Leptomeningeal Disease hi eng nge ni? Kan sawi dawn nia!

Cancer i vei tih i hriat huna i hlauhthawn leh lungkhamna chu thu hmanga sawi a harsa hle. Cancer i do lai hian taksa peng dangah pawh a darh thei tih kan hre vek tawh. Vawiin hian cancer hian kan thluak, kan ruhro vel a membrane leh kan cerebrospinal fluid a nghawng theih dan pakhat kan sawi dawn a ni. Doctor te chuan hei hi Leptomeningeal Disease an ti a , a then chuan LMD emaw LM emaw an ti bawk .

A awlsam zawngin, Leptomeningeal Disease hi eng nge ni?

Okay, hei hi tlem han titawp ila. Kan thluak leh kan ruhro (spinal cord) vengtu (thin membrane) pathum a awm a. Chungte chu meninges kan ti a. Heng meninges chhunga awm membrane te tak te pahnih hi leptomeninges an ti a . Lehkhabu cover ang bawkin heng membrane te hian heng kan nervous system pawimawh ber pahnih hi a venghim a ni.

A dawtah chuan kan thluak chhungah leh kan ruhro vel a luang chhuak tui bik a awm a. Hei hi cerebrospinal fluid (CSF) an ti a. He tui hian thluak leh ruhro a chawm a, a venghim a, bawlhhlawh a paih chhuak bawk.

Tunah chuan leptomeningeal disease (LMD) chu taksa hmun dangah cancer, hnute cancer emaw lung cancer emaw ang chi chu a darh a, chu kan sawi tawh leptomeningeal membrane leh cerebrospinal fluid (CSF)-ah a lut a ni. Chu chu cancer cell te chu he tuiah hian an inphah tan tihna a ni a, tuiah bawlhhlawh a inphah ang mai a ni. Hei hi cancer natna khirh tak anga ngaih a ni.

Leptomeningeal disease (LMD) hi engtiang chiahin nge a hluar?

Leptomeningeal disease (LMD) hi a takah chuan chutiang chuan a awm lo. Mahse, cancer natna vei rei zawka dam theihna tur damdawi lama hmasawnna a awm avangin a hluar chho zel a ni. A vaiin LMD hi cancer vei 5% vel ah a awm thin.

He LMD natna hi a hnuaia cancer chi hrang hrang nei te zingah hian hmuh tur a tam ber a ni:

• Breast cancer: Hnute cancer hi LMD nena inzawm hnute cancer chi khat a ni. Hmeichhia hnute cancer vei zinga 3% atanga 5% vel a nghawng a ni. Zirna hrang hrangah chuan hmeichhia ``Triple negative breast cancer'' tih chi leh subtype ``Lobular breast cancer'' nei te chu LMD vei an tam zawk tih hmuhchhuah a ni.
• Lung cancer: Non-small cell lung cancer (NSCLC) leh small cell lung cancer (SCLC) te hi leptomeninges leh cerebrospinal fluid-ah te a darh thei a ni. Doctor-te chuan NSCLC vei zinga 4% leh 7% inkar chuan LMD an vei niin an chhut. He rate hi SCLC vei zinga 11% velin a pung a ni.
• Melanoma: Hei hi vun cancer chi khat na tak a ni. Melanoma vei zinga 5% velLMD a lo awm thei.
• Acute lymphocytic leukemia (ALL): Hei hi thisen cancer a ni. ALL vei zinga 1% leh 10% inkar chuan LMD an vei thei a ni.
• Non-Hodgkin’s lymphoma (NHL): Hei hi lymphatic system cancer a ni bawk. NHL vei zinga 5% leh 10% inkar chuan NHL an vei thei a ni.

Brain metastases leh leptomeningeal disease (LMD) te hi eng nge an danglamna?

Heng pahnih hi cancer a darh hian a thleng a, mahse a danglamna tlem a awm.

Brain metastases chu cancer cell te thluak tissue-a direct-a kal a, chutah chuan tumor siam a ni.

Mahse, leptomeningeal disease (LMD) chu cancer cell-te chu cerebrospinal fluid (CSF) leh thluak leh ruhro hual vel leptomeningeal membrane- a an kal hian a ni Hetah hian cancer cell te hi fluid chhungah an inphah emaw, membrane chung lamah an darh emaw a ni thei.

A châng chuan heng dinhmun pahnih hi a awm dun thei a, a hranpain a thleng thei bawk.

He natna lan chhuah dan engte nge ni?

Leptomeningeal disease (LMD) hi chhinchhiahna tam tak a awm thei a, chu chuan kan nervous system pumpui ni thin thluak leh ruhro a nghawng avangin. Mahse, a lan chhuah dan tlangpui thenkhat chu hetiang hi a ni:

• Lu na: Hei hi mi tam zawkin an tawn ber a ni. Lu na pangngai ang a ni lo, a na deuh thei a, a chang chuan zing lamah a na zual bawk.
• Nausea leh vomiting: Nausea leh vomiting a awm thei a, a bik takin zing lamah a awm thei.
• Kal dan inthlak danglamna: I kal laiin thunun theih loh leh tlu ang maiin i inhria thei.
• Hriatna hloh: Hriatna hloh hi a thleng thut thei a, i beng chhungah thawm hrang hrang i hre tan thei bawk.
• Mit lama harsatna: Double vision leh blurred vision a awm thei.
• Seizures : Thil hriatna hloh nghal mai leh convulsion a awm thei.
• Buaina leh hriatna, rilru put hmang, a nih loh leh nungchang inthlak danglamna: Thil ngaihtuah harsa, hriatrengna hloh, thinrim, leh buaina a awm thei.
• Hnung leh ke na: Hnung leh ke dungah natna a awm thei.
• Ke emaw, hnute emaw a hring emaw, chak lohna emaw: I ke chu a hring leh nunna nei lo angin a lang thei.
• Zun emaw, bawlhhlawh paih emaw lama harsatna: Zun leh ek thunun a harsa thei.
• Neurological problem thar dang: Hei bakah hian neurological symptom thar a lo lang thei a, chu chu tawng harsa leh hmai hmun thenkhatah a bengchheng thei a ni.

A pawimawh ber chu cancer i vei a nih chuan heng ang symptom thar i neih chuan doctor hnenah hrilh nghal tur a ni.

Engvangin nge leptomeningeal disease (LMD) hi a lo awm?

A awlsam zawngin sawi ila, LMD hi cancer cell-te chu taksaa cancer awmna hmun (e.g., hnute, lung) atanga an inthen a, thisen emaw lymphatic system emaw kal tlanga an kal a, kan sawi tawh ang khan cerebrospinal fluid (CSF) leh leptomeninges-a an luh hian a lo awm thin. Hei hian cancer hi eng chen nge a darh tawh tih a tilang chiang hle.

A tlangpuiin cerebrospinal fluid (CSF) hi kan thluaka siam a ni a, chutah chuan thluak leh ruhro vel a fang kual a, thisenah a lut leh thin. Hei hi cycle khatah a thleng thin. Mahse, cancer cell-te chu he CSF-ah hian an luh chuan he tui kal dan pangngai chu an tibuai thei a ni. Tichuan CSF chu a pung khawm thei a, thluak chhunga pressure a ti sang thei a ni. Chuvang chuan symptom tam tak a lo lang thin. Tin, cancer cell te chu leptomeninges membrane ah an darh chuan chu membrane leh a inzawm nerve te chu an tichhe thei bawk.

Doctor-te hian engtin nge hei hi an hriat?

LMD i vei nia i rinhlelh chuan doctor-te chuan test lian pahnih an ti ang:

1. MRI scan (Magnetic Resonance Imaging - MRI): I thluak leh/ emaw i ruhro (spinal cord) MRI scan hmangin cancer cells leptomeninges-a darh leh CSF kal dan a tikhawlo em tih enfiah thin a ni.

2. Lumbar puncture / Spinal Tap: He test ah hian i hnungzang hnuai lam ah needle te tak te dahin, i spinal cord tihchhiat loh nan fimkhur takin, cerebrospinal fluid (CSF) sample tlemte lakchhuah nan. Chumi hnuah sample chu lab-ah test a ni a, cancer cell a awm leh awm loh enfiah a ni.

A chang chuan cancer cell darh dan hi a fiah lo hle (microscopic) a nih chuan MRI scan-ah hmuh theih a ni lo. Chutiang hunah chuan natna hriatchhuah chu a harsa deuh thei a ni. Chuvang chuan i natna lan chhuah dan dik tak doctor hrilh a pawimawh.

Hei hi damdawi famkim a awm em?

Vanduaithlak takin tunah hian leptomeningeal disease (LMD) hi damdawi a la awm lo. Cancer natna pawi tak, darh zau tak a nih avangin enkawlna tum ber chu cancer darh zel control te, a lan chhuah dan tihtlem leh a nuam thei ang bera nun pui te, nunphung tha vawng reng te hi a ni.

Enkawl dan tur chu a tir lama i cancer chi hrang hrang, cancer a darh dan leh i hriselna zawng zawngah a innghat a ni. Enkawlna hman tlanglawn tak tak thenkhat chu:

• Radiation therapy: Radiation therapy hi thluak emaw ruhro (spinal cord) a natna hmun thenkhatah pek thin a ni. Hei hian symptom thenkhat (e.g., natna, nerve chak lohna) a tihziaawm thei a, nerve function thenkhat a ti tha thei bawk.
• Chemotherapy hmanga enkawlna:Damdawi hi cancer cell thah nan an pe thin. Heng damdawi te hi pill angin ei theih a ni a, vein-ah injection angin pek theih a ni a, a chang chuan cerebrospinal fluid (CSF)-ah direct-a inject theih a ni bawk. Hei hi ``Intrathecal chemotherapy'' an ti a, hei hi thluaka tube te tak te dah, ``ventricular access device'' tih hmanga tih a ni.

Hetiang thil thleng hi tihtlem dan tur a awm em?

Dik tak chuan tun dinhmunah hian LMD hi taksaa awm tawh cancer darh zel avanga lo awm a nih avangin a lo awm tur venna tur kawng chiang tak a awm lo.

He natna hi eng chen nge i dam theih ang?

Hei hi zawhna zawh harsa tak a ni tih ka hria. LMD hi cancer natna dinhmun sang tak a ni. Chumi awmzia chu hetiang dinhmun hi a lo awm chuan damlo chu cancer na ber stage-ah a awm tihna a ni.

A vaiin, enkawlna dawngtu damlote chuan an natna an hmuhchhuah hnuah thla thum aṭanga thla ruk chhung an dam theih an beisei thei a ni . Enkawlna dawng lo tan chuan he hun hi thla khat vel a ni thei.

Mahse, hei hi mi tin a inang lo thei. Thil tam takah a innghat a, chu chu cancer chi i neih leh i taksain enkawlna a dawn danah a innghat a ni. Hemi chungchangah hian i doctor hi a tha ber a ni.

Engtin nge ka in enkawl ang? Hospice care hi ka ngaihtuah tur em ni?

LMD i neih chuan i dinhmun hi chiang taka hriatthiam a pawimawh. LMD hi cancer natna hlauhawm tak, tihdam theih loh a ni. I dinhmun a zirin i doctor hnenah eng nge i beisei tur tih zawt rawh. Chutiang chuan i natna lan chhuah dante chu i enkawl thei a, a nuam thei ang bera i awm thei a, i tana pawimawh thilte chu i dah pawimawh ber thei bawk.

Hengte hi sawipui awlsam a ni lo, nangmah emaw, i doctor emaw nen pawh nise. Mahse an pawimawh em em a ni. I doctor hian i taksaa thil thleng leh nakin lawka thil thleng thei turte hriatthiamna a pe thei che a ni. I duhthlan turte ngaihtuah turin a pui thei bawk che a, a tul chuan support services-ah a refer thei bawk che a ni.

Hospice care hi nun tikhawtlai thei, thihpui theih natna nei te chu an ni hnuhnung berte chu nuam taka, zahawm taka, an thununna hnuaia awm, leh nunphung sang tak nena nunpui thei service a ni. Natna khirh tak kan do hian kan hun leh tha tam zawk chu inenkawlnaah kan hmang thin. Hospice care chungchang ngaihtuah hian natna ngei pawh ngaihtuah lovin, hun la awm chu engtin nge hman dan tur tih hi ngaihtuah zawk a ni. LMD hian i nun a nghawng dan tur te, i cancer chi hrang hrang enkawlna tur te, leh chu enkawlna atanga i beisei tur te chu i doctor nen inbiakna hmangin i tana tha ber tur thutlukna i siam thei a ni.

LMD i neih chuan cancer na tak, enkawl ni mahse i taksa pum puia darh tawh nen i khawsa a ni mai thei. Dam theih loh, harsatna lian tak i nei tih i hriat chuan, i mangang a, i thinrim a, i hlauthawng thei bawk. "Engvangin nge hetiang hi ka chungah a thlen?" Hetiang dinhmunah hian nangmah chauh i awm lo. I doctor hnenah tanpuina dil rawh. I thil tawn chu an hrethiam a, an theih ang tawkin an pui ang che.

Hriat reng tur pawimawh ber berte (Take-Home Message) .

• Leptomeningeal disease (LMD) chu thluak leh ruhro khuh tu membrane-a cancer darh leh cerebrospinal fluid-a darh a ni.
• Hei hi natna khirh tak, tihdam theih loh a ni.
• Neurological symptoms , lu na, luak chhuak, kal harsa, mit/beihna lama harsatna, leh buaina te a awm thei.
• He natna hi MRI scan leh lumbar puncture hmanga hriat theih a ni.
• Enkawlna tum ber chu symptoms control leh quality of life vawng reng a ni.
• I dinhmun te, i hmalam hun te, leh hospice care ang chi duhthlan tur te chu i doctor nen zalen taka sawipui hlau suh. He hun harsa tak paltlang tur hian nang leh i chhungte mamawh tanpuina dawng rawh.

` Leptomeningeal Disease, Cancer, Thluak, Spinal Cord, Cerebrospinal Fluid, Symptoms, Cancer darh zel