He aha te HNPCC (Hereditary Nonpolyposis Colorectal Cancer)? He hītori mate pukupuku tō tō whānau?

I ētahi wā ka kite tātou he maha ngā mema o te whānau e pāngia ana e te momo mate pukupuku kotahi. E kīia ana rānei he nui ake te tūponotanga o te pāngia o ngā mema o te whānau kotahi e te mate. Koinei te mea ka kōrerohia e tātou i tēnei rā. Ahakoa he kaupapa uaua tēnei, me ngana tātou ki te mārama ngāwari.

He aha te HNPCC me te Lynch Syndrome?

Ki te whakarapopoto, ko te HNPCC (Hereditary Nonpolyposis Colorectal Cancer) he momo mate pukupuku colorectal i puta mai i ngā whakarerekētanga ira. Nā te mea ko ētahi ira e riro mai ana i ō tātou mātua ka nui ake te tūponotanga ka pā mai he pūtau mate pukupuku ki a tātou.

Kua rongo pea koe i te mate Lynch, e kiia ana hoki ko te mate Lynch . He whanaunga te HNPCC me te mate Lynch, engari kāore i te tino ōrite. Ka kīia te HNPCC ko te mate pukupuku e pā ana ki te mate Lynch kua kitea i mua i te 50 tau te pakeke. Kāore pea i te mate pukupuku koroni anake tēnei, engari ko ngā mate pukupuku o te arai o te kōpū (endometrium), te whekau iti, te ureter, me te pelvis whatukuhu. I roto i te HNPCC, ko te mate pukupuku te mea tino kitea i te taha matau o te koroni.

He pēhea te noa o te HNPCC?

E 2% ki te 4% o ngā mate pukupuku koroni katoa te HNPCC. Ka pā mai pea i ngā tau katoa, engari he maha ngā wā ka puta ngā tohu, ā, ka kitea te mate i mua i te 50 tau.

He aha ngā tohu o te HNPCC?

I ngā wāhanga tōmua, kāore pea he tohu e puta mai i te HNPCC. Ko te tikanga ka taea e te mate pukupuku te tipu i roto i tō tinana me te kore koe e rongo i tetahi mea. Engari i te tipu haere o te mate pukupuku, ka pāngia pea koe e ngā tohu pēnei i:

• Te mamae o te puku, te pupuhi rānei.
• Kāore he reka o te kai.
• He toto kei roto i te tūtae. (He tohu tino nui tēnei, kaua e warewarehia!)
• Te ngenge tonu.
• Te whakahekenga taumaha me te kore he take mārama.

He aha ngā take o te HNPCC?

E ai ki tā mātou i kōrero ai i mua ake nei, ko te HNPCC te take o ngā whakarerekētanga ira i tukuna iho mai i ō tātou mātua. Ina tukuna iho ēnei hapa ira mai i tētahi whakatipuranga ki tētahi whakatipuranga, ka piki ake te mōrearea o te mate pukupuku i roto i taua whānau. Ka kiia tēnei he 'mate pukupuku whānau'.

Ko te mate pukupuku whānau matua e puta ai te HNPCC ko te mate Lynch . Ka puta mai i ngā whakarerekētanga ira i roto i ngā ira MLH1, MSH2, MSH6, PMS2, me te EPCAM . Ko te mahi a ēnei ira he whakatika i ngā hapa e puta ana i te wā o te tāruarua DNA i te wā e wehea ana ō tātou pūtau. Whakaarohia, ki te kore ēnei ira e mahi tika ana, kāore aua hapa e whakatikahia. Kātahi ka nui ake te tūponotanga o ngā pūtau noa kia huri hei pūtau matepukupuku.

He mate hopuhopu te HNPCC?

Kāo, ehara te HNPCC i te mate hopuhopu. Ko te tikanga tēnei kāore e horapa mai i tētahi tangata ki tētahi atu mā te pā atu, mā te tihe rānei. Heoi, ko te whakarerekētanga ira e puta ai te HNPCC ka tukuna iho i tētahi whakatipuranga ki tētahi whakatipuranga . Nō reira, he maha ngā mema o ngā whānau e pāngia ana e tēnei whakarerekētanga ira ka pāngia e te mate pukupuku koroni, e ētahi atu mate pukupuku rānei e pā ana ki te mate Lynch.

Ko te mea nui, ka taea te tuku iho i tēnei ira hapa me te mōrearea o te whakawhanake i te HNPCC mai i ngā mātua ki ngā tamariki.

Me pēhea te tautuhi a ngā tākuta i te mate pukupuku koroni?

I te nuinga o te wā ka tirotirohia e ngā tākuta te tinana hei tirotiro mēnā he matepukupuku koroni. Kātahi ka tūtohu rātou kia whakamahia he koroni , arā, te whakauru i tētahi ngongo iti, he rama kei roto i tō nono hei tirotiro i te roto o tō koroni.

Mena kei te pāngia tetahi o tō whānau e te HNPCC, me kōrero koe ki tō tākuta . He mea tino nui tēnei.

He aha ngā whakamātautau e mahia ana hei whakaū i te HNPCC?

Tērā pea ka tūtohu tō tākuta kia whakamātauria he whakamātautau ira hei whakatau mēnā kei a koe te whakarerekētanga ira e pā ana ki te mate Lynch. Ka pātai atu anō tō tākuta mō:

• Kua pāngia tetahi o tō whānau tata (whaea, pāpā, tuākana/teina) e te mate pukupuku koroni? Ina koa mēnā i kitea i mua i te 50 tau te pakeke.
• Ka whakarite hoki kāore koe e pāngia e tētahi atu mate pukupuku koroni ira tuku iho e kiia nei ko te Familial Adenomatous Polyposis (FAP) , e puta mai ana i tētahi whakarerekētanga ira rerekē i te HNPCC.

He mea tika te pokanga mō te HNPCC?

Ae, he maha ngā wā ka rongoatia te HNPCC mā te pokanga. Ka kiia tēnei pokanga he colectomy . Ko te tango i tētahi wāhanga, i te katoa rānei o te whekau nui. He maha ngā momo pokanga:

• Te tango i te wāhanga o te koroni me te mate pukupuku: I roto i tēnei, ko te wāhanga anake o te koroni me te mate pukupuku ka tangohia.
• Proctectomy: Ko te tango i te koroni me te rectum.
• Ko te tango katoa i te koroni: I roto i tēnei, ka tangohia te koroni katoa.

He aha atu ngā maimoatanga e wātea ana mō te HNPCC?

Mena kua horapa te mate pukupuku koroni (metastasized) ki ētahi atu wāhanga o te tinana, ka tūtohu pea tō tākuta i ngā maimoatanga pēnei i:

• Te rongoā matū: Kei roto i tēnei ko te hoatu rongoā hei whakangaro i ngā pūtau matepukupuku.
• Te rongoā ārai mate: Kei roto i tēnei ko te whakaoho i te pūnaha ārai mate o tō tātou tinana kia whawhai ki ngā pūtau matepukupuku.

He pai ake ki ngā tākuta te rongoā ārai mate nā te mea he nui ake te whai huatanga , ā, he iti ake ngā pānga taha.

Ka taea te ārai i te HNPCC?

Ko ēnei mate pukupuku whānau ka puta mai i ngā whakarerekētanga ira tuku iho. Nō reira, kāore he huarahi hei ārai i ēnei whakarerekētanga ira kei puta . Heoi, ki te mea he mate Lynch, he HNPCC rānei tō tētahi o tō whānau, he mea tino nui kia kōrero koe ki tō tākuta mō te mea me whai whakamātautau ira anō hoki koe.

Mā te tirotiro auau, me te pokanga ārai mēnā e tika ana, ka taea te whakaiti i te mōrearea o te mate mō te hunga whai HNPCC.

Me pēhea taku mōhio mēnā kei te tūpono ahau ki te whakawhanake i te HNPCC?

Mena ka whakaūtia e te whakamātautau ira he whakarerekētanga ira tōu e pā ana ki te mate Lynch, ka tūtohu pea tō tākuta kia tīmata te tirotiro i te mate pukupuku koroni i roto i ō tau 20. Mena ka kitea wawe te mate pukupuku, ka nui ake te tūponotanga ka angitu te maimoatanga.

Mena kei a au te HNPCC, he aha atu ngā mea hei tumanako māku?

Mena kei a koe te HNPCC, tera pea ka nui ake tō tūponotanga ki te whakawhanake i ētahi atu mate pukupuku e pā ana ki te HNPCC. Nō reira, ka tirotirohia pea koe e tō tākuta mō ēnei momo mate pukupuku:

• Matepukupuku roro
• Matepukupuku whatukuhu
• Matepukupuku ate
• Matepukupuku ovarian
• Matepukupuku puku
• Matepukupuku kiri
• Matepukupuku kōpū/Endometrial

Ka taea te rongoā i te HNPCC?

Kāore e taea te whakaora katoa i te mate Lynch nā te mea he mate ira. Heoi, mā te pokanga hei tango i te koroni katoa (total colectomy) ka taea te rongoā i te HNPCC me te ārai i te whanaketanga o te mate pukupuku koroni .

He aha te āhua o te mate mō te hunga whai HNPCC?

Tata ki te 60% o te hunga kua tāpaetia he HNPCC kei te ora tonu i muri i ngā tau e rima . Ko te tikanga, e 60 i roto i te 100 o ngā tūroro kei te ora tonu i ngā tau e rima i muri i tā rātou tāpaetanga HNPCC. Ko te reiti oranga 10-tau mō te hunga e pāngia ana e te mate Lynch kei waenga i te 70% me te 88%. Tērā pea he āhua whakamataku ēnei tatauranga, engari kia mahara mā te kitenga wawe me te maimoatanga tika, ka taea te whakahaere i tēnei āhuatanga .

Me pēhea taku tiaki i ahau anō mēnā kei a au te HNPCC?

Mena kei a koe ētahi tohu hou o te matepukupuku koroni, me kōrero tonu atu ki tō tākuta . Hei āwhina i te ārai i te matepukupuku koroni, ka taea e koe te mahi i ēnei mea:

• Kaua e kai hikareti.
• Kai i tētahi kai hauora.
• Whakakorikori tinana i ia wā, i ia wā.
• Me whai i ngā whakamātautau mate pukupuku katoa i tūtohutia e tō tākuta.
• Whakawhāitihia te inu waipiro.
• Kia mau tonu te taumaha hauora.

Kei te mōrearea taku tamaiti ki te pāngia e te HNPCC?

Mena kei a koe te mate Lynch syndrome, e 50% te tūponotanga o tāu tamaiti ki te whiwhi i te whakarerekētanga ira e hua ai taua whakarerekētanga. Ko te tikanga tēnei, ki te rua āu tamariki, ka riro pea i tētahi te ira, engari kāore pea i tētahi. Mena ka riro mai taua whakarerekētanga ira, ka nui ake te tūponotanga o taua tamaiti ki te pāngia e te HNPCC.

He rite tonu ngā matepukupuku kōpiro FAP me te HNPCC?

He mate pukupuku koroni ira te HNPCC me te FAP (Familial Adenomatous Polyposis) , engari he rerekē ngā ira e puta ai.

He maha ngā polyp e puta mai ana i roto i te koroni o te hunga whai FAP. I ētahi wā he mano tini o ēnei tipu ririki e kiia nei ko ngā polyp. Heoi, kāore e maha ngā polyp e puta mai ana i te hunga whai HNPCC, ā, i ētahi wā ka taea e te mate pukupuku te puta mai me te kore he polyp. Ko ngā polyp e puta mai ana i roto i te HNPCC he papatahi noa iho.

Ko ngā polyp e tupu ana i roto i ēnei āhuatanga e rua e kiia ana he mate pukupuku o mua , arā, ka taea e rātou te huri hei mate pukupuku i roto i te wā poto.

Ko ngā mea tino nui hei maumahara mā tātou i tēnei pūrākau ko

Ko te HNPCC (Hereditary Nonpolyposis Colorectal Cancer) he momo mate pukupuku colorectal i puta mai i tētahi hapa ira ka tukuna iho i roto i ngā whakatipuranga. E pā ana hoki ki te mate Lynch.

• Mena he hītori whānau tō te mate pukupuku, he mea tino nui kia kōrero koe ki tō tākuta mō tēnei.
• Ahakoa kāore he tohu, ki te mea kei roto koe i te mōrearea , me tirotiro tonu koe.
• Ki te kitea wawe, he nui ake te tūponotanga ka angitu te maimoatanga.
• Ehara te HNPCC i te mate hopuhopu, engari ka taea te tuku iho i ngā ira.
• He mea tino nui te whai i ngā tohutohu hauora me te whai i ngā tohutohu a te taote.

Mena he pātai anō āu mō tēnei, kaua e wehi ki te pātai atu ki tō tākuta. Mā rātou koe e āwhina.

` HNPCC, te mate Lynch, te mate pukupuku koroni, te mate pukupuku koroni, te mate pukupuku repe, ngā whakarerekētanga ira, te mate pukupuku tuku iho, te tirotiro mate pukupuku, te koroni, te pokanga, te chemotherapy, te immunotherapy