Natna mak tak maiin thluak a khawih tih i hre tawh em? Creutzfeldt-Jakob Disease (CJD) chungchang hi i zir chiang ang u.

He natna hming i hriat khan, "He natna mak tak hi eng nge ni?" Creutzfeldt-Jakob natna, a nih loh leh CJD (Creutzfeldt-Jakob Disease) kan tih ang chi hi a awm lo hle a, mahse a na hle a, kan thluak hnathawh a tichhe thei a ni A awlsam zawngin sawi ila, thil thleng chu kan thluak cell te hi zawi zawiin a chhe vek a ni. Hei hian hriatrengna hloh, buaina, chubakah nungchang inthlak danglamna leh kal harsatna te a thlen thei a ni.

CJD natna lan chhuah dante chu engte nge ni?

He natna lan chhuah dan hi vawi khatah a lang vek lo. Zawi zawiin an lo thang chho zel a. Tlemte atanga tan a, hun kal zelah a na zual thei bawk. A lan chhuahna bulpui ber berte chu i en ang u, a hmasa ber atanga a na ber thlengin:

• Theihnghilh leh hriatrengna lama harsatna: Thil tenau te theihnghilh atanga tan a ni. I chabi awmna hmun, mi hming ang chi thil. Mahse hei hi theihnghilh pangngai mai ni lovin tlem a ni.
• Buaina leh ngaihtuahna buai: I awmna hmun leh engtik lai nge tih ang chi thil hriat reng harsa. Hmun hriat lar takah pawh kawng zawn harsa.
• Nungchang leh mize inthlâk danglamna: A hma ang bawka awm lo, nungchang chhuak lo, thil mak tak taka thinrim, a nih loh leh rang taka ngawi renga awm. Khawtlang atanga inhnukdawk tum.
• Mit lama harsatna leh i thil hmuh hriatthiam harsa: A chang chuan a let hnih i hmu a, a nih loh leh i thil hmuh chu i chhui chhuak thei lo.
• Hallucinations emaw delusions emaw: Thil awm lo hmuh emaw hriat emaw, midangte’n an tihnat tum che tih rinna dik lo neih emaw.
• Balance hloh leh coordination lama harsatna (ataxia): Kal lai, tlu leh tlu laia thunun theih loh anga inhriatna. Limbs control harsat.
• Muscle twitching (myoclonus) leh muscle stiffness (dystonia) thunun loh: Taksa chhunga muscle te chu a rawn inher nghal vat a, ke ruhte chu a khur nghal vek. A châng chuan taksa ruhte chu a nghet a, a danglamin a inher chhuak ṭhin.
• Seizures: Fit ang maiin a lo thleng thei.
• Paralysis: Hun kal zelah taksa peng thenkhat chu a paralyze thei a.
• Muscle atrophy: Muscle atrophy a, taksa a thim thin.

Heng symptoms te hi mi zawng zawng tan hian kawng inang emaw, speed inang emaw a lo thleng lo a, mahse nangmah emaw, i hriat miin emaw heng symptoms zinga pakhat tal i neih chuan a rang thei ang bera doctor pan a tha ber.

Engvangin nge CJD hi a lo awm? Eng thilin nge a thlen?

Hei hi hriatthiam harsa deuhin a lang thei a, mahse awlsam takin ka sawifiah ang. Kan taksa hian protein chi khat protein an tih chu a nei a . Chûngte chu machine tê tê, pakhat hnu pakhata an hna thawk ang mai an ni. Heng protein te hian hna an thawh that theih nan chuan an "fold" a ngai a, an pianzia bik ah an "fold" a ngai a ni. Origami hnah ang maiin han ngaihtuah teh, i fold dik chuan a pianzia mawi tak i hmu a ni.

Chuvangin, a chang chuan heng protein te hi an fold dik lo thin. Protein fold dik lo chu kan thluak cell te hian an hmang thei lo. CJD hi chutiang protein fold dik lo, pangngai lo zinga pakhat vang a ni. Chungte chu "prion" an ti a.

Heng prion protein te hi thluak cell chhungah an awm khawm tan a. Cell-te hian an paih chhuah theih loh avangin zawi zawiin cell-te chu an tichhia a, a tawpah chuan an thi ta a ni. A hlauhawm ber chu heng prions te hian protein pangngai te pawh an misfold thei a, prion ah an chantir thei bawk. Natna hrik kai ang maiin heng prions te hi an pung a, thluak zawng zawngah an darh zau zel a ni. Hei vang hian natna hi a na zual nghal vat thin.

Ngaihtuah teh, he prion hian apple ro tak ang maiin a che a, chu chuan apple tha dang zawng zawng a tichhe vek a ni.

CJD chi hrang hrang a awm em?

Ni e, CJD hi chi hrang hrang lian tak tak a awm. Chungte chu an lo thanlen dan azirin an thliar hrang a ni.

1. Sporadic CJD: Hei hi a tam ber chi a ni. A lo thanglian nghal a, a chhan bik nei lovin. A chhan dik tak erawh hriat a la ni lo.

2. Genetic CJD: Hei hi nu leh pa pakhat emaw, nu leh pa pahnih emaw atanga gene pangngai lo rochun a nih chuan a thleng thin. Hei hi chi hnih a awm a, chungte chu Gerstmann-Sträussler-Scheinker (GSS) syndrome leh Fatal Familial Insomnia . Hengte hi a tlem hle.

3. Acquired CJD: Hei hi pawn lam thil avanga lo awm a ni. Entirnan, organ transplant , tissue transplant , a nih loh leh surgery hmanrua sterilized tha lo hman a nih vang a ni thei. Mahse, tunlai hian hengte hi a tlem hle a, a chhan chu medical technology a lo thang chak em em a ni.

4. Variant CJD (vCJD): Hei hi natna "Mad Cow Disease" emaw Bovine Spongiform Encephalopathy (BSE) emaw nen a inzawm tih i hre tawh mai thei. BSE vei bawng sa ei hian vCJD i nei thei. BSE thlentu prion hi mihringah pawh kai theih a ni. Amaherawhchu tunah chuan khawvelah hei hi a tlem hle a, ran vulh kawngah himna tur ruahmanna an siam vang a ni.

Tute nge CJD vei tam ber? Hri kai theih a ni em?

Dik tak chuan tu pawhin CJD an nei thei. A châng chuan i taksaah kum tam tak chhung chu prion hi i nei thei a, natna lan chhuahna engmah a awm lo. Mahse, symptoms a lan chhuah chuan thluak a chhiat avangin natna chu a na nghal thei a ni.

He natna hian kum 50 leh 80 inkar te a vei tlangpui a, mahse, CJD hi kum 30 leh 50 inkar te zingah hian genetic forms hi hmuh tur a awm fo thin.

Tunah chuan hei hi natna hrik kai theih a ni em tih i ngaihtuah mai thei . CJD vei chu mi pakhat atanga mi dang hnenah casual contact, thawk hah, ei tur insem hmanga kai theih a ni lo. Thil ngaihtuah tur a awm lo. CJD vei theihna awmchhun chu a hmaa kan sawi tawh ang khan CJD vei atanga taksa peng emaw tissue emaw transplant emaw, CJD vei atanga hormone thenkhat injection emaw a ni.

Variant CJD (vCJD) hi thisen pek hmanga kai theih a ni tih hmuhchhuah a ni a , mahse chu pawh chu a tlem hle. Khawvel pumah vCJD chi hi a tlem hle bawk.

Engtin nge doctor-te hian CJD hi dik taka an hriat theih?

CJD symptoms nei nia i inhriat chuan doctor-in a tih hmasak ber tur chu i symptoms te ngun taka ngaithla a, physical leh neurological exam tih hi a ni. A châng chuan i thluak hnathawh dân an hriat theih nân thil tê tê tih tûrin an ti ang che.

CJD hi natna chi hrang hrang Transmissible Spongiform Encephalopathy tih zingah a tel a ni . He hming hi prions-in a tihchhiat thluak chu microscope hmanga en chuan sponge, zungbun nei ang maia lang a nih vang a ni.

Doctor-te chuan CJD finfiah nan test eng emaw zat an kalpui leh mek a ni.

• MRI (Magnetic Resonance Imaging) scan: Hei hian thluak chipchiar taka thlalak a la a, thluaka thil dik lo awm leh awm loh a enfiah thin.
• Spinal tap emaw lumbar puncture: Hei hi ruh atanga tui sample lak a, prion proteins test a ni.
• EEG (Electroencephalogram) test: Hei hian thluaka electrical activity a teh a, thil awm dan pangngai lo a zawng thin. CJD-ah hian pattern bik hmuh tur a awm.

Chu bakah, CJD nena inmil symptom nei condition dang awm lo turin test dang neih belh theih a ni bawk.

• Thisen test a ni
• Genetic testing: Genetic CJD nia rinhlelh a nih chuan.
• Urinalysis tih a ni
• Brain biopsy: Hei hi tih a tlem hle a, test dang zawng zawngin a natna hmuhchhuah a nih loh chuan tih a ni a, a chhan chu surgical procedure tenau tak a nih vang a ni.

CJD enkawlna tur a awm em?

Vanduaithlak takin tunah hian CJD damdawi a la awm lo va, natna darh zel tur venna tur damdawi a awm lo va, a tikhawtlai thei tur damdawi pawh a la awm lo . Hei hi he natna avanga lungchhiatthlak ber a ni.

Mahse, natna lan chhuahna avanga harsatna awm thei tihziaawmna tur leh damlo tan hahdamna engemaw chen pek theih nan palliative care pek theih a ni. Entirnan, damdawi chu seizure control nan te, nungchang inthlak danglamna enkawl nan te, a nih loh leh control loh taksa ruh (muscle spasm) tihtlem nan te pek theih a ni. Mahse, heng enkawlnate hlawkna hi a tlem hle.

Hetiang dinhmun hi a na zual thuai thei a, chuvangin damlo leh chhungte tan chuan tanpuitu enkawlna dawn a pawimawh hle. Natna a tawp berah chuan hospice service hian damlo chu a rilru hahdam leh natna nei lo turin a pui thin.

A châng chuan, i tlin chuan i medical team pawhin clinical trial-ah tel ve turin an rawt thei bawk a, chu chuan enkawlna thar zir chianna a ni.

CJD i vei chuan eng nge i beisei theih ang?

CJD hi tihdam theih loh leh damdawi a neih loh avangin he natna hi beiseina a tlem hle. Symptoms a intan hnuah chuan hnathawh theihna te, kal theihna te, leh thusawi theihna te chu hun kal zelah a tlahniam zauh zauh thin.

Hrilhfiahna hi a thleng thuai thei a, chuvangin i healthcare team te nen thawhhona tha tak neiin i duh leh mamawh te sawiho a, thutlukna siam a pawimawh hle. Dik tak chuan, natna kan neih leh neih loh pawh ngaihtuah lovin, advance directive ang chi document neih hi kan zavaia tan chuan thil tha tak a ni . Chumi awmzia chu i ngaihtuahna i sawi chhuak thei lo a nih chuan eng damdawi lam enkawlna nge i duh leh i duh loh i ziak chhuak tawh tihna a ni. A bik takin CJD ang natna darh chak takah hian hetiang hi tih hmasak a pawimawh hle.

He natna hi a nasat em avangin, nang leh i hmangaih tak takte tan rilru lam hriselna lama mithiamte hnen atanga thurawn lak hi a \angkai hle thei a ni . Chûng inthlâk danglamnate nêna insiamrem leh i inrintawkna siam chu chakna ropui tak a ni thei a ni.

CJD vei dam rei zawng chu engzat nge ni ang?

CJD vei tam zawk hi an hmuhchhuah atanga thla engemaw zat emaw kum khat emaw chhungin an thi thin. A danglamna awm chhun chu genetic CJD , a ni a, chutah chuan miten an natna lan chhuah tirh atanga kum khat atanga kum sawm thleng an dam thei a ni.

I doctor chuan i dinhmun chungchangah thu chiang tak, tunlai tak tak a pe thei che a ni. Statistics hi generalization a ni tih hre reng la, mi tin hi kan danglam vek a ni.

CJD hi ven theih a ni em?

CJD chi tam tak hi ven theih a ni lo. A bik takin sporadic CJD, mahni chauha lo awm thin hian a veng thei lo.

A ven theih chi awmchhun chu variant CJD (vCJD) a ni. BSE ("mad cow disease") nei bawngsa ei avanga lo awm a ni a, ven theih a ni.

Ran test hian BSE hri kai bawngte chu food chain-ah an lut thei lo. Mahse, sa test loh leh siam dik loh chu hlauhawm tak a ni thei. Chuvangin, sa ei loh leh test loh sa ei loh hi a him ber a, a bik takin thluak leh ruhro ang chi parts nei ei loh hi a him ber .

A tawp berah chuan thil hriat reng tur

CJD hmuhchhuah hi nun tidanglam thei thil a ni thei. Nang leh i chhehvel khawvel chu mit khap kar lek chhungin i bo tawh ang maiin a lang thei. Chutiang inthlâk danglamna chu nang leh i hmangaihte tân chuan tuar harsa tak a ni thei a.

Hemi chungchangah hian engtin nge i ngaihtuah ang tih emaw, engtin nge i kalpui ang tih emaw i hriat chian loh chuan i medical team te chu tanpui turin an awm a ni. Anni hian ruahmanna siam lawk leh thil lo thleng tur atana inbuatsaih turin an pui thei che a ni. Nangmah chauh i ni lo tih hre reng mai rawh.

` Creutzfeldt-Jakob natna, CJD, Prion, Thluak natna, Thluak lam natna, Hriatrengna hloh, Dementia, BSE, Mad Cow Disease