HNPCC (Hereditary Nonpolyposis Colorectal Cancer) tih hi eng nge ni? I chhungkuaah cancer vei tawhna history a awm em?

A châng chuan chhûngkaw pakhata mi engemaw zât chuan cancer chi khat an vei tih kan hmu ṭhîn. A nih loh leh chhungkaw khata mite hian he natna hi an vei theihna a sang zawk niin an sawi bawk. Chu chu vawiinah kan sawi dawn a ni. Hei hi thupui buaithlak deuh mahse, awlsam taka hriatthiam tum ila.

HNPCC leh Lynch Syndrome hi eng nge ni?

A awlsam zawngin sawi ila, HNPCC (Hereditary Nonpolyposis Colorectal Cancer) hi colorectal cancer chi khat a ni a, genetic mutations avanga lo awm a ni. Hei hi a chhan chu kan nu leh pate hnen atanga kan rochun gene thenkhat hian cancer cells kan neih theihna a tipung zawk a ni.

Lynch syndrome tih hi i hre tawh mai thei, chu chu Lynch syndrome an ti bawk . HNPCC leh Lynch syndrome hi a takin an inzawm a, mahse an inang chiah lo. HNPCC hi a bik takin kum 50 hmaa Lynch syndrome nena inzawm cancer hmuhchhuah a ni tih kan sawi a, hei hian colon cancer chauh ni lovin, uterus lining (endometrium), small intestine, ureter, leh renal pelvis cancer te pawh a huam thei a ni. HNPCC-ah chuan cancer hi colon dinglam lamah a tam ber.

HNPCC hi engtiang chiahin nge a hluar?

HNPCC hian colorectal cancer zawng zawng zinga 2% leh 4% inkar a huam a ni. Kum eng pawhah a awm thei a, mahse a lan chhuah dan a lang fo a, kum 50 an tlin hmain natna hi hmuhchhuah a ni.

HNPCC natna lanchhuahna chu engte nge ni?

A tir lamah chuan HNPCC hian symptom a nei lo thei. Chumi awmzia chu i taksa chhungah cancer chu engmah hre lovin a lo thang lian thei tihna a ni. Mahse cancer a lo lian zel chuan hetiang hian symptoms i nei thei a:

• Pum na emaw, pum na emaw.
• Chaw chu a thlum lo.
• Thisen chhuak chu stool ah a awm. (Hei hi chhinchhiahna pawimawh tak a ni a, ngaihthah suh!)
• Chau tih hriat reng (Fatigue).
• Chhan chiang tak awm lovin taksa rihna tihtlem.

HNPCC awm chhante chu engte nge ni?

Kan sawi tawh ang khan HNPCC hi kan nu leh pate hnen atanga kan rochun gene mutations avanga lo awm a ni. Heng genetic defects te hi thlah khat atanga thlah dangah an kal zel chuan chu chhungkuaah chuan cancer vei theihna a sang chho zel a ni. Hei hi ‘chhungkaw cancer syndrome’ kan ti a.

HNPCC thlentu chhungkaw cancer syndrome ber chu Lynch syndrome a ni . Gene MLH1, MSH2, MSH6, PMS2, leh EPCAM -a mutations avanga lo awm a ni. Heng genes te hnathawh chu kan cell te inthen darh huna DNA replication laia tihsual lo awm thin siamthat hi a ni. Ngaihtuah teh, heng gene-te hian hna an thawk tha lo a nih chuan chu tihsualte chu siamthat a ni lo. Tichuan cell pangngai cancer cell nih theihna chance a sang zawk hle.

HNPCC hi hri kai a ni em?

Ni lo, HNPCC hi natna hrik kai theih a ni lo. Chumi awmzia chu khawih emaw, hrual emaw a\anga mi dangah a darh lo tihna a ni. Mahse, HNPCC thlentu gene mutation hi thlah khat atanga thlah dangah a kal zel a ni . Chuvangin, he gene mutation nei chhungkaw member engemaw zatin colon cancer emaw, Lynch syndrome nena inzawm cancer dang emaw an vei thei a ni.

A pawimawh ber chu he gene chhia leh HNPCC vei theihna hlauhawmna hi nu leh pa atanga fate rochun theih a ni.

Doctor-te hian engtin nge colon cancer hi an hriat theih?

Doctor-te hian colon cancer a awm leh awm loh enfiah nan taksa enfiahna an nei tlangpui. Chumi hnuah chuan colonoscopy , an rawt a, chu chu i hnute kal tlanga tube te tak te, eng nei tak dahin i ril chhung lam enfiah a ngai a ni.

I chhungte zingah HNPCC nei an awm chuan i doctor hnenah i hrilh ngei ang . A pawimawh hle mai.

HNPCC finfiah nan eng test nge tih thin?

I doctor chuan Lynch syndrome nena inzawm gene mutation i neih leh neih loh hriat nan genetic test neih a rawt thei ang. I doctor chuan hetiang hian a zawt bawk ang:

• I chhungte hnai ber (nu, pa, unau) zingah hian colon cancer vei an awm tawh em? A bik takin kum 50 a tlin hmaa hmuhchhuah a nih chuan.
• Tin, hereditary colon cancer condition dang Familial Adenomatous Polyposis (FAP) , HNPCC aiin genetic mutation danglam tak avanga lo awm a ni lo tih a tichiang bawk.

HNPCC tan hian surgery a ngai em?

Ni e, HNPCC hi operation hmanga enkawl a ni fo. He surgery hi colectomy an ti a . Chu chu intestine lian thenkhat emaw, a pum emaw lak chhuah a ni. Surgery hi chi hrang hrang a awm a:

• Partial colectomy emaw segmental colectomy: Hetah hian colon cancer awmna hmun chauh lakchhuah a ni.
• Protectomy: Hei hian colon leh rectum lakchhuah a ni.
• Total colectomy: Hetah hian colon pumpui chu lakchhuah a ni.

HNPCC tan hian eng enkawlna dang nge awm?

Colon cancer hi taksa peng dangah a darh (metastasized) a nih chuan i doctor chuan enkawl dan tur a rawt thei ang:

• Chemotherapy: Hei hian cancer cell tichhe thei damdawi pek a ni.
• Immunotherapy: Hei hian cancer cells do turin kan taksa ngeia immune system tihchak a huam a ni.

Doctor-te chuan immunotherapy hi an duh zawk fo a, a chhan chu a hlawk zawk fo a, side effect a nei tlem zawk bawk.

HNPCC hi ven theih a ni em?

Heng chhungkaw cancer syndrome te hi inherited genetic mutations avanga lo awm a ni. Chuvangin, heng genetic mutations lo awm tur hi ven theih a ni lo . Mahse, i chhungkuaa mi tu emaw chuan Lynch syndrome emaw HNPCC emaw a neih chuan i doctor nen pawh i genetic testing neih tur nge tih chungchang sawipui a pawimawh hle.

Screening neih fo leh a tul chuan preventive surgery neih hian HNPCC vei te thihna a ti tlem thei a ni.

HNPCC vei theihna hlauhawm ka nih leh nih loh engtin nge ka hriat theih ang?

Genetic testing-in Lynch syndrome nena inzawm gene mutation i nei tih a nemnghet a nih chuan, i doctor chuan kum 20 hnuai lam atanga colorectal cancer screening neih a rawt thei ang Cancer hi a hmaa hmuhchhuah a nih chuan enkawl hlawhtling theihna chance a sang hle.

HNPCC ka neih chuan eng thil dang nge ka beisei ang?

HNPCC i neih chuan HNPCC nena inzawm cancer dang i vei theihna a sang zawk mai thei. Chuvangin i doctor pawhin heng cancer chi hrang hrangte hi a screen fo thei bawk che a ni:

• Thluak cancer a ni
• Kidney cancer a ni
• Liver cancer a ni
• Ovarian cancer a ni
• Pum cancer a ni
• Vun cancer a ni
• Nausen pum/Endometrial cancer a ni

HNPCC hi tihdam theih a ni em?

Lynch syndrome hi genetic condition a nih avangin a dam kim thei lo. Mahse, colon pum pui lakchhuahna operation (total colectomy) hian HNPCC a tidam thei a, colon cancer lo awm tur a veng thei bawk .

HNPCC vei te tan hian eng prognosis nge ni?

HNPCC vei hmuhchhuah zinga 60% vel chu kum nga hnuah pawh an la dam . Chumi awmzia chu damlo 100 zinga 60 chu HNPCC hmuhchhuah a nih atanga kum nga hnuah pawh an la dam tihna a ni. Lynch syndrome vei te kum 10 chhunga dam rei zawng zawng chu 70% leh 88% inkar a ni. Heng statistics te hi hlauhawm tak angin a lang thei a, mahse , a hmaa hriat chhuah leh enkawl dan dik a nih chuan he natna hi a tam zawkah chuan control theih a ni tih hre reng ang che .

HNPCC ka neih chuan engtin nge ka in enkawl ang?

Colon cancer chhinchhiahna thar i neih chuan i doctor hnenah hrilh nghal rawh . Colon cancer venna atana pui turin hengte hi i ti thei ang:

• Meizial zuk loh tur.
• Ei leh in hrisel ei rawh.
• Exercise neih fo thin ang che.
• I doctor-in cancer screening a rawt zawng zawng chu ti vek rawh.
• Zu in hi tihtlem rawh.
• I taksa rihna hrisel tak vawng reng rawh.

Ka fa hi HNPCC vei theihna hlauhawmah a awm em?

Lynch syndrome i neih chuan i fa hian a thlentu gene mutation hi 50% in a rochun theihna chance a nei a ni. Chumi awmzia chu fa pahnih i neih chuan pakhatin gene a rochun thei a, pakhatin a rochun lo thei tihna a ni. Chutiang gene mutation chu rochun a nih chuan chu naupang chuan HNPCC vei theihna a sang zawk.

FAP leh HNPCC colon cancer hi a inang em?

HNPCC leh FAP (Familial Adenomatous Polyposis) te hi genetic colon cancer an ni vek a, mahse gene hrang hranga mutations avanga lo awm an ni .

FAP vei te hian an colon ah polyp tam tak an nei thin. A châng chuan heng thil te tak te, polyp an tih hi sang tam tak a awm ṭhin. Mahse, HNPCC vei te hian polyp an nei tam lo va, a chang chuan polyp nei lovin cancer a lo awm thei bawk. HNPCC-a polyp lo awmte hi a flat tlangpui.

Heng dinhmun pahniha polyp lo awm hi precancerous , hun rei lote chhungin cancer-ah a chang thei tihna a ni.

He thawnthu a\anga kan hriat reng tur pawimawh tak takte chu

HNPCC (Hereditary Nonpolyposis Colorectal Cancer) hi colorectal cancer chi khat a ni a, chu chu genetic defect avanga lo awm a ni a, thlah kal zelah a lo awm thin a ni. Lynch syndrome nen pawh a inzawm tlat a ni.

• Chhungkaw history-a cancer vei an awm chuan doctor nen inbiakna neih a pawimawh hle.
• Symptoms i nei lo a nih pawhin, i hlauhawm a nih chuan , screening neih fo thin ang che.
• A hmaa hmuhchhuah a nih chuan enkawlna a hlawhtling zawk a ni.
• HNPCC hi natna hrik kai theih a ni lo a, mahse genetically inherited a ni thei.
• Hrisel taka nun leh damdawi lam thurawn zawm a pawimawh hle.

Hemi chungchanga zawhna dang i neih chuan i doctor zawh hreh suh. An pui ang che.

` HNPCC, Lynch syndrome, colorectal cancer, colon cancer, rectal cancer, genetic mutations, hereditary cancer, cancer screening, colonoscopy, surgery, chemotherapy, immunotherapy te a ni