I taksaah hian thil mak tak tak i tawng em? Multiple System Atrophy (MSA) chungchang hriat a pawimawh mai thei!

I taksaa thil awmte chu i thunun theih loh zawnga inthlak danglam angin i inhriat ngai em? A châng chuan i kal laiin i balance i hloh ang mai a ni a, a nih loh leh i ding chhuak thut chuan i lu a buai ang. Hengte hi a chang chuan kan ngaihven vak loh thil a ni a, mahse thluak lam natna hmuh tur awm lo thenkhat chhinchhiahna a ni thei bawk. Vawiin hian chutiang dinhmun pakhat, a buaithlak deuh a, mahse hriat a pawimawh hle. Chu chu Multiple System Atrophy (MSA) a ni.

Multiple System Atrophy (MSA) hi eng nge ni tak tak?

A awlsam zawngin sawi ila, Multiple System Atrophy (MSA) hi thluak lam natna hmuh tur awm lo tak a ni a, kan thluak hmun thenkhat chu a chak lo zauh zauh a, chu chu a chhe vek tihna a ni. Hun a kal zel a, heng thluak peng hrang hrangin kan taksa hnathawh leh theihnate chu a chhe tan ta a ni. Hei hi a takah chuan natna khirh deuh a ni a, a chhan chu a pum puia dam leh a harsat vang a ni.

Tun hma chuan MSA hi hming hrang hrangin an ko thin a. `Shy-Drager syndrome`, `Sporadic olivopontocerebellar atrophy`, `Striatonigral degeneration` tih ang chi hming i hre tawh mai thei. A hnuah chauh doctor-te chuan heng natna zawng zawng hian thil inang engemaw zat a nei tih an hre ta a ni. Chuvang chuan an vai hian an inzawm khawm a, hming thar `Multiple System Atrophy` (MSA) an vuah ta a ni. Thluak peng eng ber nge chhiat a zirin symptoms hi a inang lo. Chuvangin mi tin hian symptoms combination hrang hrang an nei thin.

MSA hi chi hnih a awm a ni lawm ni? Eng nge an nih?

Ni e, MSA dinhmun chiang zawka hriat theih nan doctor-te chuan chi hnihah an ṭhen a, chu chu a lan chhuah dan azirin a ni:

1. MSA-C : Heta 'C' hi `cerebellar' tihna a ni. Hetiang chi hian i chetna inrualrem theihna a nghawng ber a ni. Chu chu i balance i hloh tihna a ni , chu chu doctor-te pawhin `ataxia' an ti bawk. Hei hi he chi chhinchhiahna ber a ni. Chutih rual chuan taksaa automatic control system-a harsatna (`autonomic dysfunction`) leh tlu fo pawh i hmu thei bawk.

2. MSA-P : Heta ‘P’ hi `parkinsonism’ tihna a ni. Hetiang chiah hian Parkinson natna ang chi symptoms hmuh tur a awm. Heng Parkinson natna lan chhuah dan hi a tir lamah langsar zawk mah se, hun kal zelah autonomic nervous system-a harsatna leh `ataxia' chhinchhiahna te pawh a lo lang thei bawk.

He MSA dinhmun hian tute nge a nghawng ber? Engtiang chiahin nge a hluar?

MSA hian puitling kum 30 chunglam a vei tlangpui a, a lan chhuah dan hi kum 50 leh 59 inkar vel a ni tlangpui a, mipa leh hmeichhia pawh nise, tu pawh a nghawng thei.

Mahse MSA hi a awm lo hle a ni . Mithiamte chuan kum khatah mi 100,000-ah hri kai thar 0.6 emaw 0.7 emaw chauh an awm niin an sawi. Hri kai zawng zawng hi mi 100,000-ah 3.4 leh 4.9 inkar nia chhut a ni. Chuvangin hei hi a tlem zia chu i hmu thei ang.

MSA vei taksaah eng nge thleng? Thluak peng engte nge a nghawng?

MSA hi natna zual zel a ni a, thluak hmun hrang hrang a nghawng a ni. Symptoms hi thluak hmun a nghawng danah a innghat a ni. MSA natnain thluak a nghawngna hmunpui berte chu:

• Basal ganglia : Hengte hi thluak lai takah a awm a. Thluak peng hrang hrang an thlunzawm a, an thawhhonaah an pui bawk. Thluak control room lian ber ang mai a ni .
• Brainstem : Hei hi kan taksa chhunga automatic process tam tak control tu a ni. Chu chu kan ngaihtuah lova thil lo thleng nghal mai, entirnan thawk, heart rate, leh thisen sang te hi a ni. Chûngte chu dam khawchhuahna atân a pawimawh hle.
• Cerebellum : Hei hi lu hnung lamah, a bul lamah a awm a. Movement control leh balance vawng reng tura mawhphurtu ber a ni. Thluak peng dang nen pawh a thawk ho bawk. Zirchiangtute chuan a hnathawh dan kimchang chu an la zir zel a, mahse finfiahna thenkhat chuan kan rilru put hmang leh thutlukna siamnaah pawh a inrawlh tih a tilang.

Chuvangin, heng thluak peng hrang hrangte hi a chhiat chuan chu peng hrang hrangin a thunun hnathawh chu a thawk tha thei lo. Entirnan, `Brainstem` a chhiat chuan automatic thil, thisen sang ang chi thila harsatna a awm thei.

MSA natna lanchhuahna chu engte nge ni? Engtin nge kan hriat chian?

MSA symptom thenkhat chu chi hnih tan hian a awm ve ve a, thenkhat chu chi tin tan bik a ni. Mahse chi hnih zinga thil pakhat chu autonomic dysfunction hi a ni. A awlsam zawngin, i taksa automatic control system te chu a kal lo.

Autonomic nervous system-a harsatna awm avanga natna lan chhuah dan:

• Orthostatic hypotension : Hei hi i thisen sang a tlahniam nghal a, luak chhuak a ni , i position i thlak a, entirnan, thut atanga i ding nghal mai hian.
• Zun control theih lohna (`urinary incontinence`) leh ek control theih lohna (`fecal incontinence`).
• Sexual dysfunction, a bik takin mipaah ​​chuan erection neih harsatna (erectile dysfunction) a ni.
• Rapid eye movement (REM) sleep behavior disorder : Parkinson natna ang bawkin, mumang i neih hian i mumang a i thil tih kha i act tak tak a ni. I au chhuak thei a, i kut i phar thei bawk.
• Thawmhnaw a tlahniam (anhidrosis).
• Mit hmuhna lama harsatna a awm.
• Kawng a vawt.
• Mut theih lohna (sleep apnea) a awm.
• Slow digestion leh constipation te.

Heng autonomic symptoms tam tak hi motor symptoms a lo lan hma thla tam tak, kum tam tak pawh ni se, a lo lang thei tih hi han ngaihtuah teh. Hei hi MSA vei zinga 20% leh 75% inkarah a thleng thin.

Rilru leh rilru lam mizia

MSA vei hmun thuma ṭhena hmun khat vel chuan ngaihtuahna leh ngaihtuahna seng kawngah harsatna an tawk ṭhin. An rilru put hmang thunun harsa an ti bawk. Hei hian rilru lam harsatna a thlen thei a, chungte chu:

• Hlauhthawnna.
• Lungngaihna.
• Emotional instability: Chu chu tap leh nuihzat lohna a ni.
• Panic attack a awm thin.
• Mahni intihhlum emaw, intihhlum emaw ngaihtuahna.

Movement nena inzawm thil chi hrang hrang

MSA-C (cerebellar type) ziarang hrang hrang: 1.1.

Hetiang chi hi `ataxia` (balance hloh) a ni ber. `Cerebellum` hi thluak peng pakhat a ni a, chu chuan taksa peng hrang hrang (muscle movement) control-na kawngah hmun pawimawh tak a chang a ni. Chuvangin, chu inremna chu a bo chuan hetiang thil hi a thleng thei a ni:

• Thunun theih loh, taksa peng hrang hrangte chetna buaithlak tak .
• Action tremor : Chumi awmzia chu thil tih i tum hian i ke ruh chhunga khur a tipung tihna a ni.
• Ke zau tak tak hmanga kal .
• Mit tiharh theih loh (nystagmus).

MSA-P (Parkinsonism type) ziarang hrang hrang: 1.1.

Hetiang symptom hi taksa sir khatah a intan fo a, chumi hnuah a sir lehlamah a darh leh fo thin. Heng symptoms te hi hetiang hian a lang tlangpui:

• Slow movements (bradykinesia), taksa chu nunna nei lo ang maia inhriatna .
• Taksaah a nghet lo leh a nghet lo tih hriatna, chu chuan hmalam pan ang maia posture a siam thin.
• Kal laiin tlu fo thin .
• Thusawi laiin ṭawngkam chhuak, thusawi chiang lo .

Engvangin nge he MSA hi a lo awm? Eng nge a chhan?

MSA hi a chhan dik tak hi hriat a la ni lo , mahse mithiamte chuan kan thluak hmun hrang hranga awmkhawm thei protein `alpha-synuclein` nen a inzawm niin an ring. He protein tho hi Parkinson natna thlentu lian ber nia rinhlelh a ni bawk.

Protein hi kan taksa hnathawhna atana chemical pawimawh tak a ni. Thil tam takah an pui a, taksa chhunga system hrang hrang inkara inbiakpawhna leh chemical compound te phurh kual vel te hi a ni. Mahse, heng proteins te hi hmun dik lovah an pungkhawm chuan chhiatna a thlen thei a ni. Mithiamte chuan he chhiatna hi MSA-a thluak tissue te zawi zawiin a thih tir thin niin an ngai.

Scientist te chuan he `alpha-synuclein` protein hi thluak hmun thenkhatah a awm khawm chhan hi an la zirchiang mek a ni. Tin, genetic mutation thenkhat hian cell thenkhatin he `alpha-synuclein` an hman dan hi a thlak danglam thei niin an ring bawk. MSA-C type hi chhungkaw hrang hrangah a kal tih finfiahna a awm bawk. Mahse, MSA-P type tan chuan chutiang genetic link chu hmuh a la ni lo.

A pawimawh ber chu MSA hi natna hrik kai theih a ni lo . Midang hnen atangin i man thei lo va, midang hnenah pawh i thehdarh thei hek lo.

Engtin nge MSA i nei tih chiang taka i hriat theih ang? Eng test nge tih thin?

MSA a awm tih100% a chiang thei tur awmchhun chu mi thih hnua thluak tissue enfiah hi a ni a, a chhan chu mi dam laiin thluak hmun thenkhatah `alpha-synuclein` a pungkhawm em tih dik taka hriat theih a awm lo.

Mi pakhat a dam lai hian doctor-te chuan MSA hi a natna lan chhuah dan, damdawi lam chanchin, chhungkaw chanchin leh enkawlna thenkhat an dawn leh dawn loh a zirin an ringhlel thin. Vawi tam tak chu, a hmuhchhuah hmasak ber chu Parkinson natna emaw, chutiang chi movement disorder dang emaw a ni a, a hnuah symptom thar a lo chhuah emaw, damdawi thenkhatin hna a thawh tawh loh emaw chuan MSA-ah an thlak leh thin.

MSA leh Parkinson natna thliar hrang thei thil pawimawh engemaw zat a awm a:

• MSA hi a kal chak hle : Parkinson natna vei tan chuan autonomic nervous system-a harsatna a awm theih nan kum tam tak a ngai a ni. Mahse MSA-ah chuan heng harsatnate hi kum khat chhungin a intan thei a ni.
• Symptom thenkhat chu a danglamin a lang : A bik takin autonomic nervous system symptoms hi MSA-ah hian a na zawk. Mahse, khur ang chi thil hi a na lo zawk thei a, a awm lo vek thei bawk. Taksa pum huapa symptoms darh dan pawh a inang lo thei bawk.
• Enkawlna a hlawhtling lo : Levodopa hi Parkinson natna damdawi ber a ni. Mahse, MSA-ah chuan levodopa hian a thawk tlem zawk. Hei hi doctor-te’n Parkinson’s ni lovin MSA a ni mai thei nia an ngaih chhan ber a ni fo.

Hemi atan hian eng test nge tih a nih?

MSA hriat theihna tura direct-a pui thei test hi a tlem hle. Test tam zawk hi natna dang a awm loh nan leh MSA a nih theih rinhlelhna thlawp turin evidence tam zawk lakkhawm nan an ti thin. Chung zinga ṭhenkhat chu:

• Magnetic resonance imaging (MRI) scan : Hei hian a chang chuan thluak hmun chhia a lantir thei. Hei hian diagnosis dik zawk siam turin a pui thei a ni. MSA-C hriatchhuahna atan pawh a tangkai hle a, thluak hmun khatah cross-striped pattern ("hot cross bun" sign) a lantir thei a ni. Amaherawhchu, he chhinchhiahna hi natna dangah pawh hmuh theih a ni a, chuvangin amah chauha MSA hriat chian a tawk lo.
• Genetic testing : Hei hian mi taksain alpha-synuclein a process dan tichhe thei genetic mutation a awm leh awm loh a enfiah thei a ni. Heng test te hian Japanese mite zingah MSA-C nena inzawm genetic mutations te chu a hriat theih zawk a ni.
• Skin biopsy : Skin biopsy chi thenkhatah chuan nerve tissue-a alpha-synuclein a punkhawmna chhinchhiahna a awm thei. Mahse, hei hi diagnostic process-a standard part ni thei tur khawpa tangkai a nih leh nih loh hriat chian nan zirchianna tam zawk neih a ngai a ni.

I doctor chuan test dang a remchan dan leh a puih theih dan tur a hrilh ang che. I tâna thu tlûkna ṭha ber siam tûrin i hrisêlna chanchin, chhûngkaw chanchin leh thil dangte an ngaihtuah ang.

MSA enkawl dan tur a awm em? Dam theih a ni em?

Tun thlengin MSA hi damdawi chiang tak hmuh a la ni lo.Chuvangin, enkawlna hian a bul berah chuan a natna lan chhuah dan chu a rei thei ang bera control a tum a ni. MSA symptoms enkawl dan hi thil tam takah a innghat a, damlo symptoms leh a nasat dan te pawh a innghat a ni.

Eng damdawi nge enkawl dan nge hman?

MSA natna lan chhuah dan tur control thei damdawi chi hrang hrang a awm a. Damdawi i dawn chi chu i natna lan chhuah dan leh thil dang dangah a innghat ang. I doctor hi i tan damdawi tha ber tur rawtna pe theitu tha ber a ni a, i dinhmun hrechiang ber an nih dawn avangin. Tin, enkawlna hrang hrangte hian a nghawng tha lo awm thei te pawh an hrilhfiah bawk ang che.

Pawimawh: MSA hi doctor trained, qualified-in a hriat theih chauh a ni. Chuvangin, Doctor biak lohvin nangmah ngeiin symptoms hriatchhuah emaw, enkawl emaw tum suh.

MSA lo thang zel tur ven dan a awm em?

Mithiamte chuan MSA hi eng nge a thlen tih leh eng thil nge a thlen tih an la hre lo. Chuvangin, tunah hian a ven theih dan leh a hlauhawmna tihtlem dan tur a awm lo .

MSA vei hian eng ang hmalam hun nge a beisei theih ang?

MSA vei te hian chetna nena inzawm symptoms an nei hmasa tlangpui. He dinhmun hi hun kal zelah a zual zauh zauh thin. Damlo zinga a chanve vel chuan he hun chhung hian kea kalna kawngah tanpuina an mamawh a ni. Hei hian cane emaw walker emaw hman tihna a ni. MSA a lo chhuah atanga kum nga vel hnuah damlo 60% velin wheelchair an hman a ngai a ni. Kum ruk atanga kum riat chhungin damlo zinga a chanve tal chu khumah an muhil thin.

Natna a lo zual zel chuan taksa hnathawh dan tur leh harsatna hlauhawm tak tak lo thleng tur venna atan tih dan dang emaw, hmalakna dang emaw a ngai thei a ni. Chung zinga ṭhenkhat chu:

• Thâwk lak chhunzawm zel nan tracheostomy tih a ni.
• Tube hmanga chaw pek (`Tube feeding` / `enteral nutrition`).
• Urinary incontinence atan indwelling catheter emaw urostomy emaw hmanga enkawl theih a ni.
• Bowel movement harsatna nei tan Colostomy tih a ni.

MSA hian eng chen nge a daih?

MSA hi dam chhung zawng, a awm reng tur a ni. He natna vei dam rei zawng hi kum ruk atanga kum sawm vel a ni . A na lo zawkah chuan kum 15 thleng a daih thei. Mahse, a na zawkah chuan dam rei zawng chu a tawi zawk thei hle. Heng natna khirh tak takte hi a tlangpuiin a hnuaia symptoms te hi a ni:

• Autonomic nervous system symptoms hi movement-related symptoms lo awm tan hmain a na zual thin.
• Diagnosis a nih laiin kum upa zawk.
• Tlu fo theihna tur movement symptoms neih.

He dinhmun chungchangah hian eng ngaihdan nge ni?

MSA hmalam hun hi a tha vak lo. Hetiang dinhmun chhinchhiahna hi a zual zauh zauh a, taksa hnathawh a tibuai fo a, thihna thlen thei harsatna a thlen fo bawk. Thihna thlen thei harsatna hrang hrangte chu:

• Pneumonia natna (Pneumonia) a ni.
• Urinary tract infection (UTI) hian sepsis (thisen rimchhia) a thlen thei a ni.
• Thihna thut (a tam zawk chu zanah, mut laiin thluak in thawk a thunun dan a tihbuai vang a ni).

Engtin nge keimah/ka hmangaih tak ka enkawl ang? Eng thil nge ka ngaihtuah tur?

MSA vei te hian symptoms progressive an nei thin. Chumi awmzia chu symptoms level engemaw chen a thlen chuan mahni inrintawkna nei lovin an nung thei tawh lo tihna a ni. Chu dinhmun chuan a tâwpah chuan nangmah ngeiin i ngaihtuah theihna, i thusawi theihna leh i thu tlûkna siam theihna a nghawng thei bawk. Chûng zawng zawng avângin, i hmangaih takte hnênah nakin hun tûra i duhzâwngte sawipui a pawimawh a, thu tlûkna i siam theih loh chuan i damdawi lam enkawlna tûr ruahmanna siam a pawimawh bawk

Engtikah nge Doctor i hmuh ang?

MSA natna lan chhuah hmasak ber tam tak hi doctor nena sawiho tur thil a ni. Chung zingah chuan:

• Mipat hmeichhiatna hmansualna.
• Orthostatic hypotension (a chhan hriat loha luak chhuak reng emaw, muhil emaw).
• Mut harsatna leh sleep apnea (mut laiin thawk hah).

Doctor-in Parkinson natna ang chi movement disorder i nei tih a hriat chuan i symptoms a inthlak danglam chuan sawipui a pawimawh hle. I doctor chuan i dinhmun enfiah tur leh i damdawi ei tur siamrem turin follow-up visit a ruahman ang. Heng tlawhnaah hian inthlak danglamna i hmuh apiang chu i sawi thei ang. Parkinson natna vei nia hriatte hian a hnuah an natna hmuhchhuah dan an thlak danglam fo thin a, chu chu natna lanchhuahna thar a lo chhuah hunah emaw, levodopa hian hna a thawh that loh hunah emaw pawh a ni thei.

MSA vei te hian symptom dang an nei fo thin a, a bik takin rilru lam harsatna an nei fo thin. MSA kaihhnawih rilru lam harsatna nei te, taksa lama natna lan chhuah dan te enkawlna zawn a pawimawh hle. I doctor chuan enkawlna a rawt thei che a, rilru lam hriselna lama mithiam hnenah a refer thei bawk che.

A tawi zawngin (Take-Home Message) .

Multiple System Atrophy (MSA) hi natna khirh tak a ni a, a tawpah chuan thihna thlen thei a ni. Vanduaithlak takin he natna hi direct-a tihdam leh enkawlna a la awm lo.

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Mahse, a symptom tam tak chu enkawl theih a ni , a nghawng leh a lan chhuah dan tih tlem theih dan a awm bawk. Enkawlna hmang hian mi tam tak chuan kum tam tak chhung an nunphung chu an vawng reng thei a, an hmangaih tak takte nen hun hlu tak an hmang thei a, an hun chu a hmang tangkai thei bawk. Chuvangin, damdawi lam thurawn mumal tak nena a natna lan chhuah dan enkawl a pawimawh a, lungngaihna thlen lovin.

`Multiple System Atrophy, MSA, Neurological Disease, Thluak Natna, Parkinson natna, Movement Disorders, Autonomic Nervous System lama harsatna te