Tiyeni tiphunzire za mankhwala apadera awa a kuthamanga kwa magazi ndi mtima? (Otsutsa Aldosterone)

Kodi muli ndi kuthamanga kwa magazi, kapena zomwe tonse timazidziwa kuti 'kupanikizika'? Kapena muli ndi madzi osungira komanso miyendo yotupa chifukwa cha matenda monga matenda a mtima? Ndiye dokotala wanu mwina anakupatsani mankhwala apadera. Umenewo ndi mtundu wa mankhwala omwe tikambirane m'nkhaniyi lero, mosavuta komanso mwaulemu. Awa timawatcha Aldosterone Antagonists.

Mwachidule, kodi Aldosterone Antagonists awa ndi chiyani?

Chabwino, tiyeni timvetse izi motere. Tili ndi ziwalo ziwiri zazing'ono m'thupi lathu zotchedwa adrenal glands. Izi zimapanga mahomoni otchedwa aldosterone. Ntchito yayikulu ya mahomoni awa ndikulamulira kuthamanga kwa magazi mwa kusunga mchere ndi madzi m'thupi pakafunika kutero. Izi si vuto kwa munthu wabwinobwino.

Koma taganizirani, ngati wina ali kale ndi kuthamanga kwa magazi, kapena ngati ali ndi madzi ambiri m'thupi mwake chifukwa cha matenda a mtima, aldosterone iyi imangowonjezera vutoli.

Apa ndi pomwe gulu la mankhwala otchedwa Aldosterone Antagonists amatithandiza. Mankhwalawa amagwira ntchito poletsa ntchito ya aldosterone hormone (antagonist amatanthauza kugwira ntchito motsutsana nayo). Ndicho chifukwa chake gulu la mankhwala amenewa limatchedwanso 'potassium-sparing diuretics'.

Kodi mitundu ikuluikulu ya mankhwala m'gulu lino ndi iti?

Pali mitundu ingapo ya mankhwala a Aldosterone Antagonist omwe nthawi zambiri amaperekedwa ndi madokotala. Mwina mwawonapo mayina awa.

Kodi mankhwalawa amagwira ntchito bwanji m'thupi?

Ndi zophweka kwambiri. Mukatenga mankhwala a Aldosterone Antagonist, amatseka ma receptors omwe amalola aldosterone hormone kumangirira ku maselo m'thupi. Ndiye chimachitika ndi chiyani?

Homoni ya aldosterone singathe kusunga mchere ndi madzi m'thupi. Chifukwa chake, impso zathu zimayamba kutulutsa mchere ndi madzi ochulukirapo kudzera mu mkodzo. Chinthu chapadera pa izi ndichakuti pamene imatulutsa mchere ndi madzi otere, imateteza thupi kuti lisataye potaziyamu wofunikira.

Kodi ndi zinthu ziti zazikulu zomwe Aldosterone Antagonists amagwiritsa ntchito?

Madokotala amalimbikitsa mtundu uwu wa mankhwala ngati mankhwala osati matenda amodzi okha, komanso matenda angapo.

• Kulephera kwa Mtima: Mtima ukakhala wofooka, madzi amasonkhana m'thupi (edema) ndipo amachititsa kutupa m'miyendo ndi m'mapapo. Mankhwalawa amathandiza kuchotsa madzi ochulukirapo ndikuchepetsa kupsinjika kwa mtima.
• Kuthamanga kwa Magazi: Mankhwalawa amathandiza kuchepetsa kuthamanga kwa magazi komwe kumakhala kovuta kulamulira ndi mankhwala ena.
• Matenda a Impso Osatha: Izi zimagwiritsidwa ntchito pochiza matenda a impso, makamaka omwe amabwera ndi matenda a shuga.
• Hyperaldosteronism: Iyi ndi vuto lomwe thupi limapanga mahomoni ambiri a aldosterone. Mankhwalawa ndi ofunikira pochiza vutoli.
• Kutupa komwe kumachitika chifukwa cha matenda a chiwindi: Izi zimaperekedwanso kuti zithetse kusungidwa kwa madzi m'thupi chifukwa cha matenda a chiwindi.
• Kuchepa kwa potaziyamu m'magazi: Mankhwalawa amaperekedwanso pa vutoli chifukwa amathandiza kuti potaziyamu akhalebe m'thupi.
• Ziphuphu: Madokotala ena a khungu amalimbikitsanso Spironolactone pa ziphuphu chifukwa imayang'anira ntchito ya mahomoni ena.

Ubwino ndi zotsatirapo zake zomwe zingachitike chifukwa cha mankhwalawa

Monga mankhwala ena aliwonse, izi zitha kukhala ndi ubwino komanso zotsatirapo zina.

Ubwino waukulu

• Amawonjezera nthawi ya moyo wa odwala matenda a mtima.
• Ali ndi mphamvu zambiri zochitira masewera olimbitsa thupi komanso kuchita ntchito za tsiku ndi tsiku.
• Amachepetsa kufunika kogonekedwa m'chipatala.
• Amachepetsa kwambiri chiopsezo cha imfa yadzidzidzi yokhudzana ndi matenda a mtima.

Zotsatirapo zomwe zingatheke

Mukamamwa mankhwalawa, mutha kukodza pafupipafupi kuposa masiku onse chifukwa ndi mankhwala ochepetsa mphamvu ya madzi m'thupi. Izi ndi zachilendo. Kuphatikiza apo, zinthu zina zimatha kuchitika.

• Chifuwa
• Chizungulire (vertigo)
• Mutu (kupweteka mutu)
• Kutsegula m'mimba
• Kuchuluka kwa potaziyamu m'magazi: Ichi ndiye chinthu chachikulu chomwe muyenera kuda nkhawa nacho. Chiwopsezochi chimakhala chachikulu makamaka kwa anthu omwe ali ndi matenda a impso. Chifukwa chake, dokotala nthawi zonse amafufuza kuchuluka kwa potaziyamu m'magazi mwa kuyezetsa magazi.

Zotsatira zoyipa za Spironolactone

Popeza mankhwala a Spironolactone amalumikizana pang'ono ndi mahomoni ena m'thupi (androgen ndi progesterone), anthu ena angakumane ndi zotsatirazi:

• Kukula kwa mabere (Gynecomastia) mwa amuna ndi akazi.
• Kulephera kugonana mwa amuna (Mavuto a kukoka kwa chiberekero).
• Kutuluka magazi kumaliseche pambuyo pa kusamba.

Pazifukwa izi, anthu ena angafune kusintha kugwiritsa ntchito Eplerenone. Koma kumbukirani kuti dokotala wanu yekha ndi amene angasankhe mankhwala oyenera kwa inu .

Nthawi yoti mulankhule ndi dokotala wanu

Ngati mukukumana ndi zotsatirapo zilizonse mukumwa mankhwalawa, musasiye kumwa nokha. Lankhulani ndi dokotala nthawi yomweyo. Iye akhoza kusintha mlingo kapena kukusinthani ku mankhwala ena.

Komanso, ngati zizindikiro zanu sizikuchepa mutagwiritsa ntchito mankhwalawa kwa milungu ingapo, dziwitsani dokotala wanu za zimenezo.

Komanso, ngati mukumwa mankhwalawa, onetsetsani kuti mwafunsa dokotala musanamwe madzi a mphesa kapena kugwiritsa ntchito njira zina zamchere, chifukwa zina mwa izi zitha kukhala ndi potaziyamu.