I doctor hian nangmah emaw i hriat mi emaw hnenah Guanidine tih pill a pe che em? He hming i hriat hian i hre duh deuh mai thei, a nih loh leh i hlau deuh pawh a ni thei. A chhan chu hei hi damdawi kan hriat fo a nih loh vang a ni. Guanidine hi damdawi a ni a, damdawi lam natna chiang tak leh hmuh tur awm lo tak enkawlna atana hman thin a ni. Chuvang chuan hei hi kan hriat chian a pawimawh hle a ni. Chuvangin, vawiinah hian heng Guanidine pills te, an damdawi lam dinhmun te, an hman dan te, leh fimkhur tur thil te kan sawi dawn a ni.
Guanidine hi eng nge ni a, eng natna nge a enkawl?
A awlsam zawngin Guanidine hi nerve tichaktu leh taksa ruh hnathawh tichaktu damdawi a ni. Damdawi lam hawi chuan `cholinergic muscle stimulants` tih damdawi class-ah a tel a ni.
He damdawi hi autoimmune condition hmuh tur awm lo tak Lambert-Eaton Myasthenic Syndrome (LEMS) tih enkawlna atan hman a ni ber.
LEMS hi eng nge a nih tih tlem han hrethiam ila.
Ngaihtuah teh, kan taksa chetna hi thluak atanga thuchah lo lutte hian a thunun a ni. Heng thuchahte hi nerve kal tlanga kal a, taksa ruh a thlen chuan kan kut leh ke kan che thei a, kan kal thei bawk. Nerve leh taksa ruh inzawmna hmunah chuan nerve tawp atang hian chemical `Acetylcholine` an tih chu a chhuak a. He chemical hian muscle a thlen chuan muscle chu a contract a, chu chu a thawk tihna a ni.
Mahse LEMS vei miah chuan taksa immune system chuan chu nerve endings chu a bei sual a ni. Chuvang chuan `Acetylcholine` mamawh zat chu a chhuak lo. Chumi rah chhuah chu taksa ruhte’n thuchah an dawn dik loh avanga chak lohna nasa tak leh hahna a ni. Muscle chak lohna hi ke leh hip-ah a tam hle.
Guanidine hian nerve tawp atanga chemical messenger (Acetylcholine) chhuahna tur a tichak a ni. Hei hian blocked message flow chu a tichak a, muscle te chu a thawk tha leh thei tihna a ni.
Damdawi ei tan hmaa doctor hnena i hrilh tur thilte
Guanidine hi fimkhur taka hman tur a ni. Chuvangin, he damdawi hi i pek hmain i medical history kimchang i doctor hnenah hriattir hmasak phawt a pawimawh hle. A hnuaia condition te hi i neih chuan hrilh ngei ang che:
- Kidney natna: Kidney nena inzawm natna i neih chuan doctor hnenah i hrilh tur a ni, chu chu taksa atanga he damdawi paih chhuahna kawngah hian kal hian hmun pawimawh tak a chang a ni.
- Liver natna: Liver function chak lohna a awm chuan sawi bawk ang che.
- Thisen cell harsatna: I thisenah thisen var, red blood cells, platelets tlahniam nia report i nih chuan chu chu thu pawimawh tak a ni.
- Rilru lam natna: In enkawl mek emaw, rilru natna nei tawh emaw i nih chuan min hriattir dawn nia.
- Allergy: Guanidine emaw damdawi dang emaw, ei tur emaw, dye dang emaw allergy i neih chuan.
- Naupai emaw, nau neih emaw: Naupai emaw, naupai tum emaw i nih chuan hei hi sawi tel ngei ngei tur a ni.
- Nau hnute pek: Nu hnute petu i nih chuan doctor hnenah pawh hrilh bawk ang che.
He damdawi hi engtin nge ka hman ang?
He damdawi hi i hman huna a pawimawh ber chu i doctor thupek dik taka zawm hi a ni.
- He pill hi tui glass khat nen ei la.
- Damdawi hi prescription label-a tarlan ang chiah khan hmang ang che. I doctor-in ei tur a tih zat aia tam emaw, tlem emaw ei suh.
- Hei hi chaw ei hma emaw ei zawhah emaw ei theih a ni. Mahse, pum na i neih chuan ei tur nena ei hian a tihziaawm thei.
- Nitin hun khata, a hun taka i damdawi ei thin kha tih danah hmang rawh.
- A pawimawh ber: Doctor thurawn tel lo chuan eng vangin damdawi ei kha bansan suh. I chawlhsan nghal chuan i symptoms te chu a lo let leh thei a, a ti na zual thei bawk.
- Naupang hnena pek a nih chuan: He damdawi hi naupang hnena pek dawnin naupang enkawltu doctor rawn a pawimawh hle.
Damdawi ka ei tam lutuk chuan engtin nge ni ang? (Overdose) a ni.
I ngaihtuah aia tam damdawi i ei palh mai thei nia i ngaih chuan tihkhawtlai suh. Colombo National Hospital-a National Poisons Information Center-ah call nghal la, a nih loh leh damdawi in hnai ber Emergency Treatment Unit (ETU)-ah kal nghal rawh.
Side effect leh interaction te pawh i zir dawn bawk ang.
Damdawi dang ang bawkin Guanidine hian side effect a nei thei a ni. Damdawi dang nen pawh a inzawm thei bawk.
Side effect awm thei te
Chung zinga ṭhenkhat chu pawi tak a ni thei a, ṭhenkhat chu a awm fo bawk. Hengte hi hriat chian a pawimawh.
| Side effect chi hrang hrang | Ziarang |
|---|---|
| Side effect na tak tak, damdawi lam pan vat ngai | |
| Allergy natna a awm thei | Vun na, a hring, a hring |
| Thâwk lak harsat | Thâwk harsa |
| Heart rate a inthlak danglam thin | Thinlung thawk chak emaw, mumal lo emaw |
| Hri kai theihna chhinchhiahna | Khawsik, ril na |
| Rilru lam inthlak danglamna | Thil tak tak ni lo hmuh emaw hriat emaw (Hallucinations) . |
| Zun lama harsatna a awm | Zun harsatna emaw, zun i siam chhuah zat inthlak danglam emaw |
| Chak lohna danglam tak | Taksa hah lutuk leh chak lohna nasa tak neia hriat |
| Liver-a nghawng a neih dan | Mit emaw vun emaw a sen (jaundice ang chi) . |
| Common side effects te chu a awm reng chuan doctor hnenah hriattir tur a ni | |
| Thiltih dan tlangpui | Kawng vawt, luak chhuak, lu na, pum na, luak/ luak, ril\am, chaw ei chak lohna |
| Nervous system-a nghawng a neih dan | Numbness, tingling, emaw taksa peng hrang hranga natna, mood inthlak danglam |
Guanidine nena inzawm damdawi dang (Drug Interactions) .
Damdawi dang i ei hian Guanidine hnathawh dan a nghawng thei a ni. Chuvangin i damdawi ei zawng zawng (vitamin leh herbal products te pawh tel) i doctor hnenah hrilh la, a bik takin a hnuaia mi i ei a nih chuan:
- Cancer natna damdawi ei thin thenkhat
- Organ transplant hnua immunity control nana damdawi pek thin
- Seizure damdawi thenkhat (e.g., `Carbamazepine`) .
- Rilru natna damdawi ``Clozapine'' ang chi te.
- Phenothiazine (e.g. Chlorpromazine) te hi a tha hle.
- Steroid chi hrang hrang damdawi (e.g. `Prednisone`, `Cortisone`) te hi a ni.
- `Sulfinpyrazone` tih a ni
He list hi a kim lo tih hre reng la, chuvangin i himna atan i ei zawng zawng doctor hnenah hrilh vek a tha ber.
Take-Home Thuchah a ni
- Guanidine hi neuromuscular disease hmuh tur awm lo, chiang tak, Lambert-Eaton Myasthenic Syndrome (LEMS) tih enkawlna atana hman a ni.
- Damdawi i ei zawng zawng chu i doctor hnenah hrilh ngei ang che, a bik takin kal, thin, thisen lama harsatna i neih chuan.
- I doctor thurawn tel lo chuan damdawi i ei tan ngai lo va, i chawlhsan tur a ni lo va, i thlak ngai lo tur a ni.
- Thawk harsa, heart rate inthlak danglam, mit sen, khawsik ang chi side effect na tak tak i neih chuan doctor rawn la nghal rawh.
- Overdose i rinhlelh chuan National Poisons Information Center emaw, damdawi in Emergency Department (ETU)-ah emaw kal nghal rawh.
- Damdawi hi hmun him takah room temperature-ah dah la, naupangte hmuh theih lohna hmunah dah rawh.
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