Damdawi inang hian mi zawng zawng tan hna a thawk em? Damdawi hmalam hun tur hi han sawi ila: Precision Medicine!

Engvangin nge damdawi leh enkawl dan inang chiah hian natna tin leh mi tin tan a thawk tha lo tih i ngaihtuah ngai em? A châng chuan natna ang chiaha i ṭhianpa hnena damdawi i pek kha i tan a thawk lo mai thei. Chuvang chuan khawvelin he damdawi hman dan thar hi a chinfelna atan an sawi a ni. Hei hi 'Precision Medicine' emaw ``(Precision Medicine)'' emaw an ti a. Hemi chungchang hi vawiinah hian chipchiar takin sawi ila.

Precision Medicine tih hi eng nge ni?

A awlsam zawngin, hei hi i tan a tha, i tan bik damdawi a ni. Ngaihtuah teh, i genes, i chenna boruak, i nunphung – hei hi heng zawng zawng chungchanga information lakna leh hriselna enkawlna tha ber pekna atana hman dan thar a ni. Chutiang chuan scientist leh doctor-te chuan natna laka inven dan chi hrang hrang, damdawi chi hrang hrang, eng ang pawl nge \ha ang tih chu a hmain an lo sawi lawk thei a ni. Hei hi ‘personalized medicine’ an ti bawk.

A tlangpuiin doctor-te hian ‘mi pangngai’ tan pawha tha thei tur angin enkawlna an ruahman fo thin tih kan hmu thin. Chu chu ‘one-size-fits-all’ approach tihna a ni. Hemiah hian mi inthlauhna tenau te hi an ngaihtuah vak lo. Chuvangin, he approach hian mi thenkhat tan, natna thenkhat tan a thawk tha hle. Mahse, mi thenkhat tan, natna thenkhat tan chuan a thawk tha lo tak zet a ni. Chu chu hei hi a chinfel dan a ni a, chu chu `(Precision Medicine)` an ti a ni. Hei hian i taksa, i genes, leh i nunphung nena inmil ber enkawlna thlan a huam a ni.

He Precision Medicine Initiative hi eng nge ni?

Hei hi United States-a National Institutes of Health (NIH) - chu chu chuta natna zirchiangtu leh hriselna tihchangtlunna tura thawktu institution lian ber - khawvel hriat hlawh research institution dang engemawzat nena thawhhona pawimawh tak, special program a ni. An hmalakna lian ber chu i genes, i chhehvel, leh i nunphung ang chi thil te hmanga natna enkawl leh venna atana hman dan tha ber berte zawn chhuah hi a ni.

He ``Precision Medicine Initiative'' hian hun rei lote leh hun rei tak chhunga thil tum a nei a.

• " Hun rei lote chhunga thil tum ber chu he ``Precision Medicine'' concept hi cancer zirchiannaah rawn luhtir hi a ni. US National Cancer Institute-a scientist-te chuan cancer biology leh genetics hi thuk zawka hriatthiam a, enkawlna thar, hlawk zawk siam chhuah an duh a ni. Ngaihtuah teh, cancer a lo awm hian eng ang cancer nge a nih leh eng genetic changes nge a thlen tih chiang taka i hriat chuan, a tana hnathawk thei damdawi i pe thei ang, a dik em?".. tiin.
• " Hun rei tak chhunga thil tum"."Hei hi he `(Precision Medicine)` hi healthcare kawng tinrengah tihzauh a tum a ni. Hei atan hian `(NIH)` chuan zirchianna program bik `(All of Us Research Program)` tih chu an tan a. He zirchianna hmang hian mi tam tak, genetic background leh nunphung hrang hrang nei te hnen atangin information an la khawm a, chu data hmang chuan mi zawng zawng tana healthcare tha zawka siam theih dan tur an zawng mek a ni.

Precision Medicine atang hian eng hlawkna nge kan hmuh?

He ``Precision Medicine'' approach hian i hriselna leh damdawi lam enkawlna i dawnte chu kawng tam takah a tichangtlung thei a ni. Heng hlawknate hi lo en ve teh:

• I doctor chuan i genetic information chu nitin damdawi lam enkawlna kawngah a pui thei a ni. Chu chu a hlut êm êm ang tih han ngaihtuah teh! Entirnan, damdawi thenkhat hian gene thenkhat nei te tan side effect a nei tam zawk thei. I genetic information hriatna chuan chutiang damdawi ei loh nan a pui thei che a ni.
• Natna lo awm chhan hriatthiamna tha zawk kan nei a. Chumi awmzia chu a natna lan chhuah dan chauh enkawl ai chuan natna bulpui chu kan enkawl thei tihna a ni.
• Eng enkawlna nge i tan a tha ber tih i hre lawk thei ang . Tichuan damdawi tul lo leh side effects te hman hi i ti tlem thei ang. Hun leh sum i humhim a ni.
• Natna laka invenna, hriatchhuahna leh enkawl dan changkang zawk a awm a. Natna thenkhat chu an lo awm hmain genetic predisposition a awm leh awm loh pawh hriat theih a ni.
• I electronic health records (EHRs) – i natna, damdawi leh test record computer system-a dah te chu awlsam zawkin i hmu thei ang. Hei hian doctor-te tan i damdawi lam chanchin leh enkawlna tur ruahmanna siam a awlsam phah ang.

Tunah hian khawiah nge Precision Medicine hi hman a nih?

Doctor-te chuan he ``Precision Medicine'' approach hi damdawi lam kawng tam takah an hmang tawh a ni. A bul tanna la ni mah se, a rah chhuah chu a lawmawm hle. Entirna tlemte chu hetiang hi a ni:

• Oncology dik tak a ni
• Cancer natna immunotherapy hmanga enkawl a ni
• Pharmacogenomics chungchang a ni
• Natna hmuh tur awm lo

Chûng zînga pakhat zel chu chipchiar zâwkin kan sawi dawn em ni? Tichuan he thil pawimawhzia hi i hrethiam lehzual ang.

Precision oncology chu eng nge ni?

Doctor-te chuan cancer hi taksa peng hrang hrang (e.g. lung cancer, hnute cancer) emaw, tissue chi hrang hrang (e.g. lymphoma) emaw hmangin an thliar hrang tlangpui. Mahse he ``Precision Medicine'' hmang hian tunah chuan cancer hrang hrangte molecular fingerprint an hmuchhuak ta a ni.Chu chu, kan kutziak ang bawkin, cancer tinte tana danglam bik chemical pattern tenau leh genetic change te kan hmuchhuak tihna a ni. Heng marker te hmang hian cancer te hi chi hrang hrang leh chi hrang hrangah an then belh leh a ni.

Zirchiangtute chuan taksa peng hrang hranga cancer lo awm hian molecular level-ah inanna tam tak a nei thei tih an hmuchhuak a. Chuvangin, he ``Precision oncology`` hian doctor te chu mi pakhat cancer ``DNA signature`` atanga enkawlna tur a thlang thei a ni. Chumi awmzia chu mi zawng zawng hnenah damdawi inang pek ai chuan chu cancer, chu genetic change nena inmil bik enkawlna an pe thei tihna a ni. Hei hian enkawlna chu a hlawhtlin theihna a tipung hle.

Cancer immunotherapy tih hi eng nge ni?

I taksa immune system hian cancer thenkhat a veng thei tih i hria em? Hei hi a chhan chu cell pangngai lo hriat theihna leh tihchhiat theihna pianpui a neih vang a ni. Mahse, a châng chuan cancer cell-te chu an finthlâk êm avângin he immune system hi an pumpelh a, an inthup a, an ṭhang lian a ni.

Mahse, he ``Cancer immunotherapy'' an tih hmang hian tunah chuan scientist te chuan cancer cell te chu an bum ta a ni! Engtin nge tih i hria em? Cancer control nan i immune system i hmang thei a, a chang chuan a tidam vek thei bawk. Hei hi a mak takzet a ni lawm ni?

Heng ``Cancer immunotherapy'' damdawi chi hrang hrangte hian i taksa natural immune system molecule te hnathawh dan an entawn thei a, a tichak thei bawk. Heng damdawi chi hrang hrangte hi:

• Anticancer antibodies te hian cancer cell te chu an inzawm khawm a, an tichhia a ni.
• I immune cells te la a, lab-a "supercharge" a, i taksaa luhtir leh theihna method.
• Treatment vaccine hi special vaccine a ni a, i immune system chu cancer cells te beih dan zirtirtu a ni.

Pharmacogenomics chu eng nge ni?

Hei hi thupui thuk deuh a ni a, mahse a pawimawh hle. Pharmacogenomics chu i DNA in damdawi i ei thinte a chhan dan zirchianna a ni. He field hian pharmacology – damdawi zir chianna – leh genomics – genes zirchianna – te chu a thlunzawm a , damdawi him, tangkai tak leh i genes-a inthlak danglamna bik ang zela dose siam a ni.

A awlsam zawngin sawi ila, ``Pharmacogenomics'' thil tum ber chu 'one size fits all'' tih atanga inthlak danglam hi a ni. Tunah chuan zirchiangtute chuan damdawi chi hrang hrang i taksain a chhân lêt dân tichhe thei thil tam tak a awm tih an hre ta. I kum, i mipa leh hmeichhia, i taksa lian leh te chauh a ni lo. Hemi kawngah hian i genes te pawh hian hmun pawimawh tak an chang a ni. ``Precision Medicine'' hian i taksa tana damdawi dik tak, a dose dik takah pek che a tum a ni. Tichuan damdawi chu a thawk tha ang a, side effect a nei tlem zawk ang.

Natna hmuh tur awm lo leh precision medicine

Zirchiangtute sawi dan chuan United States-ah ringawt pawh hian mi maktaduai 25-30 velin genetic condition hmuh tur awm lo tak tak an vei a ni. Sri Lanka-ah pawh hetiang damlo hi an awm ve tho. Heng natnate hi hriatchhuah leh enkawl hi a harsa hle. Chutiang damdawi lama harsatna khirh tak tak za tam tak chu (NIH)-a ‘Undiagnosed Disease Program’ kaltlangin zirchian a ni tawh a ni. Chu zirchianna hmang chuan chutiang natna tam tak chu an hmuchhuak thei ta a ni. Genetic technology lo awm chhoh zel avang hian heng natna hmuh tur awm lo tak takte thlentu genetic defect dik tak chu hriat theih a ni ta a ni.

Tunah chuan NIH chuan he program hi ram puma center dang engemaw zatah pawh natna tam zawk zirchian nan a tizau ta a ni. Heng natna hlauhawm tak takte enkawlna tha tak tak rang taka siam tumin thawhpui dang engemawzat nen an thawk dun mek a ni. Hetiang mite tan hian Precision Medicine hi beiseina lian tak a ni.

‘Precision Medicine’ leh ‘Personalized Medicine’ hi eng nge an danglamna?

US National Research Council-in a tarlan dan chuan ‘Personalized Medicine’ tih hi ‘Precision Medicine’ sawina atana hman thin thumal hlui a ni. Chu chu term pahnih hian awmzia a inang tihna a ni.

Mahse, council chuan miten ‘personalized’ an tih hian mi tin hian enkawl dan danglam, tailor-made treatment an dawng ang tih an ngaihtuah thin avangin an ngaihtuah deuh a ni. Mahse, ``Precision Medicine'' hian a ngaih pawimawh ber chu nangmah chauh a ni lo. Chu ai chuan, eng enkawlna nge eng pawl nge tha ber tih hriat chhuah a ni zawk – chu chu nangmah ang bawka genetic characteristic leh nunphung inang nei midangte tihna a ni. Tunah chuan ``Precision Medicine'' tih hi hman lar ber leh a dik zawka ngaih a ni ta. Mahse, miten he thumal pahnih hi inthlak danglamin an la hmang reng a ni. A pawimawh ber chu he method hian mi zawng zawng hi inang tlanga enkawl ai chuan, enkawlna dik zawk, hlawk zawk pek a tum zawk a ni.

He thawnthu atang hian eng nge kan in lama hruai haw duh ber?

I genes, i chenna boruak, i nunphung – heng zawng zawng hian i hriselna a nghawng a ni. ``Precision Medicine'' tum ber chu heng zawng zawng hi zirchian a, i humhim leh tanpui turin hma lak hi a ni. Tichuan, mi zawng zawng enkawlna inang pek ai chuan, i doctor-te chuan i duh ang natna laka invenna leh enkawl dan tur ruahmanna an siam thei ang. Doctor-te chuan damdawi lam kawng tam takah ``Precision Medicine'' an hmang tawh a. Mahse, nakin lawkah healthcare field a thlak danglam theihna tur thil tam tak a awm a, ngaihtuah harsa tak a ni. Chuvangin, hei hi kan healthcare hmalam hun atan beiseina ropui tak a ni tak zet!

"Hriat reng tur chu, ``Precision Medicine'' hi mi zawng zawng tana damdawi danglam bik siam a ni lo va, nangmah ang chiah chiah mi pawl pakhat tan enkawlna tha ber leh tangkai ber thlan hi a ni zawk.

He technology a lo thang chho zel chuan natna dang tam tak hlawhtling takin kan do thei dawn a ni. Chuvangin, hetiang thil thar hi hriat reng a pawimawh hle.

` Precision Medicine, Genetics, Cancer Enkawlna, Mimal Damdawi, Nakin lawka Damdawi, Hriselna Technology