PBC i nei em? Heng harsatna (Primary Biliary Cholangitis) te hi hriat chian a pawimawh hle.

I liver hi taksa peng mak tak a ni. ‘bile’ an tih tui a siam a, chu chuan kan ei tur thau tak takte chu kan ei theih nan min pui thin. Mahse Primary Biliary Cholangitis (PBC) tih natna nei mi pakhatah chuan he bile phurtu duct nalh tak takte chu a chhe vek a ni. Hei hian bile a luang tha lo va, liver chhungah a block ta a ni. Hun kal zelah he blocked bile hi a khauh thei a, lungah a chang thei a, natna hrik a thlen thei bawk. A tawpah chuan he bile hian a back up a, liver chhungah scarring a siam thin. Hei hi PBC nihna bulpui ber a ni.

Mahse, lungngai suh. Damdawi tha tak tak a awm a, chu chuan liver atanga bile a paih chhuak thei a, heng hliam te hi a lo awm lo thei bawk. Amaherawhchu PBC hi i enkawl that loh chuan emaw, natna hi a na deuh deuh a nih chuan harsatna engemaw zat a awm thei a ni. Vawiin hian PBC natna avanga harsatna awm tam ber leh enkawl dan tur kan sawi dawn a ni.

Cirrhosis, natna khirh tak a ni

Cirrhosis chu i liver-a cell hrisel tak takte chu scar tissue-in a thlak a ni. A awlsam zawngin, liver chu a khauh zauh zauh a, lungah a chang ta a ni. Hetiang dinhmun hi PBC stage hnuhnung berah a thleng thin. Hetih lai hian liver chu nasa takin a chhe tawh a ni.

Tun hma chuan PBC hi ‘primary biliary cirrhosis’ an ti thin a. Hei hi cirrhosis complication hi he natna nen hian a inzawm tlat vang a ni.

Hei hi engtin nge enkawl a nih?

I doctor chuan he natna hi control turin damdawi a pe ang che.

• Vawi tam tak chu enkawlna hmasa ber chu damdawi ursodeoxycholic acid (Ursodiol) an tih hi a ni. Hei hian liver atanga bile lakchhuahna leh liver chhiatna tihziaawmna hmangin hna a thawk a ni.
• He damdawi chauh hmang hian i rilru a hahdam vak lo a nih chuan i doctor chuan a bakah hian obeticholic acid (Ocaliva) tih damdawi ei tur a rawt thei bawk.
• Hei bakah hian damdawi thar elafibranor (Iqirvo) leh seladelpar (Livdelzi) te chu ursodeoxycholic acid nena hman phalsak a ni tawh bawk.
• Thil dang chu damdawi chi khat fibrates an tih hi a ni . Hengte hi thisen thau (lipids) tihhniamna atana pawm tak tak ni mahse, PBC vei, ursodeoxycholic acid dawng tha lote tan chuan a thawk tha hle tih hmuhchhuah a ni. Chutiang chuan doctor-in damdawi a pawmpuina ni lo natna dang atan a hman chuan ‘off-label’ hmanna kan ti a ni.

Mahse, eng treatment pawh hmang ila, liver-a scar tissue a tam lutuk a, liver a thawk thei lo a nih chuan a solution awmchhun chu liver transplant a ni.Chauh. Chutah chuan tih tur chu i liver chhia chu la chhuakin, donor hrisel tak atanga liver hmanga thlak a ni.

Liver chhunga vein pakhata pressure sang (Portal Hypertension) .

Hei hi harsatna lian tak dang a ni bawk. Hei hi i hrethiam ang u. Kan thin (liver)-a thisen thlentu thisen kalna kawng bulpui (main blood vessel) kan nei a. Hei hi ‘portal vein’ kan tih chu a ni.

Tunah chuan kan sawi tawh ang khan cirrhosis dinhmun avanga liver chhungah scar tissue a lo awm chuan he ‘portal vein’ kaltlanga thisen kal hi a tikhawlo a ni. Kawngpuiah traffic jam ang maiin thisen chu a luang tha thei lo va, chu vein chhungah chuan a tang ta a ni. Hetianga thisen a pung khawm chuan chu vein chhunga pressure chu a pung zauh zauh a. Doctor te chuan he natna hi portal hypertension an ti a .

Engvangin nge hei hi a hlauhawm? He pressure sang hian taksa chhunga thisen kalna kawng nalh tak takte chu a tipuak thei a, chu chuan chhungril lamah thisen a chhuah tir thei a ni . Chuvangin hei hi enkawl vat a pawimawh hle.

A hnuaia table atang hian heng harsatna pahnih hi i hrethiam mai ang.

Hei hi eng enkawlna nge ni?

I doctor chuan he ‘portal vein’-a pressure tihziaawmna turin damdawi, beta-blockers ang chi a pe thei ang. Hengte hian rei lo te chhungin i thisen sang a control thei a ni.

Mahse, hre reng ang che, portal hypertension tihtawp vek thei damdawi awmchhun leh nghet ber chu liver transplant hi a ni.Chauh. A chhan chu hei hi a bulpui ber chu cirrhosis vanga thin (liver) a tihchhiat vang a ni. Chu chhiatna chu siam ṭhat theih a nih loh avangin, a hnuhnung ber chu liver chhia chu la chhuakin, a thara thlak hi a ni.

PBC hi damdawi inenkawlna mumal leh thurawn tha tak nena invenna tha tak a ni. Chuvangin he natna hi i vei a nih chuan hlauthawng suh la, doctor nen inbiak reng la, a enkawl dan tur dik takin zawm rawh. Chu chu chutiang harsatna laka himna kawng tha ber a ni.