Kidney damlote hian MRI an tih hian hei hi an hre chiang em? Nephrogenic Systemic Fibrosis (NSF) chungchang hi han sawi ila!

Kidney lama harsatna i nei em? A nih loh leh doctor-in i kal (kidney) a thawk tha lo tih a hrilh che em? A châng chuan Magnetic Resonance Imaging (MRI) ang chi scan i neih a ngaih hunah chuan dye bik hman danah tlem fimkhur a ngai ṭhin. Vawiin hian hetiang huna lo awm thei, mahse tunah chuan a tlem hle a, mahse hriat hlawh tak a ni. Hei hi Nephrogenic Systemic Fibrosis (NSF) an ti a.

He NSF (Nephrogenic Systemic Fibrosis) hi eng nge ni? A awlsam zawngin...

A awlsam zawngin sawi ila, Nephrogenic Systemic Fibrosis (NSF) hi natna hlauhawm tak a ni. Kal natna nei te, a bik takin kal hnathawh that lohna nei teah a awm tlangpui. Hetiang dinhmun hi mi pakhatin scan a neih laiin gadolinium-based contrast agents (GBCAs) a pek hnuah chauh a awm thei a, chu chu MRI ang chi a ni a, chu chuan a thlalakte chu a chiang zawk a ni.

Ngaihtuah teh, kan kal (kidney) hian kan taksaa thil duh loh zawng zawng a filter chhuak a, zun hmangin a chhuah tir thin. Chuvangin, heng ``GBCA'' an tihte hi mi pakhat, a kal (kidney) hnathawk tha lo taksaa an luh chuan taksa atangin an chhuak tha lo. Chutah chuan NSF hlauhawmna a lo chhuak ta a ni.

NSF thlentu hi i hria em? I vun chu a thim thei a, a tight thei a, a hring thei a, a hring thei bawk. A châng chuan, joint pawh a nghet thei a, hmun khatah a lock thei bawk. Hei hi ``joint contracture'' an ti a. Chu mai ni lovin, mi thenkhatah chuan he natna hian taksa chhunga taksa peng hrang hrang, rilru ruh, thinlung leh lungte pawh a nghawng thei a ni. Thil thleng chu chu taksa peng hrang hrang chhehvela tissue te pawh a thim a, a tight ta a ni.

A pawimawh ber chu, NSF a lo awm tawh chuan tunah hian tihtawp emaw, tihdanglam emaw theihna tur enkawlna chiang tak a awm lo.

Mahse, lungngai suh! US Food & Drug Administration (FDA) pawhin kal damlote tan GBCA upa zawk thenkhat hman loh nan nasa takin a fuih a ni. Market-a GBCA thar zawkte hian kal damlote zingah NSF a thlen nia sawi a la ni lo. Chu chu thlamuanna lian tak a ni.

Tunah hian NSF hi engtiang chiahin nge a awm?

Dik tak chuan tunah chuan a tlem hle hle mai. Dik tak chuan kum 10 chuang chhungin NSF vei thar an awm lo. Kum 2006 hnu lama damdawi lam pawlin heng ``(GBCAs)`` leh kal natna inzawmna an hriat chuan he natna report hi nasa takin a tlahniam a ni.

Engtin nge NSF hi a lo thanglian? Eng nge a lan chhuah dan?

NSF symptoms hi gadolinium-containing contrast agents (GBCAs) taksaa inject ni vek hian a lang thei a ni. A nih loh leh, thla tam tak hnuah pawh an rawn lang thei bawk. Zirchianna pakhatah chuan mi 50% velin ni 12 chhungin natna lanchhuahna an nei tih hmuhchhuah a ni.

A lan chhuah dan tlangpui chu:

• Vun hring, tight leh thickening: Hei hian kut, ke, leh rilru leh pum ang chi hmun a nghawng tam ber. Hmai a nghawng tlem hle.
• Vunah hmun dum emaw, bumps emaw: A chang chuan vun hi a hring thei a, orange peel ang maiin a hring thei bawk.
• Vun a hring, a hring emaw, a na emaw a awm.
• Vun thick leh swelling avanga taksa peng leh ruh te chu a pangngaia a che thei lo.

Mi thenkhat tan chuan heng symptoms te hian taksa chhungril lam leh taksa peng hrang hrang a nghawng thei bawk. I tawn theih ṭhenkhat chu hetiang hi a ni:

• Muscle chak lohna nasa tak.
• Muscle tightness avang hian ke ruhte chu a ben tha thei lo va, a zau thei lo bawk (i.e., range of motion a tlahniam).

He fibrosis, a nih loh leh tissue thickening hi a lo zual zel chuan taksa ruh, lung, chaw kawng, mit, leh thinlung thlengin thil khauh tak tak a siam thei a ni. Hei hian heng taksa peng hrang hrangte hnathawh a tichhe thei a ni. Hei hian hun rei tak chhung, chatuan atan rualbanlohna a thlen thei a, a then phei chuan thihna thlengin a thlen thei bawk.

NSF awm chhan ber chu eng nge ni?

NSF hi a chunga kan sawi tak `(gadolinium-based contrast agents - GBCAs)` nena inzawmna avanga lo awm a nih a rinawm ber. He chemical gadolinium an tih hi `(MRI)` scan-a thlalak chiang zawka siam nan hman a ni. Gadolinium hian engtin nge NSF a thlen tih chiang takin a la chiang lo. Mahse, kal natna leh `(GBCAs)` inkarah hian inzawmna a awm tih a chiang hle. Tin, taksaa gadolinium pek zat a tam chuan, emaw, `(GBCAs)` chi hrang hrang hman a nih chuan a hlauhawmna a sang tih hmuhchhuah a ni bawk .

NSF hi chronic kidney disease (CKD) vei leh kidney failure vanga dialysis nei te zingah a tam ber a ni.

Mahse, kum 15 dawn lai NSF vei thar an awm lo tih hre reng ang che!

Hei hi a chhan chu tuna GBCA te hi a stable zawk a, toxic a tlem zawk bawk. Tin, gadolinium hman hi kal natna nei tan chauh tihkhawtlai a ni bawk. FDA pawhin kal natna nei emaw, kal lama harsatna nei emaw chuan GBCA hlui zawk hmang lo turin a rawt a ni.

He thil hi tuin nge nei tam ber? (Risk Factor hrang hrang) 1.1.

NSF vei theihna tur risk factor ber chu kidney disease emaw kidney dysfunction emaw a ni. Hei hian a hmaa kal zai tawh emaw, kal thlak tawh emaw, kal pakhat chauh neih tawh emaw a huam a ni. Tin, kal natna nei hian natna dang, thisen zam harsatna emaw, natna hrik emaw a neih chuan NSF vei theihna a sang deuh thei bawk.

Mahse, tunah chuan doctor-te chuan GBCA upa zawkte hian kal hnathawh chak lote chunga harsatna a thlen theih dan chu an hre chiang tawh zawk a ni. Chuvangin, tunlaia hmanraw him zawk awm tawhte nen chuan he natna hi i vei theihna chance a hniam zawk hle.

NSF avanga harsatna awm thei te chu engte nge ni?

NSF harsatna hi a na hle thei a, a chang chuan thihna pawh a thlen thei bawk. A chhinchhiahna hmasa ber chu vun thicking emaw thickening emaw a ni. Mahse, a natna a zual zel chuan he natna hian taksa chhunga taksa peng leh thau te pawh a nghawng thei a ni. Entirnan, i taksa ruh leh ruhte chu a nghet lutuk a, i che thei lo thei a, chu chuan kal pawh a ti harsa thei a ni. NSF hian lung emaw thinlung emaw a nghawng chuan thawk harsatna a thlen thei a, thinlung thisen pump theihna a tichhe thei bawk.

Engtin nge he natna hi dik taka hriat theih a nih? (Diagnosis) tih a ni.

NSF i neih leh neih loh hriat chian theihna awmchhun chu vun biopsy neih hi a ni. Hei hian doctor chuan i vun sample te tak te a la a, lab-ah a thawn a, a enfiah a ngai a ni. Mahse, doctor chuan i medical history a lak hnu leh taksa enfiahna a neih hnuah NSF i vei thei tih rinhlelhna dik tak an neih phawt chuan he test hi a ti ang.

NSF enkawlna tur engte nge ni?

Dik tak chuan tunah hian NSF tan hian enkawlna bik pawm a la awm lo. He natna hi a tlem em avangin a enkawl dan tur zirchianna a tlem hle. Mahse, NSF vei thenkhat tan chuan hahdamna engemaw chen pe thei nia sawi enkawlna tlemte a awm a:

• MRI hnuah dialysis hmangin taksa atanga gadolinium chu a paih chhuak thei a ni. Hei hi kal natna khirh tak nei tan chuan a \angkai thei hle. Mahse, hei hian NSF hmasawnna a titawp vek dawn tih finfiahna a awm lo.
• Physical therapy hian ruh (joint)-a flexibility leh movement awm reng turin a pui thei a ni.
• Kidney transplant hi NSF vei thenkhatin an ngaihtuah theih tur option a ni.

Kidney natna i neih chuan gadolinium nena inhnamhnawih loh hi a tha ber. Mahse, a chang chuan MRI atanga thlalak tha ber ber hmuh theih nan gadolinium hi a ngai mai thei. Chutiang hunah chuan doctor-te chuan MRI hlawkna leh gadolinium-a inhriat theihna tur hlauhawmna chu an tehkhin a ngai a ni. Kidney lama harsatna i neih a, i doctor-in dye hmanga MRI a tih chuan NSF vei theihna i neih leh neih loh zawt ngei ang che.

NSF pumpelh dan tur a awm em? (Invenna) 1.1.

NSF ven dan tha ber chu kal natna nei te tan GBCA hlui zawk hman loh hi a ni. GBCA thar zawk hi kal damlo tan chuan a him zawk a, a toxic lo zawk bawk.

FDA chuan kal natna thenkhat nei te chu duhthlan tur dang a awm loh chuan gadolinium awmna dye hmang lo turin a rawt a ni.

Kidney function pangngai nei tan chuan GBCAs hman hian hlauhawmna a awm lo niin a lang.

NSF vanga thihna rate hi engzat nge ni?

Kum 2019 hma khan FDA hian NSF vei mi 3,094 an lo report tawh a, a kaihhnawih thi mi 742 an awm tawh bawk. Mahse, a hmaa kan sawi tawh ang khan kum 10 chuang chhungin hri kai thar hmuh tur a awm lo. Hei hi a chhan ber chu FDA leh medical community ten GBCAs hian kidney damlote chunga nghawng a neih dan an hriat vang a ni.

Engtikah nge damdawi lam thurawn kan zawn ang?

Kidney natna i neih a, a hnuaia symptoms te hi i neih chuan NSF chhinchhiahna a nih theih avangin doctor pan nghal tur a ni:

• Vun tightening emaw thickening emaw.
• Vun natna emaw, vun hring emaw.
• Vunah hian a sen emaw, a dum emaw a awm.

Tuna safety protocol hman mek hmang hian NSF i vei theihna chance a tlem hle. Mahse, kal natna i neih a, MRI neih a ngai a nih chuan i doctor nen NSF chungchang leh i tana hlauhawmna chungchang sawipui rawh. GBCA thar zawkte hi chutiang taka toxic lo leh him anga lang mahse, i hriselna chanchin chu doctor hnenah sawi la, a hlauhawmna chungchang sawipui a tha fo.

Take-Home Thuchah a ni

Okay, chuti a nih chuan tunah chuan kan sawi thin kha i hrethiam zawk tawh a, NSF. Thil pawimawh ber berte hi han sawi nawn leh ila:

• NSF hi natna awm lo tak a ni a, a bik takin kal natna nei tan chuan MRI contrast agent hlui thenkhat vang a ni thei.
• Tunah hian NSF vei thar an awm tawh lo hle. Hei hi contrast agent thar him zawk hman leh doctor-te hriatthiamna vang a ni.
• A lan chhuah dan ber chu vun thim, tightness, itching, leh joint problem te hi a ni.
• Kidney natna i neih chuan MRI i tih hmain i doctor nen dye hman dan leh NSF vei theihna chungchang sawipui hmasa phawt ang che.
• Hlauh tur a awm lo, a chhan chu tuna hmanraw hman mek hmang hian he risk hi a tlem hle. Mahse, hriat reng a phu reng.

I hriselna enkawl hi a pawimawh ber a ni. Zawhna emaw, ngaihtuahna emaw i neih chuan damdawi lam thurawn lak chu tihkhawtlai ngai suh.

` Nephrogenic systemic fibrosis, kal natna, MRI scan, gadolinium, vun natna, GBCAs, natna tlemte