Herceptin (Trastuzumab) hmanga HER2-positive hnute cancer enkawlna chungchang zir rawh

Nangmah emaw, i chhungte zinga tu emaw chu hnute cancer vei nia hriat a nih chuan i hlauhthawnna leh lungkhamna chu thuin sawi chhuah a harsa thin. Hun emotional tak a ni. Mahse, a pawimawh ber chu tuna kan neih medical science hmasawn tak hmang hian beiseina kan nei thei a ni. I doctor chuan i tana enkawlna tha ber thlang turin thil tam tak, i cancer chi hrang hrang, i kum, leh natna dang i neih leh neih loh te a ngaihtuah ang. Hnute cancer hi surgery, chemotherapy leh radiation hmanga enkawl a ni tlangpui.

Vawiin hian enkawlna danglam deuh, chiang zawk kan sawi dawn a ni. Hei hi " targeted therapy" an ti a. Herceptin hi chutiang damdawi pakhat chu a ni. A damdawi lam hming chu Trastuzumab a ni . Kanjinti, Herzuma, Ogivri tih ang chi hming dang an vuah pawh i hre tawh mai thei. Hengte hi ``biosimilars'' an ti a, a awlsam zawngin, hengte hi Herceptin damdawi inang biological copy an ni.

Targeted Therapy leh Herceptin hi eng nge ni?

Ngaihtuah teh, chemotherapy damdawi pangngai hian cancer cell chauh ni lovin, cell hrisel, inthen darh chak tak takte pawh a nghawng a ni. Mahse targeted therapies chu chutiang chu a ni lo. Target bik target-in hna an thawk thin. Heng damdawi te hian cancer cell te tihpun leh darh zel tura puitu protein bikte chu an control a ni. Chuvang chuan cancer zawng zawng tan an thawk vek lo. Damdawi hian a target protein chu chu cancer cell-ah chuan a tam hle tur a ni.

Damdawi Herceptin hian protein HER2 tih chu a target a ni. (Hei hming kimchang chu `mihring epidermal growth factor receptor 2` tih a ni). Chuvangin, he HER2 protein hi cancer cell-ah a tam lutuk a nih chuan chu hnute cancer chi chu `HER2-positive` hnute cancer kan ti a ni. Herceptin enkawlna hi hnute cancer chi `HER2-positive` te chauh pek thin a ni.

He Herceptin damdawi hian taksa chhungah engtin nge hna a thawh?

Hei hi hrethiam tur chuan HER2 hi eng nge a nih kan en hmasa phawt ang u. HER2 hi cell chunglama receptor a ni a. Cell chunglama antenna te tak te angin han ngaihtuah teh. Heng antenna te hi cell pawn lam atanga signal dawngtu leh a chunga thawktu an ni. Cell hrisel takah chuan HER2 receptor te hi cell thanna control turin an awm a.

Mahse `HER2-positive` cancer cell-ah chuan thil danglam tak a thleng thin. Heng cell te hian HER2 protein siamtu genes extra copy an nei a. Chuvangin, heng cell te hian HER2 protein hi an siam tam lutuk a ni. Cell chhungah hian antenna tam lutuk ang mai a ni. Tichuan, cancer cell te hian signal tam lutuk an hmu a, "a thang lian, an inthen" a, an lo thang lian a, thunun theih lohvin an thang lian a, rang takin.

Herceptin enkawlna hi ka cancer tan a tha em?

Hei hi zawhna pawimawh tak a ni. I hnute cancer chu `HER2-negative` a nih chuan, chu chu cancer cell-te hian HER2 protein extra an nei lo tihna a nih chuan Herceptin enkawlna hian hna a thawk dawn lo. Hnute cancer tam zawk hi `HER2-negative` an ni. 20% vel chu HER2-positive an ni. I doctor chuan test hmangin eng cancer chi nge i neih tih chiang takin a hrilh ang che.

Herceptin enkawlna hi hnute cancer tan tirh lamah hman a ni a, chubakah cancer a darh tawhna (metastatic) nasat lai pawhin hman a ni bawk.

• Cancer hmasa ber tan: I cancer chu HER2-positive leh early-stage a nih chuan Herceptin hi operation hnua cancer a lo let leh loh nan pek thin a ni. Hei hi chemotherapy emaw endocrine therapy emaw hmanga pek a ni fo. He enkawlna hi cancer a lian emaw, lymph node-ah a darh tawh emaw a nih chuan pek a rinawm zawk.

• Cancer zual tan: Cancer hi taksa hmun hla tak takah a darh tawh (metastatic) a nih chuan Herceptin hian a thanna a titawp emaw, a ti hniam emaw thei a ni. A chang chuan tumor lian lutuk, operation hmanga lakchhuah theih loh chuan Herceptin leh enkawlna dang hmangin operation hmain a ti tlem thei a ni.

Enkawlna i dawn hunah eng nge i beisei ang?

Herceptin hi infusion (intravenous - IV) angin vein pakhatah pek thin a ni. Saline solution angin pek a ni. Hei hi damdawi chu thisenah direct-a inject a ngaih avangin tih a ni. Minute 30 leh 90 inkar vel a awh thei.

Hei hi a chi khat pawh a awm a, chu chu injection anga pek a ni. `Herceptin Hylecta` tih a ni. Zirna hrang hrangah chuan hei hi IV ang bawkin a hlawk hle tih hmuhchhuah a ni. I doctor chuan eng method nge i tan a tha ber tih a rel ang.

Herceptin hi eng chen nge i ei a ngai a, eng chen nge i ei a ngai tih chu i cancer stage leh damdawi dang i ei danah a innghat a ni. Cancer hi a zual (metastatic) a nih chuan damdawi hian hna a thawh chhung leh side effect na tak a awm loh chhung chuan enkawl chhunzawm zel a ngai mai thei.

Pawimawh tak: Herceptin enkawl hma leh enkawl lai hian i doctor chuan i thinlung hnathawh dan a enfiah fo ang , he damdawi hian a chang chuan thinlung a nghawng thei a ni.

Hei bakah hian side effect dang pawh a awm thei bawk. Chuvangin, enkawl tan hmain eng symptom nge fimkhur tur tih leh engtikah nge doctor hriattir nghal tur tih hi uluk takin i zir hmasa tur a ni. Herceptin enkawlna hi hmeichhe naupai emaw, naupai tum emaw tan pek a ni lo.

He enkawlna hi engtiang chiahin nge a hlawhtlin?

Herceptin hi kum 1998-a pawm a nih hnuah HER2-positive breast cancer enkawlna kawngah nasa takin a tidanglam a ni.

• Cancer natna zual tan: Herceptin hi amah chauh emaw, chemotherapy hmanga pek a nih chuan cancer thanna a tikhawlo thei a, damlote chu dam rei zawkah a pui thei bawk. Mahse, a chang chuan damdawi hian hun engemaw chen hna a thawk thei a, chutah chuan hna a thawk tawh lo.

• Cancer hmasa ber tan: Hetah hian hlawhtlinna lian ber hmuh tur a awm. Zirna hrang hrangah chuan operation hnua chemotherapy-a Herceptin dah hian cancer lo kir leh theihna chu 50% velin a tihziaawm thei tih a tarlang . Hei hian Herceptin ei thin hmeichhia tam zawk chu cancer nei lovin an dam rei zawk tihna a ni.

A tir lamah chuan kum khat emaw kum hnih emaw chhung enkawl ni mahse, tun hnaia zirchianna atanga a lan dan chuan mi tam tak tan chuan Herceptin hi thla 6 chauh ei hi a tawk a ni. Hei hi side effects ngaihtuah thin tan chuan chanchin lawmawm tak a ni.