Nangmah emaw, i hnaih ber emaw chu hnute cancer vei nia hriat a nih chuan, enkawlna kawng hrang hrang sawiho hunah rilru hah leh buai taka inhriat hi thil pangngai a ni. Damdawi thar hming hriat reng chu doctor-te’n an sawi lai hian a harsa thei hle. Vawiin hian chutiang damdawi pakhat, abemaciclib chungchang kan sawi dawn a ni. He damdawi hi eng nge a nih, a hnathawh dan leh ei huna fimkhur tur thilte chu awlsam tak leh chiang takin sawi ila.
Verzenio hi eng damdawi nge a nih a, engtin nge a hnathawh?
A awlsam zawngin sawi ila, Verzenio hi cancer cells te tihpunna titawptu damdawi chi khat a ni. Damdawi lam hawi chuan damdawi chi khat ``kinase inhibitors'' an tih zingah a tel a ni.
Tunah chuan kan taksa cell chhungah hian thuchah thawntu te te an awm tih han ngaihtuah teh. Hetiang thuchah inthlengna hian cell pakhat chu a inthen darh tur nge a lo thang lian tur tih a hril a ni. Heng messenger te hi enzyme kan ti a. Cancer-ah chuan heng palai thenkhat hi an thawkrim lutuk a, cancer cell-te hnenah thu dik lo an thawn fo thin a, "inthen thuai, thang thuai" turin an ti thin.
Verzenio hian special messenger pahnih `cyclin-dependent kinases 4 leh 6`, a tawi zawngin CDK4 leh CDK6 tih te chu a target a ni. Heng pahnih hi cancer cell te tihpun leh inthen darh tura puitu ber an ni. Verzenio hian hetiang chiah hian a ti a, heng messenger pahnih thiltih hi "block" a ni. Chu thuchah chu cancer cell-a kal chu a titawp a ni. Tichuan cancer cell te hian an thanlenna leh an inthen darh theihna tur signal an hloh ta a ni. Hei hian cancer cell te chu a tipung tawh lo emaw, tumor lian tham tak a ti tlem emaw a ni.
Verzenio hi eng hnute cancer atan nge pek a nih?
Verzenio hi hnute cancer zawng zawng enkawlna a ni lo. Cancer chi hrang hrang nei tan bik hman a ni.
Anni chu:
- Hormone Receptor (HR)-positive: Chumi awmzia chu heng cancer cell te hian hormone, estrogen ang chi te hi an lo thang lian thin tihna a ni. Chumi awmzia chu hormone hi heng cancer te "chaw" a ni tihna a ni.
- HER2-negative: Tin, he cancer chi hian a chung lamah protein `HER2` tih a siam lo.
Verzenio hi heng mizia pahnih nei, early-stage breast cancer nei , enkawl hnua cancer lo kir leh theihna chance sang tak nei te tan pek a ni tlangpui. "Early-stage" tih awmzia chu cancer hi hnute piah lamah emaw, a bul hnaia lymph node emaw atanga darh lo tihna a ni.
A pawimawh ber chu Verzenio hi stand-alone drug a ni lo. Primary treatment surgery leh chemotherapy tih zawh hnuah hormone therapy nen pek dun a ni.
He damdawi hi engtin nge ka hman ang?
Verzenio hi pill i ei thin a ni. A hman hunah heng thilte hi fimkhur hle ang che.
- Dosage: A tlangpuiin ni khatah vawi hnih ei tur a ni.
- Nitin hun: Nitin i damdawi ei hun khata ei tum la, zing leh tlaiah a tha ber. Hei hian i taksaa damdawi awm zat inang reng turin a pui ang.
- Chaw ei ruala ei: He pill hi ei tur nen emaw ei loh pawhin ei theih a ni. Chumi chungchangah chuan buaina a awm lo.
- Em dan: Hei hi a pawimawh hle mai! Tablet chu a pumin a ei vek tur a ni . Tablet chu chil chhe ngai suh, chew ngai suh, ti chhe ngai suh. Tablet chhe emaw, chip emaw i neih chuan hmang lo la, doctor hnenah hrilh rawh.
- I luak chhuah chuan: Damdawi i ei zawh veleh i luak chhuak nghal a nih chuan, chu dose chu skip rawh . Pill dang ei suh. I dose lo awm tur chu a hun ruatah ei rawh.
Verzenio enkawlna hi hnute cancer hmasa ber tan kum 2 thleng pek thin a ni. Hei hian cancer a lo let leh chuan, side effect na tak i neih chuan, kum 2 chhung a tawp chuan enkawlna tihtawp a ni tihna a ni. Side effect engemaw zat i neih chuan i doctor chuan i dose a tihhniam thei a, damdawi ei chu rei vak lo a chawlhsan thei a, chutah chuan a tan leh thei bawk.
Verzenio hi engtiang chiahin nge a thawh hlawk?
Verzenio hlawhtlinna hi clinical trial lian tak tak hmangin an finfiah tawh a ni. Chung zinga pawimawh ber chu clinical trial `monarchE` tih hi a ni.
He zirchiannaah hian a chunga kan sawi tak hnute cancer chi hrang hrang vei mi 5,637 an hmang a ni. Pawl hnih ah an inthen a.
1. Group pakhat chu Verzenio hmanga hormone therapy pek an ni.
2. Group dang chu hormone treatment chauh pek an ni .
Tichuan heng mite hi kum li chhung zet an zui ta a ni. Cancer lo kir leh lo, cancer thar nei lo, thi lo mi engzat nge dam chhuak tih an en a. Hetiang tehfung hi invasive disease-free survival (IDFS) an ti a.
Kum 4 hnua result chu hetiang hi a ni:
- Verzenio hmanga hormone therapy dawngtu IDFS chu 85.5% a ni.
- Hormone therapy chauh dawngtu IDFS chu 78.6% a ni .
Hei hian Verzenio dah belh hian cancer lo lang leh theihna chu 6.9% velin nasa takin a tihziaawm tih a tilang chiang hle.Hei hi cancer enkawlna hmasa lama hmasawnna lian tak a ni.
Enkawl lai hian engtin nge enkawl i nih ang?
Verzenio hian i ei tan ni atang khan i taksaah hna a thawk tan thin. I doctor chuan i enkawlna kal zel dan enfiah turin thil chi hrang hrang a ti ang.
- Scans: A tlangpuiin, enkawl tan atanga kar 6 vel hnuah scan i nei ang a, cancer hian enkawlna a chhan dan tur i hmu ang. Mahse, he hun hi i dinhmun a zirin i doctor-in a siamrem thei a ni.
- Thisen Test: Hei hi a pawimawh hle. Verzenio hian a chang chuan taksaa thisen var (white blood cells) a ti tlem thei a ni. Hetiang dinhmun hi ``neutropenia'' an ti a, thisen var hi kan taksaa sipai ang mai an ni a, natna lakah min venghim a ni. An tlem chuan natna khirh tak tak a awm thei. Chuvangin, i doctor chuan thisen test a nei fo ang a, thisen var, neutrophil leh platelet level a enfiah ang. Hei hian damdawi ei chhunzawm a him tih a tichiang ang.
Side effects te hi engtin nge kan enkawl ang?
Cancer enkawlna hian side effect a neih hi thil pangngai a ni. A pawimawh ber chu hlauthawng lo tur leh a side effect awm apiang chu a rang thei ang bera doctor hnenah report tur a ni . An serious em tih an hre thei a, a tul angin thurawn an pe thei che a ni.
Hetah hian side effects awm tam ber leh a hmachhawn dan tur tarlan a ni.
| Side effect awm fo thin | Engtin nge kan enkawl ang |
|---|---|
| Kawthalo | Hei hi a hluar hle. I doctor zawt la, ril\amna damdawi (e.g. Loperamide) chu i kutah dah rawh. Chaw rimtui leh hriak nei ei loh tur. Tui leh tui tam tak in thin ang che. Diarrhea na tak i neih chuan doctor hnenah hrilh nghal rawh. |
| Nausea leh Luak chhuak | Vawi khata chaw lian tak ei ai chuan ni khatah vawi eng emaw zat chaw te te ei thin ang che. Ginger tea leh crackers ang chi thilte hian a pui thei a ni. A tul chuan i doctor chuan luak tur damdawi a pe ang che. |
| Chau | A theih ang angin chawlh hahdam rawh. Exercise light (e.g. kea kal) hian a chang chuan chakna a pe thei che a ni. Chaw tha tak tak ei rawh. |
| Ei duhna hloh | Ei a harsa a nih pawhin chakna i neih theih nan soup, thei tui, leh nutritional drinks te ang chi thil te enchhin la. |
Chu bakah, i doctor chuan side effect na tak tak, lung lama harsatna (khuh, thawk harsa) emaw thisen zam (swelling, ke na) emaw te pawh a zirtir bawk ang che . Chung zinga pakhat tal i tawn chuan damdawi lam thurawn lak nghal a pawimawh hle.
Verzenio ka ei lai hian eng nge ka pumpelh tur?
Verzenio ei hian ei tur thenkhat leh damdawi dang nena inzawmna a awm thei. Chungte chuan damdawi hnathawh dan a tidanglam thei a, a side effect pawh a tipung thei bawk.
| Eng nge pumpelh tur | Chhan |
|---|---|
| Grapefruit a ni | Jumbo shrimp ei leh jumbo shrimp tui in loh tur. Jumbo shrimp-a thil awmte hian taksain Verzenio a tihchhiat (metabolizing) loh nan a veng thei a ni. Hei hian taksaah damdawi hi a tul lovah a tam thei a, side effects a thlen theihna a tipung thei a ni. |
| A damdawi chu Ketoconazole a ni | Hei hi fungal infection damdawi a ni. Hei hian jumbo ball ang chiah a thlen bawk. Taksaah Verzenio level hlauhawm takin a tisang thei a ni. |
Chuvangin, Verzenio i tan hmain i doctor hnenah tuna i damdawi ei zawng zawng (vitamin, herbal remedies, leh supplement te pawh tel) te hrilh hmasa phawt ang che. Tin, damdawi dang, thin natna ang chi i neih chuan doctor hnenah hrilh bawk ang che. Chumi hnuah chuan i doctor chuan i tan a him ber tur a ruat thei ang.
Take-Home Thuchah a ni
- Verzenio hi hnute cancer chi khat , HR-positive, HER2-negative tia koh, hormone therapy nena hman dun a ni.
- Hei hian cancer cell te lo thanglian leh inthen darhtu signal te chu a block a, cancer chu a control ta a ni.
- Pill chu chil emaw, chew emaw ngai suh . A pumin ei rawh.
- Enkawl lai hian side effects, diarrhea, nausea, leh hahna te a awm thei a, chuvangin i harsatna awm apiang chu doctor hnenah hriattir nghal rawh.
- Enkawl lai hian grapefruit ei vek loh tur .
- Damdawi dang i ei zawng zawng leh i damdawi lam harsatna dang i neih apiang i doctor hriattir a pawimawh hle.
- Hriselna a awm theih nan doctor-in thisen test a tihte chu a hun takah tih ngei ngei tur a ni .
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