Pum a na em? Chaw ei a digest thei lo em ni? Hawh teh, (Prokinetic Agents) chungchang hi han sawi teh ang!

A châng chuan chaw ei zawhah chaw ei kham emaw, ei ṭhat loh emaw i nei ṭhin em? A nih loh leh heartburn emaw indigestion emaw ang chi harsatna i nei em? A châng chuan heng harsatnate hi kan intestines hnathawh that loh vang a ni thei. Vawiin hian damdawi chi khat, chutiang huna chhanchhuahna atana lo kal thin chungchang kan sawi dawn a ni. Chungte chu (Prokinetic Agents) an ti a.

Heng (Prokinetic Agents) te hi engte nge ni? A awlsam zawngin...

A awlsam zawngin, (Prokinetic Agents) hi damdawi chi khat a ni a, chu chuan i chaw ei kawng, chu chu i intestines a kal chakna tipungtu a ni. Chaw kan ei hian kan chaw ei kawng (digestive tract)-a taksa peng hrang hrangte chu a chung atanga a hnuai thlengin thlipui (wave) inzawm ang maiin a inzawm tan thin. Hei hi (Perstalsis) an ti a. Chaw ei hnuai lam nawr ang mai a ni. Hei hi chaw chu kawr atanga chaw kawng hnuai lam, pum chhunga lut, chuta tang chuan intestines-ah a kal dan a ni. He kan zin chhung hian kan taksa hian a mamawh ei tur tha tak tak a hip lut thin.

Mahse, natna thenkhat emaw, chhan dang emaw avang hian he Peristalsis'' an tih hian hna a thawk tha lo mai thei. Hei hi natna lan chhuah dan, chaw ei kham loh, lungphu chawl, chaw ei loha chaw ei kham tih ang chi a lo awm hian a ni. Chaw ei chu pum chhungah rei tak a awm thei a, chumi hnuah taksain a mamawh ei tur a hmu lo thei bawk.

Chutah chuan heng damdawi (Prokinetic Agents) an tih te hi an rawn chhanchhuak ta a ni. Hengte hian intestines movement a tipung a, ei tur chu digestive tract-ah rang zawkin a kal theih nan a pui bawk. Mahse hriat reng tur pawimawh ber chu heng damdawi te hian side effect lian tak tak a nei thei tih hi a ni. Chuvangin doctor ten heng damdawi te hi an pe nghal mai lo tlangpui. A tam zawkah chuan (Proton Pump Inhibitors - PPIs) emaw (H2 Blockers) emaw damdawi dang pek a ni a, chumi hnuah (Prokinetic Agents) chu chhanchhuahna a pe lo a nih chauhvin ngaihtuah a ni. Mahse, i damdawi lam dinhmun a zirin i doctor pawhin he damdawi hi a pe thei bawk.

Engtin nge heng (Prokinetic Agents) te hian hna an thawh?

Heng damdawi te hnathawh dan hi a buaithlak deuh a, mahse ka sawi awlsam ang. Anni hian a bul berah chuan i digestive system-a nerve te chu an tichak a, taksa ruh (muscles) te chu an inzawm khawm theih nan an pui bawk.

Chumi awmzia chu:

• I esophagus (food pipe)-a contraction a tipung a, chaw chu chaw ei tur chu rang taka pum chhunga a luh theih nan a pui a ni.
• I chaw kawng hnuai lama Lower Esophageal Sphincter (LES) chu tichak rawh. LES hi valve ang mai a ni. I chaw kawng (esophagus) atanga i pum leh i chaw kawng inzawmkhawmtu a ni. A khar tha lo a, a lo chhuak a nih chuan stomach acid hi i esophagus leh i rilruah a rawn chho leh thei a ni. Chutah chuan chu thinlung natna, thinlung natna, leh rilru natna chu i nei thin. Hei hi Acid Reflux emaw GERD emaw an ti bawk.
• Pum natna a tipung a, ei tur chu small intestine-ah rang taka a kal theih nan a pui bawk.
• Pum ruak hun chhung a ti tlem a ni. Hei hian (Acid Reflux) ang bawkin, pum chhunga thil awmte chu a rawn chho leh theihna chance a ti tlem a ni.

Ngaihtuah teh, he damdawi hian traffic jam ang maiin hna a thawk a, police-te chu an lo kal a, lirthei tlan chakna tur kawng an hawng a.

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Eng condition atan nge (Prokinetic Agents) hi hman?

Heng damdawi te hi a hnuaia natna hrang hrang tan hian hman a ni ber:

• Gastroparesis (stomach muscle dysfunction/delayed digestion): Hetiang dinhmunah hian pum ruh te hi a inzawm tha lo a, chuvangin chaw ei kham a tlai thin. Prokinetic damdawi hian heng contraction te hi a tipung a, pum chu a ti hring rang zawk thin. Zunthlum vei te pawhin he natna hi Diabetic Gastroparesis an tih hi an nei thei bawk. Tunah hian United States-ah hian he damdawi atan hian Metoclopramide chauh hi FDA-in a pawmpui a ni. I doctor chuan enkawlna dangin a puih loh chuan hei hi a pe thei ang.

• GERD (Gastroesophageal Reflux Disease): Hei hi chaw kawng acid atanga ka chhunga a rawn lut leh thin hi a ni. Hei hi a hmaa ka sawi tawh LES (Lessive Esophageal Suppression System) kha a khar tha lo a nih chuan a thleng thin. Prokinetic agents chauh hian GERD hi a pui dawn lo. Amaherawhchu, i pum chu a hring lo a nih chuan i doctor chuan hengte hi damdawi dang nen a pe thei ang.

• Functional Dyspepsia: Hei hi chaw ei zawha pum chhunga harsatna awm reng, mahse a chhan chiang tak hmuh theih loh hun a ni. Mi thenkhat chuan heng damdawi te hian natna lan chhuah dan tihtlem nan a pui thei tih an hmu mai thei. Zirchiangtute chuan heng damdawi te hian pum na a tipung a, empty a ti chak bawk niin an sawi.

• Nausea leh vomiting: Doctor chuan he damdawi hi acute emaw chronic vomiting, enkawlna dang dawng lo tan a pe thei a ni. Cancer natna damdawi chemotherapy avanga luak chhuak atan pawh an hmang \hin.

• Chronic Intestinal Pseudo-obstruction: Hei hi intestine-a blockage tak tak awm lo mahse blockage symptoms a awm lai a ni Researcher te chuan prokinetic agents thenkhat hian he natna hi a pui thei em tih an la chhui mek a ni.

(Prokinetic Agents) chi hrang hrangte chu engte nge ni?

Heng damdawi te hi chi hnih ah then theih a ni a, chungte chu (Agonists) leh (Antagonists) te an ni.

• (Agonists): Hengte hi kan nervous system-a (Neurotransmitters) (nerve inkara thuchah kengtu chemical) thenkhat angin an che thin. Chu chu heng (Agonists) te hi an kal a, nerve pakhatah an inzawm a, chu nerve chu "contract" turin an hrilh a ni. A kaihhnawih (Neurotransmitters) pawhin chutiang bawk chu an tih ang bawkin.
• (Antagonists): Hengte hian (Neurotransmitters) thenkhat chu nerve pakhata an inzawmna tur venna hmangin hna an thawk thin. A bik takin, (Peristalsis) kalphung tibuaitu (Neurotransmitters) an awm chuan heng (Antagonists) te hian nerve nena inzawmna nei lo turin an block thin.

Heng Prokinetic Agents'' te hi damdawi tin hnathawh dan azirin category hrang hrangah then belh leh a ni:

• (Cholinergic Agonists te) tih hi a ni.Hengte hian (Neurotransmitter) (Acetylcholine) an tih angin hna an thawk a ni. (Acetylcholine) hian intestine chhunga muscle te contraction a tichak a. Entirnan: (Baclofen), (Bethanechol), (Neostigmine), (Pyridostigmine) te hi a ni.
• (Motilin Agonists) (Macrolide Antibiotics): Hengte hian (Neurotransmitter) (Motilin) ​​an tih angin hna an thawk a. (Motilin) hian small intestine-a contractions a tichak a. He group-a damdawi thenkhat hi a takah chuan (Antibiotics), bacteria infection enkawlna atana pek an ni. Entirnan: (Erythromycin), (Azithromycin) tih te hi a ni.
• Serotonin Agonists: Hengte hian neurotransmitter serotonin angin hna an thawk a. Serotonin ang bawkin intestinal contractions a tichak a, pum chu a hring chhuak thei bawk. Entirnan: Cisapride, Prucalopride, Tegaserod te hi a awm thei.
• (Dopamine Antagonists): Hengte hian (Neurotransmitter) (Dopamine) an tih chu nerve cell-ah a inzawm lo. (Dopamine) hian pum leh intestines chetna a ti tlem a, (LES) pawh a ti hahdam bawk. Chuvangin, (Dopamine) hian a binding a chawlhsan chuan heng (Dopamine Antagonists) te hian chu effect chu an tidanglam leh thin (i.e. movement tihpun). Entirnan: (Metoclopramide), (Domperidone) tih te hi a ni.

(Prokinetic Agents) tih entirnan thenkhat

Tunah hian Prokinetic damdawi chi hrang hrang enkawlna atana hman a awm a, a then chu United States ang ramah chuan a side effect avangin khap a ni a, thenkhat chu research stage-ah a la awm bawk.

• Azithromycin (Zithromax®): Motilin hmanga enkawltu a ni. Doctor-te chuan gastroparesis atan off-label-in an pe ṭhin.
• Baclofen (ED baclofen®): Chu chu cholinergic agonist a ni. GERD tana a hlawkna tur chu zirchian mek a ni.
• (Bethanechol) (Urecholine®): A (Cholinergic Agonist) a ni a, a rilru a hah lutuk a, a rilru a buai em em bawk a. (Gastroparesis) leh (GERD) symptoms te tan a pui thin. Mahse, a tam zawkah chuan hman a ni lo a, a chhan chu side effect na tak tak, muscle spasms leh blurred vision a thlen thei a ni.
• Cisapride (Propulsid®): Serotonin tihdamna atana hman tur a ni. Pum chu a hring rang zawk nan a pui thin. Tun hma chuan GERD atan hman thin a ni. Heart-related side effects vangin US market atanga paih a ni.
• (Domperidone) (Motilium®): A (Dopamine dotu) a ni. United States-ah chuan phalna bik nei lo chuan awlsam taka hmuh theih a ni lo. Lung lam harsatna lian tak tak a thlen thei a, chu chu thinlung thawk mumal lo leh thinlung natna a thlen thei a ni.
• Erythromycin (EES®): Motilin hmanga enkawltu a ni. Doctor chuan gastroparesis atan off-label-in a pe thei.
• Metoclopramide (Reglan®, Maxeran®, Gimoti®): Dopamine dotu a ni. Gastroparesis damdawi FDA-in a pawmpui awmchhun a ni. Tin, GERD, enkawlna pangngaia chhan let lo enkawlna atan pawh hman a ni. Mahse, nervous system tichhe thei side effect a thlen thei tih vaukhânna a keng tel a ni.
• (Prucalopride) (Motegrity®) tih a ni a, a chhuahna tur hmun leh a hmanna tur hmun:A (Serotonin Agonist) tih a ni. Chronic constipation tan pek a ni. Tin, pum chu a ruak nghal vat theih nan a pui bawk.
• Pyridostigmine (Mestinon®): Chu chu cholinergic agonist a ni. Myasthenia Gravis enkawlna atan hman a ni ber a, mahse Gastroparesis enkawlna atan pawh hman a ni bawk.

Heng (Prokinetic Agents) hman hian eng side effect nge a neih?

Hei hi fimkhur tur pawimawh ber a ni. Prokinetic agents hian side effect na tak a nei thei a ni. Chuvang chuan doctor ten damdawi an pek an hreh fo thin. Mahse, GERD atana PPI ang chi enkawlna pangngaiin a thawh loh chuan doctor chuan prokinetic agent pek a tum mai thei. A nih loh leh, fimkhur nan, a dose tlem zawk emaw, hun rei lo zawk emaw atan pawh pek theih a ni.

Doctor-in prokinetic agent a pe che a nih chuan, chu damdawi chuan a side effect chiang tak chu zawt ngei ang che.

Side effects tlangpui chu:

• Pum a na
• Nausea leh luak chhuak
• Diarrhea (bloating) 1.1.
• Mit hmuh a fiah lo
• Lu na (lu na) .
• Chau lutuk
• Mutthilh, hah lutuk, mutthilh fo (Lethargy) .
• Lungngaihna
• Hlauhthawnna
• Muscle contraction control theih loh (Dystonia) .
• Hmai ruh inthlak danglamna (Tardive Dyskinesia) .

Ruihhlo (Cisapride), (Domperidone) leh (Tegaserod) te chu lung lam harsatna lian tham a thlen theihna tur a nih avangin bazar atangin lakchhuah a ni. Chu chu:

• Lung natna (Bradycardia) .
• Thinlung thawk mumal lo (Arrhythmia) .
• Lung natna

Tuna prokinetic agents thar chungchanga zirchianna chu damdawi siam chhuah a ni a, chu chuan intestinal contractions tichaktu hlawkna a pe a, chutih rualin chutiang side effects awm theihna a ti tlem bawk.

(Prokinetic Agents) hman tam berte chu engte nge ni?

Prokinetic agents pek chhuah tam ber chu Metoclopramide leh Domperidone te an ni. United States-ah chuan Metoclopramide hi FDA-in gastroparesis damdawi a pawmpui awmchhun a ni. Mahse, doctor chuan FDA phalna la hmasain Domperidone a pe thei a ni.

Prokinetic agents hi ei leh in lama harsatna enkawlnaah a thatna leh a him dan a inang lo. Side effect a awm theih avangin doctor chuan prokinetic agent a pek hmain damdawi dang a enchhin thei a ni. Mahse, i ril a inzawm tha lo vanga natna lanchhuahna na tak i neih chuan prokinetic agent hian i mamawh em em chu a pe thei a ni. Prokinetic agent ei i ngaihtuah a nih chuan i doctor nen a thatna leh a hlauhawm dan sawiho a pawimawh hle.