Thluak super messenger: Glutamate chungchanga hriat tur i neihte!

I thluaka information chu engtin nge a kal leh zel tih i ngaihtuah ngai em? Thil thar kan zir hian, thil hlui kan hriatreng hian chemical messenger te tak te, mahse pawimawh tak mai, hnunglam atanga heng zawng zawng ti tura min puitu a awm a. Chu chu Glutamate an ti a . Dik tak chuan a tel lo chuan kan thluak hi a buai hle ang. Chuvangin vawiin hian he Glutamate hi eng nge a nih, kan taksaah eng hna nge a thawh tih te, a bik takin thluaka a hnathawh te, engvangin nge a pawimawh loh tih te, mahse a tam lutuk emaw a tlem emaw chuan eng harsatna nge a awm theih tih te pawh kan sawi dawn a ni. A awlsam zawngin, heng zawng zawng hi in hriatthiam theih turin kan sawi dawn a ni.

Glutamate hi eng nge ni tak tak?

A awlsam zawngin Glutamate hi neurotransmitter a ni . Neurotransmitters hi kan thluaka nerve cell (neurons) inkara thuchah kengtu thuchah te tak te angin han ngaihtuah teh. Chungte chu nerve cell pakhat atanga nerve cell dangah information leh signal thawn chhuaktu an ni.

Kan thluak ah hian glutamate hi excitatory neurotransmitter ber a ni . "Excitatory" tih hian nerve cell a tichak tihna a ni a, chu chu "a tiharh" tihna a ni. Tichuan chu thuchah chu nerve cell dang pan theihna chance a sang chho ta a ni. Mi pakhat kawngka kik a kaihthawh ang mai a ni. Chuvangin, thluak hnathawh that nan glutamate hi a pawimawh hle.

Tunah chuan engtin nge leh khawiah nge he glutamate hi siam chhuah a nih tih i ngaihtuah mai thei. Glutamate hi kan thluaka cell chi khat bik glial cells tih hian recycle leh siam thar a ni . Glial cells hi thluaka nerve cells te puitu, chawmtu leh venghimtu support cell chi khat a ni. Heng glial cells te hian glutamate hman tawh chu la in compound dang glutamine an tih ah an chantir thin . Tichuan, he glutamine hian nerve cells terminal area a thlen leh chuan glutamate ah a chang leh ta a ni. Mechanism mak tak mai a ni lo maw?

Chu mai pawh ni lovin, glutamate hi neurotransmitter pawimawh dang, gamma-aminobutyric acid (GABA) siamna atan pawh a pawimawh hle. GABA hi "calming" neurotransmitter tia hriat a ni. GABA hian mutthilh, chawlh hahdamna, lungkhamna thunun, leh taksa peng hrang hrang hnathawhna kawngah a pui a ni. Chuvangin, glutamate hian kawng khatah a tichak a, kawng dangah chuan calming agent siamnaah a pui bawk.

Glutamate hi neurotransmitter chauh a ni lo. Amino acid a ni bawk. Amino acids hi protein siamtu bulpui ber a ni. Building block ang maiin. Glutamate hi kan taksaah amino acid tam ber a ni. Taksaah hian Glutamate hi siam chhuah a ni a, taksa peng hrang hrang (muscle tissue)-ah a dah khawm a ni.

Tin, glutamate hi i hre tam ber a ni mai thei, a chhan chu food additive monosodium glutamate (MSG) vang a ni. Glutamate hi food flavoring agent MSG ah pawh a awm bawk.

Chuti a nih chuan engtin nge he glutamate hian hna a thawh? A mak khawp mai!

Glutamate ang chi neurotransmitter hi nerve cells te ngeiin an siam chhuak a ni. Nerve cell axon terminal-a synaptic vesicles an tih bawm te tak teah an dah khawm a ni. Hengte hi bubble te tak te angin ngaihtuah rawh. Bubble pakhatah hian heng neurotransmitter molecule sang tam tak a awm thei!

Tunah chuan, message emaw signal emaw chu nerve cell-ah a kal chuan, chu signal electrical nature chuan chu glutamate-a khat vesicles te te chu a inhawng a, glutamate chu nerve cell pahnih inkara synapse an tih, fluid-a khat gap tlemteah a chhuah tir a ni. Bridge ang mai a ni. He gap lehlamah hian nerve cell lo awm tur chu a awm a. Tunah chuan he glutamate hian a kal a ngai a, thuchah dawngtu nerve cell dang a special receptor te chu a binding a ngai ta a ni. Lock chhunga chabi fit ang mai a ni. Vawikhat a inzawm chuan glutamate hian chu nerve cell lo awm tur ah chuan inthlak danglamna emaw thiltih emaw engemaw zat a siam thin. Chutah chuan message chu nerve cell atanga nerve cell dangah a kal chhunzawm zel a ni.

Neurotransmitter dang tam zawk ang lo takin glutamate hian receptor hrang hrang pali a binding thei ! Master key pakhat hmanga lock pali hawn angin ngaihtuah rawh. Hetiang theihna hian glutamate hian thluak pumpuiah nghawng hrang hrang a nei thei a, nerve cell dangte nen pawh a inbiak theih phah bawk. Glutamate hian mihring thluaka excitatory activity 90% aia tam a thawk a ni. Chu chu a pawimawh zia chu i ngaihtuah thei em?

Kan thluak chhungah hian nerve cells te chu an inzawm khawm a, circuit tenau tak tak an siam a. Heng circuit tenau te hian hriatrengna hriatrengna ang chi hna tenau tak takah an pui thin. Tin, network lian zawk, zau zawkte chuan hna lian tak tak, thil harsa tak tak, hmuh, hriat, leh inthlak danglamnaah te a pui bawk. Glutamate hi neurotransmitter lian ber a ni a, heng circuit leh network kaltlangin chemical message a keng tel a ni. Nerve cell inkara synapse-a glutamate hnathawh dan hian heng cell inkara inbiakpawhna signal chu a tichak emaw, a tichak lo emaw a ni. Hna kaihhnawih tih dan tur a nghawng nghal vek a ni. Glutamate hi a hun takah, hmun dik takah leh a zat dik takah a chhuah loh chuan inbiakpawhna a tichhe thin. Chutiang bawkin glutamate a sang lutuk chuan nerve cell a tichhe thei a, inbiakpawhna network ngei pawh a tichhe thei bawk.

Glutamate hian kan taksa tan eng service nge a pek?

Glutamate hian kan taksaa hna pawimawh tak tak a thawh te chu hetiang hi a ni:

• Zirna leh hriatrengna:Kan sawi tawh ang khan receptor hrang hrang pali nena inzawmna a neih theih avangin glutamate hian nerve cell inkara thuchah hlawhtling leh rang taka thawn chhuah theihna chance a nei sang zawk a ni. Hetiang signal inthlakthleng leh information processing chak tak hi zirlai leh hriatrengna atan a pawimawh hle. Chu mai pawh ni lovin glutamate hian nerve cell te chu a inzawm thu leh hla inzawmkhawmna a siamsak bawk. Hei hi hriatrengna bulpui ber a ni. Ngaihtuah teh, thil thar i zir hian thluaka kawng thar a lo piang chhuak thin.
• Thluak cell te tana chakna petu: Kan taksa chakna bulpui ber glucose a tlem chuan glutamate hian thluak cell te tan chakna a pe thei a ni. Backup power supply ang mai a ni.
• Chemical messenger: Hei hi a hna ber a ni. Glutamate hian nerve cell inkarah chemical message a thawn chhuak thei a ni.
• Sleep-wake cycle management: Rannung zirchianna atanga a lan dan chuan kan harh lai leh mut ``Rapid Eye Movement'' (REM) phase lai hian glutamate level a sang hle. Nun hrisel nei tur chuan mut hrisel a pawimawh.
• A pain signal: Glutamate level sang leh natna hriatna level sang hi inzawmna a awm a. Chumi awmzia chu kan hliam hian chu natna chu thluak hnena thlen turin a pui bawk tihna a ni.

Engtin nge kan thluaka glutamate hi a pung?

A chang chuan kan thluaka glutamate awm zat hi a sang lutuk thei. Hei hi chhan hrang hrang a awm thei a:

• Nerve cell atanga glutamate chhuah tam lutuk .
• Glutamate hi thluaka glial cells atanga direct a chhuak a ni a, chu chuan thluaka glutamate awm zawng zawng a tipung a ni.
• Glutamate tam lutuk chu nerve cell (the synapse) inkar gap te tak te ah hian a awm reng a ni . Tichuan, glutamate receptor tam tak chu an thawk chhunzawm zel a, nerve cell te chu an tichak chhunzawm thei a ni.
• Nerve cell-a receptor te chu glutamate lakah an sensitive lutuk thin . Chumi awmzia chu glutamate molecule tlemte pawhin anmahni tichak turin an siam chhuak tihna a ni.

Glutamate a pun chuan eng nge thleng ang? Hei hi a hlauhawm khawp mai!

Thluaka glutamate a tam lutuk chuan nerve cell te chu a overstimulated thei a ni. He overstimulation hian thluak cell a tichhe thei a , a that thei bawk . Chutiang a nih chuan glutamate hi excitotoxin an ti a. Chu chu a rualin stimulant leh poison angin a thawk tihna a ni.

Thluaka glutamate level sang hi damdawi lam thil hrang hrang nen a inzawm tih hmuhchhuah a ni a, chung zingah chuan:

• A rilru a hah lutuk chuan a rilru a buai em em a, a rilru a hah lutuk chuan a rilru a buai em em bawk a.Chutiang a nih chuan taksa ruhte chu a chak lo zauh zauh a.
• Multiple Sclerosis: Natna chi khat, nervous system tichhe thei.
• Alzheimer natna: I hre tawh mai thei, natna tlanglawn tak, hriatrengna hlohna thlentu a ni.
• Parkinson natna: Taksa che vel a nghawng a, ke leh ke ruh thawm ang chi symptoms hmuh tur a awm thei.
• Huntington natna: Thluak cell tichhe thei, rochun natna a ni.
• Stroke: Thluaka thisen kalna tur a tihbuai avanga natna lo awm.
• Fibromyalgia: Taksa pumpuiah natna leh hahna a thlen thin.
• Chronic fatigue syndrome: Hun rei tak chhunga hah lutuk.

Glutamate siam chhuah emaw hman emaw avanga harsatna awm nia ngaih rilru lam harsatna pawh a awm bawk:

• Mood leh lungkhamna lama harsatna nei .
• Autism a awm avangin .
• Lungngaihna .
• Obsessive-compulsive disorder (OCD) hi ngaihtuahna leh thiltih duh loh zawnga hriat theih natna a ni .
Schizophrenia hi rilru lam thil a ni .

Pawimawh: Glutamate imbalance hi heng natna thlentu pakhat a nih theih laiin, hengte hi thil buaithlak tak tak, chhan dang tam tak nei thei an ni. Doctor chauhvin dik takin a diagnosis thei.

Chuti a nih chuan glutamate a tlahniam chuan eng nge thleng ang?

Glutamate tihpun bakah hian thluaka glutamate level tlahniam pawh hi harsatna a ni. Hei hian a hnuaia mite hi a thlen thei niin an ngai:

• Trouble concentrating : Hnathawh emaw lehkha zir emaw lama ngaihtuahna seng harsa.
• Rilru hahna : Thluak hi a chau hlein a hria.
• Insomnia : Zana mut harsa.
• Energy hniam : Engmah awm lo ang maia inhriatna.

A tawp berah chuan hriat reng tur (Take-Home Message) .

Chuvangin, tunah chuan kan thluak leh central nervous system tan neurotransmitter glutamate hi a pawimawhzia leh a pawimawh em em tih i hrethiam tawh mai thei. Glutamate hian kan thluak hnathawh dan dik takah hmun pawimawh tak a chang a, a bik takin zirlai leh hriatrengna ang chi thil siamnaah hian hmun pawimawh tak a chang a ni.

Mahse a pawimawh ber chu glutamate hi a hun takah, hmun dik takah leh a concentration dik takah a awm tur a ni.Glutamate hi thluaka awm, hmun dik lo, concentration sang lutuk, rei lutuk a awm chuan thluak cell te a tichhe thei a, a that thei hial a ni. Kan sawi tawh neurodegenerative natna thenkhat, Parkinson’s disease, Alzheimer’s disease, leh Huntington’s disease te hi he nerve cells overstimulation nen hian a inzawm tlat a ni. Glutamate siam emaw hman emaw chungchanga harsatna awmte hi rilru lam harsatna, autism, depression, leh schizophrenia te nen pawh a inzawm thei bawk.

Chuvang chuan kan taksaa he chemical messenger mak tak mai hi kan hriat chian a pawimawh hle. Hemi chungchangah hian harsatna emaw rinhlelhna emaw i neih chuan damdawi lam thurawn lak a tha ber. A chhan chu heng zawng zawng hi inthlau taka vawn reng hi nun hrisel neihna atana thil pawimawh ber a ni.

` Glutamate, Thluak, Neurotransmitter, Hriatrengna, Zirna, MSG, Rilru hriselna, Thluak lam natna