I pum na hi pum na mai a ni lo em ni? GIST (Gastrointestinal Stromal Tumor) chungchang hi han sawi ila!

Tin, a chang chuan pum na, emaw, pum na emaw, i rit tih hriatna emaw i nei bawk em? A châng chuan chaw pakhat chu a chhe, "gastric upset", emaw "flatulence" mai maiah kan ngai ṭhin. Mahse, han ngaihtuah teh, a chang chuan hetiang symptom tenau tak hnuaiah hian thawnthu pawi zawk a awm thei. Chutiang pakhat, chutiang taka awm lo, mahse cancer natna chungchanga hriat tur pawimawh tak chu GIST a ni a, chu chu Gastrointestinal Stromal Tumor tihna a ni. Hemi chungchang hi chipchiar deuhin han sawi ila, mahse awlsam takin, okay?

He gastrointestinal stromal tumor (GIST) hi eng nge ni?

A awlsam zawngin, GISTs hi cancer natna hrik, i chaw ei kawng (digestive tract) bang-a lo awm —i taksa peng pakhat, ei leh in tur i kâ atanga i pum thlenga kal a, chuta tang chuan i chaw ei tur kal tlanga i chaw ei tur kalna hmun a ni. Heng tumor te hi a dik tak chuan doctor-te’n ‘ soft tissue sarcoma’ an tihah an tla a ni.

Tunah chuan han ngaihtuah teh, GIST tumor thenkhat chu a te hle a, pencil eraser emaw pea emaw ang chi hi a ni. Tumor te tak te a nih chuan i hre lo pawh a ni thei a, natna pawh i hre lo mai thei. Mahse, tumor thenkhat chu hun kal zelah an lo thang tan thin. Chutih lai chuan heng GIST te hian symptom hrang hrang leh hriselna lama harsatna dang a thlen tan thei che a ni. A tam zawkah chuan doctor-te chuan he GIST condition hi surgery hmangin tumor emaw tumor emaw chu paih vek turin an enkawl thin.

Hetiang dinhmun hi engtiang chiahin nge GIST tia koh a nih?

Dik tak chuan GIST hi cancer chi khat hmuh tur awm lo tak a ni . Khawvel ram dang nena khaikhin pawhin a inang reng a ni. Entirnan, United States ang ramah chuan kum tin GIST vei thar 4,000 atanga 6,000 vel chauh hmuhchhuah a ni. Chuvangin he dinhmun hi a tlem zia chu i ngaihtuah thei ang. Chuvang chuan hriat chian a pawimawh a, chutiang chuan symptom i neih chuan doctor thurawn i la vat thei ang.

GIST natna lan chhuahna chu engte nge ni?

Kan sawi tawh ang khan GIST tumor te hi a te lutuk a nih chuan symptoms i nei lo mai thei. A tam zawkah chuan GIST tumor hi test neih laiin, abdominal scan emaw, surgery dang emaw neih laiin accident-in hmuhchhuah a ni.

Mahse, lump a lian deuh deuh chuan, a nih loh leh a awmna hmun a zirin symptom thenkhat a lang thei. Hengte hi a lan chhuah dan tlangpui chu an ni:

• Pum na emaw, nuam lo emaw hriat . Hei hi i pum chhunga thil awm emaw, i pum chhunga thil awm emaw chauh a ni thei.
• I ek chhungah thisen emaw, thisen chhuak bawlhhlawh emaw. A chang chuan ek chu a dum dum thei a, chu chu chhungril thisen chhuahna chhinchhiahna a ni bawk.
• Constipation tih awmzia chu ni engemaw zat chhung chu chaw ei loh tihna a ni.
• EnglaipawhinChau leh chau lutuk tih hriatna . Taksaah nunna awm lo ang maiin.
• I tum lova taksa rihna tihtlem.
• Anorexia tih awmzia chu ei duh loh tihna a ni.
• Thisen chhuak . Hei hi eng emaw chen chu chhinchhiahna pawi tak a ni.

Hun engemaw chen heng symptoms pakhat emaw a aia tam emaw i lo neih tawh chuan , "Eng nge chu chu?"

GIST awm chhante chu engte nge ni?

A tam zawkah chuan GIST hi kan taksaa KIT an tih gene-a inthlak danglamna, a nih loh leh mutation a awm hian a lo awm thin. Ngaihtuah teh he KIT gene hi kan chaw ei kawng chhunga cell thenkhat "divide and multiply" tura hrilhtu messenger te tak te ang mai a ni. Chuvangin, he gene-ah hian chhiatna a awm chuan, chu cell-te chu rang lutuk leh thunun theih lohvin an inthen darh a, an pung chho ta a ni. Chu lump, a nih loh leh GIST chu chu cell-te chu thunun theih loha an lo ṭhan chhoh chuan a lo awm a ni. He gene mutation hi kan pian hnuah, kan dam chhungin a thleng tlangpui. Nu leh pa atanga fate rochun thil a ni lo.

He KIT gene hian cell te chu KIT CD117 tih protein siam turin a hrilh a ni. He protein hian chaw ei kawng chhunga cell inthen darhna a tichak a ni. GIST-ah chuan he thil hi a kal sual a, tumor a lo awm ta a ni.

Mahse, a tlem hle nachungin, thlahtu natna thenkhat chuan GIST vei theihna a tipung deuh thei a ni. Chung dinhmun thenkhat chu:

• Family GIST syndrome: Hei hi a tlem hle. Heta thil thleng chu KIT gene-a chhiatna pakhat chu nu leh pa atanga fate rochun a ni. Chutiang a nih chuan GIST vei theihna a sang hle. Tin, GIST hi a tlangpui aia kum naupang zawkah a lo awm thei a, tumor pakhat aia tam a lo awm thei bawk.
• Neurofibromatosis type 1: Hei hi genetic natna a ni bawk. Cell chi hrang hrang chu thunun theih lohvin a tipung a, taksa hmun hrang hrangah tumor a siam a ni. GIST hi tumor chi khat a ni a, hetiang hian a lo awm thei a ni.
• Carney-Stratakis syndrome: Hei pawh hi thil awm lo tak, thlahtute atanga lo chhuak a ni. Hetiang natna vei te pawh hi midang aiin GIST vei theihna an nei sang zawk bawk.

Engtin nge GIST hi hmuhchhuah a nih?

A chunga kan sawi tak symptoms nei doctor i pan chuan i symptoms te, eng chen nge a awm tawh tih te a zawt hmasa ang che a, chutah chuan taksa enfiahna a nei ang Hei hian i pum hriatna ang chi thil a kawk a ni.

Chu bâkah, i doctor chuan GIST i neih leh neih loh, a lian leh te, a darh leh darh loh finfiah nân test dang engemaw zât a ti thei bawk. A bulpui berte chu:

• Upper endoscopy hmanga enfiah a ni:Hei hian i hmuiah camera te tak te hmanga tube dah a, i rilru chhungril, chaw kawng (food pipe) leh i pum te enfiah a huam a ni. Hei hian engmah a awm leh awm loh, lump ang chi chu direct-in i hmu thei a ni.
• CT scan: Hei hian X-ray hmangin i pum chhung lam chipchiar takin thlalak a la thin. Hei hian lump lian leh te awmna hmun hriat theih nan a pui thei a ni.
• Positron emission tomography (PET) scan: Hei hi scan chi khat bik a ni bawk. Cancer cells te hi engtiang chiahin nge an thawk tih leh taksa hmun dangah an darh tawh em tih hriat nan a pui thin.
• Biopsy: Hei hi GIST i neih leh neih loh finfiahna atana hman thin test a ni. Hei hian lump atanga tissue te tak te tak te lak chhuah a , microscope hmanga pathologist te enfiah tir a ngai a ni . Hei hian GIST nge thil dang a nih leh nih loh hriat theih nan a pui ang. A chang chuan biopsy hi endoscopy nen a rualin tih theih a ni.

GIST hi engtin nge enkawl a nih?

GIST enkawltu ber chu oncologist a ni . GIST hi a tlangpuiin surgery hmanga enkawl a ni a, tumor lakchhuah a ni. Mahse, i tana tha tur enkawlna chi chu test-in a hmuh danah a innghat ang. Chumi awmzia chu doctor-te chuan tumor lian tham tak, a awmna hmun, a bul tanna hmun atanga a darh (metastasized) leh tawh loh te an en dawn tihna a ni.

Entir nan:

• Lump hi a te lutuk a nih chuan i oncology surgeon chuan operation hmangin a la chhuak vek thei mai thei. Tichuan, enkawlna dang a ngai tawh lo mai thei.
• Mahse, tumor chu a lian hle emaw, operation harsa hmuna a awm emaw a nih chuan, i oncologist chuan operation hmaa tumor tihtlem nan damdawi chi khat , targeted therapy tih chu pe che a rel mai thei. Heng damdawi te hian GIST cells te tihpunna tura puitu thil bikte chu an target a, an bei bawk. Hei hian tumor chu a ti tlem a, operation pawh a ti awlsam hle. A châng chuan, heng targeted therapies te hi operation hnuah pawh GIST lo kir leh tawh lohna turin chhunzawm theih a ni.

GIST vei zawng zawng hian enkawlna inang an dawng vek lo tih hre reng ang che. I medical team chuan i dinhmun atana enkawlna tur ruahmanna tha ber tur an sawiho ang che.

Enkawlna hian eng side effect nge a neih?

Damdawi dang ang bawkin GIST enkawlna hian side effect engemaw zat a nei thei a ni.

Target therapy hmanga side effect awm thei thenkhat:

• Thil tihbuai
• Diarrhea (ril a na) .
• Chauhna leh hahna
• Muscle a ti na hle
• Nausea (riltam ang maia awm) .

Surgery neih chhunga side effects awm thei tlangpui:

• Anesthesia avanga thil thleng (e.g., luak chhuak, luak chhuak) .
• Surgery neihna hmuna natna
• Thisen chhuak

Heng side effects te hi mi zawng zawngah a thleng dan inang vek lo. Mi thenkhat chuan eng emaw zat an tawng thei a, thenkhat erawh chuan an tawng lo mai thei. Harsatna i neih chuan i doctor emaw nurse emaw hnenah hrilh ngei ang che. Side effect tam zawk hi chu enkawl theih a ni.

GIST ka neih chuan eng nge ka beisei leh ang?

Enkawlna zawh hnuah pawh i oncologist chuan a lo enkawl chhunzawm zel ang che. Hei hian a awmzia chu i dam leh dan leh hriselna tlangpui enfiah turin a hun takah follow-up appointment nei turin an rawn lut ang che tihna a ni. Heng appointment te hi thla thum atanga thla ruk danah neih thin a ni tlangpui.

Heng tlawhnaah hian i doctor chuan i natna lan chhuah dan a zawt ang che a, a enfiah ang che a, test dang, scan ang chi te pawh a ti thei bawk a, GIST chu a lo kir leh tawh em tih emaw, enkawlna a dawn dan tur emaw a enfiah thei bawk ang. Test hman tlanglawn tak takte chu:

• Liver leh pelvis CT scan hmanga enfiah a ni .
• MRI scan (Magnetic resonance imaging (MRI) hmanga enfiah) .
• PET scan hmangin targeted therapies-te chhanna hmuh theih a ni.

I doctor chuan heng test te hi eng chen nge i tih tur tih chu i dinhmun a zirin a rel ang.

GIST hmanga damchhuah zat hi engzat nge ni?

Hei hi thil sensitive tak a ni. GIST vei damchhuah zat hi mi hrang hrangah a inang lo. Hei hi tihfelna atan hian thil engemaw zat a kal a ni. Entirnan, GIST hmuhchhuah a nih huna tumor lian leh te, a active dan te, i hriselna zawng zawng te, leh tumor hian enkawlna a dawn dan te.

US National Cancer Institute (NCI) ang institution atanga data an lakkhawm dan chuan GIST vei zinga 85% vel chu he natna hi an hmuhchhuah atanga kum nga hnuah pawh an la dam a ni.

Mahse, hetiang statistics i hmuh hian thil tlemte i ngaihtuah tur a ni:

• Hengte hi chhut dan mai a ni: GIST nei tawh mi tam tak thil tawn atanga siam a ni. I dinhmun chu a danglam hle mai thei. Entirnan, i kum leh damdawi dang i neih leh neih loh te hian heng number te hi a nghawng thei a ni.
• Heng number te hi historical a ni: kum nga danah velin data an khawlkhawm thin. Chuvangin, enkawlna thar ber berte nghawng hi heng number-ah hian a tel lo. Enkawlna thar a awm chuan heng zat hi a tha lehzual thei ang.
• Survival rates leh dam rei zawng hi thil chi hrang hrang pahnih a ni: Survival rate hian eng chen nge i dam dawn tih a sawi lo. A bik takin GIST vei tan chuan dam rei zawng data hmuh a harsa hle.

Chuvangin, heng number te hian min ti buai suh. Zawhna i neih chuan i oncologist zawt la. Heng statistics te hi i dinhmun a hman dan tur a sawifiah thei ang.

Engtin nge i in enkawl ang?

I hriselna zawng zawng enkawl hi GIST enkawl lai leh enkawl hnuah pawh i tan thil tha ber a ni.

• Ei tha: Ei leh in chi hrang hrang, protein tamna, thau tlem leh a theih ang anga ei tum ang che. Nitin i ei tur ah hian greens, thlai leh thei chi hrang hrang te telh thin ang che. Ei leh in inthlau tak chuan i taksa chu a dam thuai theih nan chakna a pe ang.
• Exercise engemaw zat nei rawh: Natna chu a buaithlak thei hle. Enkawlna atanga i dam leh lai hian exercise light (kea kal ang chi) hian stress tihziaawmna a pe thei che a ni. Mahse, exercise thar i tan hmain emaw, exercise i tih tawh i tan leh hmain doctor nen in inbia fo tur a ni .
• Meizial zuk loh vek: Zuk leh hmuam chi hrang hrang (electronic cigarette pawh tel) hman hian cancer thar vei theihna a tipung a, GIST lo awm leh theihna a tipung bawk.

GIST ang natna hian a tir lamah chuan symptom lian tham a nei lo thei. I tih pawhin chaw ei kham loh emaw, pumpui natna emaw chauh a ni tih i ngaihtuah mai thei. Chuvangin, hetiang cancer tumor hmuh tur awm lo tak i nei tih i hriat hian thil mak tak a ni thei. Hetiang natna i neih chuan hun engemaw chen hmang la, he natna hmuh tur awm lo tak leh i enkawl dan tur te hi inzirtir rawh. Thil tam takah chuan enkawlna hian i natna lan chhuah dan a tiziaawm thei a, GIST pawh a tidam thei bawk. Zawhna tam tak i nei ang. I medical team te chu an zawng zawng chhanna tur leh thlawp turin an awm reng ang.

A tawp berah chuan thil hriat reng tur

GIST hi hlauh tur ni mahse, i hriat chian a, a hun taka enkawl i nih chuan result tha tak nei thei dinhmun a ni.

• Ngaihthah suh: I pum natna danglam tak, awm reng, thisen chhuak chhinchhiahna emaw, sawifiah theih loha i taksa rihna tlahniam emaw i neih chuan doctor thurawn la rawh.
• Diagnosis dik a pawimawh: GIST hriat theih nan test bik neih a ngai a ni. Chuvangin specialist ngaihdan zawng rawh.
• Enkawlna a awm: GIST enkawlna tha tak tak a awm a, chu chu surgery leh targeted therapy te hi a ni.
• Nangmah chauh i ni lo: i medical team, chhungte leh i ṭhiante chuan he zinkawngah hian an pui ang che.

A pawimawh ber chu chak taka awm a, damdawi lam thurawn zawm hi a ni.

` Gastrointestinal stromal tumor, GIST, cancer, chaw ei dan, KIT gene, surgery, targeted therapy te a awm bawk