I taksaah thisen cell tam lutuk i siam chhuak em? Heng Myeloproliferative Neoplasms (MPN) te hi i zir dawn teh ang!

I ruhro hian i taksa chhungah thisen cell tam lutuk a siam chhuak a nih chuan eng nge thleng ang tih i ngaihtuah ngai em? Chutiang chu myeloproliferative neoplasms, a tawi zawngin MPN tih hi a ni. Hei hi thisen cancer hmuh tur awm lo, mahse nunna atana hlauhawm tak a ni a, uluk taka enkawl loh chuan thihna thlen thei a ni. I hriatthiam theih khawpin a awlsam zawngin sawi ila.

He myeloproliferative neoplasm (MPN) hi eng nge ni?

A awlsam zawngin, myeloproliferative neoplasms (MPNs) hi i ruhro (i ruh chhunga tissue nem tak) hian thisen sen, thisen var, emaw platelet (i thisen zam tura puitu cell) a siam tamna dinhmun a ni. Factory-a thil siam tam lutuk ang maiin han ngaihtuah teh. Hei hi thisen cell siamna kawngah thil dik lo a awm chuan a thleng thin.

Heng MPN dinhmunte hi a lo thang zawi zawi hle fo thin . Chuvangin mi thenkhat chuan kum tam tak chhung chu symptoms an nei lo mai thei. Chuvangin "chronic" emaw long-term myeloproliferative neoplasms an ti bawk. Mahse, a tlem berah chuan heng MPN dinhmunte hi thil pawi zawkah a lo chang thei a ni.

Mahse lungngai suh, he natna lan chhuah dan control tur leh a nasat loh nan enkawlna tha tak tak a awm .

MPN chi hrang hrang eng nge awm?

MPN chi hrang hrang a awm a. Type tin hian i ruhro hian thisen cell chi hrang hrang a siam tam lutuk chu a nghawng a ni. A châng chuan thisen zam (red blood cells) chauh a lo chhuak thei a, a châng chuan thisen var emaw, platelet emaw chauh a lo chhuak thei bawk. MPN chi thenkhatah chuan heng cell chi hrang hrangte inzawmkhawm hi a tam lutuk thei a ni. A chhan dang leh chu heng cell tam lutuk te hi thisen cell hrisel tak takte nen hian an awm dan a danglam thei a ni.

He dinhmun hian tute nge a nghawng ber?

MPN lo awm chhan lian ber pahnih chu i kum leh i mipa leh hmeichhia te hi a ni .

• Kum: MPN hi kum hrang hrangah a awm thei a, mahse kum 50, 60, a aia upa zingah a awm tam ber .
• Gender: Entirnan, MPN chi khat polycythemia vera hi mipaah ​​a tam zawk. Essential thrombocythemia hi hmeichhiaah a tam zawk. MPN chi dang hian mipa leh hmeichhia a nghawng dan inang tlangin a nghawng thei a ni.

Engtin nge MPN hian i taksa a nghawng?

Heng thisen kaihhnawih natna te hi i ruhro hian i taksa mamawh aia tam thisen cell chi khat a siam chhuah hian a lo awm thin. Chuvangin, hei hian i taksa a nghawng dan chu eng thisen cell chi nge a tam lutuk tih ah a innghat a ni . Entirnan, MPN chi khat hian heart attack emaw stroke emaw i neih theihna a tipung thei a ni. A chi dang chuan thisen tlakchhamna (anemia) a thlen thei bawk.

Heng thil awm lo tak takte hi hrethiam zawk tur chuan i ruhro leh thisen cell siam dan tlem tal hriatthiamna neih a \angkai hle. Kan thisen cell zawng zawng hi i ruhroah stem cell angin a intan vek a. He ruhro hi i ruh chhunga tissue nem tak, spongy ang maia awm a ni. Chuta tang chuan stem cell lo piang chhuak chu myeloid stem cell emaw lymphoid stem cell emaw a lo ni thei a ni.

• Lymphoid stem cells hi thisen var chi hrang hrang, natna hrik dotu chi hrang hrang a ni.
• Myeloid stem cells hian thisen sen (taksa zawng zawnga oxygen phurtu), thisen var chi dang, leh platelet (thisen a lo chhuah huna thisen chhuah tihtawp nan a pui) te a siam thei a ni.

Cell dang zawng zawng ang bawkin heng stem cell te hian gene-in a pek dan angin hna an thawk a ni. A tlangpuiin heng stem cell te hi i ruhroah a tul angin an inthen a, an pung a, cell thar an siam thin. Mahse, heng gene-ah hian mutation a awm a nih chuan, chu chu gene-te a inthlak a nih chuan, chu gene-te chuan stem cell-te chu in\hen leh pun zel turin thupek dik lo a thawn a ni. A tawpah chuan heng thisen cell tam lutuk hi ruhroah emaw, thisen kalna kawngah emaw a awm khawm a, thisen kal dan a tikhawlo a ni. He thisen kal dan hi tihkhawtlai a nih chuan hriselna lama harsatna lian tak a awm thei a ni.

MPN chi hrang hrang hman tlanglawn ber berte chu engte nge ni?

MPN hi chi thum a awm a, chungte chu polycythemia vera, essential thrombocythemia, leh primary myelofibrosis te an ni.

Polycythemia Vera tih a ni

Hei hi MPN chi khat hman tlanglawn ber a ni . I ruhro hian thisen sen (red blood cells) a siam tam lutuk hian a thleng thin . Hei hian i thisen a ti thim a, a ti slow thin. Polycythemia vera vei te hian thisen zam an vei theihna a sang hle. Heng clots te hian heart attack leh stroke a thlen thei a ni. A tlem hle a, he natna hi thisen cancer na tak, acute leukemia an tihah a lo chang thei a ni.

Myelofibrosis natna (Myelofibrosis) a awm

Hei hi MPN chi hrang hrang aggressive ber nia ngaih a ni . Myelofibrosis-ah chuan i ruhro hian stem cell pangngai lo a siam chhuak thin. Heng cell te hi an inflamed a, bone marrow chhungah scar tissue an siam thin. Hun a kal zel a, ruhro chu he scar tissue hian a khat ta vek a ni. Chumi hnuah chuan ruhro hian taksa chhunga oxygen phur thei tur thisen sen (red blood cells) a siam tling thei tawh lo. Hei hian thisen tlakchhamna (anemia) a thlen thei a ni. Platelet siam chhuah tlem i nei bawk. Myelofibrosis vei thenkhat chuan acute myeloid leukemia (AML) an vei thei bawk.

Thrombocythemia pawimawh tak a ni

Essential thrombocythemia hi i ruhro hian platelet a siam tam lutuk tihna a ni.Making tih a ni. A tlangpuiin thisen kalna kawng a puak chuan platelet te chu an inzawm khawm a, clot an siam a, thisen chhuah chu a titawp thin. Mahse hetiang dinhmunah hian chhan awm lovin ruhroah platelet siam a ni. Heng extra platelet te hian thisen a tikhawlo thei a, heart attack leh stroke te a tipung thei bawk. MPN dang ang bawkin symptoms hi zawi zawiin a lo lang chhuak thin. Mi tam zawk chuan thisen test pangngaia platelet level sang tak a hmuh chuan he natna hi an vei tih hmuhchhuah a ni. Mi thenkhatah chuan he natna hi leukemia thlengin a kal thei a ni.

MPN chi dang a awm em?

Ni e, MPN chi dang engemaw zat a awm bawk. Chung zinga ṭhenkhat chu:

• Chronic eosinophilic leukemia (CEL): Hei hi thisen var chi khat, eosinophil an tih, a tam lutukna a ni. A tlangpuiin spleen-ah a lo thang lian thin. A tlem berah chuan acute myeloid leukemia (AML) thlengin a kal thei. Hei hi hypereosinophilic syndrome an ti bawk.
• Chronic myelogenous leukemia (CML): Hei hi thisen var chi khat granulocytes an tih, a siam chhuah tam lutuk a ni. Heng cell te hi an pungkhawm a, ruhro tan thisen cell mamawh dang siam a harsat phah a ni.
• Chronic neutrophilic leukemia (CNL): Hetah hian thisen var chi khat neutrophils an tih chu a tam lutuk a siam chhuak thin.
• Myeloproliferative neoplasm, unclassificable (MPN-U): Hei hi MPN chi khat a ni a, category dang pakhatah pawh a in fit lo. Thisen cell chi hrang hrang, thisen var, thisen sen, a nih loh leh platelet te chu a siam tam lutuk thei a ni.

MPN natna lanchhuahna chu engte nge ni?

A tir lamah chuan symptoms engmah i nei lo mai thei . A natna a lo zual zel chuan, i rilru a na (splenomegaly) chhinchhiahna i hmu thei. I spleen hi i veilam sir ah i ruh hnuaiah a awm a. A khat a, a nghet lo va, a nuam lo thei bawk. Hetianga swelling of spleen hi MPN chi hrang hrangah chuan a awm fo nain, essential thrombocythemia-ah chuan a awm lo.

Symptom dangte chu MPN chi hrang hrang a zirin a inang lo .

Chronic eosinophilic leukemia (CEL) natna a awm thei lo.

• A lan chhuah dan tlangpui chu vun rawng a ni .
• I chau a, i khawsik pawh i nei thei.
• Symptom dangte chu i eosinophil level sang lutuk avanga i taksa peng hrang hrang a nghawng danah a innghat a ni.

Chronic myelogenous leukemia (CML) leh chronic neutrophilic leukemia (CNL) te a awm bawk.

• Ruh natna
• Zan a thawk hah
• Khawsik leh hahna
• Bruising awlsam tak a ni
• Chaw ei chakna hloh leh taksa rihna tlahniam

Thrombocythemia pawimawh tak a ni

• Bruising awlsam tak a ni
• Hnar, ka leh hmui atanga chhan awm lova thisen chhuak
• Pum emaw, intestines emaw atanga thisen chhuak
• Thisen chu zun chhungah a awm

Polycythemia vera tih a ni

• Lu na
• Luak chhuak thei
• Chau lutuk
• Blurred vision emaw double vision emaw a awm thei

A hmasa berin myelofibrosis a awm

• Thisen tlakchhamna (chau, chak lohna, thawk hah) chhinchhiahna a lo lang thei.
• Thil dangte chu:
• Vun dum (pale skin) a ni
• Zan a thawk hah
• Khawsik
• Vun a na
• Chaw ei tam lutuk emaw, ei zawh hnua chaw ei kham nghal vat (early satiety) .
• Rihna tihtlem
• Ruh natna

Eng thilin nge MPN a thlen?

MPN condition zawng zawng hi acquired genetic disorders a ni vek a . Chumi awmzia chu i nu leh pate hnen atanga rochun an ni lo tihna a ni. Cell thanna control tu genes-a mutations emaw changes emaw a awm a, thisen cells te chu a lo thang dik lo a nih chuan an lo awm thin.

Medical researcher-te chuan MPN thlentu genetic mutations chungchangah hian hetiang hian an hmuchhuak a ni:

• Janus kinase (JAK) mutations: Polycythemia vera, primary myelofibrosis, leh essential thrombocythemia te hi Janus kinase 2 (JAK2) tih gene a mutations avanga lo awm a ni fo thin. He mutation hian cell te chu thunun theih lohvin a inthen darh thei a ni.
• MPL gene emaw CALR gene-a mutations: Essential thrombocythemia leh primary myelofibrosis nei te hian an MPL gene emaw CALR gene-ah mutations an nei fo thin.
• Chromosome errors: Chronic myelogenous leukemia (CML) vei te hian an chromosome (genes awmna structure) ah error bik an nei a. CML-ah chuan chromosome pakhat chi khat chu chromosome dang nen a inthlak a, "Philadelphia chromosome" a siam a ni.

Heng thil hmuhchhuahte hian genetic changes thlentu dik tak sawifiah lo mah se, doctor-te chu natna hriatchhuahna leh heng genetic mutations target-a enkawlna siam turin a pui a ni.

MPN vei theihna tur risk factors te chu engte nge ni?

Chhungkaw history (heng natna hi acquired diseases ni mahse, chhungkaw thenkhat chuan predisposition an lantir thei), kum leh mipa leh hmeichhia te hian MPN vei theihna a tipung thei a ni.

Researcher te chuan MPN leh toxin leh radiation thenkhat nena inzawmna a awm tih an hmuchhuak bawk . Zirna thenkhatah chuan radiation sang tak leh toxin thenkhat, benzene ang chi hmanga inhriat thinte chu MPNs, polycythemia vera, primary myelofibrosis, leh chronic myelogenous leukemia te an vei theihna a sang hle tih a tarlang.

Engtin nge MPN hi hmuhchhuah a nih?

I doctor chuan i symptoms leh health history te a zawt ang che. Tichuan, taksa enfiahna an nei ang a, MPN chhinchhiahna a awm leh awm loh an enfiah ang. I thisen leh ruhro an test ang a, natna hriat theih a ni.

• Thisen chhiar kimchang (CBC): 1.1.Hei hian i thisen cell chi hrang hrang level a teh vek a ni. Essential thrombocythemia-ah chuan platelet level an enfiah thin. Polycythemia vera-ah chuan hemoglobin (thisen sen chhunga protein awm) bakah thisen var leh platelet level te an enfiah thin.
• Peripheral blood smear (PBS): He test hian thisen cell-a pianzia dik lo a zawng thei a, chu chuan damdawi lam dinhmun hriat theihna a pe thei a ni.
• Thisen chemistry test: Hengte hian i thisena chemical chi hrang hrang (protein, enzyme, leh glucose ang chi) awm zat a teh thei a ni. Heng number te hian i taksa peng hrang hrangte hnathawh dan tur clues a pe thei a, hei hian MPN pakhat tan rinhlelhna a siam thei a ni.
• Bone marrow biopsy: I doctor chuan bone marrow aspiration emaw bone marrow biopsy emaw a ti thei ang. Hei hian i ruhro sample lak a, thisen cell awm leh awm loh enfiah a huam a ni. Chumi hnuah chuan medical pathologist-te chuan thisen cell leh tissue te chu microscope hmangin an enfiah a, cell pangngai leh cell pangngai lo inthlauhna an zawng a ni. Tin, stem cell pangngai lo eng pawh an zawng ang. Chromosomal change leh MPN chi khat tilang thei genetic abnormalities dang an zawng bawk ang.
• Genetic testing: Doctor ten i thisen cell te chu an zirchiang thei a, thisen cell siamchhuahna tichhe thei gene ah hian inthlak danglamna a awm em tih an hmu thei.

MPN hi a dam kim thei ang em? Enkawlnate chu engte nge ni?

Tunah hian heng natna te hi a tidam thei awmchhun chu allogeneic stem cell transplantation a ni . Vanduaithlak takin mi tam tak chuan he stem cell transplantation hi an nei thei lo a, a chhan chu thil harsa leh taksa mamawh tak a nih vang a ni.

I doctor chuan i dinhmun enkawl dan tur, i thisen cell zat tihtlem nan, natna lanchhuahna tihziaawmna tur leh harsatna awm lo tur venna tur damdawi a pe ang che. Enkawlna thenkhatah chuan natna hi remission-ah pawh a dah thei a ni. MPN enkawl dan hi a chi hrang hrangah a inang lo:

• Chronic eosinophilic leukemia (CEL): I doctor chuan i eosinophil level tihhniam nan chemotherapy, corticosteroids emaw immunotherapy emaw a hmang thei a.
• Chronic myelogenous leukemia (CML): Enkawlna hman tlanglawn ber chu targeted therapy a ni a, hei hian cell te chu thunun theih loha an pung zel tur a titawp a ni. Enkawlna dangte chu chemotherapy, immunotherapy, radiation therapy, leh stem cell transplant te a ni.
• Chronic neutrophilic leukemia (CNL): Enkawlnaah hian chemotherapy, immunotherapy, leh stem cell transplant te pawh a tel thei.
• Thrombocythemia pawimawh tak takte:Symptoms i neih loh chuan i doctor chuan i dinhmun hi uluk taka enfiah a tum mai thei a, enkawlna pe lovin i dinhmun chu uluk taka enfiah a tum mai thei. Symptoms i neih chuan, cell-te thunun theih loh khawpa pung zel tur titawp thei damdawi i ei a ngai mai thei. Thisen zam hlauhawmna tihtlem nan emaw, i ruhroin platelet tam lutuk a siam loh nan emaw damdawi i ei a ngai thei bawk.
• Polycythemia vera: Phlebotomy hi polycythemia vera enkawlna atana hman tlanglawn ber a ni. Hetiang tih danah hian i doctor chuan i thisen volume tihtlem nan leh thisen sen tam lutuk paih chhuah nan thisen tlemte (thisen pek ang chi) chu a la chhuak fo ang. Symptoms i neih chuan targeted therapy pek i ni thei a, chu chuan cells te chu control theih loha an pung zel loh nan a titawp thei a ni. Thisen zam tihziaawmna damdawi (Aspirin ang chi) emaw, thisen zam (red blood cells) tihziaawmna damdawi emaw pek i ni thei bawk.
• Primary myelofibrosis: I natna lan chhuah dan i neih loh chuan i doctor chuan i dinhmun hi uluk taka enfiah a tum mai thei. Anemia enkawlna atan hian hmanraw hrang hrang emaw damdawi chi hrang hrang hman theih a awm a. Entîr nân, i bone marrow-in thisen zam (red blood cells) a siam tling lo a nih chuan thisen pêk a ngai mai thei. Thisen cell tam zawk siam turin ruhro tichaktu damdawi i ei a ngai mai thei bawk. Enkawlna dangte chu targeted therapy, chemotherapy, immunotherapy, radiation therapy, leh stem cell transplant te a ni.

MPN vei hi eng chen nge a dam theih ang?

Hei hi mi hrang hrangah a inang lo hle . Hei hi thil tam takin a nghawng a, chung zingah chuan MPN chi hrang hrang, natna hmuhchhuah hma leh enkawlna i dawn dan te pawh a tel. Monitoring leh treatment tha tak nen chuan mi tam tak chu kum tam tak an dam . Heng dinhmunte hi prognosis pakhat chauh emaw, result beisei tur emaw a awm lo. A tlangpuiin MPN vei hmuhchhuah tam zawk hi kum nga hnuah pawh an la dam.

MPN chi hrang hrang damchhuah zat chu hetiang hi a ni:

• Chronic myelogenous leukemia (CML): Target therapies thar hlawhtlinna avang hian CML nena inzawm damchhuahna rate a pung nasa hle. CML vei kum nga chhunga damchhuah zat chu 90% a ni.
• Chronic neutrophilic leukemia (CNL) leh polycythemia vera: Enkawlna tha tak a awm chuan mi tam zawk chu an hmuhchhuah atanga kum 20 vel an dam a ni.
• Essential thrombocythemia: Mi tam tak chu thisen zam ang chi nunna atana hlauhawm harsatna awm thei tur damdawi an ei hian kum tam tak an dam thin.
• Primary myelofibrosis: Primary myelofibrosis vei tam zawk hi an hmuhchhuah atanga kum nga atanga kum sawm chhungin an dam thin.

Hetiang dinhmun hi i neih chuan i doctor hnenah i prognosis zawt rawh. Prognosis tichhe thei zawng zawng hre vek an ni. Tin, a pawimawh ber chu nangmah, i kum leh i hriselna zawng zawng te, chubakah prognosis nghawng thei risk factors te pawh an hre chiang hle bawk.

Heng natnate hi thihna thlen thei an ni em?

Hengte hi anmahni chauha thihna thlen thei natna an ni lo , mahse MPN chi thenkhat chuan nunna atana hlauhawm tak tak, heart attack leh stroke te a thlen thei a ni.

Doctor hnenah eng zawhna nge ka zawh ang?

MPN hi natna khirh tak a ni. Enkawlna kawng hrang hrang a awm a, a chang chuan side effect pawh a awm bawk. Tin, i dinhmun a zirin harsatna tam tak a awm thei bawk. Eng symptom nge i hriat tur tih hriat a pawimawh. I doctor nen inbia la, i natna hmuhchhuah dan hrethiam la, enkawlna chungchangah thutlukna siam rawh.

Zawhna i zawh theih ṭhenkhat chu:

• Enkawlnain eng nge a tum ber (natna tihziaawmna tur, a lan chhuah dan tihziaawmna tur, harsatna lo thleng tur venna tur, etc.)?
• Ka enkawl dan tur chu engte nge ni?
• Enkawlna avanga nghawng tha lo awm thei te chu engte nge ni?
• Ka dinhmun hi eng chen nge enkawl ka mamawh ang?
• Ka dinhmun enfiah nan engzat nge test (imaging emaw thisen hnathawh) ka neih a ngai ang?
• Ka dinhmun a ṭhat leh ṭhat loh hriat theihna tur chhinchhiahna engte nge ni?
• Complication ka neih theihna tura min vaukhântu symptoms te chu engte nge ni?
• Eng harsatna nge emergency medical treatment mamawh?
• Ka dinhmun tur hian eng prognosis nge beisei ang?
• Ka dinhmun leh enkawlna avanga a side effects te enkawl nan eng nunphung thlak danglamna nge i rawt?

Engtin nge ka in enkawl ang? (I tan thil pawimawh thenkhat)

MPN nena nun hi a chang chuan a buaithlak deuh thei. I dam tha a, harsatna i nei lo mai thei, mahse, a natna lan chhuah dan tur venna atana ka tih theih tur a awm em tih i ngaihtuah mai thei. Enkawlna i dawng a nih chuan enkawlna avanga a nghawng tha lo leh a natna lan chhuah dan tur enkawlna kawngah tanpuina i mamawh mai thei. Mahse, he natna hi kum tam tak chhung chu i nunpui a ngai dawn a ni. I ṭanpui thei tur rawtna ṭhenkhat chu hetiang hi a ni:

• I hriselna dinhmun hrethiam rawh: MPN symptom tam tak hi natna dang, na lo zawkte nen a inang a ni. Symptom thenkhat chu damdawi lama harsatna lian tak tak chhinchhiahna a ni thei bawk. A danglamna hriat a harsa thei a, clues pawimawh tak tak i hloh ang maiin i inhria thei bawk. He natna hian engtin nge a nghawng theih che tih doctor hnenah hrilh rawh. Beisei tûr hriatna chuan i dinhmun chungchânga inrintawkna nei zâwk tûrin a ṭanpui thei che a ni.
• I rilru hahna chu thunun rawh: Hun rei tak natna nena nun chu lungkhamna a thlen thei a ni. I dinhmun chungchangah i lungkham a nih chuan i doctor nen sawiho rawh. Tuna i tanpui theihna tura an tih theihte leh nakin lawka tanpui theihna tura an tih theihte chu an sawifiah thei a ni.
• Ei leh in hrisel inthlau tak ei rawh:Ei leh in tha hian i dinhmun a enkawl thei che a ni. Ei leh in hrisel siam tura tanpuina i mamawh chuan nutritionist nen inbiakna nei rawh.
• Exercise engemaw zat nei rawh: Exercise hi stress tihreh nan a tha hle.
• Find support: MPN hi natna hmuh tur awm lo tak a ni. Support group te hi i thil tawn hre chiangtute nena inzawmna leh inbiakna neihna tha tak a ni thei.

Hetiang dinhmun hi i nei a nih pawhin, fimkhur leh damdawi lam thurawn zawm hian nun tha tak i hmang thei tih hre reng ang che.

Engtikah nge Doctor ka hmuh ang?

MPN i nei a, mahse symptomatic i nih chuan, emaw i taksaah symptoms awm thei tur thil danglam i hmuh chuan doctor pan nghal rawh.

MPN hi a takah chuan thuruk deuh a ni. Zirchiangtute chuan MPN hi thisen cell than dan pangngai lo nen a inzawm tih an hria a. Genetic disorder an nih thu pawh an hria a, mahse MPN thlentu genetic mutations awm chhan dik tak chu hriat a la ni lo . Hengte hi natna rare tak an nih avangin MPN nena khawsak hi eng ang nge tih hi mi tam takin an hre lo. Mahse doctor leh zirchiangtute chuan MPN chungchang hi an zir belh zel a, a bik takin symptoms enkawl dan tha zawk leh damdawi lama harsatna lian tham tak tak awm theihna tur tihtlem dan tur an zir belh zel a ni. Chuvângin, beiseina chu bânsan ngai suh .

` Myeloproliferative neoplasm, MPN, thisen cancer, bone marrow, thisen sen, thisen var, platelet, symptoms, enkawl dan