I hmangaih tak, i nu, i pa, i pi emaw, i pi emaw pawhin Alzheimer natna a vei em? Zawi zawiin hriatrengna hloh leh hmel hriat tawhte theihnghilh avanga lungngaihna leh tanpui theih lohna chu kan hre vek a ni. Alzheimer natna hi a takah chuan hriatrengna hloh, thluak tihchhiat leh thihna thleng thei dinhmun a ni. He natna hi damdawi awm lo mah se, a ti hniam thei leh damlo tan hahdamna engemaw chen pe thei damdawi a awm. Vawiin hian chutiang ruihhlo chi hrang hrang pakhat chungchang kan sawi dawn a ni. Chu chu NMDA Receptor Antagonists a ni. A hming hi a buaithlak deuh nachungin, awlsam takin i hrethiam ang u.
Thluak chhunga thil thleng chemical story tlemte
Kan thluak hi hmun mak tak a ni. Nerve cell, a nih loh leh `neurons` maktaduai tam tak a awm a ni. Chûng cell-te chuan thu hriatte chu an process a, thu hriatte an hre reng a, taksa pêng dangte chu electrical leh chemical signal an thawn leh inthlâkthlengna hmangin an tih tûr an hrilh a ni.
Heng chemical signal phurtu messenger te hi `neurotransmitters` kan ti a. Chutiang tirhkoh zinga pakhat chu `glutamate` a ni.
Glutamate hi nerve cell pakhat atanga nerve cell dang thlenga thuchah kengtu lawng angin ngaihtuah mai rawh. He lawng hian cell dang pan tur leh lawng chawlhna tur hian dock bik a mamawh a ni. Chu dock chu NMDA receptor (`N-methyl-D-aspartate` receptor) kan tih chu a ni. He NMDA port-ah hian lawng glutamate an tih chu a inzawm chuan thil pawimawh dang `calcium` an tih chu cell chhungah a thawn lut leh thin. He calcium hian chu thuchah ti famkimtu leh thil engemaw zir leh hriatrengna min puitu a ni. Hei hi thluak hrisel takah chuan thil pangngai tak a ni.
Chuti a nih chuan Alzheimer natnaah hian eng nge thleng?
Alzheimer natna vei thluak cell ah chuan glutamate tam lutuk a lo chhuak tan thin . Thil thleng chu chu nerve cell-ah chuan calcium tam lutuk a luang lut a ni. Tui dahna hmuna tui tam lutuk i khat chuan eng nge thleng ang tih han ngaihtuah teh? A overflow ta vek mai. Chutiang bawkin, cell chhunga calcium tam lutuk a punkhawm chuan chu cell te chu a chhe tan thin. He chhiatna hian Alzheimer’s symptoms a tipung zauh zauh a ni.
Hetah hian NMDA Receptor Antagonists te hian an puih dan chu kan rawn tarlang e
NMDA receptor antagonists an tih damdawi class hian chutiang extra glutamate lawngte chu NMDA receptor-a an dock theihna hmun tihtlem hmangin hna a thawk a ni. Chu chu ruihhlo hian lawng chawlhna hmun thenkhat a block tihna a ni. Mahse a pawimawh ber chu heng damdawi te hian thuchah pawimawh tak tak a luang chhuak thei a ni . Chu chu thluak hnathawh dan pangngai tibuaitu lian tham siam lovin calcium tihchhiatna thlentu chu an control chauh tihna a ni. Hei hian nerve cells chhiatna a tihziaawm bakah natna chakna a control bawk.
Alzheimer natna enkawlnaah hian doctor-te chuan neurotransmitter dang acetylcholine tih chu target-tu damdawi an hmang tam ber. Mahse NMDA receptor antagonists hi damdawi class pawimawh tak a ni a, kawng danglam takin hna a thawk a ni.
Tuna Alzheimer natna enkawlna atana pawm NMDA receptor antagonist ber chu memantine (brand name `Namenda XR`) a ni. A tlangpuiin doctor-te chuan natna stage hniam lam atanga na tak thlenga an pek thin a ni. A châng chuan memantine hi a hmaa kan sawi tawh `cholinesterase inhibitors` te nen pek dun a ni a, chu chuan acetylcholine level a tisang a ni. Hei hian damlo thenkhatah result tha zawk a thlen thei a ni.
Mahse, hre reng ang che, heng damdawi te hian mi zawng zawng tan hna a inang vek lo.
A side effects te pawh i fimkhur ang u.
Damdawi zawng zawng ang bawkin he damdawi hian side effect tenau te a nei thei bawk.
- Luak chhuak hi a lan chhuah tam ber a ni.
- Chu bakah, lu na leh chaw ei kham ang chi thil te pawh a awm thei bawk.
- A tlem hle a, thluaka buaina awm theihna a awm .
Nang emaw i damlo emaw hian heng zinga pakhat tal i tawn chuan i doctor hnenah i hriattir nghal tur a ni . Damdawi ei kha bansan emaw, mahni chauha a dose thlak emaw hi thil tha tak a ni ngai lo.
He chhungkuaa ruihhlo dang leh an hman dan
He chhungkaw zingah hian damdawi dang NMDA receptor antagonists tih te pawh a awm bawk. Thenkhat chu nitin nunah kan hmu thin. Ṭhenkhat chu tlem a hlauhawm deuh a, ruihhlo anga hmansual an ni. Scientist-te chuan he damdawi chi hrang hrangte hian thluak lam natna dang, Parkinson’s disease leh ALS (amyotrophic lateral sclerosis) te tan pawh a hlawkpui dan an zirchiang mek bawk.
A hnuaia table atang hian i zir belh leh ang u.
| Ruihhlo Hming | A hmanna ber | Point pawimawh leh risk te |
|---|---|---|
| Dextromethorphan a ni | Cough syrup-ah a awm a. | A tlangpuiin a him a, mahse a tam zawka ei chuan a hlauhawm thei. |
| Ketamine a ni | Anesthetic drug (mihring leh rannung tan). | Operation laiin natna tihziaawmna atan hman thin. Mahse "club drug" anga hmansual a ni. Hallucinations leh taksa atanga inlakhran theihna a thlen thei. Depression ang chi natna atana hman dan tur zirchianna kalpui mek a ni. |
| Phencyclidine (PCP) hmanga siam a ni. | Ruihhlo anga hmansual a ni. | A tir chuan anesthetic anga siam a ni a, a side effect na tak (hallucinations, confusion) vangin hman a ni lo. Ruihhlo hlauhawm tak "Angel Dust" tia hriat a ni. Tharum thawhna nena inzawm. |
Take-Home Thuchah a ni
- Alzheimer natna hi tihdam kim theih ni lo mah se, NMDA receptor antagonist damdawi memantine te hian thluak cell chhiatna a tihziaawm avangin natna stage hniam lam atanga na tak tak te chu a enkawl thei a ni.
- Heng damdawi te hian thluaka glutamate tam lutuk lakah nerve cell te venhimna hmangin hna an thawk a ni.
- Damdawi dang ang bawkin side effects, luak chhuak ang chi pawh a awm thei. Hei hi doctor nen sawiho fo ang che. Dose thlak ngai suh la, nangmah chauhin damdawi ei kha bansan ngai suh.
- He class of drugs, Ketamine leh PCP te hi ruihhlo anga hmansual a ni a, a hlauhawm hle. Hengte leh Alzheimer natna atana damdawi an pekte hi a danglamna lian tak a awm a ni.
💬 Comments (0)
Comment a la awm lo. Hetah hian i comment hi a vawikhatna atan add rawh.
I comment kha add rawh