Kua rongo koe i te Lynch Syndrome? Tērā pea he ingoa hou tēnei ki a koe. Engari he mate ira tēnei e tukuna iho ana i ia whakatipuranga, e whakanui ana i te tūponotanga o te mate pukupuku. Ka whakanui ake tēnei i te tūponotanga o te mate pukupuku, inā koa i mua i te 50 tau te pakeke. He mea noa te mataku ina rongo koe i ngā kupu "tērā pea ka pāngia koe e te mate pukupuku". Engari ko te mea nui ko te mōhio ki ēnei mate. Nō reira, i tēnei rā ka kōrerohia e tātou tēnei mea kia māmā noa iho, kia mārama ai koe.
He aha te Lynch Syndrome?
Whakaarohia he rite tō tātou tinana ki tētahi mīhini uaua e mahi ana i runga i tētahi pukapuka tohutohu nui (DNA). He rite ō tātou ira ki ngā reta i roto i tēnei pukapuka tohutohu. I ētahi wā, he hapa kei roto i tēnei pukapuka tohutohu, arā, ngā 'hapa pato'. I roto i te rongoā, ka kiia tēnei ko ngā whakarerekētanga ira.
Ko te mate Lynch he mate i puta mai i te whakarerekētanga ira. He momo ira motuhake tō roto i tō tātou tinana e kite ana, e whakatika ana hoki i ngā hapa o roto i tō tātou DNA. Ka kiia tēnei ko te ira "mismatch repair (MMR)". He rite ki tētahi "rōpū whakatika" i roto i tō tātou tinana. He hapa kei roto i tētahi o ngā ira o roto i tēnei "rōpū whakatika" o tētahi tangata whai mate Lynch. Nō reira, kāore e whakatikahia tika ngā hapa o roto i te DNA. Ka kohikohi ngā pūtau me ēnei hapa, ā, i roto i te wā, ka nui ake te tūponotanga ka noho hei matepukupuku.
Ka pā tēnei mate ki te tangata katoa. Nā te mea he mate ira. I ētahi wā ka taea e koe te tuku iho i tēnei ira hapa mai i tō whaea, i tō pāpā rānei. He tino onge te puta o tēnei whakarerekētanga ira i roto i te tinana o tētahi tangata hou, engari kāore he tangata o te whānau. Ki te tirohia ngā tatauranga i tētahi whenua pērā i Amerika, e kiia ana tata ki te kotahi i roto i te 279 tāngata kua pāngia e tēnei mate.
He aha ngā tohu ka pā ki te tangata whai Lynch syndrome?
Ko te mea nui kia mōhiotia i konei, kāore he tohu motuhake o te mate Lynch syndrome. Engari, he tohu ia nō ngā mate pukupuku e puta mai ana i te mate. Ko te mea tino noa ko te mate pukupuku colorectal.
Nā, anei ētahi tohu noa e pā ana ki te mate pukupuku koroni:
| Tohu | Whakaahuatanga |
|---|---|
| Te toto i roto i te tūtae | Tērā pea he whero, he mangu pouri rānei te tūtae, ā, he toto kei roto. |
| Mamae puku, whakapairuaki rānei | Te mamae pinepine o te puku, te koretake rānei. |
| Te huringa o ngā tikanga puku | Te tīmatanga ohorere o te mate pāwera, te mate korere rānei, te kikokore rānei o ngā tūtae i te tikanga. |
| Ngenge auau | Te ngenge tonu ahakoa te okiokinga pai. |
| Te pupuhi, te pupuhi rānei | Te mākona, te pupuhi rānei ahakoa i muri i te kai iti. |
| Whakapairuaki, ruaki rānei | Whakapairuaki, ruaki rānei, kāore he take e kitea ana. |
Ko te mea nui, kāore e pāngia te katoa e ēnei tohu. I ētahi wā, kāore pea te mate pukupuku e whakaatu i tētahi tohu tae noa ki tōna whanaketanga nui. Nō reira, ki te mau tonu tētahi, ētahi rānei o ēnei tohu ki a koe, me toro atu ki tō tākuta mō ētahi tohutohu.
He aha ngā momo mate pukupuku ka puta mai i tēnei mate?
Ehara te mate Lynch i te mate e whakatuwhera ana i te kuaha ki te momo mate pukupuku kotahi anake. Ka whakanui ake i te mōrearea o te whakawhanake i te mate pukupuku i roto i ngā wāhanga rerekē o te tinana. Ka rerekē pea ngā okana e mōrearea ana i runga i te ira hapa. Ko 'MLHL', 'MSH2', 'MSH6', 'PMS2' me 'EPCAM' ngā ira matua e rima e whai wāhi ana.
Kei raro nei ētahi momo mate pukupuku ka piki ake te mōrearea o te mate Lynch syndrome.
| Momo mate pukupuku | Te wāhanga tinana e pā ana |
|---|---|
| Te mate pukupuku o te koroni me te rectum | Pūnaha nakunaku |
| Matepukupuku kōpū/Endometrial | Pūnaha whakaputa uri wahine |
| Matepukupuku ovarian | Pūnaha whakaputa uri wahine |
| Matepukupuku puku | Pūnaha nakunaku |
| Matepukupuku whekau iti | Pūnaha nakunaku |
| Matepukupuku repeure | Pūnaha nakunaku |
| Te mate pukupuku o te ara mimi o runga | Pūnaha mimi |
| Matepukupuku roro | Pūnaha io |
| Matepukupuku kiri | Kiri |
He rerekē ngā mate pukupuku koroni e puta mai ana i te mate Lynch. He tere ake te tipu i ngā mate pukupuku e tupu noa ana.Ahakoa e 10 tau te roa ka huri te polyp iti o te tangata noa hei mate pukupuku, kotahi, e rua rānei tau te roa mō te tangata e pāngia ana e te mate Lynch.
Nā tēnei āhuatanga anō hoki, he nui ake te tūponotanga o te tangata kua pāngia e te mate pukupuku koroni, ā, kua ora, ki te pāngia anō e te momo mate pukupuku taua.
Whakaarohia, e 15% te mōrearea o te whanaketanga anō o te mate pukupuku i roto i ngā tau 10 i muri i te tangohanga o te mate pukupuku tuatahi mā te pokanga. Ka piki ake pea tēnei mōrearea ki te 40% i muri i ngā tau 20, ā, ki te 60% i muri i ngā tau 30. E whakaatu ana tēnei i te hiranga o te tirotiro auau.
Me pēhea te tuku iho i tēnei i roto i ngā whakatipuranga?
Ko te mate Lynch he mate e tukuna iho ana i tētahi whakatipuranga ki tētahi whakatipuranga i runga i te tikanga "autosomal dominant". Ko te tikanga o tēnei ahakoa kotahi anake te mātua , te whaea, te pāpā rānei, kei a ia te ira hapa, e 50% te tūponotanga ka riro i te tamaiti. Ko te tikanga o tēnei, e 50% te tūponotanga ka riro i ia tamaiti, ā, e 50% te tūponotanga kāore e riro i a ia.
Nō reira, ki te mea kua tāpaetia koe, tētahi rānei o tō whānau ki te mate Lynch, he mea tino nui kia whakamōhiotia te toenga o tō whānau. Me whakamōhio atu ki ō tuākana, tuākana rānei, ki ō tamariki, me ō mātua mō tēnei mōrearea. Mā te tuku i a rātou ki te whakamātautau ira me te tohutohu ira ka ora pea rātou.
Me pēhea taku mōhio mēnā kei a au tēnei mate? He aha ngā whakamātautau me mahi e au?
Ko te huarahi pai ki te whakaū mēnā kei a koe te mate Lynch ko te whakamātautau ira . Ko te tikanga, ko te tango toto. Ka tangohia rānei he ūkui i roto i tō waha mai i te waha. Ka taea e tēnei whakamātautau te kite tika mēnā he whakarerekētanga ira kei roto i ngā ira i kōrerohia e tātou i mua ake nei, pērā i te MLHL me te MSH2.
Mena kua tāpaetia koe kei te mate Lynch syndrome, ko te mea nui e whai ake nei ko te tirotiro i ia wā kia kitea wawe ai te mate pukupuku. Ka whakawhanakehia e tō tākuta he kaupapa tirotiro e tika ana māu.
| Whakamātautau | Me pēhea te mahi me te wā e taunakitia ana |
|---|---|
| Te tirotiro koroni | He tikanga te colonoscopy e whakaurua ai he ngongo angiangi me te kāmera mā roto i te nono hei tirotiro i te koroni. E taunakihia ana kia mahia i ia tau, i ia rua rānei tau . |
| Te Whakamātautau Ultrasound Transvaginal | Mō ngā wāhine, e taunakihia ana kia tirotirohia te hope, arā, kia whakauruhia he taputapu matawai mā roto i te tenetene me te tirotiro i te kōpū me ngā ovaries, i ia tau, i ia rua rānei tau . |
| Te tātaritanga mimi | Whiwhi māramatanga taketake mō ngā mate pukupuku e pā ana ki te whatukuhu mā te whakamātautau i tētahi tauira mimi. He mea tika kia mahia tēnei i ia tau . |
| Endoscopy o Runga | He ngongo me te kāmera e whakaurua ana mā te waha hei tirotiro i te puku me te wāhanga o runga o te whekau iti. E taunakihia ana i ia 3-5 tau . |
| Te koiora | Mena ka kitea he kiko whakapae, he pukupuku rānei i te wā o te whakamātautau i runga ake nei, ka tangohia he tauira iti ka whakamatautauria mō ngā pūtau matepukupuku. |
Me pēhea te rongoā mō te mate Lynch?
Kāore anō kia kitea he rongoā mō te mate ira Lynch syndrome i tēnei wā. Nō reira, ko te arotahi matua o te maimoatanga ko te kimi me te tango pokanga i ngā pūtau matepukupuku mai i te tinana. Mena ka taea te kimi me te tango i te matepukupuku i mua i te horapa ki ētahi atu wāhanga o te tinana, ka tino angitu ngā hua.
Me whai rōpū tākuta maha-mātauranga tēnei. Hei tauira, ka mahi tahi ngā tākuta puku, ngā taote pokanga, ngā tākuta matepukupuku wahine, me ngā tākuta matepukupuku ki te rongoā i tēnei mate.
Ko ētahi tāngata, inā koa ko ngā wāhine kua oti ā rātou whānau, ka whiriwhiri kia tangohia te kōpū, kia tangohia rānei te kōpū i mua i te whanaketanga o tētahi mate hei whakaiti i te tūponotanga o te mate pukupuku kōpū, te mate pukupuku whēkau rānei ā muri ake nei. Waihoki, ko te hunga he nui te tūponotanga o te mate pukupuku koroni ka whiriwhiri pea kia tangohia te kōpū. He whakatau whaiaro ēnei, ā, me mahi i muri i te kōrero roa ki tō tākuta.
He rite tonu te Lynch syndrome me te HNPCC?
Tērā pea kua rongo koe i te ingoa 'HNPCC (Hereditary Non-Polyposis Colorectal Cancer)'. He maha ngā wā ka whakamahia ngātahitia te Lynch syndrome me te HNPCC, engari he rerekētanga hangarau paku noa iho i waenganui i ngā mea e rua.
I te whakarapopototanga, ko te ingoa HNPCC e whakamahia ana i runga i te hītori whānau. Arā, ki te mea he maha ngā mema o te whānau kua pāngia e tēnei momo mate pukupuku, ka kiia he HNPCC tō taua whānau. Engari ko te Lynch syndrome te ingoa i hoatu i muri i te tautuhi i te whakarerekētanga ira motuhake e puta ai. Nō reira, ka taea e ngā mema katoa o te whānau me te HNPCC te pāngia e te whakarerekētanga ira o te Lynch syndrome. Waihoki, ko te tangata e pāngia ana e te whakarerekētanga ira hou me te kore he tangata kē atu i roto i te whānau, ka taea hoki te kī he Lynch syndrome tōna.
Kāore he tangata e pai ki te whakarongo ki ngā kupu, "He mate pukupuku tōu." Tērā pea ka rongo te tangata whai mate Lynch i aua kupu i tētahi wā o tōna oranga. Engari ehara i te mutunga o te ao. Ki te mōhio koe ki tō āhua, ki te mahi tahi me tō tākuta, me te tirotiro i te mate pukupuku i ia wā, ka taea te kite me te whakaora i tētahi mate pukupuku i tōna wā tōmua. Ko te kite wawe me te maimoatanga te huarahi pai ki te ora hauora, harikoa.
Karere Tangohia ki te Kāinga
- Ko te mate Lynch he mate ira e tukuna iho ana i tetahi whakatipuranga ki tetahi whakatipuranga, ā, ka nui ake te mōrearea ki te pāngia e te mate pukupuku.
- Ahakoa kotahi anake te mātua kei a ia tēnei ira hapa, e 50% te tūponotanga ka riro mai i te tamaiti tēnei ira.
- Mena kua tāpaetia koe, tētahi rānei o tō whānau kua pāngia e tēnei mate, he mea tino nui kia whakamōhiotia atu koe ki ētahi atu mema o te whānau tata.
- Ahakoa kāore e taea te rongoā i tēnei mate ira, ko te huarahi pai ki te ārai, ki te kite wawe rānei i te mate pukupuku ko te whai i ngā tirotiro hauora auau.
- Mā te kitenga wawe me te rongoā i te mate pukupuku ka puta he hua tino angitu, ā, ka taea hoki e koe te ora i te oranga hauora.
- Me kōrero tonu ki tō tākuta hei whakarite i tētahi wā whakamātautau e tika ana māu, hei whakatika hoki i ō āwangawanga.
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