I thisen chu a tul lovah a clot em? Factor V Leiden Thrombophilia chungchang hi han sawi ila!

Kan taksa hmun dangah pawh hliam emaw, hliam emaw kan neih hian thisen chhuah tihtawp nan thisen zam hi a pawimawh hle a ni . Kan taksa invenna mechanism a ni. Mahse, taksa chhunga thisen kalna kawng chhungah chhan awm lovin thisen zam a lo awm a nih chuan eng nge thleng ang? Chu chu a hlauhawm deuh thei. Vawiin hian hetiang chi thlahtu natna, a tul lo taka thisen zam theihna tipungtu chungchang kan sawi dawn a ni. Chu chu Factor V Leiden thrombophilia a ni .

A awlsam zawngin Factor V Leiden hi eng nge ni?

Factor V Leiden thrombophilia hi i pian tirh atanga i rochun genetic mutation avanga lo awm a ni a . Hei hian i thisen chu a pangngai aiin a dik lo zawngin a tikhawlo thei zawk a ni. A hming hi “factor five Leiden” tia lam a ni. V hi Roman numeral panga tihna a ni.

Hetiang natna vei zawng zawng hian thisen zam an nei vek dawn lo. Mahse, he genetic variation nei lo mi nen khaikhin chuan thisen zam (blood clots) i neih theihna chance a sang zawk a ni. Hei hian dinhmun hlauhawm tak pahnih a thlen thei a:

• Deep vein thrombosis ( DVT ): Hei hi taksa chhung thuk taka thisen kalna kawngkhar a thisen zam (blood clot) a lo awm hi a ni. A tam zawkah chuan hengte hi ke emaw kut zungtang emaw vein-ah a lo awm thin. Mahse, a châng chuan liver , kidney , thluak, a nih loh leh mit thisenah pawh an lo awm thei bawk.
• Pulmonary embolism (PE): Hei hi tlem a hlauhawm zawk. Heta thil thleng chu thisen zam lo awm tawh chu a chhe vek a, thisen nen a kal a, lungah a tang ta a ni .

He natna hi hriat theihna tur symptoms te chu engte nge ni?

Dik tak chuan he genetic mutation nena inzawm symptoms a awm lo. Hriat lohvin i nun pumpui i hmang thei a ni. Mahse, thisen zam a lo awm chuan symptoms i nei tan ang.

Pawimawh tak: A hnuaia DVT emaw PE emaw chhinchhiahna i neih chuan damdawi in Emergency Department (ETU)-ah kal la, ambulance ko nghal rawh . Hei hi tihkhawtlai tur thil a ni lo.

Engvangin nge hetiang hi a lo awm? Hei hi eng nge a chhan?

Factor V Leiden hi genetic mutation avanga lo awm a ni. Hei hi a awlsam deuh deuhin han sawifiah teh ang.

Kan thisen zam tur atana puitu protein chi hrang hrang a awm a. Chungte chu ‘coagulation factors’ an ti a. Chutiang protein pawimawh tak pakhat chu "Coagulation factor V" hi a ni. Kan taksa hi he protein hi siam turin `F5` tih gene hmangin a hriattir a ni.

A tlangpuiin he `F5` gene copy hrisel pahnih neiin kan piang vek a ni. Mahse, Factor V Leiden condition nei chuan he `F5` gene copy pakhat emaw pahnih emaw a nei a, chu chu a chhia a ni. He gene chhia hi Netherlands rama `Leiden` khawpuiah zirchiangtu pawl pakhatin an hmuchhuak hmasa ber a ni. Chuvang chuan a hming a pu ta a ni.

`F5` gene chhia atanga thupek kan dawn avang hian taksain a siam Factor V protein hi a structure ah hian a danglam deuh hlek a ni. Hetianga inthlak danglamna tlemte avang hian protein dang `protein C` leh `protein S` tia koh, thisen zam control, chu chu a tul lo taka thisen zam tihtawp tirtu te hian he Factor V protein danglam tak hi an control thei lo. Brake nei lo car ang mai a ni. Chuvangin, a tul loh hunah pawh thisen a inzawm tan thin.

Hei hi thlah kal zel atanga lo chhuak thil a ni em?

Awle. Hei hi i nu emaw, i pa emaw, an pahnih emaw hnen atangin i rochun thei a ni. ``Autosomal dominant`` pattern-a rochun a ni. Chumi awmzia chu he gene chhia hi i nu emaw i pa emaw hnen atangin i rochun thei tihna a ni.

• Mi tam zawk (heterozygous) hian he gene chhia hi copy pakhat chauh (nu emaw pa emaw hnen atangin) an rochun thin.
• A tlem hle a, mi (homozygous) hian he gene chhia copy pahnih (nu leh pa atang pawhin) a rochun thei a ni. Heng mite hi thisen zam vei theihna chance a sang zawk hle.

Eng thil nge thisen zam awm theihna tipung?

Factor V Leiden i neih chuan a hnuaia thilte hian thisen zam i neih theihna a tipung thei a ni. Chuvangin he thu hi i doctor nen sawiho a pawimawh hle.

Engtin nge doctor-te hian he natna hi an hriat theih? Enkawlnate chu engte nge ni?

DVT emaw PE emaw i neih tawh chuan, a bik takin kum naupang takah emaw, i chhungte zinga mi pakhatin hetiang natna hi a nei tawh a nih chuan, i doctor chuan Factor V Leiden hi a ringhlel mai thei.

Hei hi hriat theih nan thisen test bik (genetic test telin) an nei thin. Hei hian he gene dik lo hi i nei em tih chiang takin a hrilh thei che a, a awm a nih chuan copy pakhat emaw pahnih emaw i neih leh neih loh a hriattir thei bawk.

Enkawl dan tur

Hei hi dam chhung zawnga genetic condition a nih avangin gene thlak danglam theihna tur damdawi a awm lo. Chu ai chuan enkawlnate chuan thisen zam awm tawhte chu tihthianghlim a, nakin lawka thisen zam awm theihna tur tihtlem nan hna a thawk a ni. Chutianga tih theih nan chuan i doctor chuan a hnuaia mite hi a rawt thei ang:

• Anticoagulant damdawi: Hengte hi ``blood thinners'' an ti bawk.Heng damdawi hian thisen zam a tithianghlim a, thisen zam thar a siam loh nan a veng bawk. I doctor chuan i risk a zirin heng damdawi te hi eng chen nge i ei tur tih a rel ang.
• Compression stockings: Hengte hian kea thisen kal dan a tichak a, thisen zam a tihziaawm bawk.
• Vena cava filter: Hei hi filter ang chi hmanrua te tak te, taksa chhunga thisen zam lian takah dah a ni a, kea thisen zam lo awm chu lung lam pan lo turin a veng a ni.
• Surgery: A then phei chuan thisen zam chu surgery hmanga lakchhuah a ngai thin.

Factor V Leiden hmang hian engtin nge hrisel taka kan nun theih ang?

Hetiang natna vei tam zawk tan chuan dam rei zawng hi a nghawng lo. Thisen zam a lo awm a nih pawhin a hmaa enkawl chuan a rah chhuah pawi tak a veng thei a ni. Chuvangin hlauthawng suh. Amaherawhchu, i nunphung i ngaihtuah thiam a pawimawh hle.

• Meizial zuk loh vek tur a ni.
• Hmun khatah rei lutuk lo thut suh. A bik takin thlawhna rei takah chuan tho la, kal kual la, darkar khatah vawi khat tal i ke kha han phar rawh.
• Taksa rihna hrisel tak vawng reng rawh.
• Doctor thurawn lo chuan estrogen awmna hormone therapy hmang suh.

Factor V Leiden thrombophilia i vei tih i hriat chuan hlauhna leh lungkhamna i neih hi thil pangngai a ni. Mahse, he natna vei tam zawk hi harsatna nei lovin nun pangngai an hmang thei tih hre reng ang che. A pawimawh ber chu i dinhmun hriat chian a, doctor thurawn zawm hi a ni.

Factor V Leiden, thisen zam, DVT, Pulmonary Embolism, thrombophilia, genetic natna, thisen kalna kawnga thisen zam, Sri Lanka