Nang pawh i na nghal em? He natna chhan awm lova lo awm hi eng nge ni? (Mast Cell tihchakna Syndrome) tih hi a ni.

A châng chuan a rang thei ang bera natna nasa tak i nei ṭhin em? Allergy na tak nei ang mai a ni. I taksa pum pui a sen a, a hnim a, a hring a, pum a na a, i luak a, thawk harsatna i nei emaw pawh a ni thei. Mahse heng thilte hi thil i ei vang emaw, thil i khawih vang emaw a ni lo. Heng thilte hi chhan hriat loha thleng ta se, `Mast Cell Activation Syndrome (MCAS) an tih natna a ni thei.` Vawiin hian he thu hi chipchiar zawkin han sawi ila.

``Mast Cell Activation Syndrome (MCAS)'' tih hi eng nge ni?

A awlsam zawngin sawi ila, MCAS hi kan taksaa cell chi khat ``mast cells'' an tih chu chhan hriat lohvin a overactive a, symptom na tak tak a thlen thinna a ni. Tunah chuan, "Chu chu allergy chu a ni," tih i ngaihtuah mai thei. Ni e, allergy hian ``mast cells'' activation a keng tel bawk a ni. Mahse allergy hian a chhan chiang tak a nei tlangpui . Entirnan, mi thenkhat chuan shrimp, peanuts, emaw dust mites te hi allergy an nei thin. Mahse MCAS-ah chuan a chhan chiang tak hmuh a harsa hle. Heng symptoms te hi a lo lang nghal vek a.

A then phei chuan heng mast cells te activation hian allergic reaction na tak, nunna atana hlauhawm tak anaphylaxis an tih chu a thlen thei a ni. Hei hian thawk harsatna a thlen thei a, thisen sang pawh hlauhawm takin a tlahniam thei bawk. Anaphylaxis natna khirh tak i neih chuan 911 call emaw, emergency room hnai ber pan nghal emaw tur a ni.

Mast cells hi kan immune system-a sipai ang mai an ni. Infection dona kawngah an pui thin. Chuvangin, heng undiagnosed symptoms te hi i neih hian hlauhna i neih hi thil pangngai a ni. Mahse mast cells te hi an activate hi thil pangngai a ni. Entirnan, mast cells hi allergic rhinitis, asthma, damdawi emaw ei tur emaw anaphylaxis, leh mastocytosis ang chi condition-ah te activate a ni. Hei hian heng natna tibuaitu, a chang chuan hlauhawm tak tak te hi min neih tir thin a ni.

Mahse, ``Mast Cell Activation Syndrome (MCAS)`` hi a awm lo hle a ni . Doctor-te chuan MCAS hi a hnuaia thil awmte hi a awm chuan an hmuchhuak thin:

• A chhan hriat loha anaphylaxis ni thei tura i ngaih symptoms lo lang leh thin i neih chuan.
• Heng symptoms te hian a ruala i taksa system pakhat aia tam (entir nan, vun leh intestines pahnih) a nghawng a nih chuan.
• Test-naah mast cells activate tih finfiahna a awm chuan.
• Mast cells target damdawi hmanga i symptoms tihtlem a nih chuan.

Mast cell leh an chanvo

Mast cells hi kan immune system cell a ni a .Bung hrang. An hna pangngai chu kan taksaa natna hrik (e.g. parasites, virus) emaw, thil tha lo dang kan taksaa lut laka kan taksa venhim hi a ni. Heng cell te hi kan tissue ah an thu a, thil tha lo nia an hriat an hmuh chuan histamine ang chi chemical an chhuah a, chu chuan immune system a tichak a, a rawn luttu chu do let tumin a bei thin.

A châng chuan, an chhân lêt loh tûr thilte chu an chhân lêt ṭhîn. Chutah chuan allergy kan nei thin . Mahse allergy hian symptom tenau te, mit na leh hnar luang te a thlen tlangpui. MCAS-a thil thleng chu chhan hriat lohvin natna lan chhuahna na zawk a awm hi a ni.

``Mast Cell Activation Syndrome (MCAS)'' hi engtiang chiahin nge a pawi?

MCAS nasat dan hi i symptoms i tawn danah a innghat a ni. Mi thenkhat chuan symptoms na lo tak tak an nei thei a, vun symptoms chauh an nei thei. Mi dangte chuan natna khirh zawk, anaphylaxis ang chi an nei thei bawk. Anaphylaxis hi enkawl that loh chuan thihna thlen thei a ni. Mahse, MCAS avanga nunna atana hlauhawm thei thil hi a tlem hle .

`Mast Cell Activation Syndrome (MCAS)` natna lan chhuah dante chu engte nge ni?

MCAS hian i taksa hmun hrang hrangah natna khirh tak, a lo lang leh thei a ni. Heng symptoms te hi a hnuaia mi ang hian a ni thei:

• Thisen sang hniam.
• Vun chu a sen, pink, leh lum (`Flushing`) a lo awm ta.
• Vun a na.
• Hnar hnar (hnar congestion) a awm.
• Swelling - a bik takin hmai, hmui, mit, lei emaw kawr (`Angioedema`).
• Constipation emaw diarrhea (a pahnih inkara inthlak danglam pawh a ni thei).
• Pum natna.
• Thâwk harsa.
• Chak lohna emaw, muhil emaw.
• Hriatrengna hloh emaw ngaihtuah harsa (brain fog).
• Numbness a awm.
• Joint natna.
• Anaphylaxis (a chunga kan sawi tak symptom pakhat emaw a aia tam emaw neia allergy na tak).

MCAS rinhlelh tur chuan heng symptoms te hian i taksa system pahnih tal a nghawng tur a ni. Chu chu:

• Nervous system (thluak leh nerve) te.
• Thluak lam (lung leh thawkna kawng).
• Cardiovascular system (thinlung leh thisen kalna kawng).
• Digestive system (ril leh ril) te.

Mast cells te chu a lo thawk nghal vek a nih chuan engtin nge a awm?

Allergy i neih tawh chuan mast cells activate a nih hian eng ang nge a nih tih i hre tawh ngei ang. Mahse MCAS vei tan chuan allergy pangngai aiin a na zawk a, taksa peng hrang hrang a nghawng a ni. I vun a hring thei a, a sen thei a, a hring tan thei a, thisen pawh a chhuak thei bawk. Diarrhea leh luak chhuak i nei thei bawk. A nasat chuan i hmai leh i kawr a lo hring thei a, i thisen sang pawh a tlahniam thei bawk. Heng natna khirh tak takte hi i neih chuan 911 emaw, damdawi in hnai ber pan nghal emaw tur a ni tih hre reng ang che.

`Mast Cell Activation Syndrome (MCAS)` awm chhante chu engte nge ni?

MCAS hi i mast cells te hian an react loh tur laiin an react vang a ni. Mast cell te hian taksaah thil tha lo a lut tawh niin an ngai a, venhim a ngai a ni. Chutah chuan symptoms thlentu proteins te chu an chhuah tir thin. Allergy-ah chuan taksain a tihbuai chhan chu eng nge ni tih kan hre thei a ni. Mahse MCAS ah chuan mast cells te hian heng protein te hi an chhuah chhan chiang tak hmuh a harsa hle.

Dik tak chuan, mast cell-te hian thil duh loh zawnga an sensitive em em chhan hi tumahin an la hre chiang lo.

Mast cell activation chhan awm thei te chu engte nge ni?

Thil tam tak, ei leh in leh pollen te hian mast cells te chu a tichak a, histamine a chhuah tir thei a, mahse MCAS natna lan chhuahna na tak hi allergen bik avanga lo awm a ni tih sawi theih a ni lo. Mahse, heng symptoms te hi i nun emaw, i chhehvel emaw a inthlak danglamna a awm chuan a na zawk tih i hmu thei a, entirnan, stress nasa tak i neih lai emaw, khaw lum a inthlak lai emaw a ni. Thil chiang tak i tawn hnuah chauh i symptoms a lo lang a nih chuan doctor hnenah hrilh rawh. Chutiang a nih chuan MCAS i nei lo mai thei a, allergy i nei zawk mai thei.

Engtin nge Mast Cell Activation Syndrome (MCAS) hi hmuhchhuah a nih?

Doctor chuan i enfiah hnuah, i symptoms te, leh medical history te a sawi hnuah MCAS i vei tih a ringhlel mai thei. Doctor-te chuan a hnuaia thil awmte hi i tlin chuan MCAS i nei tih an hmuchhuak ang che:

• Mast cell activation symptoms i neih chuan.
• Mast cell activation enkawlna atana i chhanna tha tak i neih chuan.
• Test-naah mast cell activation chhinchhiahna a awm chuan.
• I taksaah mast cell zat pangngai i neih chuan (mast cell tam lutuk hian mast cell disorder dang, mastocytosis ang chi i nei thei tihna a ni).

MCAS test neih a ni

MCAS enfiah tur chuan i doctor chuan thisen test a ti thei a, i thisenah chemical ``tryptase'' an tih chu a enfiah thei ang. ``tryptase'' hi ``mast cells'' tihchak a nih chuan a pung zel a ni. He test hi vawi tam tak tih a ngai dawn a ni – i dam lai leh natna lanchhuahna na tak i neih lai pawhin. Mahse, ``tryptase'' hi damdawi dang dangah pawh a sang thei tih hre reng ang che. Chuvangin ``tryptase'' level chauh hian MCAS i neih leh neih loh a hre thei lo. Mi thenkhat chuan symptom nei lo pawhin beisei aia tam ``tryptase'' level an nei thei.

I doctor chuan allergy skin test emaw allergy blood test emaw a ti thei bawk a, a chhan dang a awm leh awm loh a enfiah thei bawk.

Pawimawh: Histamine thisen test-ah histamine level sang tak a awm a nih pawhin doctor-te chuan MCAS i nei tih an sawi chhuak lo.

Mast Cell Activation Syndrome (MCAS) hi engtin nge enkawl a nih?

Doctor-te chuan MCAS hriatchhuah nan leh i natna lan chhuah dan tihtlem nan enkawlna an hmang thin. Mast cells target damdawi hmanga i dam loh chuan MCAS i nei lo mai thei.

I natna lan chhuah dan azirin i doctor chuan hetiang damdawi hi a pe thei ang:

• Histamine type 1 receptor blockers (Antihistamines) : Heng damdawi hi allergy symptoms enkawlna atana hman thin damdawi a ni. Entirnan: Loratadine, Cetirizine, Fexofenadine te hi a tha hle.
• Histamine type 2 receptor blockers (antihistamines that recutive stomach acid) : Hengte hi nausen leh pum na tan pek thin a ni. Entirnan: Ranitidine emaw Famotidine emaw.
• Aspirin : Flushing tihziaawm nan aspirin pek theih a ni.
• Leukotriene modifiers : Hengte hian thawk a ti awlsam hle. Entirnan: Montelukast, Zafirlukast-ah te pawh a awm.
• Omalizumab (XOLAIR®) : Hei hian anaphylaxis vei theihna a tiziaawm thei a ni.
• Epinephrine : Doctor ten anaphylaxis tihtawp nan epinephrine an hmang thin. Anaphylaxis i neih palh hlauh chuan epinephrine injector (EpiPen®, Auvi-Q®) chu i kutah i dah thei ang.
• Mast cell stabilizers : Cromolyn sodium ang damdawi hian mast cell atanga chemical chhuak (degranulation) a veng a ni.
• Corticosteroids : Hengte hian inflammation a tiziaawm a, thawkna kawng a hawng a, tissue-a tui awmte a ti tlem bawk. Mahse, side effect a awm theih avangin doctor-te chuan MCAS atan steroid an pe fo lo.

Mast Cell Activation Syndrome (MCAS) hi a dam vek dawn em ni?

Ni lo, MCAS damdawi a awm lo . MCAS i neih chuan damdawi hmanga enkawl a ngai dawn a ni.

MCAS vei dam rei zawng chu engzat nge ni ang?

Doctor-te chuan MCAS vei tam zawk chu MCAS nei lo mi pakhat angin an dam rei ang tih an beisei. Mahse hei hi natna hmuhchhuah thar a nih avangin dam chhung a nghawng dan tur chu chiang takin kan sawi thei lo.

Engtin nge ka in enkawl ang?

MCAS hmanga i in enkawl dan tur thenkhat chu hetiang hi a ni:

• I natna lan chhuah dan diary-ah dah la. I natna lan chhuah dan te, chutih laia i ei leh in te, leh exposure i neih tawh zawng zawng te chu ziak rawh. Heng hun lai hian symptom i neih loh lai nen khaikhin chuan eng nge danglam tih kha han ngaihtuah teh. Pattern i hmuh chuan doctor hnenah hrilh rawh.
• Hetiang dinhmunah hian i ṭhian hnai ber berte, i chhungte emaw, i inhmu fo ṭhin mite emaw hrilh la, i epinephrine injector emaw, emergency damdawi dang emaw chu khawiah nge a awm tih hrilh bawk ang che.

Engtikah nge Emergency Department (ETU) ah ka kal ang ?

MCAS avanga natna khirh tak chu a tlem hle nachungin, allergy na tak emaw anaphylaxis emaw i neih chuan epinephrine injector i neih chuan hmang thin ang che. Tichuan 911 call emaw, emergency room hnai ber pan nghal emaw rawh. Anaphylaxis natna lan chhuah dan chu:

• Hmai, hmui, lei emaw, kawr emaw a hring chhuak.
• Thâwk harsa emaw, ei harsa emaw.
• Lung na tak tak.
• Thisen sang hniam.

Doctor hnenah eng zawhna nge ka zawh ang?

I doctor hnenah hetiang zawhna hi zawh hi a \angkai thei ang:

• He dinhmun hi ka tan a lo zual/zual nghal a nih chuan engtin nge ka tih ang?
• Engtin nge ka damdawi hi ka ei ang?
• Engtin nge ka epinephrine injector hi ka hman ang a, engtikah nge ka hman ang?
• Engtikah nge emergency room-ah ka kal ang?
• Engtikah nge ka rawn hmu leh ang che?

``Mast cell activation'' hi autoimmune natna a ni em?

Ni lo, MCAS hi autoimmune disorder a ni lo.

Siren a rawn lang ang tih han mitthla teh. Security force te an rawn kal dawn a. I ``mast cell`` te hian hlauhawm an hmuchhuak a, tanpuina an dil mek a ni. Mahse... hlauhawm a awm tak tak lo. Pesky clown ang maiin i ``mast cells`` te hian hmanhmawhthlak takin alarm bell an ri mai mai a ni. Natna laka venghim che ai chuan anni hian natna tirtu che an ni.

Mi thenkhat mast cells overreact chhan chiang tak kan hre lo nain MCAS hi enkawl dan tur a awm. Reaction a awm tih hriattirna hmasa berte chu hre rawh. I symptoms te chu kut atanga chhuak anga i hriat chuan i doctor nen inbia ang che. A pawimawh ber chu epinephrine injector keng reng tur leh hman dan tur leh hman hun tur hriat hi a ni. I mamawh ngai lo mai thei, mahse beisei loh thil thleng tûra inbuatsaih chuan rilru hahdamna a pe thei che a ni.

I hriat tur thil (Take-Home Message) .

• Mast cell activation syndrome (MCAS) hi thil awm lo tak a ni a, a chhan chiang tak awm lovin allergic symptom na tak tak a thlen thin.
• Hei hian vawi khatah taksa system engemaw zat a nghawng thei a ni.
• `Anaphylaxis` ang chi nunna atana hlauhawm tak tak a awm thei a, chuvangin natna lanchhuahna na tak a awm chuan damdawi lam thurawn zawng nghal tur a ni.
• MCAS hi tihdam kim theih ni lo mah se, a natna lan chhuah dan chu damdawi hmanga control theih a ni.
• I natna lan chhuah dante hre reng la, emergency hman atan epinephrine injector chu i kutah dah la, i chhungte hnenah hriattir rawh.
• MCAS chungchanga zawhna i neih chuan i doctor zawh hreh suh.

` Mast cells, MCAS, allergy, anaphylaxis, histamine, tryptase, immune system te a awm bawk