I taksaah pawh chhan awm lovin thisen zam i nei em? He TTP (Thrombotic Thrombocytopenic Purpura) hlauhawm tak hi i zir dawn teh ang!

Thrombotic Thrombocytopenic Purpura, a tawi zawngin TTP tih hi i hre tawh em? Hei hi thisen lama harsatna awm lo mahse na tak a ni. I taksa chhunga thisen kalna kawng te tak teah thisen zam (thrombi) a lo awm thinna a ni. Tui pipe-a clog ang mai a ni. Hei hian i taksa peng pawimawh ber ber, thluak, kal leh thinlunga thisen kal chu a titawp thei a ni. Hei hian harsatna lian tak a thlen thei a ni. Chuvang chuan TTP hi fimkhur a pawimawh hle.

TTP chu eng nge ni? A hming awmzia hi i hrethiam mai ang u.

He natna hming hi a sei deuhin a lang mai thei. Mahse he hming hmun thum hian he natna hi eng ang nge tih hriatna tha tak min pe a ni. Engtin nge a nih i en ang u?

1. Thrombotic: Hei hian thisen kalna kawng chhunga thisen zam (thrombi) lo awm, a hmaa ka sawi tawh ang khan a kawk a ni. Heng thisen zamte hi harsatna bulpui ber a ni.

2. Thrombocytopenic: Hei hian i thisenah platelet a tlem tihna a ni. Platelets hi sipai te tak te ang a ni a, kan hliam hian thisen chhuah tihtawp nan a pui thin. Mahse TTP a lo awm chuan heng platelet te hi a tul lovah thisen zam siam nan an hmang thin. Tichuan thisen chhuahna tihtawp a ngai tak takna hmunah chuan platelet a tlem hle.

3. Purpura: Chumi awmzia chu i vunah te te, sen hring emaw, hliam emaw a lo awm tihna a ni. Rash ang maiin a lang thei. Hengte hi a takah chuan vun hnuaia thisen chhuak te te chhinchhiahna a ni. Hei hi TTP vei zingah a awm fo thin.

A awlsam zawngin sawi ila, TTP hi natna khirh tak a ni a, kan taksa thisen kalna kawng te tak teah thisen zam a lo awm a, chu chuan platelet count a ti tlem a, vunah thisen chhuah chhinchhiahna a awm bawk. Hei hi a thleng thut fo va, chuvangin emergency medical treatment a ngai a ni . Mi thenkhat chuan enkawl hnuah pawh he natna hi an nei leh thei a ni. Mahse, natna a active lai hian symptoms a chiang tlangpui. A châng chuan virus infection, surgery emaw, naupai emaw ang chi thil a\angin a lo chhuak thei bawk. Enkawl loh chuan TTP hi nunna atana hlauhawm tak a ni thei.

TTP natna lan chhuah dan chu engte nge ni?

TTP hi a rawn on nghal vat tlangpui. Mi thenkhat chu an dam leh a, chutah chuan an lo let leh thin a, mahse a natna lan chhuah dan chu a lo thleng leh lo. Anni chu a awm reng a, a langsar hle bawk. Amah chauhin a bo lo va, enkawl a ngai tak zet a ni.

TTP hian taksa pum puia thisen kalna kawng te tak teah thisen zam a siam a. Heng clots te hian organ eng pawh a nghawng thei a, mahse symptoms hi thluak ah a lang hmasa fo thin.

Ngaihtuah teh, heng thisen zamte hi thinlungah a lo awm a nih chuan thinlung hnathawhna nasa takin a nghawng thei a, thihna pawh a thlen thei a ni. TTP hian thisen tlakchhamna (thisen tlem) leh platelet level hniam (thrombocytopenia) a thlen thin. Mi thenkhat chuan thisen an nei ve thei bawk a, mahse hei hi a tam lo hle.

TTP natna lan chhuah dan tlangpui thenkhat chu hetiang hi a ni:

• Rilru dinhmun danglam: Thil buai nghal, buai, emaw, hriatna hloh emaw.
• Buaina: Eng thil nge thleng tih leh khawiah nge i awm tih hriat loh.
• Chauhna nasa tak: Engmah tih theih loh khawpa chau lutuk.
• Lu na: Lu na pangngai aia na zawk lu na.
• Nausea leh vomiting: Pum natna, luak chhuak.
• Pale or yellow skin (Jaundice): Taksa chhunga thisen tlakchham vangin vun a rawn sen thei a, chubakah thin a nghawng avangin vun a sen thei bawk.
• Thâwk harsa (Dyspnea): Thâwk harsa ang maia inhriatna.
• Vun hnuaia dots te te, sen emaw purple emaw (Petechiae): Vunah hian thisen hring te te a lo lang a, pin-in a hliam ang maiin a lang.
• Hematuria: Zun chhunga thisen awm .
• Mit a inthlak danglam: Mit a fiah lo, a chang chuan thil pahnih vawi khatah hmuh (diplopia).

Heng symptoms pakhat emaw a aia tam emaw i tawn thut chuan hun khawhral lova doctor pan tur a ni.

Engvangin nge he TTP hi a lo awm? A chhante chu engte nge ni?

TTP-a harsatna thlentu thisen zam hi taksaah ADAMTS13 tih enzyme a tlakchham tawk hian a lo awm thin. He ADAMTS13 enzyme hian a tih chu kan mamawh loh hunah platelets inzawmkhawm leh thisen zam siam chu a titawp a ni. Traffic cop angin ngaihtuah la, a tul lo taka traffic jam awm loh nan. Chuvangin, he ADAMTS13 hi a tlahniam chuan taksa pum puia thisen kalna kawng te tak teah thisen zam (blood clots) a lo awm tan thin. Heng thisen zamte hi an inhnaih chuan thisen sen (red blood cells) pawh a chhe thei a, a chhe thei bawk.

Platelet tam tak chu a tul lo taka thisen zam siam nan hman a nih avangin, hliam avanga thisen chhuah kan tihtawp a ngai tak tak lai hian platelet hman tur a la tlem hle. I platelet count a tlahniam lutuk chuan awlsam takin i hliam thei a, a tlangpui aia thisen a chhuak thei bawk.

TTP hi kawng lian pahnih a awm thei a:

1. Acquired TTP (hei hi a tam ber): Hei hi i taksa ngeia immune system-in a tihsual palh avanga ADAMTS13 enzyme hnathawh that lohna tur antibody a siam hian a ni. Nangmah sipai ngeiin anmahni an beih ang mai a ni.

2. Inherited TTP (rare): Hei hi naupangin nu leh pa pahnih atanga ADAMTS13 enzyme siamtu gene-a chhiatna a rochun hian a thleng thin. Naupai lai emaw, lungkhamna nasa tak awm lai emaw hian natna lan chhuah dan a intan fo thin.

TTP thlen thei trigger bik a awm em?

Mithiamte chuan thrombotic thrombocytopenic purpura symptoms thlentu hi eng nge ni tih chiang takin an la hre lo. Mahse, mi thenkhat chuan he natna hi an nei tam zawk a, chu chu:

• HIV hrik kai
• Autoimmune natna, lupus ang chi te
• Naupai lai
• Damdawi thenkhat, entirnan chemotherapy damdawi, cyclosporine A , leh quinine .

TTP avanga harsatna awm thei te chu engte nge ni?

Thrombotic thrombocytopenic purpura hi enkawl loh chuan nunna atana hlauhawm tak a ni. Thisen zam hian thisen kal dan a tikhawlo thei a, harsatna lian tak tak a thlen thei a, chungte chu:

• Thluak a chhiat phah
• Lung natna
• Kidney a thawk tha lo
• Nau pai (Naupai hloh) .
• Seizures a awm thin
• Thai

Chuvangin TTP symptoms i neih chuan enkawlna zawng nghal a pawimawh hle kan ti.

Doctor-te hian engtin nge TTP hi an hriat theih?

I doctor chuan a enfiah hmasa ang che a, i symptoms leh health history te a zawt ang che. TTP nia rinhlelh a nih chuan test eng emaw zat an order thei a, chungte chu:

• ADAMTS13 assay: He test hian ADAMTS13 enzyme hnathawh dan a teh thin. A level a hniam chuan TTP a awm tih a nemnghet thei a ni.
• Complete blood count (CBC): CBC hian i thisena cell chi hrang hrang a chhiar a. TTP vei te hian thisen sen (red blood cell) leh platelet count an nei tlem hle.
• Peripheral blood smear (PBS): Hei hian i thisen sample lak a, microscope hmanga enfiah a huam a ni. TTP i neih chuan i thisen sen (red blood cells) te chu a chhe thei a, a chhe thei bawk ( schistocytes an ti bawk ).
• Bilirubin test: Bilirubin hi thisen sen (red blood cells) chhiat avanga bawlhhlawh siam chhuah a ni. Bilirubin level sang hi TTP i neih theihna tur clue pakhat a ni.
• Kidney function test: Heng test te hian i doctor hian i kal a thawk tha em tih a hriat theih nan a pui thei a ni. TTP i neih chuan i zun chhungah thisen cell emaw protein emaw i nei thei.
• Lactate dehydrogenase test (LDH): Lactate dehydrogenase (LDH) hi i taksa tissue a chhiat chuan enzyme a chhuak thin. TTP hian thisenah LDH level a tisang a.

TTP enkawl dan tur chu engte nge ni?

A tam zawkah chuan doctor-te chuan TTP enkawl nan plasma therapy an hmang thin. Hei bakah hian ruihhlo enkawl dan a awm bawk.

Plasma hmanga enkawl dan tur

Enkawlna hman tlanglawn ber berte chu:

• Plasma exchange: Hei hian i plasma pangngai lo (i thisen liquid part) chu lakchhuah a, chu chu donor hrisel tak plasma hmanga thlak a ni. Hei hi acquired TTP vei tan chuan nunna chhanhimna a ni.
• Corticosteroids: Heng damdawi te hian acute TTP control nan a pui a, symptoms a ti tlem a, swelling a ti tlem bawk.

Plasma therapy hi damdawi inah pek a ni a, i natna lan chhuah dan a reh hma loh chuan ni tam tak emaw, kar tam tak emaw chhung pek chhunzawm theih a ni.

Damdawi ei tur

Damdawi thenkhat chu ADAMTS13 enzyme (anti-ADAMTS13 antibodies) laka antibodies siam tihtlem emaw titawp thei emaw a awm. Doctor ten TTP enkawlna atana an hman damdawi thenkhat chu:

• Glucocorticoids: He enkawlna hian i taksa hriselna a titawp a. Hei hi TTP tan chuan a \angkai hle mai thei.
• Caplacizumab: He damdawi hian acute TTP a tidam a. Plasma exchange chauh aiin platelet count a tipung rang zawk a, natna chu rang zawkin a tidanglam thei a ni.
• Rituximab: He enkawlna hian corticosteroid leh plasma exchange hmanga enkawlna hnuah natna a lo let leh tawh loh nan a pui a ni.
• Recombinant ADAMTS13: He enkawlna hian ADAMTS13 enzyme chu a siam tha leh a ni. U.S. Food and Drug Administration (FDA) chuan TTP rochun nei te tan emergency-a hman atan a pawm a ni. A châng chuan, Doctor-te pawhin thisen chhuah tam lutuk loh nan an hmang bawk. Immune-mediated TTP tan a tangkai zia zirchian mek a ni.

Inzai

A tlem hle a, i doctor chuan i spleen chu surgery hmanga lakchhuah (splenectomy) a rawt mai thei. Hei hi TTP na tak, enkawlna dawng tha lo emaw, a lo awm leh zel emaw chauhvin tih theih a ni.

TTP enkawlna atanga dam leh theih nan eng chen nge a duh?

Recovery hun chhung hi thil engemaw zatah a innghat a ni. I dinhmun nasat dan leh enkawlna chi hrang hrang hian hei hi a nghawng thei a ni. TTP avanga plasma therapy dawng tam zawkte chu an dam leh theih nan ni engemaw zat atanga kar tlemte chhung an hmang thin. Splenectomy nei te hian an dam leh theih nan kar li atanga kar ruk vel an hmang tlangpui.

TTP ka neih ka rinhlelh chuan engtikah nge doctor ka hmuh ang?

TTP symptoms hi a nasat em avangin emergency room pan a ngai tlangpui. TTP i vei nia i rinhlelh chuan doctor pangngai hmuh nghak suh – enkawl vat a pawimawh!Acute TTP enkawl nan hian hematologist leh intensive care specialist te thiamna a pawimawh hle.

TTP nena khawsa hian eng nge i beisei theih ang? Dam lehna tur prognosis chu eng nge ni?

TTP hi a hma chuan natna hlauhawm tak a ni. Mahse enkawl hmasak a nih avangin tunah chuan thihpui zat chu 10% velin a tlahniam ta a ni. Natna hi a lo lang leh thei a, chuvangin enkawl hnuah pawh i hematologist nen inbiak hnaih reng a pawimawh. I ADAMTS13 levels check fo hian a danglamna eng pawh a hriat hmasak theih nan a pui thei a ni. A lan chhuah leh hmaa ADAMTS13 level a hniam chuan, Rituximab ang chi venna damdawi te hian natna hi a lo intan hma pawhin a lo awm leh tawh loh nan a pui thei a ni.

TTP damchhuahna rate hi engzat nge ni?

Enkawlna tel lo chuan TTP vei mi sawm zinga pakhat chauh an dam. Mahse inenkawlna mumal tak a awm chuan mi sawm zinga pariat atanga pakua thlengin an dam thei a ni.

Chuvang chuan symptoms i neih chuan enkawlna zawn a pawimawh hle. Tin, i natna hmuhchhuah hnua i in enkawl dan tur doctor-in a tih ang chi zawm a pawimawh bawk.

Enkawlna dik tak a awm chuan Thrombotic Thrombocytopenic Purpura (TTP) vei tam zawk chu nun pangngaiin an hmang thin. I doctor chuan i dinhmun enfiah nan test neih fo a ngai tih a hrilhfiah ang che. Thisen chhuah leh thisen zam tihziaawmna turin enkawl mumal i mamawh leh tih loh pawh a hrilh ang che.

Chutih lai chuan TTP symptoms i neih chuan enkawlna zawng nghal rawh. TTP hi medical emergency a ni a. Mahse, a hmaa inenkawlna chuan i nunna a chhanhim thei a ni.

Chuti a nih chuan, kan sawi tawh atang hian eng nge hriat reng tur pawimawh ber?

Okay, TTP (Thrombotic Thrombocytopenic Purpura) chungchang hi kan sawi nasa hle. Kan hriat reng tur pawimawh tak tak chu hengte hi a ni:

• TTP hi thisen natna awm lo mahse na tak a ni a, taksa thisen kalna kawng te tak teah thisen zam (blood clots) a lo awm thin.
• Sudden confusion, lu na nasa tak, vunah purple spot awm, paleness ang chi symptoms i neih chuan TTP a ni thei. Chuvangin hun khawhral suh la, doctor pan nghal mai rawh.
• Hei hian amah chauhin a tidam dawn lo. Emergency medical treatment hi a ngai tak zet a ni.
• TTP hi hriat hmasak a, uluk taka enkawl a nih chuan tihdam theih a ni. Tunlaia enkawlna changkang tak tak awm tawhte nen chuan nunna chhanhim theihna chance a sang hle.
• Enkawl zawhah pawh Doctor thupek zawm la, test neih ngei ngei tur a ni. Hei hian natna a lo awm leh tawh loh nan a pui dawn a ni.

Nangmah emaw, i hriat miin emaw hetiang thil hi i rinhlelh chuan hlauthawng suh. Mahse, thil ti vat rawh. Damdawi lam thurawn lak hi a tha ber a ni. Hrisel takin awm rawh!

` Thrombotic Thrombocytopenic Purpura, TTP, thisen natna, thisen zam, platelet, symptoms, enkawl dan