Kia ako tātou mō te ratonga horoi tino pai i roto i tō tinana! (Autophagy)?

I tēnei rā ka kōrero tātou mō tētahi tukanga whakamiharo, tino hira hoki e puta ana i roto i tō tātou tinana. He rite ki tētahi ratonga horoi tino pai e mahi tonu ana i roto i tō tātou tinana. Kāore pea koe i rongo i mua mō tēnei mea, engari he mea nui tēnei e pā ana ki tō tātou hauora, inā koa i a tātou e pakeke haere ana. Ka karangatia e tātou ko te "Auto PH agy". He ahua rerekē te kupu, kāore? Engari me whakamārama noa iho.

He aha te "Autophagy"? He māmā noa iho...

Whakaarohia i a koe e whakamahi ana i tō whare, ka tawhito haere ia taonga o roto, ka pakaru ētahi, ka koretake ētahi. Me aha tātou i reira? Ka whakakorea e tātou ngā mea koretake, i ētahi wā ka tangohia e tātou ngā wāhanga pai o ngā mea tawhito ka hangaia he mea hou, ka horoia rānei e tātou te whare ka tiakina kia pai, tika? Ko te mea anō tēnei e tupu ana i roto i ngā pūtau, arā, ngā waeine iti rawa o roto i ō tātou tinana.

Ki te kī māmā noa, ko te `(Autophagy)` he tukanga e tangohia ai e ngā pūtau o tō tātou tinana ngā wāhanga tawhito, pakaru, koretake rānei i roto i ō rātou tinana, ka hangarua anō, ko te tikanga ka taea te whakamahi anō. He rite ki te horoi a ō tātou pūtau i a rātou anō. Ka taea hoki te kī he pūnaha "mana kounga" tēnei i roto i ō tātou pūtau. Nā te mea, ki te kohikohia ngā para koretake i roto i te pūtau, kāore e taea e taua pūtau te mahi tika. Ka tangohia e te `(Autophagy)` taua para, ā, ki te tika, ka hangaia he mea whai hua mai i roto, ka āwhina i te pūtau kia mahi pai.

He aha te hiranga o tēnei "Autophagy"?

Inaianei pea kei te whakaaro koe, "Āe, he rawe te horoi a ngā pūtau i a rātou anō, engari he aha te take nui?" He mea nui te autophagy kia ora ai ā tātou pūtau, kia mahi tika ai hoki. Me titiro tātou ki ētahi o ngā kōrero matua:

• Ka whakatikahia ngā wāhanga pūtau kua pakaru, ā, ka mahi anō: Pērā i te hanga o tētahi tēpu hou mā te tango i ngā wahi rakau pai mai i tētahi tūru pakaru, ka hanga hoki ngā pūtau i ngā wāhanga hou, whai hua mai i ō rātou wāhanga tawhito.
• Ka tango i ngā wāhanga koretake, e pau ana te wāhi: Ina kī tonu te pūtau i ngā mea kāore e hiahiatia, ka kore e taea e ia te mahi tika. Ka tangohia e te autophagy tēnei taumahatanga kāore e hiahiatia, ka hangaia he taiao mō te pūtau kia mahi noa.
• Ka whakangaro i ngā mea pēnei i ngā iroriki, ngā huakita, me ngā huaketo e kino ana i ngā pūtau: Ka taea e tēnei tukanga te tautuhi me te whakangaro i ētahi mea kino e uru ana ki roto i ō tātou pūtau. Arā, ka āwhina anō hoki tēnei i tō tātou pūnaha ārai mate .

Hei tāpiritanga ki tēnei, he hononga nui tō te "Autophagy" ki te āhua o tō tātou koroheketanga me te roa o te wā e ora hauora ai tātou.I te nuinga o te wā, i a tātou e pakeke haere ana, ka pōturi haere tēnei tukanga o te "Autophagy". Ko te mea ka tupu, ka tīmata te kohikohi o ngā para ki roto i ngā pūtau, ā, ka heke te mahi a ngā pūtau. Nō reira, he mea nui te pupuri i tēnei tukanga kia ora pai ai, kia roa ai hoki te ora.

He pēhea te puta o tēnei tukanga `(Autophagy)`?

Āe, me titiro tātou ki te mahi a tēnei tukanga horoi whakamiharo i roto i te pūtau. Tērā pea he ahua pūtaiao tēnei, engari me whakamārama noa iho.

Ka āwhinahia tēnei tukanga `(Autophagy)` e tētahi momo pūmua motuhake. Ka kiia ēnei ko `(Autophagy-related proteins)` ko `(ATGs)` rānei. Ka kohia e ēnei `(ATGs)` ngā para i roto i te pūtau, arā, ngā wāhanga tawhito me ngā wāhanga pakaru, ā, ka hangaia he hanganga rite ki te kiriuhi huri noa i a rātou. Ka kiia tēnei ko `(Autophagosome)`. Whakaarohia he pēke para.

Kātahi ka haere tēnei "Autophagosome", arā, taua putea para, ki tētahi atu wāhanga motuhake o te pūtau. Ko tōna ingoa ko "Lysosome". He rite tēnei "Lysosome" ki tētahi "pūnaha whakakore para" i roto i te pūtau. Ko tāna mahi he nakunaku i ngā mea i roto i taua putea para, arā, he wawahi i a rātou kia iti ake.

Ko te kupu "Autophagy" i ahu mai i ngā kupu Kariki e rua. Ko te tikanga o "Autos" ko "whaiaro" me "Phagomai" ko "kai." Ko tōna tikanga ko "kai i a ia anō." He rite ki te pūtau e "kai" ana i ōna ake wāhanga kāore e hiahiatia, tika?

Nō reira, i muri i te nakunaku o te para e te `(Lysosome)`, ka tukuna ngā wāhanga pai (pēnei i ngā rauemi mata) ka taea te whakamahi anō. Kātahi ka whakamahia e te pūtau aua rauemi mata hei hanga i ngā wāhanga hou e hiahiatia ana e ia. He mea whakamiharo tēnā?

Āhea te wā ka whakaohokia ai tēnei tukanga "Autophagy" i roto i tō tātou tinana?

Ka tere ake tēnei tukanga o te "Autophagy" ina kore ngā pūtau e whiwhi i ngā matūkai, i te hāora rānei e hiahiatia ana e rātou, ina pakaru rānei ngā pūtau.

Whakaarohia pēnei: ​​Ko te '(Autophagy)' he tukanga hangarua e āwhina ana i te pūtau ki te whakamahi pai i ana rauemi. Nō reira, ina iti ngā rauemi e wātea ana ki te pūtau mai i waho (pēnei i te kai, te hāora), me whakamahi pai te pūtau i ana rauemi. Ko te wā tēnā ka kaha ake te mahi a tēnei tukanga '(Autophagy)'.

He rite ki te pūtau e "kai" ana i a ia anō, e ngana ana kia ora. Engari ko te mea pai mō tēnei ko te tīmatanga o te mahi a ngā pūtau kia pai ake ai te whai hua nā tēnei ngana ki te ora.

Ka taea e tātou te whakaoho i tēnei tukanga o te "Autophagy"?

Inaianei pea kei te whakaaro koe, "Āe, ka taea e tātou te tīmata i tēnei i te ara e hiahia ana tātou? He rawe tēnā!" Āe, kei reira ētahi huarahi hei " whakaaweawe " i ō tātou pūtau, hei āwhina i a rātou ki te tīmata i tēnei tukanga "Autophagy". Ko ēnei ēnei:

• Te nohopuku: Ko te tikanga o tēnei ko te kore kai mō tētahi wā. Ko te tikanga o tēnei ka mutu te whiwhi matūkai mai i te ao o waho i te tinana, ā, ka akiakihia ngā pūtau ki te hangarua i ō rātou ake wāhanga hei whakaputa pūngao.
• Te whakawhāiti i ngā kaora: Ko te whakaiti i te maha o ngā kaora ka kainga e koe i ia rā, me te kore e mutu te kai, pērā i te nohopuku. Ka taea hoki e tēnei te whakaoho i te "Autophagy" nā te mea ka ngaro ngā matūkai i ngā pūtau.
• Te huri ki tētahi kai momona nui, iti-warowaihā: Koinei te mea e kīia ana e te tini ko te "kai Keto." Ko te mea ka tupu i roto i tēnei ko te hurihanga o te whakamahinga pūngao e te tinana. Engari ko ngā warowaihā (māngaro, huka), ka tīmata te tahu ngako hei pūngao. Ka taea hoki e tēnei hurihanga te tīmata i te tukanga "Autophagy."
• Korikori Tinana: I te wā e korikori tinana ana, inā koa kei raro i te taumahatanga o ō tātou uaua, ka piki ake te mahi a ngā pūmua "ATG" kua whakahuatia ake nei, ā, ka taea hoki te whakaoho i te "Autophagy". Ka rerekē pea tēnei i runga i te momo korikori tinana me tōna kaha.

Engari, he mea tino nui hei maumahara ki konei. Ahakoa he huarahi hei whakaoho i te `(Autophagy)`, kāore e pai mō te katoa. Hei tauira, ki te mea kei te hapu koe, kei te whāngai u, kei a koe rānei tētahi mate hauora pēnei i te `(Diabetes Mellitus)`, he mea morearea te nohopuku, te whakawhāiti i ngā kaora, te huri ohorere rānei ki te `(Keto diet)`. Waihoki, ehara i te mea pai te tīmata ohorere i ngā mahi whakakori tinana me te kore kōrero ki te tākuta.

Kia pēhea te roa me nohopuku koe hei tīmata i te `(Autophagy)`?

E ai ki ngā rangahau kararehe, ka taea te whakaoho i te autophagy mā te nohopuku mō ngā haora 24 ki te 48. Heoi, kāore anō kia nui ngā rangahau mō te roa o te wā e whai hua ai te autophagy i roto i te tangata.

Nō reira, ki te mea kei te whakaaro koe ki te whakarerekē i tō kai pērā i te nohopuku, me kōrero koe ki te tākuta. Ahakoa he pai te nohopuku mō ētahi tāngata, ka kino pea ki te hauora o ētahi atu. Nō reira kaua e whakamātau i ngā mea kāore e tika ana.

He aha te whanaungatanga i waenga i te `(Autophagy)` me te mate?

I ngā wā o mua, i whakaaro ngā kaipūtaiao he mahi noa te "Autophagy" mō te horoi i ngā pūtau, he momo "whakapaipai whare." Heoi, kua whakaatuhia e ngā rangahau i ngā tau 20 kua pahure ake nei he mahi nui pea tā te "Autophagy" ki te ārai me te urupare ki ngā mate .

Hei tauira, kua whakaatuhia e ngā rangahau ko ngā raruraru o te tukanga "Autophagy" ka hono pea ki ngā āhuatanga mate e whai ake nei:

• `(Te mate a Crohn)` (Te mate a Crohn)
• `(Te mate huka)` (Te mate huka)
• Mate ngakau
• `(Te mate a Huntington)` (Te mate a Huntington)
• mate whatukuhu
• Mate ate
• `(Te mate a Parkinson)` (Te mate a Parkinson)

Waihoki, kua kitea he hononga ngā raruraru o te tukanga `(Autophagy)` ki te mate pukupuku . Ina kohia te ``para`` ki roto i te pūtau, ka piki ake te tūponotanga o ngā hapa i roto i te rauemi ira, arā, `(DNA)`. Ka taea e ēnei huringa o te `(DNA)` te whakaputa `(ngā whakarerekētanga ira)`, ka arahi pea ki te hanganga o ngā pūtau mate pukupuku.

Heoi, he uaua ki te kī he pai, he kino rānei te `(Autophagy)` mō te ārai i te mate. Hei tauira, kua whakaatuhia e ētahi rangahau ka āwhina te `(Autophagy)` ki te ārai i te hanganga o ngā pukupuku i ngā wāhanga tōmua o te mate pukupuku. Heoi, kua whakaatuhia e ētahi atu rangahau ka taea e te `(Autophagy)` te whakapai ake i te mahi a ngā pūtau pukupuku, ā, ka āwhina anō hoki i te tipu o ngā pukupuku pukupuku.

Waihoki, ko te nuinga o ngā rangahau kua oti mō te hononga i waenga i te autophagy me te mate kāore anō kia mahia ki te tangata. He maha ngā wā kua mahia ki ngā kararehe pērā i te kiore. Nō reira, i te mea ka nui ake te ako a ngā kaipūtaiao mō tēnei tukanga, tera pea ka mārama ake tā tātou tirohanga ki te pānga ki ētahi mate me tō tātou hauora mō te wā roa.

Hei whakamutunga, ngā mea hei maumahara (Karere hei tango ki te kāinga)

I ngā wā tata nei, i te wā e nui ana te kōrero mō te `(Autophagy)`, kua kīia e ētahi he "auaha hauora" noa iho - he huarahi hei noho taitamariki me te whai pūtau hauora. Heoi, ehara i te mea ngāwari te `(Autophagy)`.

He pono he mea nui te autophagy mō ngā pūtau hauora. He pono anō hoki ko ngā raruraru o te tukanga autophagy e hono ana ki ētahi mate. Heoi, kāore i te rawaka ngā rangahau hei kī he pai te whakaoho i te autophagy mō te oranga hauora.

I runga i tō hauora, he mea morearea te nohopuku, te whakaiti i ngā kaora, te whakarerekē nui i tō kai, te tīmata ohorere rānei i tētahi kaupapa whakakori tinana kaha. Nō reira, he mea nui kia kōrero koe ki tō tākuta i mua i te whakarerekē i tētahi momo noho ka pā ki ngā tukanga taiao o tō tinana. Ehara i te mea pai te whakaaro noa ki tēnei hei 'auaha' ka mutu ohorere te kai, te whakaiti i ngā kaora, te tīmata rānei i tētahi kaupapa whakakori tinana kaha. Ko tō tākuta anake te mōhio he aha te mea pai mō tō tinana.

` Autophagy, horoi pūtau, nohopuku, hauora pūtau, koroheketanga, mahi tinana, oranga hauora