tan chuan symptoms hi a lo lang nghal thei a, nunna atana hlauhawm tak a ni thei bawk. Midang tan chuan symptoms hi rei tak a awm thei. MCD vei hmuhchhuah zinga 65% leh 75% inkar chu kum nga hnuah pawh an la dam . Enkawlna thar a awm chuan he dinhmun hi a ṭhat lehzual theih beisei a ni.

Castleman natna chungchangah hian chhanna awlsam a awm lo. I thil tawn chu Castleman natna i neih chi hrang hrangah a innghat ang. Condition dang, HIV ang chi emaw, a kaihhnawih condition, TAFRO leh POEMS te pawhin i thil tawn a nghawng thei bawk. Ṭhenkhatah chuan operation leh ngun taka enfiah a ngai mai thei. A nih loh leh, harsatna i tawh loh nan i dam chhung zawngin enkawlna chi hrang hrang i mamawh thei bawk. I doctor hnenah i diagnosis hian i enkawlna leh i outlook a nghawng dan tur zawt rawh.

Chuti a nih chuan, he thil atang hian eng thil nge kan hriat reng tur pawimawh ber?

• Castleman Disease hi a awm lo hle a, mahse a na thei hle a, kan immune system chu a overactive lutuk a ni.
• A chi hnih a awm a, chungte chu UCD leh MCD te an ni. UCD-ah chuan lymph node te chu hmun khatah a hring a, MCD-ah erawh chuan hmun hrang hrangah a hring chhuak thung.
• Symptoms a inang lo. A châng chuan a lan chhuahna a awm lo thei a, a hring hring mai mai a ni. A nih loh leh, khawsik, hahna, leh taksa rihna tlahniam ang chi symptoms a awm thei bawk.
• A chhan hi engtik lai pawhin a chiang lo a, mahse HHV-8 virus hi MCD nen a inzawm tih hriat a ni. HIV vei te hi an hlauhawmna a sang zawk.
• Hriat hmasak leh enkawl dan dik chuan rah tha tak a chhuah thei fo thin. Chuvangin i taksaah hian lump, swelling, a nih loh leh symptom danglam tak tak i hmuh chuan doctor thurawn zawng nghal rawh. A pawimawh ber chu hriat reng a, hlauhthawn loh hi a ni.

` Castleman natna, Lymph Nodes, Lymphadenopathy, Immune System, UCD, MCD, HHV-8, A lan chhuah dan, Enkawl dan