Mast Cells hi eng nge a nih chiah hriat i duh bawk em? Hemi chungchang hi awlsam takin han sawi ila!

‘Mast Cells’ tih hming hi i la hre lo mai thei, a dik em? Mahse hengte hi kan taksa vengtu cell chi pawimawh tak a ni. Kan taksa chhunga vengtu te tak te ang maiin. Amaherawhchu, a chang chuan heng vengtute hi tlem an phur lutuk chuan buaina kan tawk thin. Vawiin hian chipchiar takin, awlsam takin, heng mast cell te hi eng nge an nih, kan taksaa an hnathawh dan, eng dinhmun nge an thlen theih tih te hi han sawi ila.

Mast Cell hi eng nge ni?

A awlsam zawngin, mast cells hi kan immune system-a sipai bik an ni . Kan ruhroah an siam chhuak thin . Chumi hnuah kan thisen kal tlangin an kal a, taksa pum puia tissue hrang hrangah an awm ta a ni. Ram chhung hmun hrang hranga sentinel awm ang bawkin heng mast cell te hi kan taksa hmun hrang hrangah an awm a, pawn lam hlauhawm laka min humhim turin an inpeih reng a ni. Infection hrang hrang an do thei a, kan taksa peng hrang hrangte hnathawh dan tur ruahmanna siam turin an pui thei bawk.

Mahse, a châng chuan heng mast cell-te hi an inveng nasa lutuk a, kan tâna hlauhawm lo tak takte chu an chhân lêt ṭan a ni. Seasonal allergy emaw allergic asthma emaw i neih chuan a chhan pakhat chu mast cell activity vang a ni. Thil na tak ṭhenkhatah chuan mast cell activation hian allergic reaction na tak, anaphylaxis , a thlen nghal thei a ni. Chuvangin hei hi hriat chian a pawimawh.

Mast cell hian kan taksaah eng nge a tih?

Mast cells te hi kan taksa ‘alert system’ angin an che thin . Kan taksa hi pawn lam atanga rawn lut, natna hrik , virus, bacteria leh parasites te lakah an venghim a, chubakah rulhut rimtui leh rulhut rimtui ang chi toxins te pawh an venghim bawk. Thil pawi thei nia an hriat apiang chu a ni lo a nih pawhin an dodal bawk. Chutah chuan allergic reaction kan nei thin .

Thisen var chi dang tam tak ang lo takin mast cell hian natna hrik hi direct-in a tichhia lo. Chu ai chuan kan tissue chhungah chuan veng takin an thu a, taksaah thil tha lo a lut tih signal an nghak a ni.

Engtin nge mast cells te hian hna an thawh?

I duh loh thil, entîr nân, leivut chi khat, pollen emaw, i allergy nei ei tûr emaw chu i taksaah a lut ang tih han ngaihtuah teh. Kan immune system-a cell chi dang, B cells an tih chuan he invader hi a hre chiang hle. An hriat chian hnu chuan a do turin protein bik, antibodies an tih chu an siam tan ta a ni. Hetih lai hian antibody bik siam chhuah te hi Immunoglobulin E (IgE) an ti a.Tiin.

Heng IgE antibodies te hi rang takin mast cells chunglama receptor bikteah an kal a, an inzawm khawm a, chu chu cat’s claw ang mai a ni. A dawt leha chu invader (e.g. pollen, dust) chu taksaah a rawn luh leh hunah chuan mast cells-a IgE chuan a man ang.

Chutah chuan mast cells te chu "activated" an ni. Fire alarm an ri ang mai a ni.

Chutianga mast cells te chu an activate chuan histamine an tih chemical leh chu cell chhunga bawm te tak te (storage granules)-a dah chemical dang tam tak chu an chhuah nghal a ni. Hei hi degranulation an ti a .

Heng histamines leh chemical dangte hi allergy symptoms thlentu an ni. Chung zingah chuan:

• Kan thisen kalna kawngte chu a zau a, a chhehvêla tissue-ah tui a pung khâwm a, chu chuan a hring chhuak . Hei hian immune cells te chu natna kai na hmunah rang takin a tlan lut thei a, invader te chu lymph node ah a phur a, a tichhia a ni.
• Mucus (phlegm) siam chhuah a tipung.
• Kan thawkna kawng leh gastrointestinal system (intestines)-a smooth muscles te hi an inzawm khawm a, thil hlauhawm tak takte chu wave ang maia che (peristalsis) hmangin nawr chhuah an tum thin.

Heng thilte hian i vun a ti sen thei a, a ti hring thei a, a ti na thei bawk. Hnar chhuak, thawk hah, khuh emaw i nei thei. A châng chuan luak chhuak emaw, luak chhuak emaw pawh i nei thei. A nasat em em chuan he thil kalphung hian thawkna kawng a ti hring thei a, thawk a ti harsa thei a, thisen sang pawh hlauhawm takin a tlahniam thei a, chu chuan anaphylaxis na tak, nunna atana hlauhawm tak pawh a thlen thei a ni.

Mast cell leh homeostasis te a awm bawk

Allergy a thlen bakah hian mast cells hian kan taksaa thil kalphung hrang hrangte chu a balance thei a, chu chu ‘homeostasis’ state a vawng reng tihna a ni. Entirna tlemte chu hetiang hi a ni:

• Thisen kalna kawng a lo thang lian.
• Ruh a lo thang lian.
• Thluak lam cell te tihpun leh siamthat.

Kan taksaah hian khawiah nge mast cells te hi an awm?

Thisen var chi dang nena khaikhin chuan kan thisenah hian mast cell hi a tlem hle. A tam zawkah chuan thil tha lo tak kan tawk a, chu chu thawk chhuah emaw, ei emaw, vun hliam kaltlangin emaw kan tawk a ni. Chuvangin mast cell hi a tam ber chu:

• Kan thawkna kawng leh lungah .
• Kan chaw ei dan (GI tract) (ril, intestines).

Tin, heng mast cell te hi kan thisen kalna kawng leh nerve vel ah pawh an awm bawk.

Mast cell chhunga thil awmte chu engte nge ni?

Mast cell i lak chuan a laiah nucleus a nei a, chu chu cell "thluak" a ni. He nucleus chhehvelah hian bawm ang chi thil te tak te za tam tak, granules .Heng granules chhungah hian chemical messenger (mediator) hrang hrang dahkhawm a ni. Heng tirhkohte hi taksaah thil tha lo tak a lo tawk a nih chuan chhanna pe turin signal thawn thin an ni. Heng chemical zingah hian a langsar zual thenkhat chu:

• Histamine: Hemi chungchang hi kan sawi tawh a. Thisen kalna kawng a tizau a, tui leh immune cell te chu tissue chhungah a lut thei a ni. Tin, thawkna kawng leh chaw kawng a tikhawtlai bawk a, natna hrik te hnawhchhuahna tura pui turin mucus a siam chhuak bawk.
• Proteases: (Entirnan: tryptase, chymase, carboxypeptidase A) te hi a awm thei lo. Proteases hi enzyme chi khat a ni a, protein a tichhia a. Connective tissue an ti chhe thei a, hei hian immune cells te chu awlsam zawkin chu hmun chu a thlen thei a ni.
• Cytokines/chemokines: Hengte hi protein te tak te te an ni a, immune cell dangte chu anmahni copy tam zawk siam turin signal an pe a, thisen kalna kawngte chu "sticky" turin an signal a, chutiang chuan immune cells te chu tissue ah an kal thei a, cell te chu hmun chhia tihfai leh siamthat nan an recruit bawk.
• Heparin: Hei hian thisen zam a veng a, chuvangin thisen kalna kawng hawn reng turin a pui a ni.

Mast cell receptor te hi a ni

Mast cells hian an chung lamah receptor chi hrang hrang tam tak an nei a. Chungte chu a bik taka siam protein an ni. Key pakhatin lock a fit ang bawkin heng receptor te hian signaling protein dangte nen an inzawm a, mast cells te chu an tichak a ni.

Chung zingah chuan a hmaa kan sawi tawh IgE receptor hi hriat lar ber a ni. Chu bakah, mast cells hian antibody chi dang (e.g., Immunoglobulin G / IgG) leh natna hrik (e.g., Toll-like receptor) direct-a hriat theihna tur receptor an nei bawk.

Mast cells nena inzawm natna langsar ber berte chu engte nge ni?

Mast cell nena inzawm kan hmuh tlangpui thenkhat chu:

• Environment allergy (e.g., leivut, pollen, pet dander) te hi a awm thei lo.
• Asthma natna a ni
• Chaw ei tur allergy nei
• Heat Blisters/ Hives a awm thin

Mast cell natna hmuh tur awm lo

Chu bakah, mast cell nena inzawm thil awm lo engemaw zat a awm bawk:

• Mast cell activation syndrome (MCAS): Hei hi chhan hriat lohvin allergy emaw anaphylaxis emaw symptoms a lo lang nawn fo thinna a ni.
• A chang chuan taksaa mast cell tam lutuk (Mastocytosis) a awm thin.
• Hereditary alpha-tryptasemia / chhungkaw atanga lo chhuak hypertryptasemia:Hei hi genetic condition a ni a, taksain enzyme pakhat tryptase an tih chu mast cells atanga siam a nih chuan a lo awm a ni. Mahse, he genetic condition nei tam tak hian symptoms an nei lo.

Mast cell natna lan chhuah dan tlangpui chu engte nge ni?

Mast cell natna atanga histamine chhuak hian natna lan chhuahna a thlen thei a, chungte chu:

• Vun rawng a danglam, a sen emaw, a hring emaw.
• A hring (edema) .
• Thâwk harsa.
• Anaphylaxis lo awm leh thin .

Heng natnate hi hriat chian nan eng test nge tih thin?

Doctor chuan mast cell disorder i nei nia a rinhlelh chuan i mast cells te chu a activate em tih enfiah nan hetiang test hi an ti thei ang:

• Zun test a ni.
• Thisen test a ni.
• Bone marrow test neih a ni.
• Vun test neih a ni.

Doctor chuan allergy vun test emaw thisen test emaw hmangin a chhan hriat theih a ni. A châng chuan lab pawhin i symptoms hi hereditary condition avanga lo awm a nih leh nih loh enfiah turin genetic testing an nei thei bawk.

Hei hi eng enkawlna nge ni?

Mast cell natna enkawlna chu i natna lan chhuah dan leh a chhan danah a innghat a ni. Enkawlna atan hian:

• Allergy thlentu hriat tawhte pumpelh .
• Symptoms control na tur damdawi. Chung zingah chuan antihistamine , acid tihtlemtu, leh leukotriene-modifying damdawi (e.g., montelukast) te pawh a tel thei.
• Mast cell stabilizer hmanga siam a ni. Heng damdawi te hian mast cell atanga histamine ang chi chemical chhuak tur a veng a ni.
• Anaphylaxis tihziaawmna emaw, enkawlna emaw damdawi. Chung zingah chuan damdawi epinephrine leh omalizumab te pawh a tel .
• Cytoreductive therapy/chemotherapy hmanga enkawlna . Mastocytosis natna khirh tak tan chuan cancer cell tihhlumna atana hman tlangpui chemotherapy damdawi hman thin a ni.

Chuti a nih chuan, mast cells hi a tha em, a tha lo em ni?

Mi tam zawk chuan mast cell chungchang hi thil a tihsual hunah chauh an hre thin a, chuvangin mast cell hi thil tha lo tak niin i ngai mai thei. Mahse a nihna takah chuan kan taksa hi mi hlauhawm laka humhimin kan taksa peng hrang hrangte a tidanglam thei a ni. Chuvangin, a tam zawkah chuan an tha hle.

Ngaihtuah teh, siren a ri ta. Security team te chu a hmunah an thleng ta a ni. I mast cells te chuan alarm an ti a, i immune system chuan ni chhanchhuah tumin a tlan chhuak ta a ni. Kan taksa invenna atana thil pawimawh tak an ni. Mahse mast cell hi an hnathawh tur tlem an phur lutuk hian kan ngaihven ber tlangpui. Mahse kan invenna a tichak bawk a, kan thisen kalna kawng leh taksa peng hrang hrangte a tidanglam thei bawk. Chuvangin, a dawt leha i thawk hah emaw, i hnar a luang emaw, i rilru a na deuh emaw chuan, i mast cells te fimkhur taka an awm avangin lawmthu sawi theihnghilh suh!

Thil hriat reng tur te chu a tawi zawngin

Chuvangin, heng zawng zawng atanga hriat reng tur pawimawh ber chu mast cells hi kan immune system-a sentinel te tak te pawimawh tak an ni. Pawn lam atanga natna chi hrang hrang leh toxins lakah min venghim thin. Mahse, a chang chuan tlem an sensitive lutuk hian thil hlauhawm lo tak takah an chhang let thei a, allergy ang chi condition min siam thei bawk.

Allergy symptoms i neih fo thin, vun na, hive, hnar luang, thawk hah, thawk harsa i neih chuan a tha ber chu doctor pan a, ngaihthah lovin thurawn lak hi a ni. Lungngai suh, tunlai hian heng natna tam tak hi thunun thei tur enkawlna a awm a.

` Mast cells, immune system, allergy, histamine, anaphylaxis, cell hnathawh dan, symptoms te