I hriat chian em em leh a hmaa hrisel tak mi pakhat chu rang takin thil mak deuhin a che tan ang tih han ngaihtuah teh. An hriatrengna an hloh a, kal an harsat , an thusawi laiin an thusawi an sawisel nasa hle. Thla engemaw zat chhunga heng thilte hi ngaihtuah phak loh khawpa thleng a nih chuan thluak natna hmuh tur awm lo tak, mahse na tak tak vang pawh a ni thei. Vawiin hian chutiang natna pakhat, Creutzfeldt-Jakob Disease emaw, kan tih vek CJD emaw chungchang kan sawi dawn a ni. Hei hi thupui hlauhawm deuh ni mahse, a chungchang hriat chian a pawimawh hle.
CJD leh "mad cow disease" hi thil inang an ni em?
Mi tam tak chuan CJD hi "Mad Cow Disease" tiin an buaipui thin. Amaherawhchu, an pahnih hi a inang lo.
A awlsam zawngin sawi ila, Bovine Spongiform Encephalopathy (BSE) hi thluak natna a ni a, bawngte chauh a vei a ni. A lo thlen chuan bawngte nervous system a chhiat avangin an che thei lo va, mak tak maiin an awm a ni.
Mahse, CJD chi khat a awm a, chu chu mihringin mad cow disease vei bawng sa ei avanga kai theih a ni . Variant CJD (vCJD) tih a ni. Mahse hei hi a tlem hle a, a tlem hle . Khawvel pumah hri kai hmuhchhuah hi an tlem hle. Chuvangin hetiang hian kan sawi fo thin CJD natna hi a lo awm lo.
Engvangin nge he CJD natna hi a lo awm?
CJD thlentu ber chu kan taksaa protein pakhat a inthlak danglam dan pangngai lo a ni. He protein pangngai lo, mutated hi prion an ti a.
Kan thluaka protein hrisel tak chu lehkha mawi taka hrual ang maiin han ngaihtuah teh. He mutant protein prion an tih hi a rawn kal a, he lehkhabu tha tak hi a fold dik lo hle. Tichuan, chu misfolded piece chuan paper tha dangte chu dik lo takin a fold leh ta a ni. Tin, chutiang chuan thluak cell te chu a chhe zauh zauh a ni. Microscope hmanga i en chuan he thluak tissue chhia hi sponge ang mai a ni.
Prion siam dan azirin CJD hi chi thum a awm a.
| CJD chi hrang hrang | Chhanna leh hrilhfiahna |
|---|---|
| CJD a awm fo thin | Hei hi a tam ber chi a ni. A chhan hriat lohvin protein hrisel tak chu a inthlak nghal a, prion a lo ni ta a ni. CJD vei tam zawk chuan hetiang chi hi an nei thin. |
| Chhungkaw CJD | Hei hi genetic defect vang a ni. Nu leh pa zinga pakhatin he natna thlentu gene mutated a neih chuan naupangte hnenah a kai thei a ni. Mahse hei pawh hi a tlem hle. CJD vei zinga 10%-15% vel chauh hi he category-ah hian an tel a ni. |
| CJD a lei a ni | Hei hi a rarest type a ni. Mi pakhat chuan damdawi hmanraw bawlhhlawh (e.g. operation laiin), taksa peng thlak emaw, growth hormone injection bawlhhlawh emaw hmangin CJD a vei thei a ni. Tunlai damdawi inah himna dan khauh tak siam a nih avangin he hlauhawmna hi nasa takin a tlahniam ta a ni. |
CJD natna lan chhuah dante chu engte nge ni?
CJD chungchanga hlauhawm ber chu a natna lan chhuah dan hi a intan thuai a, a zual nghal vat thin. Vawi tam tak chu heng symptoms te hi dementia symptoms nen a inang tlangpui.
Hmuh theih thil langsar ber berte chu:
- Hriatrengna hloh leh buaina
- Kal harsa leh balance hloh
- Muscle twitches nghal (jerky movements) .
- Mihring nihna a inthlak (thinrim nghal, a buai) .
- Ngaihtuahna leh thutlukna siam harsa
- Mit hmuhna lama harsatna a awm
- Mut theih lohna leh lungngaihna
CJD leh Alzheimer natna inthlauhna
Heng symptoms te hian Alzheimer natna a hriatchhuah tir thei che a ni. Mahse a danglamna ber chu speed a ni . Alzheimer natnaah chuan hriatrengna hloh ang chi hi kum tam tak chhung chu zawi zawiin a thleng thin. Mahse CJD-ah chuan damlo dinhmun chu a zual nghal vat a, heng natna lan chhuah tirh atanga kar emaw thla engemaw zat chhungin a zual zel a ni.
He natna hi engtin nge dik taka kan hriat theih ang?
Vanduaithlak takin CJD finfiah thei tur test pakhat mah a awm lo. Doctor-te chuan damlo symptoms leh an lo than chak dan azirin an diagnosis an siam thin. Amaherawhchu, natna rinhlelh a nih chuan test eng emaw zat tih a ni a, finfiah a ni.
- MRI (Magnetic Resonance Imaging) scan: Hei hian thluak chipchiar taka thlalak a la thei. CJD-a thluaka inthlak danglamna bik a zawng thei a ni.
- EEG (Electroencephalogram) test: He test hian lu vunah sensor te te inbun hmangin thluaka electrical activity a teh thin. He test hian CJD vei te mizia ang chi pattern a lantir thei a ni.
- Lumbar Puncture: Needle na tak tak hmangin spinal cord chhung atangin cerebrospinal fluid tlemte lak a ni a, CJD-a protein bik hmuh tur awm leh awm loh test a ni.
He natna hi 100% chiang taka finfiah theihna awmchhun chu thluak tissue sample (biopsy) lak a ni. Mahse, chutiang sample chu mi nung thluak atanga lak chu damlo leh doctor tan pawh a hlauhawm hle a, chuvangin a tlangpuiin tih loh a ni. Vawi tam tak chu damlo thih hnuah natna hi chiang taka finfiah a ni.
Hun kal zelah natna a zual zel dan
CJD hian hun kal zelah stage engemaw zat a paltlang a, damlo leh an chhungte tan pawh thil hrehawm tak a ni.
| Natna Stage a ni | Feature beisei awm tak tak |
|---|---|
| A tir lamah | Thusawi laiin thu sawi uar lutuk, luak chhuak, taksa peng hrang hranga rilru hahna, thil awm lo hmuh (hallucinations), chhan awm lova thinrim, khawtlang atanga inhnukdawk, leh mut theih lohna. |
| A hnu lama stage | Bowel leh bladder control theih lohna, ei leh in leh thusawi harsatna nasa tak, hriatrengna hloh nasa tak, paranoia, khumah chawlh hahdam, coma. |
CJD vei zinga 70% vel chu an hmuhchhuah hnuah an thi thin.Kum khat chhungin i thi ang. Chu thu i hriat chuan i hlauthawng hle mai thei a, i lungngai hle mai thei a, i thinrim hle bawk. Hei hi thil pangngai tak a ni. Hetiang hunah hian nangmah chauhin hrehawm tuar suh. Doctor nen inbiakna neih a pawimawh hle a, a tul angin psychological support i lak a pawimawh hle.
CJD enkawlna tur a awm em?
Vanduaithlak takin CJD hi damdawi leh enkawlna a la awm lo. Zirchiangtute chuan damdawi eng emaw zat an lo enchhin tawh a, mahse an hlawhtling lo.
Tunah hian tih theih awmchhun chu a symptoms control hi a ni . Chumi awmzia chu:
- Natna tur painkiller pek.
- Muscle stiffness leh spasms te damdawi pek.
- Damlo chu a nuam thei ang bera awm theihna tura hmanraw mamawh siamsak.
Natna a nasat tawh chuan damlo chuan full-time care a mamawh dawn a ni. Nakin lawkah he natna enkawlna tur zawng turin zirchianna kalpui mek a ni. I duh chuan i doctor hnenah damdawi thar test mek clinical trial chungchang i zawt thei ang.
Take-Home Thuchah a ni
- Creutzfeldt-Jakob Disease (CJD) hi thluak natna hlauhawm tak leh darh chak tak, thihna thlen thei a ni.
- Hei hi thluak cell te chu mutated protein prion an tih in a tihchhiat vang a ni.
- CJD leh "Mad Cow Disease" hi natna chi hrang hrang pahnih a ni. Mahse, hri kai bawnghnute ei atanga kai theih CJD (vCJD) chi khat a awm lo hle.
- He natna hi damdawi a la awm lo. A tih theih awmchhun chu a natna lan chhuah dan control a, damlo hahdam tir hi a ni.
- I hriat mi pakhatin hun rei lote chhûnga hriatrengna, nungchang, leh taksa hnathawhnaah danglamna nasa tak a neih chuan doctor pan nghâl rawh . Ruahmanna leh enkawlna mumal tak neih theih nan a rang thei ang bera hriat chian a pawimawh hle.
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