Thisen sen (red blood cells) i nei tam lutuk em? Erythrocytosis chungchang hi han sawi ila!

A châng chuan chau mai mai emaw, lu na emaw, chak lohna emaw i nei mai mai em? Heng thil tenawm tak takte hi kan ngaihven vak lo fo thin a ni lawm ni? Mahse, i taksaa thisen zam (red blood cells) awm zat chu a rawt aia tam a pung a, chu chu doctor-te’n erythrocytosis emaw polycythemia emaw an tih chu a ni a, heng chhinchhiahnate hi a lang thei a ni. Hei hi a chang chuan tlem i ngaihtuah tur a ni. Chuvangin, vawiin hian erythrocytosis chu eng nge a nih, engvangin nge a lo awm tih leh eng nge tih theih tih chipchiar takin kan sawi dawn a ni.

Erythrocytosis hi eng nge ni tak tak?

A awlsam zawngin sawi ila, Erythrocytosis chu i thisenah Red Blood Cells (Erythrocytes) a awm dan pangngai aia tam a awm chuan a ni. I hriat angin kan thisen hi hmun hnih atanga siam a ni. Pakhat chu solid part a ni a, chu chu thisen sen, thisen var leh platelet te hi a ni. A dang chu liquid part a ni a, chu chu plasma kan ti a ni. Erythrocytosis-ah chuan thisen sen (red blood cells) hi liquid part, plasma nena khaikhin chuan a pung a ni.

Thisen test i neih chuan report-ah hian value pahnih i hmu ang: Hematocrit leh Hemoglobin .

• Hematocrit (HCT): Hei hian i thisen za zela engzat nge thisen sen (red blood cells) tih a hriattir che a ni.
• Hemoglobin (HB): Hei hi thisen sen chhunga protein pawimawh tak a ni a, kan taksa pum puiah oxygen a keng tel a ni.

Erythrocytosis-ah chuan heng hematocrit leh hemoglobin value zinga pakhat emaw, pahnih emaw hi a tlangpui aia sang a ni thei.

Hetianga thisen sen pung hian taksa hi engtin nge a nghawng?

Thisen sen (red blood cells) hi kan taksa tan a pawimawh hle. Lung atang hian taksa chhunga cell leh tissue tinah oxygen an phur lut thin. Hei vang hian kan tissue te hi chaw tha leh hrisel tak an ni.

Mahse, heng thisen sen (red blood cells) te hi a pung lutuk chuan harsatna a awm thei a ni. Thisen sen (red blood cells) a pun chhanah a innghat a ni. Effect thenkhat chu a tlem hle. Lu na leh hahna ang chi thil chauh i hre mai thei. Mahse, chhan lian tham engemaw vanga thisen sen (red blood cells) a pun chuan thisen chu a thim tan thin. Tichuan , thisen zam, heart attack emaw stroke ang chi thil hlauhawm tak tak a awm thei bawk .

Chuvang chuan, chutiang symptoms i neih chuan a chhan dik tak hriat tumin doctor pan a pawimawh hle. Chumi hnuah chauh chuan enkawlna mumal i hmu thei ang a, natna lan chhuah dan i tihtlem thei ang a, dinhmun hlauhawm tak tak i veng thei ang.

Erythrocytosis chi hrang hrangte chu engte nge ni?

Heng red cells te hi an pun dan azirin Erythrocytosis hi chi hnih ah then theih a ni:

1. Absolute Erythrocytosis: Hei hi i taksaa thisen sen (red blood cells) siam chhuah zat chu a pangngai aia tam tak tak a nih chuan a ni.

2. Relative Erythrocytosis (Relative Erythrocytosis): Hei hi thisen zam (red blood cell count) chu a pangngai mai thei, mahse thisen a plasma awm zat a tlahniam a, chuvangin thisen sen (red blood cell concentration) chu a pung niin a lang. Entirnan, i luak tam a, i luak chhuak a, i taksa atanga tui tam tak i hloh chuan i thisen fluidity a tlahniam thin. Hetiang dinhmun hi hetiang hunah hian a thleng thei a ni.

Absolute Erythrocytosis hi chi hnih ah then leh a ni a, a chhan a zirin:

Erythrocytosis hmasa ber a ni

Buaina chu kan ruhroah a awm a ni. I hriat angin kan taksaah hian thisen zam (red blood cells) siamna factory lian ber chu bone marrow hi a ni. Chuvangin, he primary erythrocytosis-ah hian ruhro (bone marrow)-a stem cells (progenitor cells)-a genetic defect a awm avangin thisen sen (red blood cells) siam chhuah chu thunun theih lohvin a pung a ni. He genetic defect hi rochun (piangsual angin) a ni thei a, a nih loh leh dam chhungin a thleng thei bawk.

• Acquired Primary Erythrocytosis: Hei hi entirnan tha tak chu Polycythemia Vera tih hi a ni. Mi tam tak chuan Erythrocytosis leh Polycythemia Vera te hi natna inangah an ngai lo. Mahse, an inang lo. Polycythemia Vera hi natna bik leh na tak a ni a, Erythrocytosis a thlen thin.
• Inherited Primary Erythrocytosis: A châng chuan, nu leh pate aṭanga rochun gene-a chhiatna a awm chuan ruhro (bone marrow)-ah hian red cell tam lutuk a siam thei a ni.

Secondary Erythrocytosis natna a ni

Hetah hian buaina chu ruhroah a ni lo va, ruhro pawn lama thil dang a ni zawk. A tam zawkah chuan secondary erythrocytosis hi kan taksain erythropoietin , a nih loh leh EPO tih hormone a siam tam lutuk vang a ni. `EPO` hi chemical messenger a ni. Chu chu ruhro (bone marrow) hnenah "red cell tam zawk siam" tura hrilhtu a ni.

Ngaihtuah teh, lung natna emaw, thinlung natna emaw i nei a ni. Tichuan taksain oxygen a dawn zat chu a tlem ta hle mai. Chutih lai chuan taksa chuan hormone `EPO` siam tam zawk a tum a, chuta tang chuan ruhro chu a tichak a, red cell tam zawk siam a tum bawk. A chhan chu red cell hian oxygen a phur a ni. Mahse, chutianga red cell siam chhuah a pun lutuk chuan secondary erythrocytosis a thlen thin. He secondary erythrocytosis hi genetic condition thenkhat vang pawh a ni thei a, mahse chu genetic defects chu ruhroa awm a ni lo.

Engtin nge thisen value i check ang a, erythrocytosis i vei em tih i enfiah ang?

Dik tak chuan, thisen zam (red blood cell concentration) level pangngai anga ngaih chu mi hrang hrangah a inang lo thei a ni. Hei hi thil tam takin a nghawng a, i kum, mipa emaw hmeichhia emaw i nih leh nih loh, leh i awmna hmun (tuipui level-a awm emaw, tlangram hmuna awm emaw) san zawng te pawh a tel.

Puitlingah chuan erythrocytosis hi hematocrit (HCT) leh/ emaw hemoglobin (HB) tihpun atanga hriat a ni tlangpui. Heng value te hi thisen test ``Complete Blood Count (CBC)`` tih hmanga teh theih a ni.

Mipa tan chuan:

• Hematocrit (HCT): 50% aia tam a nih chuan .
• Hemoglobin (HB): 17.5 g/dL aia tam a nih chuan

Hmeichhe naupai lo tan chuan:

• Hematocrit (HCT): 45% aia tam a nih chuan .
• Hemoglobin (HB): 15.3 g/dL aia tam a nih chuan

Pawimawh: Heng hlutnate hi kaihhruaina tlangpui chauh a ni. I doctor chuan i hriselna zawng zawng a ngaihtuah hnuah erythrocytosis i nei em tih chiang takin a hre ang.

Relative Erythrocytosis hi engte nge ni?

Hei hi taksaa tui awm tlem vang a ni a, chu chuan thisen tui (plasma) a tihhniam bakah thisen sen (red blood cells) concentration a tipung a ni. Chuvangin, hei hi a chhan ber chu dehydration a ni .

• Luak chhuak nasa tak
• Kawthalo
• Damdawi thenkhat, entirnan, diuretics (taksa atanga tui paih chhuaktu damdawi) (Hengte hi thisen sang emaw, tui tlakchhamna emaw atan pek thin a ni).

Chutiang avang chuan taksaa tui awm zat a tlahniam thei a, relative erythrocytosis a thlen thei bawk.

Absolute Erythrocytosis hi engte nge ni?

Hei hi chhan hrang hrang pahnih a awm a, chungte chu primary leh secondary te an ni.

Primary erythrocytosis awm chhan: 1.1.

Hei hi ruhro (bone marrow) tichhe thei genetic defect vang a ni fo thin.

• Polycythemia Vera leh Myeloproliferative Neoplasm dangte: Hengte hi ruhro (bone marrow)-in thisen sen leh thisen cell dangte a siam chhuah tam lutukna dinhmun a ni. Heng zingah hian Polycythemia Vera hi a tam ber a ni.
• Pian lama piansualna: Mi thenkhat chu pianpui pianphung (genetic defect) neiin an piang a, chu chuan ruhro (bone marrow) ah thisen sen (red blood cells) a siam tam lutuk thei a ni.

Secondary erythrocytosis awm chhan hrang hrang:

Hei hi hormone `EPO` tihpun vang a ni tlangpui.

• Tissue-a oxygen tihtlem theihna dinhmun:
• Lung Natna (e.g. chronic bronchitis, emphysema) 1. A rilru a hah lutuk chuan a rilru a buai em em a.
• Lung natna (e.g. pianpui thinlung natna) .
• Mut theih lohna (sleep apnea) a ni
• Hemoglobinopathy: Hengte hi thisen sen (red blood cells)-a hemoglobin protein-in a chhiat avangin oxygen a phur tha thei lo tihna a ni.
• Kidney natna leh transplant te: 1.1.
• Renal Artery Stenosis (kidney supply tu thisen kalna kawng a tawi) .
• Hydronephrosis (zun tam lutuk avanga kal a hring) .
• Hetiang dinhmun hi a chang chuan kal thlak hnuah pawh a awm thei.
• Tumors: Cancer nei leh cancer nei lo tumor thenkhat chuan EPO hormone tam lutuk an tichhuak thei.
• Cancer natna hrik: Renal Cell Carcinoma, Hemangioblastoma, Hepatocellular Carcinoma, Parathyroid Carcinoma te hi a awm a, a natna hi a tha lo hle.
• Cancer nei lo tumor: Uterine Fibroids, Pheochromocytoma, Meningioma te hi a awm thei.
• Carbon monoxide poisoning leh meizuk: Meizial zuk nasa lutuk hian carbon monoxide poisoning a thlen thei a, chu chuan tissue-ah oxygen a tihtlem thei a ni.
• Damdawi leh damdawi thenkhat:
• Anabolic Steroids (infiammiten chakna tihpun nan an ei) .
• Hormone testosterone tih hi ei a ni.

Erythrocytosis vei chuan eng symptom nge a neih theih ang?

I natna lan chhuah dan (leh a nasat dan) chu i erythrocytosis awm chhan a innghat a ni. Entirnan, secondary erythrocytosis vei mi pakhatin a natna lan chhuahna a nei thei a:

• Lu na
• Confused state, ngaihtuahna seng harsa tak dinhmun
• Mut harsat
• Chak lo, chau tih hriatna

Primary erythrocytosis (a bik takin polycythemia vera) vei chuan a natna lan chhuahna na zawk a nei thei a:

• Thisen sang lutuk
• Zanah thawk hah lutuk
• Chhan awm lovin taksa rihna tihtlem
• Ruh natna nasa tak, vun hring, leh sen ( gout an ti bawk ) .
• Thisen chhuahna lama harsatna (hnar thisen chhuak fo, hliam tenau tak pawha thisen chhuah emaw, hliam emaw) .
• Vun a na (itching a pung thei a, a bik takin tui lum hnuah) .
• Ke leh ke ruh chhunga natna, rulhut tlan kual vel ang maia hriatna
• Hmai, kut leh keah inflammation awmin a sen.

Engtin nge doctor-te hian erythrocytosis hi an hriat theih?

I doctor chuan i red blood cell count sang chhan chu a hriat hmasak phawt ang a, test leh procedure hrang hrang hmangin.

A hmasain, i damdawi lam chanchin, i damdawi ei dan, i nunphung (e.g., i zu in em), leh i natna lan chhuah dan te zawhna an zawt ang a, relative erythrocytosis (thisen chhunga plasma tlahniam avanga lo awm) an enfiah ang. Taksa enfiahna an nei dawn bawk a ni.

A dawt leh tur chu primary emaw secondary emaw i nei em tih hi a ni . A chunga kan sawi tak information hmang hian test tlemte pawh i ti thei bawk.

Eng test nge tih a nih?

• Complete Blood Count (CBC): Hei hian i thisen sen zat, hemoglobin (HB), leh hematocrit (HCT) level te a enfiah thei a ni.
• Peripheral Blood Smear (PBS): Hei hi thisen tla khat lak a, microscope hmanga cell te en a, a pianzia leh a lian zawng a danglam em tih en a ni. Polycythemia Vera ang chi natna i neih chuan cell pangngai lo i hmu thei.
• Kidney leh Liver Function Test: Hei hian kal natna emaw, EPO tam lutuk siamtu tumor emaw a awm leh awm loh hriat theihna a pe thei.
• Pulse Oximetry: Kut zungtang chunga sensor te tak te dah hian thisena oxygen level a teh thin. Hei hian he natna hi thinlung natna emaw, lung natna emaw ang chi thil avanga lo awm a nih leh nih loh hriat theih nan a pui thei a ni.
• Erythropoietin level enfiah (EPO): `EPO` level a hniam chuan primary erythrocytosis a ni thei a, `EPO` level a san chuan secondary erythrocytosis a ni thei bawk.
• Urinalysis: Zun sample lak a, thil dik lo awm leh awm loh enfiah a ni. Zun-ah hian red cell a awm chuan kal natna vang pawh a ni thei.

Doctor chuan natna bik, polycythemia vera ang chi a rinhlelh chuan, test dang, bone marrow biopsy ang chi te pawh a ti thei bawk.

Engtin nge erythrocytosis hi enkawl a nih?

A tam zawkah chuan erythrocytosis awm chhan hi a dam kim thei lo. Mahse, enkawlna hian natna lan chhuah dan a thunun thei a, a tihziaawm thei bawk. Thil pawi tak avanga erythrocytosis a awm chuan thisen zam ang chi thil hlauhawm tak tak ven nan enkawlna hman a ni bawk.

• Phlebotomy emaw Venesection emaw hmanga tihchhuah:

Hei hi polycythemia vera enkawlna atana hman tlanglawn ber a ni. Thisen pek ang mai a ni a, mahse thisen tlemte lak chhuah a, thisen sen leh thisen volume sang lutuk tihtlem a ngai a ni. Secondary erythrocytosis hian hetiang enkawlna hi a mamawh lo fo thin.

• Damdawi hman tur: 1.1.
• Thisen zam hlauhawmna sang tak nei tan chuan doctor chuan nitin aspirin tlem zawk ei turin a rawt mai thei.
• Thisen zam (red blood cell count) ti tlem thei damdawi a awm bawk:
• Hydroxycarbamide `(Hydroxycarbamide)` hmanga siam a ni
• Hydroxyurea `(Hydroxyurea)` tih a ni
• Busulfan a ni
• Interferon alfa `(Interferon alfa)` tih a ni
• Ruxolitinib a ni

I doctor chuan i dinhmun nena inmil damdawi a pe ang che. Tin, i erythrocytosis awm chhan bulpui a zirin, a bulpui ber enkawlna pawh an pe bawk ang.

Hetiang dinhmun hi ka neih chuan eng nge ka beisei ang?

I thil tawn chu i erythrocytosis awm chhan leh a nasat danah a innghat ang. Entirnan, primary erythrocytosis natna (hereditary condition) thenkhat chuan natna lan chhuahna tlemte chauh a thlen a, nunna atana hlauhawm a ni lo. Mahse, natna khirh zawk, polycythemia vera ang chite chuan dam chhung enkawl a ngai thei a ni.

Engtin nge ka in enkawl ang?

A pawimawh ber chu i doctor thupek dik taka zawm hi a ni. Chutih lai chuan, nunphung tihdanglamna tlemte a awm a, chu chuan a pui thei che a ni:

• Meizial i zu a nih chuan titawp rawh.
• Taksa rihna hrisel tak vawng reng rawh.
• Thisen sang i neih chuan control la.
• Tuipui atanga hmun sang tak tak (tlang hmun) thlenga zin chu a theih ang angin pumpelh tur a ni.

Engtikah nge damdawi inah hmanhmawh taka ka kal ang (ETU) ?

Erythrocytosis nena inzawm, thisen zam hlauhawmna i neih chuan thisen zam natna lan chhuah dan hriat a pawimawh. A hnuaia symptoms te hi i neih chuan doctor pan nghal rawh:

• Deep Vein Thrombosis (DVT): Ke pakhatah a hring, a na leh a sen.
• Lung chhunga thisen zam (Pulmonary Embolism - PE): Chhung na, thawk harsa, luak chhuak.
• Stroke: Taksa sir khata balance, coordination hloh nghal, taksa ruh chak lohna emaw, rilru hahna emaw.
• Heart Attack: Chhung na, thawk hah, luak chhuak, thawk hah.

Heng symptoms te hi i neih chuan tihkhawtlai lohvin Doctor pan nghal mai tur a ni.

A tawp berah chuan thil hriat reng tur (Take-Home Message) .

Erythrocytosis hi i thisenah thisen sen (red blood cells) a punna a ni. Hei hi dinhmun tenau tak a ni thei a, a chang chuan natna khirh tak chhinchhiahna a ni thei bawk.

• I natna lan chhuah dan danglam (a bik takin chau reng, lu na, vun rawng, thawk harsa, thawk harsa) i neih chuan doctor pan rawh.
• Doctor chuan i thisen zam (red blood cell count) a san chhan dik tak chu a hre vek ang.
• A châng chuan nunphung tihdanglam awlsam tak (e.g., damdawi ei tlem, tui tlakchhamna enkawl) hian he harsatna hi a chinfel theih a ni.
• Erythrocytosis hi natna khirh zawk avanga lo awm a nih chuan i doctor chuan a enkawl reng ang che a, a tul anga enkawlna a pe ang che.

I hriselna enkawl hi a pawimawh hle a, chuvangin harsatna i neih chuan Doctor biak pawh hlau suh.

` Erythrocytosis, polycythemia, thisen sen, hemoglobin, hematocrit, thisen zam, ruhro