I taksaah hian endothelin chu eng nge awm tih chiang takin i hria em? Kan thisen sang a nghawng dan hi!

‘Endothelin’ tih tawngkam hi i hre ngai em? Damdawi chungchang sawiin nangmah emaw, i chhungte zinga mi emaw hnenah he hming hi doctor-in a sawi i hre tawh mai thei a, natna chungchang i chhiar lai pawhin khawi emaw laiah i hmu tawh mai thei bawk. Hei hi a takah chuan kan taksa chhunga thil tenawm tak ni mah se, kan thisen sang, a nih loh leh kan hriat zawng zawnga ‘pressure’ chu a level dik takah a vawn tlat avangin hna ropui tak a thawk a ni. Mahse, he endothelin hi taksaah a tul aia tam a pun chuan hriselna lama harsatna chi hrang hrang a awm thei a ni. Chuvangin, vawiin hian he endothelin hi eng nge a nih leh kan taksa a tih theih dan tur chu awlsam takin i hriatthiam theih turin kan sawi dawn a ni.

Chuti a nih chuan he endothelin hi eng nge ni?

A awlsam zawngin sawi ila, endothelin hi protein te tak te a ni a, kan taksaa thisen kalna kawng a tikhawlo thei a ni. A dik tak chuan peptide a ni. Peptide hi protein chain tawi tak tak, thil tenau amino acid an tih atanga siam a ni. Hengte hian kan taksaah protein lian zawk siam turin a pui bawk.

He endothelin siamtu hi i hria em? Kan thisen kalna kawng chhungah hian cell layer a awm a. Endothelium an ti a. Hei hi kan taksaa endothelin siamtu hmunpui ber a ni.

Endothelium chu eng nge ni? Tlem i hrilhfiah thei ang em?

Kan taksa pum puia thisen kalna kawngte hi tui phurtu pipe network angin han ngaihtuah teh. Chu pipe chhungril, thisen kalna lam chu cell layer te tak te in a khuh a. Chu cell layer chu endothelium an ti a . Mak ang maiin kan taksa peng lian ber zinga mi anga ngaih a ni bawk!

Heng endothelial cell te hian thil chi hrang hrang an paih chhuak thin. Heng thilte hian kan thisen kalna kawng zau zawng leh inkharkhip (dilation and constriction) an thunun a, chu chu vascular tone an ti a ni. He vascular tone hian kan thinlungin thisen a pump nasat dan leh taksa pum puia thisen a kal kual theih nan a thawhrimna tur a hril a ni.

Endothelium leh endothelin te hian hna pawimawh dang engemaw zat an thawk dun a:

• Thisen zam a pui thin. Hei hi hliam i neih huna thisen chhuah tihtawp nan a pawimawh hle.
• Kan thisena tui leh chi (electrolytes) awm zat a control a ni.
• Tin, kan tissue-a toxins lut tur venna hmangin inflammation control turin a pui bawk.

Chuti a nih chuan endothelin hian taksaah eng nge a tih?

Endothelin hi thisen kalna kawng tikhawtlai thei thil a nih thu kan sawi tawh a. Dik tak chuan endothelin hi kan taksaa vasoconstrictor chak ber a ni. He thumal hi tlem han then ila:

• "Vaso" tih hian kan cardiovascular system-a thisen kalna kawngte a kawk a ni.
• "Constrictor" emaw, "constriction" emaw a ni.Constriction tih awmzia chu thisen kalna kawng a zim emaw, a inkhai emaw tihna a ni. Hei hian thisen kalna a tikhawlo a, a chang chuan a titawp hial a ni.

Chuvangin, endothelin hian a tih chu kan thisen sang a tisang a ni. Thisen kalna kawng a inkharkhip chuan thisen pump turin thinlung hian nasa zawkin hna a thawk a ngai a ni. Chuvang chuan pressure a sang chho zel a ni.

Endothelin level a san chuan eng nge thleng ang?

A tlangpuiin endothelin hian kan taksa tan hlawkna tha takin hna a thawk thin. Mahse, eng emaw chhan vanga he endothelin level hi taksaah a san chuan natna engemaw zat a thlen thei a, chu chuan kan thinlung leh kan lung a tichhe thei a ni . Tui pipe a inkhar lutuk chuan eng nge thleng ang tih han ngaihtuah teh. Chutiang chu a ni.

Endothelin level sang lutuk avanga lo awm thei thenkhat chu:

• Atherosclerosis (arterial disease): Hetah hian thisen kalna kawngah thau a awm khawm a , thisen kalna kawng a ti tawi a ni .
• Broken heart syndrome : Stress nghal vanga thinlung chak lo.
• Cancer chi hrang hrang .
• Cardiomyopathy : Lung ruh chak lo.
• Cardiovascular (thinlung) natna leh heart failure te.
• Coronary artery disease , chubakah endothelial dysfunction an tih natna a awm bawk .
• Thisen sang leh preeclampsia .
• Kidney natna leh kidney failure te .
• Pulmonary fibrosis leh pulmonary hypertension te a awm bawk .
• Scleroderma : Vun leh connective tissue a thick.

Ngaihtuah teh, Nimal hian hun engemaw chen chu thisen sang a nei tawh a. Doctor chuan a thisen kalna kawng chu a zim deuh niin a sawi a, a endothelin level pawhin a nghawng ve mai thei tih a sawi bawk. Damdawi a ei that loh chuan heart attack a thlen theih thu a vaukhân bawk. Chuvangin, he endothelin thil hi awlsam taka ngaih a tha lo.

Endothelin chi hrang hrang a awm em?

Ni e, endothelin chi hrang hrang a awm. Medical researcher-te chuan kum 1987 khan an hmuchhuak hmasa ber a, endothelin chi thum a awm a, chungte chu amino acid peptide pali atanga siam a ni. An pathum hian vasoconstrictor an ni vek.

Kan taksaa endothelin chi hrang hrang awm tam ber leh chak ber chu endothelin-1 (ET-1) a ni. Zirchiangtute chuan chi dang pahnih, endothelin-2 (ET-2) leh endothelin-3 (ET-3) te hian kan taksa a nghawng dan hi an la zir mek a ni. Tunah hian ngaihven ber chu ET-1 lam a ni.

Endothelin receptor te hi eng nge ni?

Kan taksaa tissue tin hian endothelin receptor kan nei vek a. Heng receptor te hi kawngkhar khar ang mai an ni. Endothelin molecule te an lo kal a, heng receptor te hi an inzawm chuan chu cell te hnenah chuan thil engemaw ti turin thuchah an thawn thin. Hei hi endothelin hian kan taksa pum puia cell te nen a inbiak dan a ni.

Engtin nge endothelin level hi an teh thin?

Doctor-te chuan i endothelin level engzat nge tih hriat an duh chuan thisen test an ti ang . Hei hian endothelin-1 (ET-1) level a teh a ni. Thisen peng pakhat, plasma an tihah a awm a. Plasma chu thisen a liquid part, thisen sen, thisen var, leh platelet te lakchhuah hnua a awm thin chu a ni.

He thisen test hi i doctor office-ah emaw, damdawi inah emaw, lab-ah emaw tih theih a ni. Hetiang hian thisenah endothelin chi dang teh a harsa hle.

Endothelin tehna unit chu picograms per milliliter (pg/mL) a ni.

• Puitling pakhatah chuan ET-1 plasma level pangngai chu 1 pg/mL atanga 2 pg/mL vel a ni.
• Naupang tê tête ET-1 level hi a sang deuh hlek a ni.
• Tin, hnam hrang hrang zingah heng level-ah hian danglamna tlem a awm thei bawk.

A tlangpuiin thinlung emaw lung lam natna thenkhat, pulmonary arterial hypertension nei te hian ET-1 level a sang hle. Tin, thinlung enkawlna thenkhat, balloon angioplasty ang chi te hian endothelin level chu rei lo te chhung atan a tisang thei bawk.

Endothelin Receptor Antagonists (ERA) hi engte nge ni?

Hengte hi damdawi chi khat, endothelin level a san chuan pek thin a ni. Endothelin Receptor Antagonists (ERA) hian kan taksaa endothelin awm zat tihtlem nan hna a thawk a.

Hengte hi enkawlna chi khat ``targeted therapy`` tih a ni.`` Chu chu heng damdawi te hi an kal dik a, harsatna nei cell te chauh an bei a, cell hrisel te chu a tichhe nasa lo tihna a ni. Sniper ang maiin an target chiah chu an kap ta a ni. ERA damdawi hi lung chhunga thisen sang chi hrang hrang (pulmonary arterial hypertension) enkawlna atan hman a ni ber.

Heng ERA damdawi te hian side effect a nei em?

Damdawi dang ang bawkin ERA damdawi hian side effect engemaw zat a nei thei a ni.

• Hmeichhe naupai emaw, nau pai tum emaw chuan heng ERA damdawi te hi ei loh tur a ni. Hei hi a chhan chu heng damdawi te hian nausen piang laiah piansualna a thlen thei a ni. Hei hi thil pawimawh tak a ni.
• A tlem hle a, he damdawi hian thin a tichhia thei. Chuvangin, i doctor chuan i thin (liver) hriselna enfiah fo turin thisen test turin a ti mai thei.
• Side effect dang awm thei chu:
• Ek khal.
• Hmai hring (edema) emaw, a sen hring emaw.
• Lu na .
• Nausea leh luak chhuak.
• Pulse leh heart rate chak tak.

Hetiang thil i hriat chuan i doctor hnenah a tul anga hma a lak theih nan i hrilh nghal tur a ni.

Chuti a nih chuan, he thawnthu atang hian eng thil nge kan hriat reng tur? (In lama hruai tur thuchah)

Okay, endothelin chungchang hi kan sawi nasa hle. A tawi zawngin:

• Endothelin hi taksaa protein pawimawh tak siam a ni a, kan thisen kalna kawng a tikhawlo a, thisen sang a control bawk.
• Hei hi kan thisen kalna kawng chhunga line siamtu endothelium an tih cell layer atanga siam a ni.
• Endothelin level a san lutuk chuan thisen kalna kawng a inkhar lutuk thei a, chu chuan thisen sang, thinlung natna, leh lung natna ang chi harsatna a thlen thei a ni .
• Thisen a Endothelin-1 (ET-1) level hi thisen test hmangin teh theih a ni .
• Endothelin receptor antagonists (ERAs) hi damdawi chi khat a ni a, endothelin level tihhniamna a ni. A bik takin lungah thisen sang tan an hmang thin.
• ERA damdawi i ei a nih chuan naupai lai leh i thin hriselna chungchangah fimkhur hle tur a ni.

Chuvangin, nangmah emaw, i hriat emaw hian Endothelin chungchangah harsatna i neih chuan doctor thurawn lak a tha ber. He thuziak hian hriatthiamna engemaw chen a pek che ka beisei. Hrisel takin awm rawh!

` Endothelin, thisen sang, lung natna, lung natna, endothelium, peptides