Pum a na em? Chaw ei a digest thei lo em ni? Hawh teh, (Prokinetic Agents) chungchang hi han sawi teh ang!

A châng chuan chaw ei zawhah chaw ei kham emaw, ei ṭhat loh emaw i nei ṭhin em? A nih loh leh heartburn emaw indigestion emaw ang chi harsatna i nei em? A châng chuan heng harsatnate hi kan intestines hnathawh that loh vang a ni thei. Vawiin hian damdawi chi khat, chutiang huna chhanchhuahna atana lo kal thin chungchang kan sawi dawn a ni. Chungte chu `(Prokinetic Agents)` an ti a.

Heng `(Prokinetic Agents)` te hi engte nge ni? A awlsam zawngin...

A awlsam zawngin, `(Prokinetic Agents)` hi damdawi chi khat a ni a, chu chuan i chaw ei kawng, chu chu i intestines a kal chakna tipungtu a ni. Chaw kan ei hian kan chaw ei kawng (digestive tract)-a taksa peng hrang hrangte chu a chung atanga a hnuai thlengin thlipui (wave) inzawm ang maiin a inzawm tan thin. Hei hi `(Perstalsis)` an ti a. Chaw ei hnuai lam nawr ang mai a ni. Hei hi chaw chu kawr atanga chaw kawng hnuai lam, pum chhunga lut, chuta tang chuan intestines-ah a kal dan a ni. He kan zin chhung hian kan taksa hian a mamawh ei tur tha tak tak a hip lut thin.

Mahse, natna thenkhat emaw, chhan dang emaw avang hian he ``Peristalsis'' an tih hian hna a thawk tha lo mai thei. Hei hi natna lan chhuah dan, chaw ei kham loh, lungphu chawl, chaw ei loha chaw ei kham tih ang chi a lo awm hian a ni. Chaw ei chu pum chhungah rei tak a awm thei a, chumi hnuah taksain a mamawh ei tur a hmu lo thei bawk.

Chutah chuan heng damdawi `(Prokinetic Agents)` an tih te hi an rawn chhanchhuak ta a ni. Hengte hian intestines movement a tipung a, ei tur chu digestive tract-ah rang zawkin a kal theih nan a pui bawk. Mahse hriat reng tur pawimawh ber chu heng damdawi te hian side effect lian tak tak a nei thei tih hi a ni. Chuvangin doctor ten heng damdawi te hi an pe nghal mai lo tlangpui. A tam zawkah chuan `(Proton Pump Inhibitors - PPIs)` emaw `(H2 Blockers)` emaw damdawi dang pek a ni a, chumi hnuah `(Prokinetic Agents)` chu chhanchhuahna a pe lo a nih chauhvin ngaihtuah a ni. Mahse, i damdawi lam dinhmun a zirin i doctor pawhin he damdawi hi a pe thei bawk.

Engtin nge heng `(Prokinetic Agents)` te hian hna an thawh?

Heng damdawi te hnathawh dan hi a buaithlak deuh a, mahse ka sawi awlsam ang. Anni hian a bul berah chuan i digestive system-a nerve te chu an tichak a, taksa ruh (muscles) te chu an inzawm khawm theih nan an pui bawk.

Chumi awmzia chu:

• I esophagus (food pipe)-a contraction a tipung a, chaw chu chaw ei tur chu rang taka pum chhunga a luh theih nan a pui a ni.
• I chaw kawng hnuai lama Lower Esophageal Sphincter (LES) chu tichak rawh. LES hi valve ang mai a ni. I chaw kawng (esophagus) atanga i pum leh i chaw kawng inzawmkhawmtu a ni. A khar tha lo a, a lo chhuak a nih chuan stomach acid hi i esophagus leh i rilruah a rawn chho leh thei a ni. Chutah chuan chu thinlung natna, thinlung natna, leh rilru natna chu i nei thin. Hei hi Acid Reflux emaw GERD emaw an ti bawk.
• Pum natna a tipung a, ei tur chu small intestine-ah rang taka a kal theih nan a pui bawk.
• Pum ruak hun chhung a ti tlem a ni. Hei hian `(Acid Reflux)` ang bawkin, pum chhunga thil awmte chu a rawn chho leh theihna chance a ti tlem a ni.

Ngaihtuah teh, he damdawi hian traffic jam ang maiin hna a thawk a, police-te chu an lo kal a, lirthei tlan chakna tur kawng an hawng a.

Eng condition atan nge `(Prokinetic Agents)` hi hman?

Heng damdawi te hi a hnuaia natna hrang hrang tan hian hman a ni ber:

• Gastroparesis (stomach muscle dysfunction/delayed digestion): Hetiang dinhmunah hian pum ruh te hi a inzawm tha lo a, chuvangin chaw ei kham a tlai thin. Prokinetic damdawi hian heng contraction te hi a tipung a, pum chu a ti hring rang zawk thin. Zunthlum vei te pawhin he natna hi Diabetic Gastroparesis an tih hi an nei thei bawk. Tunah hian United States-ah hian he damdawi atan hian Metoclopramide chauh hi FDA-in a pawmpui a ni. I doctor chuan enkawlna dangin a puih loh chuan hei hi a pe thei ang.

• GERD (Gastroesophageal Reflux Disease): Hei hi chaw kawng acid atanga ka chhunga a rawn lut leh thin hi a ni. Hei hi a hmaa ka sawi tawh LES (Lessive Esophageal Suppression System) kha a khar tha lo a nih chuan a thleng thin. Prokinetic agents chauh hian GERD hi a pui dawn lo. Amaherawhchu, i pum chu a hring lo a nih chuan i doctor chuan hengte hi damdawi dang nen a pe thei ang.

• Functional Dyspepsia: Hei hi chaw ei zawha pum chhunga harsatna awm reng, mahse a chhan chiang tak hmuh theih loh hun a ni. Mi thenkhat chuan heng damdawi te hian natna lan chhuah dan tihtlem nan a pui thei tih an hmu mai thei. Zirchiangtute chuan heng damdawi te hian pum na a tipung a, empty a ti chak bawk niin an sawi.

• Nausea leh vomiting: Doctor chuan he damdawi hi acute emaw chronic vomiting, enkawlna dang dawng lo tan a pe thei a ni. Cancer natna damdawi chemotherapy avanga luak chhuak atan pawh an hmang \hin.

• Chronic Intestinal Pseudo-obstruction: Hei hi intestine-a blockage tak tak awm lo mahse blockage symptoms a awm lai a ni Researcher te chuan prokinetic agents thenkhat hian he natna hi a pui thei em tih an la chhui mek a ni.

`(Prokinetic Agents)` chi hrang hrangte chu engte nge ni?

Heng damdawi te hi chi hnih ah then theih a ni a, chungte chu `(Agonists)` leh `(Antagonists)` te an ni.

• `(Agonists)`: Hengte hi kan nervous system-a `(Neurotransmitters)` (nerve inkara thuchah kengtu chemical) thenkhat angin an che thin. Chu chu heng `(Agonists)` te hi an kal a, nerve pakhatah an inzawm a, chu nerve chu "contract" turin an hrilh a ni. A kaihhnawih `(Neurotransmitters)` pawhin chutiang bawk chu an tih ang bawkin.
• `(Antagonists)`: Hengte hian `(Neurotransmitters)` thenkhat chu nerve pakhata an inzawmna tur venna hmangin hna an thawk thin. A bik takin, `(Peristalsis)` kalphung tibuaitu `(Neurotransmitters)` an awm chuan heng `(Antagonists)` te hian nerve nena inzawmna nei lo turin an block thin.

Heng ``Prokinetic Agents'' te hi damdawi tin hnathawh dan azirin category hrang hrangah then belh leh a ni:

• `(Cholinergic Agonists te)` tih hi a ni.Hengte hian ``(Neurotransmitter)`` `(Acetylcholine)` an tih angin hna an thawk a ni. `(Acetylcholine)` hian intestine chhunga muscle te contraction a tichak a. Entirnan: `(Baclofen)`, `(Bethanechol)`, `(Neostigmine)`, `(Pyridostigmine)` te hi a ni.
• `(Motilin Agonists)` (Macrolide Antibiotics): Hengte hian `(Neurotransmitter)` `(Motilin) ​​an tih angin hna an thawk a. `(Motilin)` hian small intestine-a contractions a tichak a. He group-a damdawi thenkhat hi a takah chuan `(Antibiotics)`, bacteria infection enkawlna atana pek an ni. Entirnan: `(Erythromycin)`, `(Azithromycin)` tih te hi a ni.
• Serotonin Agonists: Hengte hian neurotransmitter serotonin angin hna an thawk a. Serotonin ang bawkin intestinal contractions a tichak a, pum chu a hring chhuak thei bawk. Entirnan: Cisapride, Prucalopride, Tegaserod te hi a awm thei.
• `(Dopamine Antagonists)`: Hengte hian `(Neurotransmitter)` `(Dopamine)` an tih chu nerve cell-ah a inzawm lo. `(Dopamine)` hian pum leh intestines chetna a ti tlem a, `(LES)` pawh a ti hahdam bawk. Chuvangin, `(Dopamine)` hian a binding a chawlhsan chuan heng `(Dopamine Antagonists)` te hian chu effect chu an tidanglam leh thin (i.e. movement tihpun). Entirnan: `(Metoclopramide)`, `(Domperidone)` tih te hi a ni.

`(Prokinetic Agents)` tih entirnan thenkhat

Tunah hian ``Prokinetic`` damdawi chi hrang hrang enkawlna atana hman a awm a, a then chu United States ang ramah chuan a side effect avangin khap a ni a, thenkhat chu research stage-ah a la awm bawk.

• Azithromycin (Zithromax®): Motilin hmanga enkawltu a ni. Doctor-te chuan gastroparesis atan off-label-in an pe ṭhin.
• Baclofen (ED baclofen®): Chu chu cholinergic agonist a ni. GERD tana a hlawkna tur chu zirchian mek a ni.
• `(Bethanechol)` (Urecholine®): A `(Cholinergic Agonist) a ni a, a rilru a hah lutuk a, a rilru a buai em em bawk a. `(Gastroparesis)` leh `(GERD)` symptoms te tan a pui thin. Mahse, a tam zawkah chuan hman a ni lo a, a chhan chu side effect na tak tak, muscle spasms leh blurred vision a thlen thei a ni.
• Cisapride (Propulsid®): Serotonin tihdamna atana hman tur a ni. Pum chu a hring rang zawk nan a pui thin. Tun hma chuan GERD atan hman thin a ni. Heart-related side effects vangin US market atanga paih a ni.
• `(Domperidone)` (Motilium®): A `(Dopamine dotu) a ni. United States-ah chuan phalna bik nei lo chuan awlsam taka hmuh theih a ni lo. Lung lam harsatna lian tak tak a thlen thei a, chu chu thinlung thawk mumal lo leh thinlung natna a thlen thei a ni.
• Erythromycin (EES®): Motilin hmanga enkawltu a ni. Doctor chuan gastroparesis atan off-label-in a pe thei.
• Metoclopramide (Reglan®, Maxeran®, Gimoti®): Dopamine dotu a ni. Gastroparesis damdawi FDA-in a pawmpui awmchhun a ni. Tin, GERD, enkawlna pangngaia chhan let lo enkawlna atan pawh hman a ni. Mahse, nervous system tichhe thei side effect a thlen thei tih vaukhânna a keng tel a ni.
• `(Prucalopride)` (Motegrity®) tih a ni a, a chhuahna tur hmun leh a hmanna tur hmun:A `(Serotonin Agonist)` tih a ni. Chronic constipation tan pek a ni. Tin, pum chu a ruak nghal vat theih nan a pui bawk.
• Pyridostigmine (Mestinon®): Chu chu cholinergic agonist a ni. Myasthenia Gravis enkawlna atan hman a ni ber a, mahse Gastroparesis enkawlna atan pawh hman a ni bawk.

Heng `(Prokinetic Agents)` hman hian eng side effect nge a neih?

Hei hi fimkhur tur pawimawh ber a ni. Prokinetic agents hian side effect na tak a nei thei a ni. Chuvang chuan doctor ten damdawi an pek an hreh fo thin. Mahse, GERD atana PPI ang chi enkawlna pangngaiin a thawh loh chuan doctor chuan prokinetic agent pek a tum mai thei. A nih loh leh, fimkhur nan, a dose tlem zawk emaw, hun rei lo zawk emaw atan pawh pek theih a ni.

Doctor-in prokinetic agent a pe che a nih chuan, chu damdawi chuan a side effect chiang tak chu zawt ngei ang che.

Side effects tlangpui chu:

• Pum a na
• Nausea leh luak chhuak
• Diarrhea (bloating) 1.1.
• Mit hmuh a fiah lo
• Lu na (lu na) .
• Chau lutuk
• Mutthilh, hah lutuk, mutthilh fo (Lethargy) .
• Lungngaihna
• Hlauhthawnna
• Muscle contraction control theih loh (Dystonia) .
• Hmai ruh inthlak danglamna (Tardive Dyskinesia) .

Ruihhlo `(Cisapride)`, `(Domperidone)` leh `(Tegaserod)` te chu lung lam harsatna lian tham a thlen theihna tur a nih avangin bazar atangin lakchhuah a ni. Chu chu:

• Lung natna (Bradycardia) .
• Thinlung thawk mumal lo (Arrhythmia) .
• Lung natna

Tuna prokinetic agents thar chungchanga zirchianna chu damdawi siam chhuah a ni a, chu chuan intestinal contractions tichaktu hlawkna a pe a, chutih rualin chutiang side effects awm theihna a ti tlem bawk.

`(Prokinetic Agents)` hman tam berte chu engte nge ni?

Prokinetic agents pek chhuah tam ber chu Metoclopramide leh Domperidone te an ni. United States-ah chuan Metoclopramide hi FDA-in gastroparesis damdawi a pawmpui awmchhun a ni. Mahse, doctor chuan FDA phalna la hmasain Domperidone a pe thei a ni.

Prokinetic agents hi ei leh in lama harsatna enkawlnaah a thatna leh a him dan a inang lo. Side effect a awm theih avangin doctor chuan prokinetic agent a pek hmain damdawi dang a enchhin thei a ni. Mahse, i ril a inzawm tha lo vanga natna lanchhuahna na tak i neih chuan prokinetic agent hian i mamawh em em chu a pe thei a ni. Prokinetic agent ei i ngaihtuah a nih chuan i doctor nen a thatna leh a hlauhawm dan sawiho a pawimawh hle.

Hriat reng tur pawimawh ber berte (Take-Home Message) .

Chuvangin, `(Prokinetic Agents)` chungchanga kan sawiho atang hian thil in zir chhuah ka beisei. A tawi zawngin:

• Prokinetic agents hi damdawi chi khat a ni a, chu chuan chaw ei kawng a tichak a, chaw ei kawngah a pui bawk.
• Hengte hi `(Gastroparesis)` leh `(GERD)` ang chi natna thenkhat tan pawh hman a ni a, chubakah natna leh riltam ang chi thil atan pawh hman a ni.
• He damdawi hian intestine chhunga nerve te tichakin hna a thawk a, taksa ruh te a tikhawlo a ni.
• A pawimawh ber chu heng damdawi te hian a chang chuan side effect na tak tak a nei thei a, chuvangin doctor chuan fimkhur takin a pe ang.
• Hetiang damdawi hi doctor rawn hmasa lovin hmang ngai suh. Doctor chuan eng damdawi nge i tana tha tur tih leh eng chen nge i ei tur tih a rel tur a ni.

Hetiang taka pum na emaw chaw ei lama harsatna i neih chuan a tha ber chu Doctor hmu a, sawipui hi a ni. Tichuan enkawlna dik tak i hmu thei ang.

` prokinetic agents, pum natna, chaw ei kham lohna, chaw ei loh, GERD, gastroparesis, metoclopramide te a ni